chloral hydrate has been researched along with Heart Defects, Congenital in 10 studies
Heart Defects, Congenital: Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the effectiveness of oral midazolam and chloral hydrate on anxiety and sedation at various stages of pre-operative period in congenital heart surgery patients." | 3.78 | Effectiveness of premedication at the time of separation from parent and mask induction in paediatric patients coming for congenital heart disease surgery. ( Akhtar, I; Hamid, M; Khan, MA; Khatri, A, 2012) |
| "Chloral hydrate has limited availability in some countries, creating the need for alternative effective sedatives." | 2.82 | Comparison of dexmedetomidine and chloral hydrate sedation for transthoracic echocardiography in infants and toddlers: a randomized clinical trial. ( Hossain, M; Kurth, D; Loepke, A; Miller, J; Xue, B; Zhang, MZ, 2016) |
| "Chloral hydrate was administered orally or rectally to infants using doses of 50 mg/kg." | 1.46 | Safety and efficacy of chloral hydrate for conscious sedation of infants in the pediatric cardiovascular intensive care unit. ( Chen, ML; Chen, Q; Su, XY; Tu, XZ; Xu, F; Zhang, JX, 2017) |
| "Chloral hydrate (100mg/kg) was given orally for the induction of moderate to deep sedation 15 minutes before OSC; then the operative field was infiltrated with 1% lidocaine." | 1.39 | Central venous cutdown in neonates: feasibility as a bedside procedure without general anesthesia. ( Hong, SM; Lee, HS; Moon, SB, 2013) |
| " The purpose of this study was to describe the physiologic responses to chloral hydrate sedation, to report the occurrence of adverse events, and to identify any risk factors that predicted these adverse events in children who underwent sedation for echocardiography at our institution." | 1.33 | Chloral hydrate sedation for pediatric echocardiography: physiologic responses, adverse events, and risk factors. ( Coursey, M; Heistein, LC; Lemler, MS; Ramaciotti, C; Scott, WA; Sheeran, PW, 2006) |
| " The median dosage of CH given was 75 mg/kg (ranging 50 and 100 mg), with either oral or rectal administration." | 1.31 | Chloralhydrate in children undergoing echocardiography. ( Coskun, S; Onag, A; Yuksel, H, 2001) |
| "Chloral hydrate is a safe and effective agent for sedation of children with known or suspected congenital heart disease who are undergoing echocardiography in the outpatient cardiology clinic." | 1.29 | Safety and efficacy of chloral hydrate sedation in children undergoing echocardiography. ( Ingall, CG; Martin, GR; Napoli, KL, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hong, SM | 1 |
| Lee, HS | 1 |
| Moon, SB | 1 |
| Miller, J | 1 |
| Xue, B | 1 |
| Hossain, M | 1 |
| Zhang, MZ | 1 |
| Loepke, A | 1 |
| Kurth, D | 1 |
| Chen, ML | 1 |
| Chen, Q | 1 |
| Xu, F | 1 |
| Zhang, JX | 1 |
| Su, XY | 1 |
| Tu, XZ | 1 |
| Hamid, M | 1 |
| Khan, MA | 1 |
| Khatri, A | 1 |
| Akhtar, I | 1 |
| Heistein, LC | 1 |
| Ramaciotti, C | 1 |
| Scott, WA | 1 |
| Coursey, M | 1 |
| Sheeran, PW | 1 |
| Lemler, MS | 1 |
| Napoli, KL | 1 |
| Ingall, CG | 1 |
| Martin, GR | 1 |
| Johnson, PD | 1 |
| Dawson, BV | 1 |
| Goldberg, SJ | 1 |
| Coskun, S | 1 |
| Yuksel, H | 1 |
| Onag, A | 1 |
| Jaffe, RB | 1 |
| Hirsch, IA | 1 |
| Zauder, HL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT02239445] | Phase 4 | 158 participants (Actual) | Interventional | 2014-09-30 | Completed | ||
| Effect of Television Cartoons in Patients Younger Than 3.5 Years During Echocardiography.A Prospective Randomized Study[NCT02498743] | 58 participants (Actual) | Interventional | 2015-02-28 | Completed | |||
| Effect of Increasing Depth of Dexmedetomidine and Propofol Anesthesia on Upper Airway Morphology in Children With History of Obstructive Sleep Apnea[NCT01344759] | Phase 4 | 60 participants (Actual) | Interventional | 2009-06-30 | Completed | ||
| Intranasal Dexmedetomidine vs Oral Triclofos Sodium Sedation for Children With Autism Undergoing Electroencephalograms - A Randomized Controlled Trial.[NCT04270708] | Phase 4 | 200 participants (Anticipated) | Interventional | 2020-03-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
This is the count of the number of patients who needed an artificial airway. (NCT01344759)
Timeframe: During MRI and until recovery room discharge - approximately 30-250 minutes
| Intervention | Number of artifical airway events (Number) |
|---|---|
| Mild OSA and Dexmedetomidine | 0 |
| Mild OSA and Propofol | 1 |
| Moderate OSA and Dexmedetomidine | 1 |
| Moderate OSA and Propofol | 1 |
| Severe OSA and Dexmedetomidine | 2 |
| Severe OSA and Propofol | 5 |
The Obstructive Index is a count of the obstructive apnea events per hour of sleep (NCT01344759)
Timeframe: During MRI and until recovery room discharge - approximately 30-250 minutes
| Intervention | Apnea events/hour of sleep (Mean) |
|---|---|
| Mild OSA and Dexmedetomidine | 4.2 |
| Mild OSA and Propofol | 3.0 |
| Moderate OSA and Dexmedetomidine | 8.0 |
| Moderate OSA and Propofol | 8.0 |
| Severe OSA and Dexmedetomidine | 16.7 |
| Severe OSA and Propofol | 17.1 |
The respiratory disturbance index is a count of respiratory disturbance events per hour of sleep. (NCT01344759)
Timeframe: During MRI and until recovery room discharge - approximately 30-250 minutes
| Intervention | respir.disturbance events/hr of sleep (Mean) |
|---|---|
| Mild OSA and Dexmedetomidine | 5.1 |
| Mild OSA and Propofol | 3.2 |
| Moderate OSA and Dexmedetomidine | 8.8 |
| Moderate OSA and Propofol | 7.1 |
| Severe OSA and Dexmedetomidine | 16.6 |
| Severe OSA and Propofol | 25.2 |
The patient's oxygen saturation on room air. (NCT01344759)
Timeframe: During MRI and until recovery room discharge - approximately 30-250 minutes
| Intervention | percentage of SpO2 (Mean) |
|---|---|
| Mild OSA and Dexmedetomidine | 87.2 |
| Mild OSA and Propofol | 88.0 |
| Moderate OSA and Dexmedetomidine | 86.3 |
| Moderate OSA and Propofol | 89.0 |
| Severe OSA and Dexmedetomidine | 84.0 |
| Severe OSA and Propofol | 88.0 |
The primary outcome measures will be the cross sectional area of the pharyngeal airway of the patients measured at two levels soft palate (nasopharyngeal) and base of the tongue (retroglossal). Magnetic resonance images of the airway were obtained during low (1 mcg/kg/hr) and high (3 mcg/kg/hr) doses of DEX or low (100 mcg/kg/m) and high (200 mcg/kg/m) doses of Propofol. All were administered through an intravenous (IV) catheter. (NCT01344759)
Timeframe: during MRI within first 10 minutes of scanning
| Intervention | mm^2 (Median) | |||
|---|---|---|---|---|
| Low Dose Sedative, Nasopharyngeal measurement | High Dose Sedative, Nasopharyngeal measurement | Low Dose Sedative, Retroglossal measurement | High dose sedative, Retroglossal measurement | |
| Dexmedetomidine | 178.5 | 235.4 | 120.9 | 120.5 |
| Propofol | 239.9 | 201.6 | 115.1 | 108.1 |
1 trial available for chloral hydrate and Heart Defects, Congenital
| Article | Year |
|---|---|
Comparison of dexmedetomidine and chloral hydrate sedation for transthoracic echocardiography in infants and toddlers: a randomized clinical trial.
Topics: Administration, Intranasal; Administration, Oral; Chloral Hydrate; Dexmedetomidine; Echocardiography | 2016 |
9 other studies available for chloral hydrate and Heart Defects, Congenital
| Article | Year |
|---|---|
Central venous cutdown in neonates: feasibility as a bedside procedure without general anesthesia.
Topics: Administration, Oral; Anesthesia, Local; Anesthetics, Local; Catheterization, Central Venous; Chlora | 2013 |
Safety and efficacy of chloral hydrate for conscious sedation of infants in the pediatric cardiovascular intensive care unit.
Topics: Anesthesia Recovery Period; Cardiovascular Surgical Procedures; China; Chloral Hydrate; Conscious Se | 2017 |
Effectiveness of premedication at the time of separation from parent and mask induction in paediatric patients coming for congenital heart disease surgery.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Cardiac Surgical Procedures; Chi-Square Distribution; Child; Ch | 2012 |
Chloral hydrate sedation for pediatric echocardiography: physiologic responses, adverse events, and risk factors.
Topics: Blood Pressure; Child, Preschool; Chloral Hydrate; Conscious Sedation; Contraindications; Echocardio | 2006 |
Safety and efficacy of chloral hydrate sedation in children undergoing echocardiography.
Topics: Adolescent; Age Factors; Ambulatory Care; Blood Pressure; Child; Child, Preschool; Chloral Hydrate; | 1996 |
Cardiac teratogenicity of trichloroethylene metabolites.
Topics: Abnormalities, Drug-Induced; Acetaldehyde; Acetates; Animals; Chloral Hydrate; Cystine; Dichloroethy | 1998 |
Chloralhydrate in children undergoing echocardiography.
Topics: Analysis of Variance; Child; Child, Preschool; Chloral Hydrate; Echocardiography; Female; Heart Defe | 2001 |
Sedation and imaging protocol.
Topics: Child; Child, Preschool; Chloral Hydrate; Electrocardiography; Fentanyl; Heart Defects, Congenital; | 1990 |
Chloral hydrate: a potential cause of arrhythmias.
Topics: Child; Child, Preschool; Chloral Hydrate; Digoxin; Female; Heart Defects, Congenital; Humans; Infant | 1986 |