chlorambucil has been researched along with Abnormalities, Drug-Induced in 19 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The widely accepted standard therapy for cutaneous sarcoidosis includes corticosteroids, antimalarials, and methotrexate." | 4.84 | Cutaneous sarcoidosis therapy updated. ( Badgwell, C; Rosen, T, 2007) |
| "Chlorambucil was three times more potent than cyclophosphamide on an mg/kg basis." | 1.26 | Aspects of the teratology of cyclophosphamide (NSC-26271). ( Ashby, R; Davis, L; Dewhurst, BB; Espinal, R; Penn, RN; Upshall, DG, 1976) |
| " They type and frequency of malformations differed according to the dosage and day of treatment." | 1.25 | Teratogenic effects of chlorambucil on in vivo and in vitro organogenesis in mice. ( Kochhar, DM; Salder, TW, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (89.47) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| RUGH, R | 1 |
| SKAREDOFF, L | 1 |
| Badgwell, C | 1 |
| Rosen, T | 1 |
| Soukup, S | 1 |
| Takacs, E | 1 |
| Warkany, J | 1 |
| Fujii, T | 1 |
| Nakatsuka, T | 1 |
| Mirkes, PE | 1 |
| Greenaway, JC | 1 |
| Steege, JF | 1 |
| Caldwell, DS | 1 |
| Bermas, BL | 1 |
| Hill, JA | 1 |
| Ross, GT | 1 |
| Majewski, F | 1 |
| Schaison, G | 1 |
| Jacquillat, C | 1 |
| Auclerc, G | 1 |
| Weil, M | 1 |
| Salder, TW | 1 |
| Kochhar, DM | 1 |
| Ashby, R | 1 |
| Davis, L | 1 |
| Dewhurst, BB | 1 |
| Espinal, R | 1 |
| Penn, RN | 1 |
| Upshall, DG | 1 |
| Tanaka, O | 1 |
| Kavlock, RJ | 1 |
| Rehnberg, BF | 1 |
| Rogers, EH | 1 |
| Kernis, MM | 2 |
| Hervet, E | 1 |
| Barrat, J | 1 |
| Darbois, Y | 1 |
| Faguer, C | 1 |
| Shepard, TH | 1 |
| Skinner, MD | 1 |
| Schwartz, RS | 1 |
4 reviews available for chlorambucil and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Cutaneous sarcoidosis therapy updated.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Allopurinol; Animals; Anti-Inflammatory Agents | 2007 |
Effects of immunosuppressive drugs during pregnancy.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Animals; Azathioprine; Chlorambucil; Cyclophos | 1995 |
[On certain embryopathies induced by teratogenic agents (author's transl].
Topics: Abnormalities, Drug-Induced; Aminopterin; Busulfan; Chlorambucil; Cyclophosphamide; Ethanol; Germany | 1977 |
Immunosuppressive therapy. 2.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Adult; Azathioprine; Child; Chlorambucil; Clin | 1972 |
1 trial available for chlorambucil and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Immunosuppressive therapy. 2.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Adult; Azathioprine; Child; Chlorambucil; Clin | 1972 |
15 other studies available for chlorambucil and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
RADIATION AND RADIOMIMETRIC CHLORAMBUCIL AND THE FETAL RETINA.
Topics: Abnormalities, Drug-Induced; Animals; Biomedical Research; Chlorambucil; Congenital Abnormalities; E | 1965 |
Chromosome changes in embryos treated with various teratogens.
Topics: Abnormalities, Drug-Induced; Animals; Chlorambucil; Chromosome Aberrations; Diet; Female; Hydroxyure | 1967 |
Potentiating effects of caffeine on teratogenicity of alkylating agents in mice.
Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Alkylating Agents; Animals; Antibioti | 1983 |
Teratogenicity of chlorambucil in rat embryos in vitro.
Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Chlorambucil; Cyclophosphamide; Dose-Respon | 1982 |
Renal agenesis after first trimester exposure to chlorambucil.
Topics: Abnormalities, Drug-Induced; Abortion, Therapeutic; Adult; Chlorambucil; Female; Humans; Kidney; Mal | 1980 |
Congenital anomalies among children born of mothers receiving chemotherapy for gestational trophoblastic neoplasms.
Topics: Abnormalities, Drug-Induced; Antineoplastic Agents; Chlorambucil; Drug Therapy, Combination; Female; | 1976 |
[Fetal risk of cancer chemotherapy (author's transl)].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Alkaloids; Animals; Antibiotics, Antineop | 1979 |
Teratogenic effects of chlorambucil on in vivo and in vitro organogenesis in mice.
Topics: Abnormalities, Drug-Induced; Animals; Cells, Cultured; Chlorambucil; Female; Fetus; Gestational Age; | 1975 |
Aspects of the teratology of cyclophosphamide (NSC-26271).
Topics: Abnormalities, Drug-Induced; Alkylation; Animals; Chemical Phenomena; Chemistry; Chlorambucil; Cyclo | 1976 |
[Abnormalities of brain differentiation induced by chemical agents].
Topics: Abnormalities, Drug-Induced; Animals; Brain; Chlorambucil; Female; Mice; Neural Tube Defects; Oncoge | 1988 |
Critical prenatal periods for chlorambucil-induced functional alterations of the rat kidney.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Chlorambucil; Female; Gestational Age; Kidney; Li | 1987 |
Cysteine interference with chlorambucil-induced teratogenesis in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Chlorambucil; Clubfoot; Cysteine; Drug Antagonism; Ectromelia; | 1972 |
[Letter: Teratogenic effects of medications].
Topics: Abnormalities, Drug-Induced; Adult; Chlorambucil; Female; Humans; Hydroxyurea; Leukemia, Lymphoid; M | 1974 |
Teratogenicity from drugs--an increasing problem.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Aminopterin; Amniocentesis; Animals; Anti-Bact | 1974 |
Abnormal yolk sac function induced by chlorambucil.
Topics: Abnormalities, Drug-Induced; Animals; Carbon Isotopes; Chlorambucil; Embryo, Mammalian; Extraembryon | 1971 |