chlorambucil has been researched along with Acute Disease in 44 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Acute Disease: Disease having a short and relatively severe course.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixty-seven patients with acute nonlymphoblastic leukemia (ANLL) and above the age of 60 years were randomly allocated to treatment with either prednimustine + vincristine or cycles with cytosine arabinoside and thioguanine." | 9.05 | Prednimustine and vincristine compared with cytosine arabinoside and thioguanine for treatment of elderly patients with acute nonlymphoblastic leukemia. ( Andersson, B; Björkholm, M; Engstedt, L; Gahrton, G; Hast, R; Holm, G; Killander, A; Lantz, B; Lockner, D; Lönnqvist, B; Mellstedt, H; Oberg, G; Palmblad, J; Paul, C; Peterson, C; Simonsson, B; Stalfelt, AM; Udén, AM; Wadman, B, 1982) |
| "In polycythemia vera (PV), treatment with chlorambucil and radioactive phosphorus (p32) increases the risk of leukemic transformation from 1% to 13-14%." | 7.69 | Leukemogenic risk of hydroxyurea therapy in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. ( Fisher, SG; Godwin, J; Nand, S; Stock, W, 1996) |
| "Chlorambucil is useful in patients with rheumatoid arthritis (RA) refractory to other agents but there is concern about the risk of haematological malignancy with this agent." | 7.67 | The oncogenicity of chlorambucil in rheumatoid arthritis. ( Browne, CD; Champion, GD; Cohen, ML; Day, RO; Graham, S; Patapanian, H; Sambrook, PN, 1988) |
| "Prednimustine, an ester of chlorambucil and prednisolone, was evaluated for efficacy and toxicity in a selected group of leukemia patients with a poor prognosis." | 7.66 | A phase II study of prednimustine in acute non-lymphocytic leukemia, smouldering leukemia, and refractory anemia with excess blasts. ( Carter, SK; Gandara, DR; George, CB; Koretz, MM; Lewis, JP; Ries, CA; Schiff, SA, 1982) |
| "The results of a five-year study of chlorambucil in patients suffering from rheumatoid arthritis are presented." | 7.65 | Rheumatoid arthritis treated with chlorambucil: a five-year follow-up. ( Thorpe, P, 1976) |
| "In studies to determine the optimal treatment for polycythemia vera, 431 previously untreated patients whose disease met established diagnostic criteria were entered into a prospective, randomized controlled trial between 1967 and 1974." | 6.65 | Increased incidence of acute leukemia in polycythemia vera associated with chlorambucil therapy. ( Berk, PD; Donovan, PB; Ellis, JT; Goldberg, JD; Landaw, SA; Laszlo, J; Najean, Y; Pisciotta, AV; Silverstein, MN; Wasserman, LR; Weinfeld, A, 1981) |
| "Sixty-seven patients with acute nonlymphoblastic leukemia (ANLL) and above the age of 60 years were randomly allocated to treatment with either prednimustine + vincristine or cycles with cytosine arabinoside and thioguanine." | 5.05 | Prednimustine and vincristine compared with cytosine arabinoside and thioguanine for treatment of elderly patients with acute nonlymphoblastic leukemia. ( Andersson, B; Björkholm, M; Engstedt, L; Gahrton, G; Hast, R; Holm, G; Killander, A; Lantz, B; Lockner, D; Lönnqvist, B; Mellstedt, H; Oberg, G; Palmblad, J; Paul, C; Peterson, C; Simonsson, B; Stalfelt, AM; Udén, AM; Wadman, B, 1982) |
| " malariae infection that acutely reactivated after 45 y of latency following treatment with chlorambucil and methylprednisolone is reported." | 3.70 | Drug-induced acute malaria. ( Bassaris, H; Skoutelis, A; Symeonidis, A; Vassalou, E, 2000) |
| "In polycythemia vera (PV), treatment with chlorambucil and radioactive phosphorus (p32) increases the risk of leukemic transformation from 1% to 13-14%." | 3.69 | Leukemogenic risk of hydroxyurea therapy in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. ( Fisher, SG; Godwin, J; Nand, S; Stock, W, 1996) |
| " Although multi-drug therapy is known to produce myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) in patients with CTD, treatment with single-agent therapy, particularly methotrexate, has rarely been associated with secondary MDS or AML." | 3.69 | Myelodysplastic syndromes and acute myeloid leukemia in connective tissue disease after single-agent chemotherapy. ( Farhi, DC; Rosenthal, NS, 1996) |
| "Chlorambucil is useful in patients with rheumatoid arthritis (RA) refractory to other agents but there is concern about the risk of haematological malignancy with this agent." | 3.67 | The oncogenicity of chlorambucil in rheumatoid arthritis. ( Browne, CD; Champion, GD; Cohen, ML; Day, RO; Graham, S; Patapanian, H; Sambrook, PN, 1988) |
| "Prednimustine, an ester of chlorambucil and prednisolone, was evaluated for efficacy and toxicity in a selected group of leukemia patients with a poor prognosis." | 3.66 | A phase II study of prednimustine in acute non-lymphocytic leukemia, smouldering leukemia, and refractory anemia with excess blasts. ( Carter, SK; Gandara, DR; George, CB; Koretz, MM; Lewis, JP; Ries, CA; Schiff, SA, 1982) |
| "The results of a five-year study of chlorambucil in patients suffering from rheumatoid arthritis are presented." | 3.65 | Rheumatoid arthritis treated with chlorambucil: a five-year follow-up. ( Thorpe, P, 1976) |
| "Two cases of advanced ovarian carcinoma treated with chlorambucil and terminating in acute leukemia are presented and the literature reviewed." | 3.65 | Acute leukemia in advanced ovarian carcinoma after treatment with alkylating agents. ( Jafari, K; Lash, AF; Sotrel, G; Stepto, RC, 1976) |
| "Patients with chronic lymphocytic leukemia (CLL) may have disease transformation to non-Hodgkin's lymphoma or prolymphocytic leukemia; however, development of therapy-related acute myeloid leukemia (t-AML) is unusual." | 2.70 | Therapy-related myeloid leukemias are observed in patients with chronic lymphocytic leukemia after treatment with fludarabine and chlorambucil: results of an intergroup study, cancer and leukemia group B 9011. ( Appelbaum, FR; Elias, L; Hines, JD; Kolitz, JE; Larson, RA; Morrison, VA; Peterson, BL; Rai, KR; Schiffer, CA; Shepherd, L, 2002) |
| "We evaluated the occurrence of acute nonlymphocytic leukemia (ANL) among 1399 women with ovarian cancer who were treated in five randomized clinical trials." | 2.65 | Acute nonlymphocytic leukemia after therapy with alkylating agents for ovarian cancer: a study of five randomized clinical trials. ( Blessing, JA; Boice, JD; Dembo, AJ; Greene, MH; Greer, BE, 1982) |
| "In studies to determine the optimal treatment for polycythemia vera, 431 previously untreated patients whose disease met established diagnostic criteria were entered into a prospective, randomized controlled trial between 1967 and 1974." | 2.65 | Increased incidence of acute leukemia in polycythemia vera associated with chlorambucil therapy. ( Berk, PD; Donovan, PB; Ellis, JT; Goldberg, JD; Landaw, SA; Laszlo, J; Najean, Y; Pisciotta, AV; Silverstein, MN; Wasserman, LR; Weinfeld, A, 1981) |
| "acute lymphoblastic leukemia-type chemotherapy that incorporated high-dose cytarabine was effective in achieving an minimal residual disease-negativity rate of 69% in evaluated patients, which was also predictive of better outcome." | 1.56 | Clinicoepidemiologic Profile and Outcome Predicted by Minimal Residual Disease in Children With Mixed-phenotype Acute Leukemia Treated on a Modified MCP-841 Protocol at a Tertiary Cancer Institute in India. ( Banavali, S; Gujral, S; Myint, HH; Narula, G; Patkar, N; Prasad, M; Subramanian, P; Tandon, S; Tembhare, P, 2020) |
| "Hodgkin's disease is curable in the majority of patients, although a proportion of patients are resistant to or relapse after initial therapy." | 1.30 | High-dose BEAM chemotherapy with autologous haemopoietic stem cell transplantation for Hodgkin's disease is unlikely to be associated with a major increased risk of secondary MDS/AML. ( Devereux, S; Goldstone, AH; Gregory, W; Hancock, B; Harrison, CN; Hoskin, P; Hudson, GV; Linch, DC; MacMillan, AK; Milligan, D; Newland, AC; Winfield, D, 1999) |
| "Of 602 patients treated for non-Hodgkin's lymphomas, 9 developed overt acute nonlymphocytic leukemia or preleukemia with refractory cytopenia and cytogenetic abnormalities of the bone marrow." | 1.27 | Risk of acute nonlymphocytic leukemia and preleukemia in patients treated with cyclophosphamide for non-Hodgkin's lymphomas. Comparison with results obtained in patients treated for Hodgkin's disease and ovarian carcinoma with other alkylating agents. ( Ersbøll, J; Keiding, N; Larsen, MS; Larsen, SO; Nissen, NI; Pedersen-Bjergaard, J; Philip, P; Schultz, H; Sørensen, HM, 1985) |
| "Thirteen cases of acute nonlymphocytic leukemia occurred among 5455 patients, as compared to 0." | 1.26 | Acute leukemia after alkylating-agent therapy of ovarian cancer. ( Fraumeni, JF; Hoover, R; Reimer, RR; Young, RC, 1977) |
| " Although hematologic malignancies have been known to develop consequent to long-term use of alkylating agents, and bone marrow suppression is well known, acute myelofibrosis has not, to our knowledge, been reported as a complication of this therapy, nor has any specific myeloproliferative syndrome been described consequent to such therapy in a patient with PSS." | 1.26 | Acute myelofibrosis in progressive systemic sclerosis. Report of a case developing during long term chlorambucil therapy and discussion of pathogenetic factors. ( Chung, KB; Gisser, SD, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (61.36) | 18.7374 |
| 1990's | 8 (18.18) | 18.2507 |
| 2000's | 8 (18.18) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (2.27) | 2.80 |
| Authors | Studies |
|---|---|
| Myint, HH | 1 |
| Tandon, S | 1 |
| Narula, G | 1 |
| Prasad, M | 1 |
| Subramanian, P | 1 |
| Patkar, N | 1 |
| Tembhare, P | 1 |
| Gujral, S | 1 |
| Banavali, S | 1 |
| Mahajan, A | 1 |
| Nirmal, S | 1 |
| English, MW | 1 |
| Jenney, ME | 1 |
| Lazda, ED | 1 |
| Morrison, VA | 1 |
| Rai, KR | 1 |
| Peterson, BL | 1 |
| Kolitz, JE | 1 |
| Elias, L | 1 |
| Appelbaum, FR | 1 |
| Hines, JD | 1 |
| Shepherd, L | 1 |
| Larson, RA | 1 |
| Schiffer, CA | 1 |
| Metayer, C | 1 |
| Curtis, RE | 1 |
| Vose, J | 1 |
| Sobocinski, KA | 1 |
| Horowitz, MM | 1 |
| Bhatia, S | 1 |
| Fay, JW | 1 |
| Freytes, CO | 1 |
| Goldstein, SC | 1 |
| Herzig, RH | 1 |
| Keating, A | 1 |
| Miller, CB | 1 |
| Nevill, TJ | 1 |
| Pecora, AL | 1 |
| Rizzo, JD | 1 |
| Williams, SF | 1 |
| Li, CY | 1 |
| Travis, LB | 1 |
| Weisdorf, DJ | 1 |
| Yen, CJ | 1 |
| Huang, WT | 1 |
| Huang, JJ | 1 |
| Chen, FF | 1 |
| Sung, JM | 1 |
| Balakrishnan, C | 1 |
| Pathan, E | 1 |
| Khodaiji, S | 1 |
| Dasgupta, A | 1 |
| Mangat, G | 1 |
| Joshi, VR | 1 |
| Shanks, RH | 1 |
| Rizzieri, DA | 1 |
| Flowers, JL | 1 |
| Colvin, OM | 1 |
| Adams, DJ | 1 |
| Greene, MH | 1 |
| Boice, JD | 1 |
| Greer, BE | 1 |
| Blessing, JA | 1 |
| Dembo, AJ | 1 |
| Ayulo, MA | 1 |
| Preisler, HD | 1 |
| Berk, PD | 2 |
| Goldberg, JD | 2 |
| Silverstein, MN | 1 |
| Weinfeld, A | 1 |
| Donovan, PB | 2 |
| Ellis, JT | 2 |
| Landaw, SA | 2 |
| Laszlo, J | 1 |
| Najean, Y | 1 |
| Pisciotta, AV | 1 |
| Wasserman, LR | 3 |
| Gandara, DR | 1 |
| Ries, CA | 1 |
| Schiff, SA | 1 |
| George, CB | 1 |
| Lewis, JP | 1 |
| Koretz, MM | 1 |
| Carter, SK | 1 |
| Lönnqvist, B | 1 |
| Andersson, B | 1 |
| Björkholm, M | 1 |
| Engstedt, L | 1 |
| Gahrton, G | 1 |
| Hast, R | 1 |
| Holm, G | 1 |
| Killander, A | 1 |
| Lantz, B | 1 |
| Lockner, D | 1 |
| Mellstedt, H | 1 |
| Palmblad, J | 1 |
| Paul, C | 1 |
| Peterson, C | 1 |
| Simonsson, B | 1 |
| Stalfelt, AM | 1 |
| Udén, AM | 1 |
| Wadman, B | 1 |
| Oberg, G | 1 |
| Fitzgerald, RH | 1 |
| Wallace, KM | 1 |
| Baker, AS | 1 |
| Najman, A | 1 |
| Gorin, NC | 1 |
| Duhamel, G | 1 |
| Roger, M | 1 |
| Dry, J | 1 |
| Ho, WK | 1 |
| Robertson, MR | 1 |
| Macdonald, GJ | 1 |
| Charlesworth, JA | 1 |
| Pussell, BA | 1 |
| Nand, S | 1 |
| Stock, W | 1 |
| Godwin, J | 1 |
| Fisher, SG | 1 |
| Rosenthal, NS | 1 |
| Farhi, DC | 1 |
| Sánchez Fayos, J | 1 |
| Román Barbero, A | 1 |
| Nevado Reviriego, I | 1 |
| Drake, WM | 1 |
| Monson, JP | 1 |
| Trainer, PJ | 1 |
| Sharief, M | 1 |
| Dick, JP | 1 |
| Kelsey, SM | 1 |
| Harrison, CN | 1 |
| Gregory, W | 1 |
| Hudson, GV | 1 |
| Devereux, S | 1 |
| Goldstone, AH | 1 |
| Hancock, B | 1 |
| Winfield, D | 1 |
| MacMillan, AK | 1 |
| Hoskin, P | 1 |
| Newland, AC | 1 |
| Milligan, D | 1 |
| Linch, DC | 1 |
| Skoutelis, A | 1 |
| Symeonidis, A | 1 |
| Vassalou, E | 1 |
| Bassaris, H | 1 |
| Pichon, N | 1 |
| Debette-Gratien, M | 1 |
| Cessot, F | 1 |
| Paraf, F | 1 |
| Labrousse, F | 1 |
| Sautereau, D | 1 |
| Pillegand, B | 1 |
| Schütterle, G | 1 |
| Goubeaud, G | 1 |
| Hoffman, R | 1 |
| Reimer, RR | 1 |
| Hoover, R | 1 |
| Fraumeni, JF | 1 |
| Young, RC | 1 |
| Gisser, SD | 1 |
| Chung, KB | 1 |
| Buriot, D | 1 |
| Prieur, AM | 1 |
| Lebranchu, Y | 1 |
| Messerschmitt, J | 1 |
| Griscelli, C | 1 |
| Morrison, J | 1 |
| Yon, JL | 1 |
| Thorpe, P | 1 |
| Andrejak, M | 1 |
| Pocheville, M | 1 |
| Giudicelli, CP | 1 |
| Masbernard, A | 1 |
| Sotrel, G | 1 |
| Jafari, K | 1 |
| Lash, AF | 1 |
| Stepto, RC | 1 |
| Brandis, M | 1 |
| Krause, PH | 1 |
| Hünermund, G | 1 |
| Bahlmann, J | 1 |
| Avilés, A | 1 |
| Díaz-Maqueo, JC | 1 |
| Ayala, JR | 1 |
| Cortés, HD | 1 |
| García, EL | 1 |
| Cullis, JO | 1 |
| Hyde, RD | 1 |
| Patapanian, H | 1 |
| Graham, S | 1 |
| Sambrook, PN | 1 |
| Browne, CD | 1 |
| Champion, GD | 1 |
| Cohen, ML | 1 |
| Day, RO | 1 |
| Fruchtman, SM | 1 |
| Berlin, NI | 1 |
| Peterson, P | 1 |
| Geller, SA | 1 |
| Rappaport, H | 1 |
| Donham, JA | 1 |
| Denning, V | 1 |
| Pedersen-Bjergaard, J | 1 |
| Ersbøll, J | 1 |
| Sørensen, HM | 1 |
| Keiding, N | 1 |
| Larsen, SO | 1 |
| Philip, P | 1 |
| Larsen, MS | 1 |
| Schultz, H | 1 |
| Nissen, NI | 1 |
| Laroche, C | 1 |
| Caquet, R | 1 |
| Remy, JM | 1 |
| Faĭnshteĭn, FE | 1 |
| Lagrue, G | 1 |
| Bariety, J | 1 |
| Druet, P | 1 |
| Hirbec, G | 1 |
| Manassero, J | 1 |
| Vaillaud, JC | 1 |
| Paglia, R | 1 |
| Geneste, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicenter Phase 2 Study of Efficacy and Safety of Pegylated Interferon-alfa 2a in Polycythemia Vera Patients[NCT00241241] | Phase 2 | 40 participants | Interventional | 2004-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for chlorambucil and Acute Disease
| Article | Year |
|---|---|
[Efficacious treatment of a fatal blood disease: polycythemia vera].
Topics: Acute Disease; Alkylating Agents; Busulfan; Chlorambucil; Humans; Hydroxyurea; Leukemia, Myeloid; Le | 1997 |
Natural history and management of polycythemia vera.
Topics: Acute Disease; Adult; Antineoplastic Agents; Bloodletting; Cell Transformation, Neoplastic; Chloramb | 1979 |
[Clinical aspects of the problem of treating leukemias].
Topics: Acute Disease; Antineoplastic Agents; Chlorambucil; Chlorine; Chronic Disease; Daunorubicin; Dimetho | 1973 |
6 trials available for chlorambucil and Acute Disease
| Article | Year |
|---|---|
Therapy-related myeloid leukemias are observed in patients with chronic lymphocytic leukemia after treatment with fludarabine and chlorambucil: results of an intergroup study, cancer and leukemia group B 9011.
Topics: Acute Disease; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Chlorambuci | 2002 |
Acute nonlymphocytic leukemia after therapy with alkylating agents for ovarian cancer: a study of five randomized clinical trials.
Topics: Acute Disease; Adult; Aged; Alkylating Agents; Animals; Chlorambucil; Clinical Trials as Topic; Fema | 1982 |
Increased incidence of acute leukemia in polycythemia vera associated with chlorambucil therapy.
Topics: Acute Disease; Chlorambucil; Clinical Trials as Topic; Dose-Response Relationship, Drug; Humans; Leu | 1981 |
Prednimustine and vincristine compared with cytosine arabinoside and thioguanine for treatment of elderly patients with acute nonlymphoblastic leukemia.
Topics: Acute Disease; Aged; Blood Cell Count; Chlorambucil; Cytarabine; Drug Therapy, Combination; Female; | 1982 |
Therapeutic recommendations in polycythemia vera based on Polycythemia Vera Study Group protocols.
Topics: Acute Disease; Age Factors; Bloodletting; Chlorambucil; Combined Modality Therapy; False Positive Re | 1986 |
Studies of the bone marrow in polycythemia vera and the evolution of myelofibrosis and second hematologic malignancies.
Topics: Acute Disease; Aged; Bloodletting; Bone Marrow; Bone Marrow Cells; Chlorambucil; Combined Modality T | 1986 |
35 other studies available for chlorambucil and Acute Disease
| Article | Year |
|---|---|
Clinicoepidemiologic Profile and Outcome Predicted by Minimal Residual Disease in Children With Mixed-phenotype Acute Leukemia Treated on a Modified MCP-841 Protocol at a Tertiary Cancer Institute in India.
Topics: Acute Disease; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; | 2020 |
Acute tumor lysis syndrome in Hodgkin disease.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Chlorambucil; Hodgk | 2002 |
Myelodysplastic syndrome and acute myeloid leukemia after autotransplantation for lymphoma: a multicenter case-control study.
Topics: Acute Disease; Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemoth | 2003 |
Prolonged chlorambucil therapy for idiopathic membranous nephropathy may induce myelodysplastic syndrome and acute leukemia: report of a case.
Topics: Acute Disease; Adult; Antineoplastic Agents, Alkylating; Chlorambucil; Chromosomes, Human, Pair 7; F | 2004 |
Myelodysplasia and acute myeloid leukaemia in a case of rheumatoid arthritis with secondary amyloidosis treated with chlorambucil.
Topics: Acute Disease; Amyloidosis; Antirheumatic Agents; Arthritis, Rheumatoid; Chlorambucil; Fatal Outcome | 2004 |
Preclinical evaluation of gemcitabine combination regimens for application in acute myeloid leukemia.
Topics: Acute Disease; Antineoplastic Agents; Apoptosis; Camptothecin; Caspase 3; Caspase 7; Caspases; Cell | 2005 |
Prednimustine in acute nonlymphocytic leukemia.
Topics: Acute Disease; Adolescent; Adult; Aged; Chlorambucil; Drug Evaluation; Female; Humans; Leukemia; Mal | 1983 |
A phase II study of prednimustine in acute non-lymphocytic leukemia, smouldering leukemia, and refractory anemia with excess blasts.
Topics: Acute Disease; Adult; Aged; Anemia, Aplastic; Chlorambucil; Drug Evaluation; Female; Humans; Leukemi | 1982 |
Acute obstructive uric acid nephropathy after treatment of neoplastic adenopathy.
Topics: Acute Disease; Chlorambucil; Constriction, Pathologic; Female; Humans; Kidney Diseases; Leukemia, Ly | 1981 |
[Acute myelofibrosis after chlorambucil treatment (author's transl)].
Topics: Acute Disease; Chlorambucil; Humans; Male; Middle Aged; Multiple Sclerosis; Primary Myelofibrosis | 1980 |
Association of acute leukaemia with chlorambucil after renal transplantation.
Topics: Acute Disease; Chlorambucil; Humans; Kidney Transplantation; Leukemia; Postoperative Complications | 1994 |
Leukemogenic risk of hydroxyurea therapy in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.
Topics: Acute Disease; Anemia, Refractory, with Excess of Blasts; Busulfan; Cell Transformation, Neoplastic; | 1996 |
Myelodysplastic syndromes and acute myeloid leukemia in connective tissue disease after single-agent chemotherapy.
Topics: Acute Disease; Adult; Aged; Antigens, CD; Antirheumatic Agents; Chlorambucil; Connective Tissue Dise | 1996 |
Acute polyneuropathy with chronic lymphocytic leukaemia and paraproteinaemia: response to chlorambucil and prednisolone.
Topics: Acute Disease; Aged; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Chlorambucil; Demy | 1998 |
High-dose BEAM chemotherapy with autologous haemopoietic stem cell transplantation for Hodgkin's disease is unlikely to be associated with a major increased risk of secondary MDS/AML.
Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; | 1999 |
Drug-induced acute malaria.
Topics: Acute Disease; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Chlorambucil; Female; Hu | 2000 |
[Acute cholestatic hepatitis due to chlorambucil].
Topics: Acute Disease; Aged; Antineoplastic Agents, Alkylating; Biopsy, Needle; Chemical and Drug Induced Li | 2001 |
[Possibilities and limitations of immunosuppressive therapy for glomerulonephritis].
Topics: Acute Disease; Antilymphocyte Serum; Azathioprine; Chlorambucil; Chronic Disease; Cyclophosphamide; | 1977 |
Acute leukemia after alkylating-agent therapy of ovarian cancer.
Topics: Acute Disease; Alkylating Agents; Altretamine; Chlorambucil; Cyclophosphamide; Female; Fluorouracil; | 1977 |
Acute myelofibrosis in progressive systemic sclerosis. Report of a case developing during long term chlorambucil therapy and discussion of pathogenetic factors.
Topics: Acute Disease; Adult; Bone Marrow; Cell Division; Chlorambucil; Female; Fibroblasts; Hematopoietic S | 1979 |
[Acute leukemia in 3 children with chronic juvenile arthritis treated with chlorambucil].
Topics: Acute Disease; Alkylating Agents; Arthritis, Juvenile; Child; Child, Preschool; Chlorambucil; Chromo | 1979 |
Acute leukemia following chlorambucil therapy of advanced ovarian and fallopian tube carcinoma.
Topics: Acute Disease; Carcinoma; Chlorambucil; Fallopian Tube Neoplasms; Female; Humans; Leukemia; Middle A | 1978 |
Rheumatoid arthritis treated with chlorambucil: a five-year follow-up.
Topics: Acute Disease; Aged; Arthritis, Rheumatoid; Chlorambucil; Chronic Disease; Female; Follow-Up Studies | 1976 |
[Iatrogenic acute colitis caused by sulfamethoxazole-trimethoprim].
Topics: Acute Disease; Adult; Chlorambucil; Colitis; Drug Combinations; Humans; Iatrogenic Disease; Male; Su | 1976 |
Acute leukemia in advanced ovarian carcinoma after treatment with alkylating agents.
Topics: Acute Disease; Adenocarcinoma, Papillary; Adult; Alkylating Agents; Chlorambucil; Cystadenoma; Femal | 1976 |
[Rapidly progressive glomerulonephritis in a child. Clinical and histological observation over 3 1/2 years (author's transl)].
Topics: Acute Disease; Anuria; Biopsy, Needle; Child; Chlorambucil; Glomerular Filtration Rate; Glomerulonep | 1976 |
Hodgkin's disease and acute leukemia. Is it a true association?
Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil | 1992 |
Acute epiglottitis in immunocompromised patients--a report of two cases.
Topics: Acute Disease; Chlorambucil; Cyclophosphamide; Epiglottitis; Humans; Immunocompromised Host; Leukemi | 1991 |
The oncogenicity of chlorambucil in rheumatoid arthritis.
Topics: Acute Disease; Arthritis, Rheumatoid; Azathioprine; Carcinogens; Chlorambucil; Humans; Leukemia, Mye | 1988 |
Acute leukemia in polycythemia vera.
Topics: Acute Disease; Antigens, Neoplasm; Bloodletting; Chlorambucil; Chromosome Aberrations; Chromosome Di | 1986 |
Cold agglutinin syndrome: nursing management.
Topics: Acute Disease; Anemia, Hemolytic, Autoimmune; Blood Transfusion; Chlorambucil; Chronic Disease; Comb | 1985 |
Risk of acute nonlymphocytic leukemia and preleukemia in patients treated with cyclophosphamide for non-Hodgkin's lymphomas. Comparison with results obtained in patients treated for Hodgkin's disease and ovarian carcinoma with other alkylating agents.
Topics: Acute Disease; Adolescent; Adult; Aged; Alkylating Agents; Antineoplastic Combined Chemotherapy Prot | 1985 |
[Acute erythroleukemia following treatment of malignant exophthalmos with chlorambucil].
Topics: Acute Disease; Aged; Chlorambucil; Female; Graves Disease; Humans; Leukemia, Erythroblastic, Acute; | 1972 |
[2 cases of apparently primary glomerulopathies with deposits. Recovery with immunodepressive agents. Secondary onset of an acute S.L.E. without renal involvement].
Topics: Acute Disease; Biopsy; Chlorambucil; Glomerulonephritis; Humans; Inclusion Bodies, Viral; Kidney Glo | 1972 |
[A case of acute glomerulonephritis supposed to be malignant. Complete clinical, biological and histological remission after a combined chlorambucil and indomethacin treatment].
Topics: Acute Disease; Child; Chlorambucil; Diagnosis, Differential; Female; Glomerulonephritis; Humans; Ind | 1970 |