chloral hydrate has been researched along with Disease Models, Animal in 19 studies
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chloral hydrate preconditioning significantly improved the neurological outcomes and reduced the infarction and brain edema after ischemia." | 7.81 | Chloral Hydrate Preconditioning Protects Against Ischemic Stroke via Upregulating Annexin A1. ( Feng, D; Li, XF; Liu, JH; Pei, L; Shang, Y; Wu, Y; Zhang, YF, 2015) |
| "Since an ethical issue has been raised regarding the use of the well-known anesthetic agent chloral hydrate, owing to its mutagenic and carcinogenic effects in animals, attention of neuroscientists has turned to finding out an alternative agent able to meet not only potency, safety, and analgesic efficacy, but also reduced neuroprotective effect for stroke research." | 7.80 | Evidence for the use of isoflurane as a replacement for chloral hydrate anesthesia in experimental stroke: an ethical issue. ( Cédrick, L; Maud, P; Michèle, B; Olivier, P; Régis, B; Thavarak, O; Vincent, B, 2014) |
| "This study aims to establish pilocarpine-induced rat model of status epilepticus (SE), observe the activity of calpain I in the rat hippocampus and the subsequent neuronal death, and explore the relationship between calpain I activity and neuronal death in the hippocampus." | 7.79 | Calpain I activity and its relationship with hippocampal neuronal death in pilocarpine-induced status epilepticus rat model. ( Gao, H; Geng, Z, 2013) |
| "Thiopental is an anesthetic used for controlling high intracranial pressure (ICP) caused by brain surgery, brain trauma, and severe stroke." | 7.75 | Thiopental exaggerates ischemic brain damage and neurological deficits after experimental stroke in spontaneously hypertensive rats. ( Duan, WM; Duan, YF; Liu, C; Zhao, LR; Zhao, YF, 2009) |
| "Chloral hydrate has been long used as a safe sedative and hypnotic drug in humans." | 5.37 | Cardiac arrhythmias induced by chloral hydrate in rhesus monkeys. ( Han, P; Kang, YJ; Song, H; Xie, H; Yang, P, 2011) |
| "In order to determine the role of the adrenergic system in bupivacaine-induced cardiotoxicity, a series of experiments were performed." | 3.88 | Beta-adrenergic activation induces cardiac collapse by aggravating cardiomyocyte contractile dysfunction in bupivacaine intoxication. ( Chen, Y; Cheng, Y; Chu, L; Duan, R; Li, H; Li, J; Xia, D; Yuan, J; Zhang, J; Zhang, Y; Zhao, S; Zhao, X, 2018) |
| "Chloral hydrate preconditioning significantly improved the neurological outcomes and reduced the infarction and brain edema after ischemia." | 3.81 | Chloral Hydrate Preconditioning Protects Against Ischemic Stroke via Upregulating Annexin A1. ( Feng, D; Li, XF; Liu, JH; Pei, L; Shang, Y; Wu, Y; Zhang, YF, 2015) |
| "Since an ethical issue has been raised regarding the use of the well-known anesthetic agent chloral hydrate, owing to its mutagenic and carcinogenic effects in animals, attention of neuroscientists has turned to finding out an alternative agent able to meet not only potency, safety, and analgesic efficacy, but also reduced neuroprotective effect for stroke research." | 3.80 | Evidence for the use of isoflurane as a replacement for chloral hydrate anesthesia in experimental stroke: an ethical issue. ( Cédrick, L; Maud, P; Michèle, B; Olivier, P; Régis, B; Thavarak, O; Vincent, B, 2014) |
| "This study aims to establish pilocarpine-induced rat model of status epilepticus (SE), observe the activity of calpain I in the rat hippocampus and the subsequent neuronal death, and explore the relationship between calpain I activity and neuronal death in the hippocampus." | 3.79 | Calpain I activity and its relationship with hippocampal neuronal death in pilocarpine-induced status epilepticus rat model. ( Gao, H; Geng, Z, 2013) |
| "Thiopental is an anesthetic used for controlling high intracranial pressure (ICP) caused by brain surgery, brain trauma, and severe stroke." | 3.75 | Thiopental exaggerates ischemic brain damage and neurological deficits after experimental stroke in spontaneously hypertensive rats. ( Duan, WM; Duan, YF; Liu, C; Zhao, LR; Zhao, YF, 2009) |
| " Mean firing rates were substantially higher in awake animals than in subjects anesthetized with chloral hydrate, perhaps reflecting anesthesia-induced decreases in excitatory input to striatal neurons." | 3.71 | In vivo extracellular recording of striatal neurons in the awake rat following unilateral 6-hydroxydopamine lesions. ( Chen, MT; Hoffer, BJ; Janak, PH; Morales, M; Woodward, DJ, 2001) |
| " Although anesthesia by halothane via face-mask allowed better control of depth of anesthesia than chloral hydrate, we have found this method to be unsatisfactory due to insufficient control of ventilation and waste of anesthetic gases." | 3.71 | Anesthetic methods in rats determine outcome after experimental focal cerebral ischemia: mechanical ventilation is required to obtain controlled experimental conditions. ( Baethmann, A; Schmid-Elsaesser, R; Zausinger, S, 2002) |
| "Chloral hydrate has been long used as a safe sedative and hypnotic drug in humans." | 1.37 | Cardiac arrhythmias induced by chloral hydrate in rhesus monkeys. ( Han, P; Kang, YJ; Song, H; Xie, H; Yang, P, 2011) |
| "Transgenic R6/2 mice carrying the Huntington's disease (HD) mutation show disrupted circadian rhythms that worsen as the disease progresses." | 1.34 | Pharmacological imposition of sleep slows cognitive decline and reverses dysregulation of circadian gene expression in a transgenic mouse model of Huntington's disease. ( Chesham, JE; Dyball, R; Hastings, MH; Inyushkin, AN; Maywood, ES; Morton, AJ; Pallier, PN; Zheng, Z, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.53) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 7 (36.84) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Büki, A | 1 |
| Kalmár, G | 1 |
| Kekesi, G | 1 |
| Benedek, G | 1 |
| Nyúl, LG | 1 |
| Horvath, G | 1 |
| Li, J | 1 |
| Duan, R | 1 |
| Zhang, Y | 1 |
| Zhao, X | 1 |
| Cheng, Y | 1 |
| Chen, Y | 1 |
| Yuan, J | 1 |
| Li, H | 1 |
| Zhang, J | 1 |
| Chu, L | 1 |
| Xia, D | 1 |
| Zhao, S | 1 |
| Maud, P | 1 |
| Thavarak, O | 1 |
| Cédrick, L | 1 |
| Michèle, B | 1 |
| Vincent, B | 1 |
| Olivier, P | 1 |
| Régis, B | 1 |
| Liu, JH | 1 |
| Feng, D | 1 |
| Zhang, YF | 1 |
| Shang, Y | 1 |
| Wu, Y | 1 |
| Li, XF | 1 |
| Pei, L | 1 |
| Wenzl, MV | 1 |
| Wölkart, G | 1 |
| Stessel, H | 1 |
| Beretta, M | 1 |
| Schmidt, K | 1 |
| Mayer, B | 1 |
| Duan, YF | 1 |
| Liu, C | 1 |
| Zhao, YF | 1 |
| Duan, WM | 1 |
| Zhao, LR | 1 |
| Han, P | 1 |
| Song, H | 1 |
| Yang, P | 1 |
| Xie, H | 1 |
| Kang, YJ | 1 |
| Gao, H | 1 |
| Geng, Z | 1 |
| Sandberg, KL | 1 |
| Poole, SD | 1 |
| Sundell, HW | 1 |
| Sonn, J | 1 |
| Mayevsky, A | 1 |
| Pallier, PN | 1 |
| Maywood, ES | 1 |
| Zheng, Z | 1 |
| Chesham, JE | 1 |
| Inyushkin, AN | 1 |
| Dyball, R | 1 |
| Hastings, MH | 1 |
| Morton, AJ | 1 |
| Marzella, L | 1 |
| Warnick, JE | 1 |
| Suguihara, C | 1 |
| Bancalari, E | 1 |
| Hehre, D | 1 |
| Duara, S | 1 |
| Gerhardt, T | 1 |
| Magloczky, Z | 1 |
| Freund, TF | 1 |
| Chen, MT | 1 |
| Morales, M | 1 |
| Woodward, DJ | 1 |
| Hoffer, BJ | 1 |
| Janak, PH | 1 |
| Zausinger, S | 1 |
| Baethmann, A | 1 |
| Schmid-Elsaesser, R | 1 |
| Silbergeld, EK | 1 |
| Goldberg, AM | 1 |
| Matsushita, S | 1 |
| Sogani, RK | 1 |
| Raben, MS | 1 |
19 other studies available for chloral hydrate and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Impaired pupillary control in "schizophrenia-like" WISKET rats.
Topics: Anesthetics; Animals; Chloral Hydrate; Cognition; Disease Models, Animal; Ketamine; Male; Motivation | 2018 |
Beta-adrenergic activation induces cardiac collapse by aggravating cardiomyocyte contractile dysfunction in bupivacaine intoxication.
Topics: Anesthesia; Animals; Blood Pressure; Bupivacaine; Cardiotoxicity; Chloral Hydrate; Disease Models, A | 2018 |
Evidence for the use of isoflurane as a replacement for chloral hydrate anesthesia in experimental stroke: an ethical issue.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Bioethical Issues; Chloral Hydrate; Disease Models, An | 2014 |
Chloral Hydrate Preconditioning Protects Against Ischemic Stroke via Upregulating Annexin A1.
Topics: Animals; Annexin A1; Brain; Brain Edema; Brain Ischemia; Chloral Hydrate; Cytokines; Disease Models, | 2015 |
Different effects of ascorbate deprivation and classical vascular nitrate tolerance on aldehyde dehydrogenase-catalysed bioactivation of nitroglycerin.
Topics: Aldehyde Dehydrogenase; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Biotransformation; Chloral | 2009 |
Thiopental exaggerates ischemic brain damage and neurological deficits after experimental stroke in spontaneously hypertensive rats.
Topics: Anesthetics, Intravenous; Animals; Brain; Brain Ischemia; Chloral Hydrate; Disease Models, Animal; D | 2009 |
Cardiac arrhythmias induced by chloral hydrate in rhesus monkeys.
Topics: Animals; Arrhythmias, Cardiac; Chloral Hydrate; Disease Models, Animal; Electrocardiography; Macaca | 2011 |
Calpain I activity and its relationship with hippocampal neuronal death in pilocarpine-induced status epilepticus rat model.
Topics: Animals; Apoptosis; Atropine; Calpain; Chloral Hydrate; Disease Models, Animal; Hippocampus; Hypnoti | 2013 |
Cardio-respiratory response to moderate chloral hydrate sedation in young lambs.
Topics: Animals; Cardiovascular System; Chloral Hydrate; Disease Models, Animal; Fetus; Functional Residual | 2013 |
Effects of anesthesia on the responses to cortical spreading depression in the rat brain in vivo.
Topics: Anesthetics; Animals; Cerebral Cortex; Cerebrovascular Circulation; Chloral Hydrate; Cortical Spread | 2006 |
Pharmacological imposition of sleep slows cognitive decline and reverses dysregulation of circadian gene expression in a transgenic mouse model of Huntington's disease.
Topics: Age Factors; Alprazolam; Animals; Cell Cycle Proteins; Chloral Hydrate; Choice Behavior; Circadian R | 2007 |
Assessment of spinal cord trauma using evoked potentials in a rat model of decompression sickness.
Topics: Action Potentials; Anesthetics; Animals; Chloral Hydrate; Decompression Sickness; Disease Models, An | 1994 |
Changes in ventilation and oxygen consumption during acute hypoxia in sedated newborn piglets.
Topics: Animals; Animals, Newborn; Carbon Dioxide; Chloral Hydrate; Disease Models, Animal; Hypoxia; Oxygen; | 1994 |
Selective neuronal death in the contralateral hippocampus following unilateral kainate injections into the CA3 subfield.
Topics: Anesthetics; Animals; Biomarkers; Calbindin 2; Cell Death; Chloral Hydrate; Disease Models, Animal; | 1993 |
In vivo extracellular recording of striatal neurons in the awake rat following unilateral 6-hydroxydopamine lesions.
Topics: Action Potentials; Anesthesia; Animals; Apomorphine; Chloral Hydrate; Corpus Striatum; Disease Model | 2001 |
Anesthetic methods in rats determine outcome after experimental focal cerebral ischemia: mechanical ventilation is required to obtain controlled experimental conditions.
Topics: Acidosis, Respiratory; Anesthesia; Anesthetics; Animals; Brain; Brain Ischemia; Cerebral Infarction; | 2002 |
Lead-induced behavioral dysfunction: an animal model of hyperactivity.
Topics: Amphetamine; Animals; Chloral Hydrate; Dextroamphetamine; Disease Models, Animal; Female; Humans; Hy | 1974 |
Ornithine decarboxylase in cardiac hypertrophy in the rat.
Topics: Anesthesia; Animals; Aorta, Thoracic; Azaguanine; Carbon Isotopes; Carboxy-Lyases; Chloral Hydrate; | 1972 |