chloral hydrate has been researched along with Abnormalities, Autosome in 12 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "In view of tissue- and sex-specific differences in chemically-induced aneuploidy, we analysed the effects of chloral hydrate (CH) on cell-cycle progression, spindle formation and aneuploidy in in vitro maturing mouse oocytes with cytogenetic and immunofluorescent methods." | 7.69 | Chloral hydrate induced spindle aberrations, metaphase I arrest and aneuploidy in mouse oocytes. ( Betzendahl, I; Eichenlaub-Ritter, U, 1995) |
| "The induction of aneuploidy in cultured Chinese hamster cells by propionaldehyde (PA) and chloral hydrate (CH) has been studied." | 7.68 | The induction of aneuploidy in cultured Chinese hamster cells by propionaldehyde and chloral hydrate. ( Dulout, FN; Furnus, CC; Terreros, MC; Ulrich, MA, 1990) |
| "The synopsis of the in vivo test results in the first collaborative CEC Aneuploidy Project with 10 selected chemicals, colchicine (COL), econazole (EZ), chloral hydrate (CH), hydroquinone (HQ), diazepam (DZ), thiabendazole (TB), cadmium chloride (CD), thimerosal (TM), pyrimethamine (PY) and vinblastine (VBL), allowed several conclusions." | 4.78 | Synopsis of the in vivo results obtained with the 10 known or suspected aneugens tested in the CEC collaborative study. ( Adler, ID, 1993) |
| "In view of tissue- and sex-specific differences in chemically-induced aneuploidy, we analysed the effects of chloral hydrate (CH) on cell-cycle progression, spindle formation and aneuploidy in in vitro maturing mouse oocytes with cytogenetic and immunofluorescent methods." | 3.69 | Chloral hydrate induced spindle aberrations, metaphase I arrest and aneuploidy in mouse oocytes. ( Betzendahl, I; Eichenlaub-Ritter, U, 1995) |
| "The induction of aneuploidy in cultured Chinese hamster cells by propionaldehyde (PA) and chloral hydrate (CH) has been studied." | 3.68 | The induction of aneuploidy in cultured Chinese hamster cells by propionaldehyde and chloral hydrate. ( Dulout, FN; Furnus, CC; Terreros, MC; Ulrich, MA, 1990) |
| "Chloral hydrate was nominated for study by the Food and Drug Administration based upon widespread human exposure and its potential hepatotoxicity and the toxicity of related chemicals." | 1.31 | NTP Technical Report on the Toxicology and Carcinogenesis Studies of Chloral Hydrate (Cas No. 302-17-0) in B6C3F1 mice (Gavage Studies). ( , 2002) |
| "Dose-related numerical chromosomal aberrations are induced by colchicine and vinblastine, the only chemicals that also induce c-mitotic effects in a wide range of doses." | 1.29 | C-mitosis and numerical chromosome aberration analyses in human lymphocytes: 10 known or suspected spindle poisons. ( Di Sibio, A; Lomi, A; Sbrana, I; Scarcelli, V, 1993) |
| "An analysis of chromosomal aberrations was carried out in bone marrow cells of mice with the first five chemicals: colchicine (COL), econazole (EZ), chloralhydrate (CH), hydroquinone (HQ) and diazepam (DIAZ)." | 1.28 | Clastogenic effects of known and suspect spindle poisons studied by chromosome analysis in mouse bone marrow cells. ( Adler, ID; Xu, W, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 9 (75.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Natarajan, AT | 1 |
| Adler, ID | 2 |
| Sbrana, I | 1 |
| Di Sibio, A | 1 |
| Lomi, A | 1 |
| Scarcelli, V | 1 |
| Marrazzini, A | 1 |
| Betti, C | 1 |
| Bernacchi, F | 1 |
| Barrai, I | 1 |
| Barale, R | 1 |
| Eichenlaub-Ritter, U | 1 |
| Betzendahl, I | 1 |
| Harrington-Brock, K | 1 |
| Doerr, CL | 1 |
| Moore, MM | 1 |
| Antoccia, A | 1 |
| Degrassi, F | 2 |
| Battistoni, A | 1 |
| Ciliutti, P | 1 |
| Tanzarella, C | 2 |
| Furnus, CC | 1 |
| Ulrich, MA | 1 |
| Terreros, MC | 1 |
| Dulout, FN | 1 |
| Xu, W | 1 |
| Käfer, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacotoxicology of Trichloroethylene Metabolites: Short-term Effect of DCA on in Vivo Tyrosine Catabolism and MAAI Expression[NCT00865514] | 2 participants (Actual) | Interventional | 2011-08-31 | Terminated (stopped due to Difficulty in obtaining the solution from the compounding pharmacies caused a two year delay in start-up; the funding ended prior to study completion.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for chloral hydrate and Abnormalities, Autosome
| Article | Year |
|---|---|
Synopsis of the in vivo results obtained with the 10 known or suspected aneugens tested in the CEC collaborative study.
Topics: Aneuploidy; Animals; Cadmium; Cadmium Chloride; Cells, Cultured; Chloral Hydrate; Chlorides; Chromos | 1993 |
11 other studies available for chloral hydrate and Abnormalities, Autosome
| Article | Year |
|---|---|
An overview of the results of testing of known or suspected aneugens using mammalian cells in vitro.
Topics: Aneuploidy; Animals; Cadmium; Cadmium Chloride; Cell Division; Cell Line; Cells, Cultured; Chloral H | 1993 |
C-mitosis and numerical chromosome aberration analyses in human lymphocytes: 10 known or suspected spindle poisons.
Topics: Cadmium; Cadmium Chloride; Cells, Cultured; Chloral Hydrate; Chlorides; Chromosome Aberrations; Colc | 1993 |
Micronucleus test and metaphase analyses in mice exposed to known and suspected spindle poisons.
Topics: Animals; Bone Marrow Cells; Cadmium; Cadmium Chloride; Cells, Cultured; Chloral Hydrate; Chlorides; | 1994 |
Chloral hydrate induced spindle aberrations, metaphase I arrest and aneuploidy in mouse oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Aneuploidy; Animals; Cell Cycle; Cells, Cultured; Chloral Hydrate; Chro | 1995 |
Mutagenicity of three disinfection by-products: di- and trichloroacetic acid and chloral hydrate in L5178Y/TK +/- (-)3.7.2C mouse lymphoma cells.
Topics: Animals; Chloral Hydrate; Chromosome Aberrations; Dichloroacetic Acid; Disinfectants; Leukemia L5178 | 1998 |
NTP Technical Report on the Toxicology and Carcinogenesis Studies of Chloral Hydrate (Cas No. 302-17-0) in B6C3F1 mice (Gavage Studies).
Topics: Adenoma; Administration, Oral; Animals; Carcinogenicity Tests; Chloral Hydrate; CHO Cells; Chromosom | 2002 |
In vitro micronucleus test with kinetochore staining: evaluation of test performance.
Topics: Aneuploidy; Antibodies, Monoclonal; Cadmium; Cadmium Chloride; Cell Line; Chloral Hydrate; Chromosom | 1991 |
The induction of aneuploidy in cultured Chinese hamster cells by propionaldehyde and chloral hydrate.
Topics: Aldehydes; Aneuploidy; Animals; Cell Line; Chloral Hydrate; Chromosome Aberrations; Cricetinae | 1990 |
Clastogenic effects of known and suspect spindle poisons studied by chromosome analysis in mouse bone marrow cells.
Topics: Aneuploidy; Animals; Bone Marrow; Bone Marrow Cells; Chloral Hydrate; Chromosome Aberrations; Colchi | 1990 |
Immunofluorescent staining of kinetochores in micronuclei: a new assay for the detection of aneuploidy.
Topics: Aneuploidy; Animals; Autoantibodies; Cell Line; Cell Nucleus; Chloral Hydrate; Chromosome Aberration | 1988 |
MMS-induced primary aneuploidy and other genotoxic effects in mitotic cells of Aspergillus.
Topics: Aneuploidy; Aspergillus; Chloral Hydrate; Chromosome Aberrations; Crossing Over, Genetic; Diploidy; | 1988 |