chloral hydrate has been researched along with Huntington Disease in 1 studies
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Transgenic R6/2 mice carrying the Huntington's disease (HD) mutation show disrupted circadian rhythms that worsen as the disease progresses." | 1.34 | Pharmacological imposition of sleep slows cognitive decline and reverses dysregulation of circadian gene expression in a transgenic mouse model of Huntington's disease. ( Chesham, JE; Dyball, R; Hastings, MH; Inyushkin, AN; Maywood, ES; Morton, AJ; Pallier, PN; Zheng, Z, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pallier, PN | 1 |
| Maywood, ES | 1 |
| Zheng, Z | 1 |
| Chesham, JE | 1 |
| Inyushkin, AN | 1 |
| Dyball, R | 1 |
| Hastings, MH | 1 |
| Morton, AJ | 1 |
1 other study available for chloral hydrate and Huntington Disease
| Article | Year |
|---|---|
Pharmacological imposition of sleep slows cognitive decline and reverses dysregulation of circadian gene expression in a transgenic mouse model of Huntington's disease.
Topics: Age Factors; Alprazolam; Animals; Cell Cycle Proteins; Chloral Hydrate; Choice Behavior; Circadian R | 2007 |