chloral hydrate has been researched along with Body Weight in 21 studies
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chloral hydrate, which is used as a sedative in pediatric medicine and is a by-product of water chlorination, is hepatocarcinogenic in B6C3F1 mice, a strain that can exhibit high rates of background liver tumor incidence, which are associated with increased body weight." | 3.72 | Dietary controlled carcinogenicity study of chloral hydrate in male B6C3F1 mice. ( Allaben, WT; Allen, LJ; Hussain, N; Latendresse, JR; Leakey, JE; Seng, JE, 2003) |
| " Chloral hydrate and its major metabolite, trichloroacetic acid, induce liver tumors in B6C3F1 mice, a strain that can exhibit high rates of background liver tumor incidence, which is associated with increased body weight." | 3.72 | Toxicokinetics of chloral hydrate in ad libitum-fed, dietary-controlled, and calorically restricted male B6C3F1 mice following short-term exposure. ( Agrawal, N; Allaben, WT; Horsley, ET; Leakey, JE; Leakey, TI; Scherer, EM; Seng, JE; Xia, S, 2003) |
| "Chloral hydrate is a clinical sedative." | 1.42 | Pre-conditioned place preference treatment of chloral hydrate interrupts the rewarding effect of morphine. ( Ma, Y; Sun, Y; Wang, J; Zhou, M; Zong, W, 2015) |
| "Chloral hydrate sedation was appropriate for pediatric MRI in patients younger than 18 months." | 1.38 | Analysis of the appropriate age and weight for pediatric patient sedation for magnetic resonance imaging. ( Jung, JH; Kim, DK; Kim, HB; Kwak, YH; Lee, YJ; Park, JH, 2012) |
| "Chloral hydrate is a safe and effective agent for sedation in children with an age and weight dependent response." | 1.33 | Chloral hydrate. An effective agent for sedation in children with age and weight dependent response. ( Al-Eissa, YA; Haidar, NA; Hijazi, OM, 2005) |
| "Trichloroethylene (TCE) is a prevalent occupational and environmental contaminant that has been reported to cause a variety of toxic effects." | 1.32 | Exposure to trichloroethylene and its metabolites causes impairment of sperm fertilizing ability in mice. ( Anupriwan, A; Forkert, PG; Leader, A; Tanphaichitr, N; Vincent, R; Wade, MG; Weerachatyanukul, W; Xu, H, 2004) |
| "Chloral hydrate was nominated for study by the Food and Drug Administration based upon widespread human exposure and its potential hepatotoxicity and the toxicity of related chemicals." | 1.31 | Toxicology and carcinogenesis study of chloral hydrate (ad libitum and dietary controlled) (CAS no. 302-17-0) in male B6C3F1 mice (gavage study). ( , 2002) |
| "Chloral hydrate has been shown to be genotoxic in numerous prokaryotic and eukaryotic assay systems including human lymphocytes in vitro." | 1.30 | NTP technical report on the toxicity and metabolism studies of chloral hydrate (CAS No. 302-17-0). Administered by gavage to F344/N rats and B6C3F1 mice. ( Beland, FA, 1999) |
| " On the basis of the mild liver toxicity (histopathological and clinical) observed in males at the highest doses (168 mg/kg-day), the no observed adverse effect level (NOAEL) for oral exposure of rats to chloral hydrate for 90 days is considered to be 96 mg/kg-day (600 mg/L)." | 1.28 | Ninety-day toxicity study of chloral hydrate in the Sprague-Dawley rat. ( Daniel, FB; Olson, GR; Page, NP; Robinson, M; Stober, JA, 1992) |
| " Five rats from each group were dosed with 7." | 1.26 | The effect of dietary protein quantity on the activity of UDP-glucuronyltransferase and its physiological significance in drug metabolism. ( Bray, TM; Merrill, JC, 1982) |
| "Chloral hydrate has been found in our drinking water supplies at levels up to 5 micrograms/1." | 1.26 | Toxicology of chloral hydrate in the mouse. ( Barnes, DW; Borzelleca, JF; Bradshaw, TJ; Douglas, KA; Kauffmann, BM; Munson, AE; Sain, LE; Sanders, VM; White, KL, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (33.33) | 18.7374 |
| 1990's | 5 (23.81) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 3 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, Y | 1 |
| Zong, W | 1 |
| Zhou, M | 1 |
| Ma, Y | 1 |
| Wang, J | 1 |
| Gan, X | 1 |
| Lin, H | 1 |
| Chen, J | 1 |
| Lin, Z | 1 |
| Lin, Y | 1 |
| Chen, W | 1 |
| Lee, YJ | 1 |
| Kim, DK | 1 |
| Kwak, YH | 1 |
| Kim, HB | 1 |
| Park, JH | 1 |
| Jung, JH | 1 |
| Leakey, JE | 3 |
| Seng, JE | 3 |
| Allaben, WT | 3 |
| Latendresse, JR | 1 |
| Hussain, N | 1 |
| Allen, LJ | 1 |
| Agrawal, N | 1 |
| Horsley, ET | 1 |
| Leakey, TI | 1 |
| Scherer, EM | 1 |
| Xia, S | 1 |
| Xu, H | 1 |
| Tanphaichitr, N | 1 |
| Forkert, PG | 1 |
| Anupriwan, A | 1 |
| Weerachatyanukul, W | 1 |
| Vincent, R | 1 |
| Leader, A | 1 |
| Wade, MG | 1 |
| Hijazi, OM | 1 |
| Haidar, NA | 1 |
| Al-Eissa, YA | 1 |
| Merrill, JC | 1 |
| Bray, TM | 1 |
| Sanders, VM | 1 |
| Kauffmann, BM | 1 |
| White, KL | 1 |
| Douglas, KA | 1 |
| Barnes, DW | 1 |
| Sain, LE | 1 |
| Bradshaw, TJ | 1 |
| Borzelleca, JF | 1 |
| Munson, AE | 1 |
| Leuschner, J | 1 |
| Beuscher, N | 1 |
| Beland, FA | 1 |
| Peters, JH | 1 |
| Gordon, GR | 1 |
| Ferguson, SA | 1 |
| Robinson, RG | 1 |
| McHugh, PR | 1 |
| Bloom, FE | 1 |
| Daniel, FB | 2 |
| Robinson, M | 1 |
| Stober, JA | 2 |
| Page, NP | 2 |
| Olson, GR | 2 |
| DeAngelo, AB | 1 |
| Dada, MO | 1 |
| Campbell, GT | 1 |
| Horacek, MJ | 1 |
| Blake, CA | 1 |
| Rikkers, LF | 1 |
| Moody, FG | 1 |
| Kuzemko, JA | 1 |
| Hartley, S | 1 |
| Shapiro, S | 1 |
| Slone, D | 1 |
| Lewis, GP | 1 |
| Jick, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised Comparison of Two Intranasal Dexmedetomidine Doses for Ophthalmic Examination Following Failed Chloral Hydrate Sedation in Children[NCT02077712] | 60 participants (Anticipated) | Interventional | 2014-02-28 | Recruiting | |||
| Pharmacotoxicology of Trichloroethylene Metabolites: Short-term Effect of DCA on in Vivo Tyrosine Catabolism and MAAI Expression[NCT00865514] | 2 participants (Actual) | Interventional | 2011-08-31 | Terminated (stopped due to Difficulty in obtaining the solution from the compounding pharmacies caused a two year delay in start-up; the funding ended prior to study completion.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for chloral hydrate and Body Weight
| Article | Year |
|---|---|
Rescue Sedation With Intranasal Dexmedetomidine for Pediatric Ophthalmic Examination After Chloral Hydrate Failure: A Randomized, Controlled Trial.
Topics: Administration, Intranasal; Body Weight; Cataract; Child, Preschool; Chloral Hydrate; Conscious Seda | 2016 |
Treatment of cerebral irritation in the newborn: double-blind trial with chloral hydrate and diazepam.
Topics: Asphyxia Neonatorum; Body Weight; Brain Diseases; Chloral Hydrate; Clinical Trials as Topic; Diazepa | 1972 |
19 other studies available for chloral hydrate and Body Weight
| Article | Year |
|---|---|
Pre-conditioned place preference treatment of chloral hydrate interrupts the rewarding effect of morphine.
Topics: Animals; Behavior, Animal; Body Weight; Chloral Hydrate; Conditioning, Operant; Cues; Hypnotics and | 2015 |
Analysis of the appropriate age and weight for pediatric patient sedation for magnetic resonance imaging.
Topics: Age Factors; Body Weight; Brain Diseases; Child; Child, Preschool; Chloral Hydrate; Conscious Sedati | 2012 |
Toxicology and carcinogenesis study of chloral hydrate (ad libitum and dietary controlled) (CAS no. 302-17-0) in male B6C3F1 mice (gavage study).
Topics: Animals; Body Weight; Chloral Hydrate; Diet; Dose-Response Relationship, Drug; Humans; Liver Neoplas | 2002 |
Body weight considerations in the B6C3F1 mouse and the use of dietary control to standardize background tumor incidence in chronic bioassays.
Topics: Adenoma, Liver Cell; Animals; Body Weight; Carcinogenicity Tests; Carcinoma, Hepatocellular; Chloral | 2003 |
Dietary controlled carcinogenicity study of chloral hydrate in male B6C3F1 mice.
Topics: Adenoma, Liver Cell; Administration, Oral; Animals; Body Weight; Carcinogenicity Tests; Carcinoma, H | 2003 |
Toxicokinetics of chloral hydrate in ad libitum-fed, dietary-controlled, and calorically restricted male B6C3F1 mice following short-term exposure.
Topics: Animals; Area Under Curve; Body Weight; Caloric Restriction; Chloral Hydrate; Chromatography, Gas; C | 2003 |
Exposure to trichloroethylene and its metabolites causes impairment of sperm fertilizing ability in mice.
Topics: Acrosome Reaction; Anesthetics, Intravenous; Animals; Body Weight; Chloral Hydrate; Epididymis; Ethy | 2004 |
Chloral hydrate. An effective agent for sedation in children with age and weight dependent response.
Topics: Administration, Oral; Age Factors; Body Weight; Child, Preschool; Chloral Hydrate; Conscious Sedatio | 2005 |
The effect of dietary protein quantity on the activity of UDP-glucuronyltransferase and its physiological significance in drug metabolism.
Topics: Animals; Body Weight; Chloral Hydrate; Cytochrome P-450 Enzyme System; Dietary Proteins; Glucuronosy | 1982 |
Toxicology of chloral hydrate in the mouse.
Topics: Administration, Oral; Animals; Blood Coagulation; Body Weight; Chloral Hydrate; Enzymes; Female; Let | 1982 |
Studies on the mutagenic and carcinogenic potential of chloral hydrate.
Topics: Animals; Body Weight; Bone Marrow; Carcinogenicity Tests; Carcinogens; Chloral Hydrate; Drinking Beh | 1998 |
NTP technical report on the toxicity and metabolism studies of chloral hydrate (CAS No. 302-17-0). Administered by gavage to F344/N rats and B6C3F1 mice.
Topics: Animals; Body Weight; Chloral Hydrate; CHO Cells; Cricetinae; DNA; DNA Adducts; Gastric Lavage; Huma | 1999 |
Chloral hydrate and meperidine: response and metabolism in squirrel and rehsus monkeys.
Topics: Animals; Blood Proteins; Body Temperature; Body Weight; Chloral Hydrate; Depression, Chemical; Haplo | 1975 |
Chlorpromazine induced hyperphagia in the rat.
Topics: Animals; Behavior, Animal; Body Weight; Chloral Hydrate; Chlorpromazine; Dose-Response Relationship, | 1975 |
Ninety-day toxicity study of chloral hydrate in the Sprague-Dawley rat.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Behavior, Animal; Blood Urea Nitrogen; B | 1992 |
Hepatocarcinogenicity of chloral hydrate, 2-chloroacetaldehyde, and dichloroacetic acid in the male B6C3F1 mouse.
Topics: Acetaldehyde; Animals; Body Weight; Carcinogens; Chloral Hydrate; Dichloroacetic Acid; Drinking Beha | 1992 |
Intraperitoneal injection of chloral hydrate causes intra-abdominal adhesions and unilateral testicular atrophy in golden Syrian hamsters.
Topics: Adipose Tissue; Animals; Atrophy; Body Weight; Chloral Hydrate; Cricetinae; Epididymis; Injections, | 1992 |
Estimation of functional hepatic mass in resected and regenerating rat liver.
Topics: Alanine Transaminase; Alkaline Phosphatase; Anesthesia; Animals; Bilirubin; Body Temperature; Body W | 1974 |
Clinical effects of hypnotics. II. An epidemiologic study.
Topics: Body Weight; Chloral Hydrate; Diphenhydramine; Female; Humans; Hypnotics and Sedatives; Male; Pentob | 1969 |