chloral hydrate has been researched along with Experimental Hepatoma in 4 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " Additional male mice were dosed as described above and their livers were excised at 24, 48 h, and 7 days after the final dose." | 1.31 | Tumorigenicity of chloral hydrate, trichloroacetic acid, trichloroethanol, malondialdehyde, 4-hydroxy-2-nonenal, crotonaldehyde, and acrolein in the B6C3F(1) neonatal mouse. ( Bucci, TJ; Chou, MW; Fu, PP; Kadlubar, FF; Samokyszyn, VM; Von Tungeln, LS; Yi, P, 2002) |
| "Chloral hydrate was nominated for study by the Food and Drug Administration based upon widespread human exposure and its potential hepatotoxicity and the toxicity of related chemicals." | 1.31 | Toxicology and carcinogenesis study of chloral hydrate (ad libitum and dietary controlled) (CAS no. 302-17-0) in male B6C3F1 mice (gavage study). ( , 2002) |
| "Chloral hydrate is a compound of environmental significance." | 1.27 | Induction of neoplastic lesions in the livers of C57BL x C3HF1 mice by chloral hydrate. ( Abrahams, C; Ghose, T; Rao, KV; Rijhsinghani, KS; Swerdlow, MA, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Von Tungeln, LS | 1 |
| Yi, P | 1 |
| Bucci, TJ | 1 |
| Samokyszyn, VM | 1 |
| Chou, MW | 1 |
| Kadlubar, FF | 1 |
| Fu, PP | 1 |
| Daniel, FB | 1 |
| DeAngelo, AB | 1 |
| Stober, JA | 1 |
| Olson, GR | 1 |
| Page, NP | 1 |
| Rijhsinghani, KS | 1 |
| Abrahams, C | 1 |
| Swerdlow, MA | 1 |
| Rao, KV | 1 |
| Ghose, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacotoxicology of Trichloroethylene Metabolites: Short-term Effect of DCA on in Vivo Tyrosine Catabolism and MAAI Expression[NCT00865514] | 2 participants (Actual) | Interventional | 2011-08-31 | Terminated (stopped due to Difficulty in obtaining the solution from the compounding pharmacies caused a two year delay in start-up; the funding ended prior to study completion.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for chloral hydrate and Experimental Hepatoma
| Article | Year |
|---|---|
Tumorigenicity of chloral hydrate, trichloroacetic acid, trichloroethanol, malondialdehyde, 4-hydroxy-2-nonenal, crotonaldehyde, and acrolein in the B6C3F(1) neonatal mouse.
Topics: Acrolein; Aldehydes; Animals; Animals, Newborn; Carcinogenicity Tests; Carcinogens; Chloral Hydrate; | 2002 |
Toxicology and carcinogenesis study of chloral hydrate (ad libitum and dietary controlled) (CAS no. 302-17-0) in male B6C3F1 mice (gavage study).
Topics: Animals; Body Weight; Chloral Hydrate; Diet; Dose-Response Relationship, Drug; Humans; Liver Neoplas | 2002 |
Hepatocarcinogenicity of chloral hydrate, 2-chloroacetaldehyde, and dichloroacetic acid in the male B6C3F1 mouse.
Topics: Acetaldehyde; Animals; Body Weight; Carcinogens; Chloral Hydrate; Dichloroacetic Acid; Drinking Beha | 1992 |
Induction of neoplastic lesions in the livers of C57BL x C3HF1 mice by chloral hydrate.
Topics: Animals; Chloral Hydrate; Cytoplasmic Granules; Immunoenzyme Techniques; Liver; Liver Neoplasms, Exp | 1986 |