chloral hydrate and Sleep Initiation and Maintenance Disorders studies

Sleep Initiation and Maintenance Disorders: Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.

Research Excerpts

Excerpt	Relevance	Reference
"Triazolam 0."	2.65	The efficacy of triazolam and chloral hydrate in geriatric insomniacs. ( Grissom, T; Kramer, M; Lutz, T; Piccione, P; Roth, T; Zorick, F, 1980)
"Only chloral hydrate was more effective in inducing and maintaining sleep than placebo."	2.65	Efficacy and side effects of chloral hydrate and tryptophan as sleeping aids in psychogeriatric patients. ( Auvinen, J; Linnoila, M; Numminen, A; Viukari, M, 1980)
"Triazolam 0-5 mg was found to be preferred and to be superior to placebo, flurazepam and chloral hydrate in the treatment of insomnia."	2.64	Preference studies of triazolam with standard hypnotics in out-patients with insomnia. ( Fabre, LF; Harris, RT; McLendon, DM, 1976)
"Complaints of insomnia, i."	2.42	[Algorithms for diagnosis and therapy of sleep disorders in general practice]. ( Berger, M; Hornyak, M; Riemann, D; Voderholzer, U, 2003)
"Among the disorders of sleep, insomnia is a far more common problem of medical management than are enuresis, narcolepsy, somnambulism or nightmares."	2.35	Sleep and hypnotic drugs. ( Johns, MW, 1975)
"Insomnia is a frequent health problem in prison, but little is known about its severity and duration."	1.32	Does insomnia in prison improve with time? Prospective study among remanded prisoners using the Pittsburgh Sleep Quality Index. ( Elger, BS, 2003)
"Insomnia is a disorder of initiation and maintenance of sleep that results in daytime somnolence."	1.27	Diagnosis and treatment of insomnia. ( Pagel, JF, 1987)

Research

Studies (44)

Authors

Clinical Trials (1)

Trial Overview

Reviews

3 reviews available for chloral hydrate and Sleep Initiation and Maintenance Disorders

Trials

13 trials available for chloral hydrate and Sleep Initiation and Maintenance Disorders

Other Studies

28 other studies available for chloral hydrate and Sleep Initiation and Maintenance Disorders

Timeframe	Studies, this research(%)	All Research%
pre-1990	38 (86.36)	18.7374
1990's	1 (2.27)	18.2507
2000's	3 (6.82)	29.6817
2010's	2 (4.55)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
BARE, WW	1
PEPINO, AT	1
Vaillancourt, R	1
Collins, M	1
Vadeboncoeur, C	1
Jacob, P	1
Graham, N	1
Foster, D	1
Splinter, W	1
Heuyer, MM	1
Le Guillant, L	1
RICKELS, K	1
BASS, H	1
LYLE, WH	1
JONES, DP	1
JONES, EA	1
MATTHEWS, V	1
LEHMANN, HE	1
BAN, TA	2
Riemann, D	1
Hornyak, M	1
Voderholzer, U	1
Berger, M	1
Elger, BS	1
Exton-Smith, AN	1
Piccione, P	1
Zorick, F	1
Lutz, T	1
Grissom, T	1
Kramer, M	1
Roth, T	1
Linnoila, M	1
Viukari, M	1
Numminen, A	1
Auvinen, J	1
Amin, MM	1
Fabre, LF	1
McLendon, DM	1
Harris, RT	1
Hartmann, E	1
Johns, MW	1
Berg, S	1
Dehlin, O	1
Falkheden, T	1
Gatzinska, R	1
Nordqvist, P	1
Pathy, MS	1
Miller, RR	1
Greenblatt, DJ	1
Freeman, C	1
Kanowski, S	1
Pagel, JF	1
Smith, GM	1
Coletta, CG	1
McBride, S	1
McPeek, B	1
Kales, A	6
Scharf, MB	4
Allen, C	2
Kales, JD	4
Tan, TL	3
Kales, J	1
Bixler, EO	2
Modell, W	1
Pearlman, CA	1
Greenberg, R	1
Lasagna, L	1
Ananth, JV	1
Bronheim, LA	1
Klingner, A	1
Davison, GC	1
Tsujimoto, RN	1
Glaros, AG	1
Haider, I	1
Brown, WT	1
Massac, CH	1
Pinard, G	1
Côte, JY	1
Tétreault, L	1
Strumia, E	1
Shapiro, S	1
Slone, D	1
Lewis, GP	1
Jick, H	1
Shaw, CW	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Pharmacotoxicology of Trichloroethylene Metabolites: Short-term Effect of DCA on in Vivo Tyrosine Catabolism and MAAI Expression[NCT00865514]				2 participants (Actual)	Interventional	2011-08-31	Terminated (stopped due to Difficulty in obtaining the solution from the compounding pharmacies caused a two year delay in start-up; the funding ended prior to study completion.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
[Algorithms for diagnosis and therapy of sleep disorders in general practice]. MMW Fortschritte der Medizin, 2003, May-26, Volume: 145 Suppl 2 Topics: Age Factors; Aged; Algorithms; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Ben	2003
Sleep and hypnotic drugs. Drugs, 1975, Volume: 9, Issue:6 Topics: Adult; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Barbiturates; Benzodiazepin	1975
Medical-psychological implications of recent sleep research. Psychiatry in medicine, 1970, Volume: 1, Issue:4 Topics: Adaptation, Psychological; Amphetamine; Barbiturates; Central Nervous System Stimulants; Chloral Hyd	1970

Article	Year
The efficacy of triazolam and chloral hydrate in geriatric insomniacs. The Journal of international medical research, 1980, Volume: 8, Issue:5 Topics: Aged; Anti-Anxiety Agents; Chloral Hydrate; Clinical Trials as Topic; Double-Blind Method; Humans; M	1980
Efficacy and side effects of chloral hydrate and tryptophan as sleeping aids in psychogeriatric patients. International pharmacopsychiatry, 1980, Volume: 15, Issue:2 Topics: Aged; Chloral Hydrate; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hypnotics and	1980
Preference studies of triazolam with standard hypnotics in out-patients with insomnia. The Journal of international medical research, 1976, Volume: 4, Issue:4 Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Chloral Hydrate; Clinical Trials as Topic; Double-Blin	1976
A comparison of two sedative/hypnotic drugs. Age and ageing, 1977, Volume: Suppl Topics: Aged; Antipyrine; Chloral Hydrate; Chlormethiazole; Clinical Trials as Topic; Dose-Response Relation	1977
Use of subjective responses to evaluate efficacy of mild analgesic-sedative combinations. Clinical pharmacology and therapeutics, 1974, Volume: 15, Issue:2 Topics: Acetaminophen; Analgesics; Chloral Hydrate; Clinical Trials as Topic; Drug Therapy, Combination; Fem	1974
Hypnotics and altered sleep-dream patterns. II. All-night EEG studies of chloral hydrate, flurazepam, and methaqualone. Archives of general psychiatry, 1970, Volume: 23, Issue:3 Topics: Adult; Benzazepines; Chloral Hydrate; Clinical Trials as Topic; Dreams; Electroencephalography; Elec	1970
Hypnotic drugs and their effectiveness. All-night EEG studies of insomniac subjects. Archives of general psychiatry, 1970, Volume: 23, Issue:3 Topics: Adult; Benzazepines; Chloral Hydrate; Clinical Trials as Topic; Electroencephalography; Electromyogr	1970
Triclofos sodium (Triclos) for insomnia. The Medical letter on drugs and therapeutics, 1972, Oct-13, Volume: 14, Issue:21 Topics: Administration, Oral; Barbiturates; Biopharmaceutics; Capsules; Chloral Hydrate; Clinical Trials as	1972
The effects of hypnotic drugs on performance. Current therapeutic research, clinical and experimental, 1973, Volume: 15, Issue:1 Topics: Attention; Chloral Hydrate; Chlordiazepoxide; Cognition; Decision Making; Glutethimide; Humans; Hypn	1973
Diazepam in the treatment of insomnia in psychiatric patients. Current therapeutic research, clinical and experimental, 1973, Volume: 15, Issue:4 Topics: Adult; Chloral Hydrate; Clinical Trials as Topic; Diazepam; Female; Humans; Hypnotics and Sedatives;	1973
A comparative trial of mandrax and dichloralphenazone. The British journal of psychiatry : the journal of mental science, 1968, Volume: 114, Issue:509 Topics: Aged; Antipyrine; Chloral Hydrate; Clinical Trials as Topic; Diphenhydramine; Humans; Mental Disorde	1968
A comparative study of three hypnotics: methyprylon, glutethimide and chloral hydrate. Canadian Medical Association journal, 1970, Mar-14, Volume: 102, Issue:5 Topics: Adjustment Disorders; Adult; Anxiety Disorders; Chloral Hydrate; Clinical Trials as Topic; Female; G	1970
[Evaluation of the hypnotic properties of promethazine in chronic schizophrenics]. Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology, 1971, Volume: 4, Issue:2 Topics: Adult; Chloral Hydrate; Humans; Male; Middle Aged; Placebos; Promethazine; Schizophrenia; Sleep; Sle	1971

Article	Year
A new tablet form of chloral hydrate (WM-1127) in the treatment of insomnia in the aged: double-blind study. Journal of the American Geriatrics Society, 1961, Volume: 9 Topics: Aged; Aged, 80 and over; Chloral Hydrate; Double-Blind Method; Humans; Sleep Initiation and Maintena	1961
Successful treatment of a seizure disorder with chronic high-dose chloral hydrate: a pediatric case report. Journal of palliative care, 2010,Winter, Volume: 26, Issue:4 Topics: Child; Chloral Hydrate; Developmental Disabilities; Electron Transport Complex III; Epilepsy; Humans	2010
[Addiction to sleeping pills. 1929]. L'Encephale, 2011, Volume: 37, Issue:4 Suppl 3 Topics: Barbiturates; Chloral Hydrate; Cyclothymic Disorder; France; History, 20th Century; Humans; Hypnotic	2011
A comparative controlled clinical trial of seven hypnotic agents in medical and psychiatric in-patients. The American journal of the medical sciences, 1963, Volume: 245 Topics: Chloral Hydrate; Glutethimide; Humans; Hypnotics and Sedatives; Meprobamate; Secobarbital; Sleep Ini	1963
AN EXPERIMENT IN THE DOMICILIARY USE OF HYPNOTICS. The Practitioner, 1963, Volume: 191 Topics: Barbiturates; Chloral Hydrate; Humans; Hypnotics and Sedatives; Placebos; Sleep Initiation and Maint	1963
DRUGS FOR INSOMNIA. Canadian Medical Association journal, 1963, Dec-28, Volume: 89 Topics: Amobarbital; Child; Chloral Hydrate; Diphenhydramine; Humans; Paraldehyde; Phenobarbital; Promethazi	1963
A COMPARATIVE STUDY OF THIRTEEN HYPNOTIC DRUGS. Applied therapeutics, 1964, Volume: 6 Topics: Barbiturates; Biomedical Research; Chloral Hydrate; Chlorprothixene; Ethchlorvynol; Glutethimide; Hu	1964
Does insomnia in prison improve with time? Prospective study among remanded prisoners using the Pittsburgh Sleep Quality Index. Medicine, science, and the law, 2003, Volume: 43, Issue:4 Topics: Adult; Benzodiazepines; Chloral Hydrate; Drug Utilization Review; Female; Humans; Hypnotics and Seda	2003
The use and abuse of hypnotics. Gerontologia clinica, 1967, Volume: 9, Issue:4 Topics: Aged; Amobarbital; Antidepressive Agents; Antipyrine; Chloral Hydrate; Humans; Hypnotics and Sedativ	1967
Hypnotic drugs. The Medical letter on drugs and therapeutics, 2000, Aug-07, Volume: 42, Issue:1084 Topics: Acetamides; Administration, Oral; Alcohol Drinking; Barbiturates; Chloral Hydrate; Ethchlorvynol; GA	2000
Drug treatment of insomnia in old age. Psychopharmacology bulletin, 1976, Volume: 12, Issue:2 Topics: Aged; Alcohols; Anti-Anxiety Agents; Barbiturates; Benzodiazepines; Chloral Hydrate; Electroencephal	1976
[Drugs against insomnia]. Der Internist, 1978, Volume: 19, Issue:9 Topics: Barbiturates; Chloral Hydrate; Diphenhydramine; Flurazepam; Glutethimide; Humans; Hypnotics and Seda	1978
Long term study of hypnotic medication in geriatric patients. A study of dixyrazine, nitrazepam and amylobarbitone. Scandinavian journal of social medicine. Supplementum, 1977, Volume: 14 Topics: Aged; Amobarbital; Chloral Hydrate; Follow-Up Studies; Humans; Hypnotics and Sedatives; Nitrazepam;	1977
Clinical effects of chloral hydrate in hospitalized medical patients. Journal of clinical pharmacology, 1979, Volume: 19, Issue:10 Topics: Adult; Aged; Blood Urea Nitrogen; Chloral Hydrate; Drug Utilization; Female; Humans; Male; Middle Ag	1979
Drug treatment of insomnia in the elderly. Connecticut medicine, 1992, Volume: 56, Issue:1 Topics: Aged; Barbiturates; Benzodiazepines; Chloral Hydrate; Humans; Hypnotics and Sedatives; Sleep Initiat	1992
Sleep disturbances and agitational states in the elderly. Therapeutic possibilities and limitations in West Germany. Acta psychiatrica Scandinavica. Supplementum, 1986, Volume: 329 Topics: Aged; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety Disorders; Benzodiazepines; Butyrophenones;	1986
Diagnosis and treatment of insomnia. American family physician, 1987, Volume: 35, Issue:3 Topics: Anti-Anxiety Agents; Antidepressive Agents; Barbiturates; Benzodiazepines; Chloral Hydrate; Humans;	1987
Effectiveness of sleep medications: all night studies of hypnotic drugs. Electroencephalography and clinical neurophysiology, 1969, Volume: 27, Issue:7 Topics: Chloral Hydrate; Electroencephalography; Electromyography; Electrooculography; Glutethimide; Humans;	1969
Evaluation, diagnosis, and treatment of clinical conditions related to sleep. JAMA, 1970, Sep-28, Volume: 213, Issue:13 Topics: Asthma; Chloral Hydrate; Coronary Disease; Duodenal Ulcer; Electroencephalography; Enuresis; Female;	1970
Chronic hypnotic-drug use. Ineffectiveness, drug-withdrawal insomnia, and dependence. JAMA, 1974, Feb-04, Volume: 227, Issue:5 Topics: Adult; Age Factors; Aged; Amobarbital; Chloral Hydrate; Chronic Disease; Dreams; Drug Therapy, Combi	1974
Updating the sleeping pill. Geriatrics, 1974, Volume: 29, Issue:2 Topics: Antidepressive Agents; Barbiturates; Benzodiazepinones; Chloral Hydrate; Drug Interactions; Drug Tol	1974
Hypnotic drugs. The New England journal of medicine, 1972, Dec-07, Volume: 287, Issue:23 Topics: Aged; Barbiturates; Benzazepines; Chloral Hydrate; Costs and Cost Analysis; Electroencephalography;	1972
Attribution and the maintenance of behavior chance in falling asleep. Journal of abnormal psychology, 1973, Volume: 82, Issue:1 Topics: Adult; Behavior Therapy; Chloral Hydrate; Female; Generalization, Psychological; Humans; Male; Persu	1973
Barbiturate and non-barbiturate hypnotics compared. The Practitioner, 1968, Volume: 201, Issue:202 Topics: Antipyrine; Barbiturates; Chloral Hydrate; Humans; Hypnotics and Sedatives; Sleep; Sleep Initiation	1968
[New complexes of chloral hydrate and their use in treatment with hypeotic and sedative drugs]. Minerva medica, 1968, Oct-13, Volume: 59, Issue:82 Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chloral Hydrate; Humans; Hypnotics and Sedatives;	1968
Clinical effects of hypnotics. II. An epidemiologic study. JAMA, 1969, Sep-29, Volume: 209, Issue:13 Topics: Body Weight; Chloral Hydrate; Diphenhydramine; Female; Humans; Hypnotics and Sedatives; Male; Pentob	1969
Quaalude and insomnia. The Medical letter on drugs and therapeutics, 1966, Apr-22, Volume: 8, Issue:8 Topics: Chloral Hydrate; Glutethimide; Humans; Hypnotics and Sedatives; Sleep Initiation and Maintenance Dis	1966
Treatment of insomnia complicated by pain using a chloral hydrate paracetamol complex. The British journal of clinical practice, 1966, Volume: 20, Issue:10 Topics: Acetaminophen; Chloral Hydrate; Drug Synergism; Humans; Pain; Sleep Initiation and Maintenance Disor	1966