chlorambucil has been researched along with ATLL in 5 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Both human lymphoblastoid interferon (HLBI) and bestrabucil, the conjugate of chlorambucil and beta-estradiol, have antitumor activity against adult T-cell leukemia-lymphoma (ATLL)." | 5.07 | A combination trial of human lymphoblastoid interferon and bestrabucil (KM2210) for adult T-cell leukemia-lymphoma. ( Ezaki, K; Hirano, M; Hirota, Y; Kimura, K; Naito, K; Ohno, R; Shirakawa, S; Yamada, K, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mentz, F | 1 |
| Baudet, S | 1 |
| Blanc, C | 1 |
| Issaly, F | 1 |
| Binet, JL | 1 |
| Merle-Beral, H | 1 |
| Cabrera, ME | 1 |
| Labra, S | 1 |
| Ford, A | 1 |
| Matutes, E | 1 |
| Kode, J | 1 |
| Advani, S | 1 |
| Chiplunkar, S | 1 |
| Tsurumi, H | 1 |
| Tani, K | 1 |
| Tsuruta, T | 1 |
| Shirato, R | 1 |
| Matsudaira, T | 1 |
| Tojo, A | 1 |
| Wada, C | 1 |
| Uchida, H | 1 |
| Ozawa, K | 1 |
| Asano, S | 1 |
| Ezaki, K | 1 |
| Hirano, M | 1 |
| Ohno, R | 1 |
| Yamada, K | 1 |
| Naito, K | 1 |
| Hirota, Y | 1 |
| Shirakawa, S | 1 |
| Kimura, K | 1 |
1 trial available for chlorambucil and ATLL
| Article | Year |
|---|---|
A combination trial of human lymphoblastoid interferon and bestrabucil (KM2210) for adult T-cell leukemia-lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Estrad | 1991 |
4 other studies available for chlorambucil and ATLL
| Article | Year |
|---|---|
Simple, fast method of detection apoptosis in lymphoid cells.
Topics: Apoptosis; Blood Cell Count; Cells, Cultured; Chlorambucil; Flow Cytometry; Humans; Immunohistochemi | 1998 |
HTLV-I induced intestinal lymphoma.
Topics: Adult; Antineoplastic Agents, Alkylating; Chile; Chlorambucil; Diarrhea; DNA, Viral; Duodenal Neopla | 1999 |
T-cell receptor gamma and delta gene rearrangements in T-cell acute lymphoblastic leukemia in Indian patients.
Topics: Adolescent; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Child; Child, | 2000 |
Adult T-cell leukemia developing during immunosuppressive treatment in a renal transplant recipient.
Topics: Adult; Antineoplastic Agents; Carrier State; Chlorambucil; Estradiol; Humans; Immunosuppression Ther | 1992 |