chlorambucil has been researched along with Abnormalities, Autosome in 42 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have studied the long-term effects of chlorambucil treatment on the chromosomes of peripheral blood lymphocytes from patients with uveitis." | 7.67 | Long-term cytogenetic follow-up study of patients with uveitis treated with chlorambucil. ( Casey, G; Dinning, WJ; Harris, H; Reeves, BR, 1985) |
| "A splenectomized patient with hairy cell leukemia (HCL) who had received chemotherapy with a low-dose alkylating agent for 2 years developed dysmyelopoietic syndrome (DMPS), the first such case to be described." | 5.27 | Development of dysmyelopoietic syndrome in a hairy cell leukemia patient treated with chlorambucil: cytogenetic and morphologic evaluation. ( Albain, KS; Golomb, HM; Le Beau, MM; Rowley, JD; Vardiman, JW, 1983) |
| "We have studied the long-term effects of chlorambucil treatment on the chromosomes of peripheral blood lymphocytes from patients with uveitis." | 3.67 | Long-term cytogenetic follow-up study of patients with uveitis treated with chlorambucil. ( Casey, G; Dinning, WJ; Harris, H; Reeves, BR, 1985) |
| "Few recurrent chromosomal abnormalities have been reported, and their prognostic value is not known." | 2.78 | Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenström's macroglobulinemia. ( Andrieux, J; Baranger, L; Barin, C; Bilhou-Nabera, C; Blons, H; Callet-Bauchu, E; Chapiro, E; Chevret, S; Chiesa, J; Daudignon, A; Eclache, V; Gachard, N; Grelier, A; Henry, C; Lambert, J; Leblondon, V; Lejeune, J; Luquet, I; Merle-Beral, H; Mossafa, H; Mould, S; Mozziconacci, MJ; Mugneret, F; Nguyen-Khac, F; Owen, R; Penther, D; Struski, S; Terre, C; Veronese, L, 2013) |
| "Patients with chronic lymphocytic leukemia (CLL) may have disease transformation to non-Hodgkin's lymphoma or prolymphocytic leukemia; however, development of therapy-related acute myeloid leukemia (t-AML) is unusual." | 2.70 | Therapy-related myeloid leukemias are observed in patients with chronic lymphocytic leukemia after treatment with fludarabine and chlorambucil: results of an intergroup study, cancer and leukemia group B 9011. ( Appelbaum, FR; Elias, L; Hines, JD; Kolitz, JE; Larson, RA; Morrison, VA; Peterson, BL; Rai, KR; Schiffer, CA; Shepherd, L, 2002) |
| "Elderly patients with chronic lymphocytic leukemia (CLL) or patients with comorbidities are often treated with chlorambucil (Chl) as front-line therapy despite relatively low response rates." | 2.55 | Treatment approach for elderly and unfit patients with chronic lymphocytic leukemia. ( Autore, F; Efremov, DG; Innocenti, I; Laurenti, L; Morelli, F; Pasquale, R, 2017) |
| "Cytogenetic analysis showed complex chromosomal abnormalities including 5q deletion, 12p deletion and monosomy 18." | 1.33 | Myelodysplastic syndrome with complex karyotypic abnormality in a patient with Waldenström's macroglobulinemia after sequential treatment with chlorambucil and fludarabine. ( Cho, HS; Chun, SH; Hyun, MS; Kim, KO; Kim, MK; Lee, KH; Shin, SJ, 2005) |
| "The most common treatment of chronic lymphocytic leukemia (CLL) is the alkylating agent chlorambucil (CLB), with or without prednisone." | 1.32 | The effect of chlorambucil treatment on cytogenetic parameters in chronic lymphocytic leukemia patients. ( Amiel, A; Biton, I; Fejgin, MD; Gaber, E; Lishner, M; Yukla, M, 2003) |
| "CBC effectively induced chromosome aberrations and SCEs in a dose-dependent manner." | 1.28 | Cytogenetic and molecular characterization of the mutagenicity of chlorambucil in V79 cells. ( Köberle, B; Menz, W; Röscheisen, C; Speit, G, 1992) |
| "A splenectomized patient with hairy cell leukemia (HCL) who had received chemotherapy with a low-dose alkylating agent for 2 years developed dysmyelopoietic syndrome (DMPS), the first such case to be described." | 1.27 | Development of dysmyelopoietic syndrome in a hairy cell leukemia patient treated with chlorambucil: cytogenetic and morphologic evaluation. ( Albain, KS; Golomb, HM; Le Beau, MM; Rowley, JD; Vardiman, JW, 1983) |
| "Thirty five patients with juvenile chronic arthritis who had not been treated with cytotoxic drugs served as controls." | 1.27 | Chlorambucil induced chromosome damage in juvenile chronic arthritis. ( Ansell, BM; Denman, AM; Doré, CJ; Palmer, RG; Varonos, S, 1985) |
| "The grounds for treating or not treating chronic lymphocytic leukemias (CLL) and chronic myelocytic leukemias (CML) are discussed in the light of results in recent years." | 1.26 | [When do we have to treat chronic leukemia?]. ( Maurice, PA, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (64.29) | 18.7374 |
| 1990's | 5 (11.90) | 18.2507 |
| 2000's | 6 (14.29) | 29.6817 |
| 2010's | 3 (7.14) | 24.3611 |
| 2020's | 1 (2.38) | 2.80 |
| Authors | Studies |
|---|---|
| Tausch, E | 1 |
| Schneider, C | 1 |
| Robrecht, S | 1 |
| Zhang, C | 1 |
| Dolnik, A | 1 |
| Bloehdorn, J | 1 |
| Bahlo, J | 1 |
| Al-Sawaf, O | 1 |
| Ritgen, M | 1 |
| Fink, AM | 1 |
| Eichhorst, B | 1 |
| Kreuzer, KA | 1 |
| Tandon, M | 1 |
| Humphrey, K | 1 |
| Jiang, Y | 1 |
| Schary, W | 1 |
| Bullinger, L | 1 |
| Mertens, D | 1 |
| Lurà, MP | 1 |
| Kneba, M | 1 |
| Döhner, H | 1 |
| Fischer, K | 1 |
| Hallek, M | 1 |
| Stilgenbauer, S | 1 |
| Innocenti, I | 1 |
| Autore, F | 1 |
| Pasquale, R | 1 |
| Morelli, F | 1 |
| Efremov, DG | 1 |
| Laurenti, L | 1 |
| Nafie, EHO | 1 |
| Khater, E | 1 |
| Awwad, M | 1 |
| Zowail, M | 1 |
| Hegazy, K | 1 |
| Nguyen-Khac, F | 1 |
| Lambert, J | 1 |
| Chapiro, E | 1 |
| Grelier, A | 1 |
| Mould, S | 1 |
| Barin, C | 1 |
| Daudignon, A | 1 |
| Gachard, N | 1 |
| Struski, S | 1 |
| Henry, C | 1 |
| Penther, D | 1 |
| Mossafa, H | 1 |
| Andrieux, J | 1 |
| Eclache, V | 1 |
| Bilhou-Nabera, C | 1 |
| Luquet, I | 1 |
| Terre, C | 1 |
| Baranger, L | 1 |
| Mugneret, F | 1 |
| Chiesa, J | 1 |
| Mozziconacci, MJ | 1 |
| Callet-Bauchu, E | 1 |
| Veronese, L | 1 |
| Blons, H | 1 |
| Owen, R | 1 |
| Lejeune, J | 1 |
| Chevret, S | 1 |
| Merle-Beral, H | 1 |
| Leblondon, V | 1 |
| Morrison, VA | 1 |
| Rai, KR | 1 |
| Peterson, BL | 1 |
| Kolitz, JE | 1 |
| Elias, L | 1 |
| Appelbaum, FR | 1 |
| Hines, JD | 1 |
| Shepherd, L | 1 |
| Larson, RA | 1 |
| Schiffer, CA | 1 |
| Novik, AA | 1 |
| Denisov, NL | 1 |
| Gershanovich, ML | 1 |
| Pozharisskiĭ, KM | 1 |
| Gorodokin, I | 1 |
| Amiel, A | 1 |
| Biton, I | 1 |
| Yukla, M | 1 |
| Gaber, E | 1 |
| Fejgin, MD | 1 |
| Lishner, M | 1 |
| MOORE, JG | 1 |
| VANCAMPENHOUT, JL | 1 |
| BRANDKAMP, WW | 1 |
| SANDBERG, AA | 1 |
| ISHIHARA, T | 1 |
| KIKUCHI, Y | 1 |
| CROSSWHITE, LH | 1 |
| Zver, S | 1 |
| Kokalj Vokac, N | 1 |
| Zagradisnik, B | 1 |
| Erjavec, A | 1 |
| Zagorac, A | 1 |
| Zupan, IP | 1 |
| Cernelc, P | 1 |
| Shin, SJ | 1 |
| Chun, SH | 1 |
| Kim, KO | 1 |
| Kim, MK | 1 |
| Lee, KH | 1 |
| Hyun, MS | 1 |
| Cho, HS | 1 |
| Efthimiou, M | 1 |
| Andrianopoulos, C | 1 |
| Stephanou, G | 1 |
| Demopoulos, NA | 1 |
| Nikolaropoulos, SS | 1 |
| Soukup, S | 1 |
| Takacs, E | 1 |
| Warkany, J | 1 |
| Tew, KD | 1 |
| Moy, BC | 1 |
| Hartley-Asp, B | 1 |
| Albain, KS | 1 |
| Le Beau, MM | 1 |
| Vardiman, JW | 1 |
| Golomb, HM | 1 |
| Rowley, JD | 1 |
| Dolgopolova, AV | 1 |
| Melikhova, NI | 2 |
| Moore, FR | 1 |
| Urda, GA | 1 |
| Krishna, G | 2 |
| Theiss, JC | 2 |
| O'Brien, S | 1 |
| del Giglio, A | 1 |
| Keating, M | 1 |
| McCarthy, CJ | 1 |
| Sheldon, S | 1 |
| Ross, CW | 1 |
| McCune, WJ | 1 |
| Littlefield, LG | 1 |
| Colyer, SP | 1 |
| Sayer, AM | 1 |
| Dufrain, RJ | 1 |
| Maurice, PA | 1 |
| Schuler, D | 1 |
| Dobos, M | 1 |
| Fekete, G | 1 |
| Miltényi, M | 1 |
| Kalmár, L | 1 |
| Fazekas, T | 1 |
| Bach, K | 1 |
| Tóth, S | 1 |
| Bodor, F | 1 |
| Westin, J | 1 |
| Kostrova, AA | 1 |
| Reeves, BR | 3 |
| Pickup, VL | 1 |
| Lawler, SD | 2 |
| Dinning, WJ | 2 |
| Perkins, ES | 1 |
| Solomon, E | 1 |
| Bobrow, M | 1 |
| Speit, G | 1 |
| Menz, W | 1 |
| Röscheisen, C | 1 |
| Köberle, B | 1 |
| Landaw, SA | 1 |
| Casey, G | 1 |
| Harris, H | 1 |
| Palmer, RG | 1 |
| Varonos, S | 1 |
| Doré, CJ | 1 |
| Denman, AM | 1 |
| Ansell, BM | 1 |
| Margoles, C | 1 |
| Buchanan, JG | 1 |
| Scott, PJ | 1 |
| McLachlan, EM | 1 |
| Smith, F | 1 |
| Richmond, DE | 1 |
| North, JD | 1 |
| Stoltz, DR | 1 |
| Stevenson, AC | 3 |
| Canellos, GP | 1 |
| De Vita, VT | 1 |
| Schein, P | 1 |
| Chabner, B | 1 |
| Young, RC | 1 |
| Lele, KP | 1 |
| Patel, C | 1 |
| Waldenström, JG | 1 |
| Fitzgerald, PH | 1 |
| Rastrick, JM | 1 |
| Hamer, JW | 1 |
| Roman, CS | 1 |
| Patel, CR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Trial Comparing the Efficacy of Chlorambucil to Fludarabine in Patients With Advanced Waldenström Macroglobulinemia,Lymphoplasmacytic Lymphoma or Splenic Marginal Zone Lymphoma[NCT00566332] | Phase 3 | 414 participants (Actual) | Interventional | 2001-06-30 | Completed | ||
| A Randomised Trial of Chlorambucil Versus Fludarabine as Initial Therapy of Waldenström's Macroglobulinaemia and Splenic Lymphoma With Villous Lymphocytes[NCT00608374] | Phase 3 | 400 participants (Anticipated) | Interventional | 2006-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for chlorambucil and Abnormalities, Autosome
| Article | Year |
|---|---|
Treatment approach for elderly and unfit patients with chronic lymphocytic leukemia.
Topics: Age Factors; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Chromosome Aberrations; C | 2017 |
[Helicobacter pylori infection and gastric MALT lymphoma: present-day approaches to research and treatment].
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Chr | 2002 |
Advances in the biology and treatment of B-cell chronic lymphocytic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Autoimmune Diseases; Bone Marrow Transplantation; Ch | 1995 |
2 trials available for chlorambucil and Abnormalities, Autosome
| Article | Year |
|---|---|
Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenström's macroglobulinemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chlorambucil; Chromosome Aberrations; Chromos | 2013 |
Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenström's macroglobulinemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chlorambucil; Chromosome Aberrations; Chromos | 2013 |
Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenström's macroglobulinemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chlorambucil; Chromosome Aberrations; Chromos | 2013 |
Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenström's macroglobulinemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chlorambucil; Chromosome Aberrations; Chromos | 2013 |
Therapy-related myeloid leukemias are observed in patients with chronic lymphocytic leukemia after treatment with fludarabine and chlorambucil: results of an intergroup study, cancer and leukemia group B 9011.
Topics: Acute Disease; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Chlorambuci | 2002 |
37 other studies available for chlorambucil and Abnormalities, Autosome
| Article | Year |
|---|---|
Prognostic and predictive impact of genetic markers in patients with CLL treated with obinutuzumab and venetoclax.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bridged Bicyclo C | 2020 |
Chlorambucil Cytotoxicity Reduction in Rats Through Bone Marrow, An
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Bone Marrow Cells | 2018 |
The effect of chlorambucil treatment on cytogenetic parameters in chronic lymphocytic leukemia patients.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Chlorambucil; Chromosome Aberrations; Ch | 2003 |
EFFECTS OF IONIZING IRRADIATION AND CHEMOTHERAPEUTIC AGENTS ON HUMAN CHROMOSOMES.
Topics: Antineoplastic Agents; Biomedical Research; Chlorambucil; Choriocarcinoma; Chromosome Aberrations; C | 1964 |
CHROMOSOMES OF LYMPHOSARCOMA AND CANCER CELLS IN BONE MARROW.
Topics: Alkaloids; Antineoplastic Agents; Bone Marrow; Bone Marrow Examination; Chlorambucil; Chromosome Abe | 1964 |
T cell prolymphocytic leukemia with new chromosome rearrangements.
Topics: Aged; Chlorambucil; Chromobox Protein Homolog 5; Chromosome Aberrations; Female; Humans; Karyotyping | 2004 |
Myelodysplastic syndrome with complex karyotypic abnormality in a patient with Waldenström's macroglobulinemia after sequential treatment with chlorambucil and fludarabine.
Topics: Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow | 2005 |
Aneugenic potential of the nitrogen mustard analogues melphalan, chlorambucil and p-N,N-bis(2-chloroethyl)aminophenylacetic acid in cell cultures in vitro.
Topics: Adult; Aneugens; Aneuploidy; Animals; Antineoplastic Agents, Alkylating; Azasteroids; Cells, Culture | 2007 |
Chromosome changes in embryos treated with various teratogens.
Topics: Abnormalities, Drug-Induced; Animals; Chlorambucil; Chromosome Aberrations; Diet; Female; Hydroxyure | 1967 |
Acquired drug resistance is accompanied by modification in the karyotype and nuclear matrix of a rat carcinoma cell line.
Topics: Animals; Carcinoma 256, Walker; Cell Line; Cell Nucleus; Chlorambucil; Chromosome Aberrations; Chrom | 1983 |
Development of dysmyelopoietic syndrome in a hairy cell leukemia patient treated with chlorambucil: cytogenetic and morphologic evaluation.
Topics: Bone Marrow; Chlorambucil; Chromosome Aberrations; Humans; Karyotyping; Leukemia, Hairy Cell; Male; | 1983 |
[Late observations of children receiving leukeran in rheumatoid arthritis].
Topics: Adolescent; Antineoplastic Agents; Arthritis, Juvenile; Child; Child, Preschool; Chlorambucil; Chrom | 1981 |
An in vivo/in vitro method for assessing micronucleus and chromosome aberration induction in rat bone marrow and spleen. 2. Studies with chlorambucil and mitomycin C.
Topics: Animals; Bone Marrow; Chlorambucil; Chromosome Aberrations; Evaluation Studies as Topic; In Vitro Te | 1995 |
Concurrent analysis of cytogenetic damage in vivo: a multiple endpoint-multiple tissue approach.
Topics: Acrylamide; Acrylamides; Animal Testing Alternatives; Animals; Bone Marrow; Bone Marrow Cells; Carci | 1995 |
Cytogenetic abnormalities and therapy-related myelodysplastic syndromes in rheumatic disease.
Topics: Adult; Aged; Alkylating Agents; Chlorambucil; Chromosome Aberrations; Chromosome Disorders; Chromoso | 1998 |
Sister-chromatid exchanges in human lymphocytes exposed during Go to four classes of DNA-damaging chemicals.
Topics: Bleomycin; Cell Cycle; Chlorambucil; Chromatids; Chromosome Aberrations; Cytarabine; DNA; Humans; Ly | 1979 |
[When do we have to treat chronic leukemia?].
Topics: Busulfan; Chlorambucil; Chromosome Aberrations; Cyclophosphamide; Drug Therapy, Combination; Female; | 1978 |
Chromosome mutations and chromosome stability in children treated with different regimes of immunosuppressive drugs.
Topics: Adolescent; Adult; Child; Child, Preschool; Chlorambucil; Chromatids; Chromosome Aberrations; Cyclop | 1979 |
[Familial occurrence of chronic lymphatic leukemia. HL-A antigen and cytogenetic studies].
Topics: Aged; Chlorambucil; Chromosome Aberrations; Chromosomes, Human, 21-22 and Y; HLA Antigens; Humans; L | 1978 |
Chromosome abnormalities after chlorambucil therapy of polycythaemia vera.
Topics: Aged; Bone Marrow; Bone Marrow Cells; Chlorambucil; Chromosome Aberrations; Chromosome Deletion; Fem | 1976 |
[Cytogenetic characteristics of lymphocytes in children with rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Child; Child, Preschool; Chlorambucil; Chromosome Aberrations; Humans; Infant | 1976 |
A chromosome study of patients with uveitis treated with chlorambucil.
Topics: Adult; Chlorambucil; Chromosome Aberrations; Female; Humans; Male; Middle Aged; Uveitis | 1975 |
Sister chromatid exchanges--a sensitive assay of agents damaging human chromosomes.
Topics: Chlorambucil; Chromatids; Chromosome Aberrations; Chromosomes; Gamma Rays; Humans; Karyotyping; Quin | 1975 |
Cytogenetic and molecular characterization of the mutagenicity of chlorambucil in V79 cells.
Topics: Animals; Cell Line; Chlorambucil; Chromatids; Chromosome Aberrations; DNA; Dose-Response Relationshi | 1992 |
Acute leukemia in polycythemia vera.
Topics: Acute Disease; Antigens, Neoplasm; Bloodletting; Chlorambucil; Chromosome Aberrations; Chromosome Di | 1986 |
Long-term cytogenetic follow-up study of patients with uveitis treated with chlorambucil.
Topics: Chlorambucil; Chromosome Aberrations; Female; Follow-Up Studies; Humans; Lymphocytes; Male; Uveitis | 1985 |
Chlorambucil induced chromosome damage in juvenile chronic arthritis.
Topics: Adolescent; Adult; Arthritis, Juvenile; Child; Child, Preschool; Chlorambucil; Chromosome Aberration | 1985 |
Preferential location of chlorambucil-induced breakage in the chromosomes of normal human lymphocytes.
Topics: Adult; Cells, Cultured; Chlorambucil; Chromatids; Chromosome Aberrations; Chromosome Mapping; Female | 1974 |
A chromosome translocation in association with periarteritis nodosa and macroglobulinemia.
Topics: Anemia; Arthritis; Blood Proteins; Chlorambucil; Chromosome Aberrations; Chromosome Disorders; Diaph | 1967 |
Letter: Effects of amylobarbitone on the frequency of chromosomal aberrations in human lymphocytes determined by chlorambucil and melphalan in vitro.
Topics: Amobarbital; Chlorambucil; Chromosome Aberrations; Humans; In Vitro Techniques; Lymphocytes; Melphal | 1974 |
Letter: Effects of amylobarbitone on the frequency of chromosomal aberrations in human lymphocytes determined by chlorambucil and melphalan in vitro.
Topics: Amobarbital; Chlorambucil; Chromosome Aberrations; Humans; In Vitro Techniques; Lymphocytes; Melphal | 1974 |
Proceedings: The chronic leukemias: current therapeutic concepts.
Topics: Bromine; Busulfan; Cell Division; Chlorambucil; Chromosome Aberrations; Cyclophosphamide; Humans; Hy | 1972 |
Chromosomal damage induced by chlorambucil in chronic lymphocytic leukaemia.
Topics: Aged; Cell Survival; Cells, Cultured; Chlorambucil; Chromatids; Chromosome Aberrations; Chromosome D | 1972 |
Effects of chlorambucil on human chromosomes.
Topics: Adult; Aged; Bone Marrow Cells; Cell Division; Cell Survival; Cells, Cultured; Chlorambucil; Chromat | 1973 |
From bad to worse? Treatment and leukemogenesis.
Topics: Antibiotics, Antineoplastic; Busulfan; Chlorambucil; Chromosome Aberrations; Chromosome Disorders; H | 1973 |
Acute plasma cell leukaemia following chronic lymphatic leukaemia: transformation or two separate diseases?
Topics: Aged; Blood Protein Electrophoresis; Body Weight; Bone Marrow Examination; Cell Transformation, Neop | 1973 |
Effects of amylobarbitone on the frequency of chromosomal aberrations in human lymphocytes determined by chlorambucil and melphalan in vitro.
Topics: Amobarbital; Cells, Cultured; Chlorambucil; Chromosome Aberrations; Humans; In Vitro Techniques; Lym | 1973 |