chloral hydrate and Absence Seizure studies

Research Excerpts

Excerpt	Relevance	Reference
"To reveal the efficacy of single-dose treatment with chloral hydrate (CH) for clustering seizures in benign convulsions with mild gastroenteritis."	7.74	Single-dose chloral hydrate for benign convulsions with mild gastroenteritis. ( Enoki, H; Matsubayashi, R; Matsubayashi, T; Nagasaki, R; Nakashima, Y; Ohro, Y; Takeda, S; Yokota, T, 2007)
"We present a patient with early infantile epileptic encephalopathy with suppression bursts (Ohtahara syndrome) with an excellent response to chloral hydrate to draw attention to a possible role of the "old" drug in the treatment of intractable epilepsy."	7.71	Successful treatment of Ohtahara syndrome with chloral hydrate. ( Komárek, V; Krsek, P; Maulisová, A; Procházka, T; Sebronová, V, 2002)
"To reveal the efficacy of single-dose treatment with chloral hydrate (CH) for clustering seizures in benign convulsions with mild gastroenteritis."	3.74	Single-dose chloral hydrate for benign convulsions with mild gastroenteritis. ( Enoki, H; Matsubayashi, R; Matsubayashi, T; Nagasaki, R; Nakashima, Y; Ohro, Y; Takeda, S; Yokota, T, 2007)
"We present a patient with early infantile epileptic encephalopathy with suppression bursts (Ohtahara syndrome) with an excellent response to chloral hydrate to draw attention to a possible role of the "old" drug in the treatment of intractable epilepsy."	3.71	Successful treatment of Ohtahara syndrome with chloral hydrate. ( Komárek, V; Krsek, P; Maulisová, A; Procházka, T; Sebronová, V, 2002)
"beta CCM to cause convulsions, suggesting that sites other than the SNpr are of prime importance in expressing the convulsant actions of systemically injected beta CCM."	1.28	Tolerance to diazepam and methyl-beta-carboline-3-carboxylate measured in substantia nigra of benzodiazepine tolerant rats. ( Chiu, TH; Rosenberg, HC; Tietz, EI; Zhang, H, 1990)
"They did not antagonize electrogenic convulsions, amphetamine potentiated motility and the action of reserpine, and had no analgetic action."	1.26	Central action of new derivatives of tetrahydropirimidinedione-4,6. ( Barczyńska, J; Felsztyńska, J; Kedzierska, L; Wilimowski, M; Witkowska, M; Wojewódzki, W, 1979)

Research

Studies (38)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Number of Patients That Reach a Score Equal or Lower Than 2 Ten Minutes After the Infusion of Dexmedetomidine (Assessed With the PSSS Pediatric Sedation State Scale)

Timeframe	Studies, this research(%)	All Research%
pre-1990	29 (76.32)	18.7374
1990's	4 (10.53)	18.2507
2000's	2 (5.26)	29.6817
2010's	1 (2.63)	24.3611
2020's	2 (5.26)	2.80

Authors	Studies
Zhang, X	1
Yi, Y	1
Cheng, L	1
Chen, H	1
Hu, Y	1
Cheng, Y	1
Yao, F	1
Chen, Y	1
Keidan, I	1
Ben-Menachem, E	1
Tzadok, M	1
Ben-Zeev, B	1
Berkenstadt, H	1
Krsek, P	1
Sebronová, V	1
Procházka, T	1
Maulisová, A	1
Komárek, V	1
SATOMI, M	2
CARNEGIE, DM	1
KEMENY, P	1
HODOSI, J	1
SZANTO, I	1
ERDMANN, G	1
CRAIG, WS	1
MACKINNON, JM	1
Pihkanen, T	1
Huhmar, E	1
PUESCHL, H	1
Enoki, H	1
Yokota, T	1
Nagasaki, R	1
Ohro, Y	1
Takeda, S	1
Nakashima, Y	1
Matsubayashi, R	1
Matsubayashi, T	1
Golbert, TM	1
Sanz, CJ	1
Rose, HD	1
Leitschuh, TH	1
Holloway, HC	1
Hales, RE	1
Watanabe, HK	1
Lindgren, S	1
Voorhoeve, HM	1
Magloczky, Z	1
Freund, TF	1
Gorniak, SL	1
Palermo Neto, J	1
Spinosa, HS	1
Muñoz, M	1
Gómez, A	1
Soult, JA	1
Márquez, C	1
Lopez-Castilla, JD	1
Cervera, A	1
Cano, M	1
Wilimowski, M	3
Witkowska, M	2
Barczyńska, J	3
Kedzierska, L	3
Wojewodzki, W	2
Felsztyńska, J	2
Ndiritu, CG	1
Enos, LR	1
Petrich, C	1
Voss, HV	1
Bretschneider, A	1
Göbel, U	1
Rosenberg, HC	1
Tietz, EI	1
Zhang, H	1
Chiu, TH	1
LaManna, JC	1
McCracken, KA	1
Patil, M	1
Prohaska, OJ	1
Mende, TJ	1
Viamonte, L	1
Kallwellis, G	1
Gessner, PK	1
Külz, J	1
Bauditz, W	2
Bartelheimer, HK	2
Degen, R	1
Prandota, J	1
Ferngren, H	1
Hellström, B	1
Wiesener, H	1
Martinius, J	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
The Use of Dexmedetomidine for Procedural Sedation During EEG in Children Affected by Behavioural Disorders[NCT03799783]	Phase 2	19 participants (Actual)	Interventional	2018-03-01	Completed
Pharmacotoxicology of Trichloroethylene Metabolites: Short-term Effect of DCA on in Vivo Tyrosine Catabolism and MAAI Expression[NCT00865514]		2 participants (Actual)	Interventional	2011-08-31	Terminated (stopped due to Difficulty in obtaining the solution from the compounding pharmacies caused a two year delay in start-up; the funding ended prior to study completion.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

the PSSS is a validated scale for assessing the level of procedural sedation. It is a 6 items scale , from 0 to 5, where 5 is an alert patient and 0 is a deep sedation with abnormal vital signs. We evaluate patients 10 minutes after the infusion of dexmedetomidine. (NCT03799783)
Timeframe: 10 minutes

Number of Patients With Adverse Events

Intervention	Participants (Count of Participants)
Dexmedetomidine	13

any adverse event potentially related with DEX-administration (NCT03799783)
Timeframe: during and immediately after DEX infusion, up to 150 minutes after DEX infusion (time to first awakening)

Article	Year
Comparative evaluation of treatments of alcohol withdrawal syndromes. JAMA, 1967, Jul-10, Volume: 201, Issue:2 Topics: Alcoholism; Chloral Hydrate; Chlordiazepoxide; Drug Synergism; Ethanol; Fever; Humans; Male; Middle	1967
Treatment of alcohol withdrawal syndromes. The Medical letter on drugs and therapeutics, 1971, Mar-05, Volume: 13, Issue:5 Topics: Chloral Hydrate; Chlordiazepoxide; Clinical Trials as Topic; Diazepam; Drug Synergism; Ethanol; Huma	1971

Article	Year
Dynamic effects of miR-20a-5p on hippocampal ripple energy after status epilepticus in rats. Experimental brain research, 2023, Volume: 241, Issue:8 Topics: Animals; Chloral Hydrate; Hippocampus; MicroRNAs; Pilocarpine; Rats; Seizures; Status Epilepticus; V	2023
A Comparative Analysis of Prehospital Emergency Treatments: Midazolam Intramuscularly, Diazepam Enema, and Chloral Hydrate Enema for Pediatric Convulsions. Alternative therapies in health and medicine, 2023, Volume: 29, Issue:8 Topics: Child; Chloral Hydrate; Diazepam; Emergency Medical Services; Enema; Humans; Midazolam; Seizures	2023
Electroencephalography for children with autistic spectrum disorder: a sedation protocol. Paediatric anaesthesia, 2015, Volume: 25, Issue:2 Topics: Analgesics; Anesthesia; Autism Spectrum Disorder; Child; Child, Preschool; Chloral Hydrate; Dexmedet	2015
Successful treatment of Ohtahara syndrome with chloral hydrate. Pediatric neurology, 2002, Volume: 27, Issue:5 Topics: Anticonvulsants; Chloral Hydrate; Drug Therapy, Combination; Electroencephalography; Female; Humans;	2002
[CONVULSIONS IN CHILDREN. (1)]. [Chiryo] [Therapy], 1964, Volume: 46 Topics: Adolescent; Child; Chloral Hydrate; Fever; Humans; Infant; Infant, Newborn; Opium; Phenobarbital; Se	1964
[CONVULSIONS IN CHILDREN (2)]. [Chiryo] [Therapy], 1964, Volume: 46 Topics: Child; Chloral Hydrate; Cytochromes; Fever; Hemiplegia; Humans; Infant; Seizures	1964
THE EMERGENCY TREATMENT OF THE CONVULSING CHILD WITH PARTICULAR REFERENCE TO GENERAL ANAESTHESIA. Developmental medicine and child neurology, 1964, Volume: 6 Topics: Anesthesia; Anesthesia, General; Anesthesia, Intravenous; Cerebral Infarction; Child; Chloral Hydrat	1964
CONTROL OF PROLONGED CONVULSIVE SEIZURES IN CHILDHOOD BY ADMINISTRATION OF INHALATION ANAESTHESIA WITH NITROUS OXIDE (N2O). Annales paediatrici. International review of pediatrics, 1964, Volume: 203 Topics: Anesthesia; Anesthesia, Inhalation; Asthma; Barbiturates; Bronchopneumonia; Child; Chloral Hydrate;	1964
[THE CONVULSIVE CHILD]. Therapie der Gegenwart, 1964, Volume: 103 Topics: Anticonvulsants; Barbiturates; Child; Chloral Hydrate; Diagnosis; Enema; Humans; Hydrotherapy; Infan	1964
CHILD CARE IN GENERAL PRACTICE. CONVULSIONS IN INFANCY AND CHILDHOOD. II. British medical journal, 1965, Feb-20, Volume: 1, Issue:5433 Topics: Acetazolamide; Anticonvulsants; Bromides; Child; Child Care; Chloral Hydrate; Diagnosis; Drug Therap	1965
True isoelectric cerebral activity as criterion for severe cortical lesion. Acta neurologica Scandinavica, 1961, Volume: 37, Issue:1 Topics: Brain Diseases; Cerebral Cortex; Chloral Hydrate; Disease; Electroencephalography; Humans; Seizures	1961
[Chloral hydrate Rectiole, the 1st stable hydrochloride micro-clysma]. Deutsches medizinisches Journal, 1961, Nov-20, Volume: 12 Topics: Child; Chloral Hydrate; Humans; Infant; Salts; Seizures	1961
Single-dose chloral hydrate for benign convulsions with mild gastroenteritis. Epilepsia, 2007, Volume: 48, Issue:5 Topics: Anticonvulsants; Child, Preschool; Chloral Hydrate; Comorbidity; Diazepam; Dose-Response Relationshi	2007
Recognition and treatment of acute alcohol withdrawal syndromes. The Psychiatric clinics of North America, 1984, Volume: 7, Issue:4 Topics: Acute Disease; Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Chloral Hydrate; Ethanol; F	1984
Effects of the glutamic acid decarboxylase inhibitor 3-mercaptopropionic acid on the synthesis of brain GABA in vivo and postmortally. Journal of neural transmission, 1983, Volume: 58, Issue:1-2 Topics: 3-Mercaptopropionic Acid; Animals; Brain Chemistry; Chloral Hydrate; Dose-Response Relationship, Dru	1983
Childhood convulsions in the tropics. Tropical doctor, 1980, Volume: 10, Issue:3 Topics: Child, Preschool; Chloral Hydrate; Diazepam; Humans; Infant; Medicine, Traditional; Rural Health; Se	1980
Selective neuronal death in the contralateral hippocampus following unilateral kainate injections into the CA3 subfield. Neuroscience, 1993, Volume: 56, Issue:2 Topics: Anesthetics; Animals; Biomarkers; Calbindin 2; Cell Death; Chloral Hydrate; Disease Models, Animal;	1993
Effect of CNS depressant drugs on acute intoxication from Palicourea marcgravii St Hill in rats. Veterinary and human toxicology, 1993, Volume: 35, Issue:1 Topics: Animals; Central Nervous System Depressants; Chloral Hydrate; Diazepam; Drug Combinations; Male; Pla	1993
Seizures caused by chloral hydrate sedative doses. The Journal of pediatrics, 1997, Volume: 131, Issue:5 Topics: Child, Preschool; Chloral Hydrate; Humans; Hypnotics and Sedatives; Male; Seizures	1997
Central action of new imido derivatives of succinic acid. Archivum immunologiae et therapiae experimentalis, 1979, Volume: 27, Issue:3 Topics: Amphetamine; Analgesics; Animals; Brain; Chloral Hydrate; Drug Synergism; Female; Hexobarbital; Levo	1979
Central action of new derivatives of tetrahydropirimidinedione-4,6. Archivum immunologiae et therapiae experimentalis, 1979, Volume: 27, Issue:3 Topics: Amphetamine; Analgesics; Animals; Brain; Chloral Hydrate; Drug Synergism; Female; Furans; Hexobarbit	1979
Adverse reactions to drugs in a veterinary hospital. Journal of the American Veterinary Medical Association, 1977, Aug-15, Volume: 171, Issue:4 Topics: Amphotericin B; Anaphylaxis; Animals; Cat Diseases; Cats; Cattle; Cattle Diseases; Chloral Hydrate;	1977
[Heroin withdrawal syndrome in newborns (author's transl]. Klinische Padiatrie, 1976, Volume: 188, Issue:6 Topics: Chloral Hydrate; Diazepam; Female; Heroin; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant	1976
Tolerance to diazepam and methyl-beta-carboline-3-carboxylate measured in substantia nigra of benzodiazepine tolerant rats. Life sciences, 1990, Volume: 46, Issue:7 Topics: Animals; Benzodiazepines; Carbolines; Chloral Hydrate; Diazepam; Drug Tolerance; Electrophysiology;	1990
Stimulus-activated changes in brain tissue temperature in the anesthetized rat. Metabolic brain disease, 1989, Volume: 4, Issue:4 Topics: Anesthesia; Animals; Body Temperature; Brain; Chloral Hydrate; Electric Stimulation; Electroencephal	1989
Studies on chloral hydrate and camphor sensitivity in rats of different ages. Gerontologia, 1967, Volume: 13, Issue:3 Topics: Age Factors; Aging; Animals; Camphor; Central Nervous System; Central Nervous System Stimulants; Chl	1967
[Cerebral convulsions as early signs of delirium tremens]. Zeitschrift fur arztliche Fortbildung, 1972, Aug-15, Volume: 66, Issue:16 Topics: Adult; Chloral Hydrate; Chlormethiazole; Diazepam; Electroencephalography; Female; Humans; Male; Mid	1972
Failure of diphenylhydantoin to prevent alcohol withdrawal convulsions in mice. European journal of pharmacology, 1974, Volume: 27, Issue:1 Topics: Animals; Chloral Hydrate; Ethanol; Humans; Male; Mice; Mice, Inbred ICR; Phenytoin; Pyrazoles; Seizu	1974
[First aid for convulsive children]. Zeitschrift fur arztliche Fortbildung, 1972, Jun-15, Volume: 66, Issue:12 Topics: Age Factors; Barbiturates; Child; Chloral Hydrate; Emergencies; First Aid; Humans; Hypernatremia; Hy	1972
[Hemodialysis treatment of a 3 1-4-year-old child with imipramine poisoning]. Archiv fur Toxikologie, 1970, Volume: 26, Issue:2 Topics: Arrhythmias, Cardiac; Charcoal; Child, Preschool; Chloral Hydrate; Electrocardiography; Electroencep	1970
[Seizure therapy in childhood with chloral hydrate-Rectiolen]. Die Medizinische Welt, 1969, Sep-20, Volume: 64, Issue:38 Topics: Anticonvulsants; Child; Child, Preschool; Chloral Hydrate; Epilepsy; Fever; Humans; Infant; Meningoe	1969
Pharmacologic properties of derivatives of 3-phenyl-3-hydroxyglutaric acid. Archivum immunologiae et therapiae experimentalis, 1970, Volume: 18, Issue:2 Topics: Animals; Azoles; Blood Pressure; Chloral Hydrate; Drug Antagonism; Drug Synergism; Glutarates; Hexob	1970
[Drugs and children. 1. Treatment of seizures in children]. Lakartidningen, 1970, Apr-13, Volume: 67 Topics: Adolescent; Barbiturates; Child; Child, Preschool; Chloral Hydrate; Diazepam; Electroencephalography	1970
[Treatment of imipramine poisoning at childhood]. Monatsschrift fur Kinderheilkunde, 1970, Volume: 118, Issue:11 Topics: Arrhythmias, Cardiac; Carbon; Child, Preschool; Chloral Hydrate; Coma; Gastric Lavage; Humans; Hypot	1970
[General measures in poisoning in childhood]. Monatsschrift fur Kinderheilkunde, 1968, Volume: 116, Issue:3 Topics: Child, Preschool; Chloral Hydrate; Glucocorticoids; Humans; Poisoning; Respiratory Insufficiency; Se	1968
[Chloral hydrate-rectiole and its indication in pediatrics]. Der Landarzt, 1968, Mar-10, Volume: 44, Issue:7 Topics: Adult; Chemical and Drug Induced Liver Injury; Chloral Hydrate; Enema; Female; Humans; Infant; Neuro	1968

chloral hydrate and Absence Seizure