chitosan has been researched along with Alloxan Diabetes in 224 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (0.45) | 18.2507 |
| 2000's | 27 (12.05) | 29.6817 |
| 2010's | 119 (53.13) | 24.3611 |
| 2020's | 77 (34.38) | 2.80 |
| Authors | Studies |
|---|---|
| Cheng, H; Cui, Z; Guo, S; Huo, Y; Mao, S; Zhang, X | 1 |
| Chen, J; Guo, Y; Hu, X; Lu, Y; Ning, N; Wang, Y; Wu, C; Wu, Y; Yang, Z; Zhang, J | 1 |
| Palei, NN; Surendran, V | 1 |
| Chen, J; E, Y; Li, H; Qi, Y; Qian, K; Shi, Y; Zhao, L | 1 |
| Cai, E; Deng, H; Gao, T; Hu, R; Pan, W; Qi, X; Shen, J; Tong, X; Xiang, Y; You, S | 1 |
| Chen, X; Cui, Z; Han, Y; Li, Y; Wang, X; Zhang, H; Zhang, M; Zhao, W | 1 |
| Abo El-Ela, FI; Ali, AA; Ali, AMA; Eid, HM; Eissa, EM; Hassan, AH; Hassan, RM | 1 |
| Abozaid, OAR; El-Sonbaty, SM; Farrag, MA; Hamam, NMA; Kodous, AS | 1 |
| Chi, J; Feng, Z; Han, B; Hu, H; Jiang, Z; Ju, R; Liu, C; Liu, W; Wang, S; Xu, T; Zhang, W; Zou, M | 1 |
| Chen, W; Ji, S; Jiang, X; Zhang, X; Zhou, S | 1 |
| Abdallah, OY; Nasra, MMA; Sheir, MM | 2 |
| Rao, SS; Rekha, PD; Venkatesan, J; Yuvarajan, S | 1 |
| Behera, A; Pattnaik, G; Sharma, DK | 1 |
| Asal, HA; El-Hagrasy, MA; Shoueir, KR; Toson, EA | 1 |
| Kurnijasanti, R; Mustafa, MR; Nugraha, J; Sudjarwo, SA; Wardani, G | 1 |
| Geng, X; Li, H; Liu, X; Qi, Y; Shi, Y; Zhao, L | 1 |
| Deng, H; Du, Y; Liu, H; Qi, L; Shi, X; Tong, J | 1 |
| Qin, D; Wang, J; Wu, D; Xu, H | 1 |
| Fauziah, AI; Herawati, VE; Saraswati, LD; Widjanarko, B | 1 |
| Cai, W; Du, B; Hou, B; Qi, M; Qiu, L; Sun, H; Wen, Y; Zhu, X | 1 |
| Chen, Y; Hu, P; Lu, H; Wu, C; Xu, L; Zhang, X; Zhou, Z | 1 |
| Abdel-Moneim, A; El-Shahawy, AAG; Eldin, ZE; Hosni, A; Hussien, M; Zanaty, MI | 1 |
| Amr, KS; Elaraby, NM; Ellakwa, DE; Mohamadin, AM; Shaaban, EM | 1 |
| Ahmed, R; Andleeb, A; Butt, H; Ejaz, A; Ghufran, H; Malik, K; Mehmood, A; Ramzan, A; Riazuddin, S; Tariq, M | 1 |
| Chang, J; Gu, Z; Guo, L; Han, B; Li, W; Ma, S; Wang, L; Zhang, H | 1 |
| Anushree, U; Bharati, S; Punj, P | 1 |
| Chiang, MT; Liu, SH; Tzeng, HP | 1 |
| Aydil, BA; Ayhan, M; Büyükakyüz, N; Gür, R | 1 |
| Chen, Z; Jiang, A; Jiang, T; Li, C; Lu, C; Nie, J; Wang, F; Yang, G; Yang, X; Zhou, C | 1 |
| Chu, C; Deng, Y; Gou, J; He, H; Liu, H; Tang, X; Wei, M; Xu, X; Yin, T; Zhang, Y | 1 |
| Ding, C; Ding, Q; Liu, W; Liu, X; Peng, Z; Sun, S; Zhang, S; Zhao, Y; Zheng, Y | 1 |
| Dong, X; Feng, J; Guan, M; Luo, F; Ma, H; Sun, Y; Zhang, J; Zhou, J | 1 |
| Geng, X; Liu, K; Shi, Y; Su, X; Wang, J; Zhao, L | 1 |
| Abdelaziz, M; Alaa, H; El-Karamany, Y; Farid, A; Magdy, S; Mansour, M; Mohsen, S; Mustafa, M | 1 |
| Abdelmonem, R; Abdulsalam, NM; Alhadhrami, NA; AlSalem, HS; Binkadem, MS; Khateeb, NA; Khedr, AM; Nadwa, EH; Shoueir, KR | 1 |
| Duan, JA; Jiang, JY; Li, WW; Liu, P; Pan, X; Shang, EX; Wang, Y; Wei, H; Zhang, HK; Zhang, YJ | 1 |
| Chamsai, B; Opanasopit, P; Samprasit, W | 1 |
| Abdel-Naim, AB; Algandaby, MM; Alhakamy, NA; Elhady, SS; Eltamany, EE; Esmat, A; Nasrullah, MZ; Rashad, OM | 1 |
| Chen, J; Dong, H; Feng, Q; He, W; Li, H; Lv, C; Xu, X; Zhu, C | 1 |
| El-Batanony, R; Kamel, R; Salama, A | 1 |
| Chen, Q; Li, Y; Liu, Y; Pan, H; Qi, W; Wong, TM; Wu, J; Yeung, KWK; Zhang, C; Zhao, X | 1 |
| Guo, X; Hou, L; Li, Z; Sun, Y; Wang, F; Wang, L; Xia, G; Zhai, D | 1 |
| Cao, J; Choi, M; Hasan, N; Hlaing, SP; Lee, J; Yoo, JW | 1 |
| Chamani, J; Gholami, L; Hadizadeh, F; Kalani, MR; Mahmoudi, A; Mohammadpour, AH; Mohammadpour, F; Sadri, K; Tafaghodi, M | 1 |
| Guo, P; Li, Z; Liang, C; Liu, Y; Song, Y; Wang, C; Wang, R; Xie, X; Yao, X; Yuan, W | 1 |
| Bansal, A; D'Sa, S; D'Souza, MJ | 1 |
| Arun, G; Gayathri, N; Kaleshkumar, K; Kandasamy, S; Rajaram, R; Sivasudha, T | 1 |
| Campos, MGN; Cardoso, NS; da Fonseca, CCP; de Oliveira, CM; Duarte, SMS; Elston, LB; Ferreira, EB; Leme, KC; Paula, FBA; Ribeiro, GP; Ribeiro, JR; Rodrigues, MR; Salles, BCC; Soares, CB; Soares, RDF; Souza, RM | 1 |
| Abbasalipourkabir, R; Goodarzi, MT; Jamshidi, M; Kalantarian, G; Mahjub, R; Saidijam, M; Soleimani Asl, S; Ziamajidi, N | 1 |
| Dai, W; Deng, H; He, B; Wang, X; Wu, P; Zhang, H; Zhang, Q; Zhang, Y; Zhao, R; Zhou, S | 1 |
| Adams, GG; Apolinário, PP; Araújo, EP; Azevedo, FF; Breder, JSC; Cantaruti, T; Consonni, SR; Jiwani, SI; Lima, MHM; Moraes, ÂM; Pires, ALR; Saad, MJA | 1 |
| Arantes, VT; Barcelos, LS; Cassini-Vieira, P; Faraco, AAG; Ferreira, FB; Ferreira, LAM; Goulart, GAC; Martins-Santos, E; Oliveira, CA | 1 |
| Cai, X; Dong, X; Liu, Z; Sun, M; Wang, Y; Xie, Q; Xu, Y | 1 |
| Amaral, AC; Casas, AA; Chagas, ALD; Correa, VLR; Diniz, DGA; Menezes, LB; Miguel, MP; Oliveira, LP; Ribeiro, MC; Silva, FKLD | 1 |
| Sharma, D; Singh, J | 1 |
| Abbasnezhad, A; Abd El-Ghafar, OA; Abhilash, L; Abouzid, KAM; Achberger, AM; Ackerman, S; Akhatayeva, Z; Akin, D; Al-Kaysi, RO; Alakhdar, AA; Alame, M; Aleksic Sabo, V; Alinezhadbalalami, N; Allen, JD; Alonso, JM; Alqatani, S; Alsayed, B; Álvarez Larraondo, M; Alvarez, M; Amini, SB; An, Z; Anasir, MI; Anderson, GH; Andremont, A; Andrés, S; Angel, S; Anigboro, AA; Anini, Y; Antonides, CFJ; Arafa, K; Arafa, RK; Aryal, UK; Asbaghi, O; Assefa, MK; Atyah, M; Avwioroko, OJ; Ayora-Talavera, G; Azpilikueta, A; Azyazov, VN; Ba, YF; Bachmann, KF; Badoual, J; Bae, SJ; Baek, SH; Bahrami, B; Bai, J; Baid-Agrawal, S; Bailey, MR; Baillie, JK; Balani, N; Balcar, VJ; Banica, T; Banks, L; Barb, J; Bardeen, CJ; Barrett, HE; Bartnikowski, N; Bashir, R; Battaglia, M; Bautista-Hernández, V; Becker, B; Beekman, FJ; Benidir, M; Benjelloun, M; Bentley, RF; Bergé, J; Berger, D; Bernsen, MR; Berraondo, P; Bhattacharya, R; Bhayani, SB; Bi, W; Bi, X; Bi, YL; Bi, Z; Bian, K; Biesecker, LG; Billadeau, DD; Blaszczyk, R; Blum, JL; Boachie, R; Boelte, K; Bogers, AJJC; Boileau, I; Bonduelle, C; Bonny, O; Bonsu, JM; Boos, LA; Borges-Argáez, R; Bouchard, PA; Boudot, C; Bourgeade-Delmas, S; Boutet-Robinet, E; Boyle, AJ; Branigan, D; Briones, S; Broniowska, KA; Brossas, JY; Brown, WA; Brzezinska, J; Buitron, G; Burnier, M; Bursulaya, B; Burton, PR; Bush, AA; Busuttil, RW; Cabello-Aguilar, S; Cáceres-Farfán, M; Cacheux, V; Caffrey, PJ; Cai, B; Cai, Q; Cai, S; Cai, Y; Calders, P; Cammarota, G; Campbell, DA; Cancelli, C; Cao, Q; Cao, WH; Cao, X; Capet, M; Capoluongo, E; Carey, ME; Carnero, M; Carrasco, LI; Carreno, J; Carrillo-Reyes, J; Casini, I; Cassar, M; Catalan, G; Cattamanchi, A; Cazares-Granillo, M; Celie, B; Cen, YK; Cena, H; Cerbo, RM; Ceron, E; Cetina-Montejo, L; Chaâbane-Banaoues, R; Chabanet, C; Chace-Donahue, F; Chalfun-Júnior, A; Chan-Balan, R; Chang, CS; Chen, CS; Chen, D; Chen, J; Chen, L; Chen, PN; Chen, Q; Chen, S; Chen, W; Chen, WP; Chen, X; Chen, Z; Cheng, H; Cheng, J; Cheng, Q; Cheng, T; Chi, T; Chianelli, D; Chieppa, M; Child, CJ; Cho, JH; Cho, JY; Chogtu, B; Choi, GH; Choi, J; Choi, M; Choi, NG; Cholu, CO; Chow, ES; Chowdhury, AH; Chu, PC; Chu, Q; Chu, S; Chua, H; Chung, T; Chunyan, L; Church, JS; Civardi, E; Cobiella, J; Colinge, J; Collado, CJ; Collins, TJ; Cong, LM; Conkrite, KL; Cope, SJ; Corbett, JA; Cornet, M; Cornillot, E; Corvaisier, S; Costes-Martineau, V; Courtioux, B; Coussens, M; Covino, M; Criado, A; Cui, J; Cui, Y; Cunitz, BW; Curry, AE; Cussó, L; D'Urzo, AD; D'Urzo, KA; Dabbous, S; Dahlgren, RA; Dai, H; Dai, T; Dai, W; Dalinghaus, M; Dang, S; Davalos, RV; Davidson, H; de Andrea, CE; De Angelis, M; de Blois, E; de Carvalho, PA; De Clercq, E; De Giuseppe, R; de Jong, M; De Langhe, S; De Oliveira, L; de Souza Pinto Lemgruber, R; de Souza, LB; de Swart, J; De Wandele, I; de Woestijne, PCV; Delaney, S; Delorme, M; Delvenne, P; Deng, L; Deng, Z; Denkinger, CM; der Meulen, MHV; Deraeve, C; Desco, M; DeSilva, S; Destere, A; Dhali, A; Di Ciano, P; Dias-Santagata, D; Diskin, SJ; Djè, MK; Doddipatla, S; Doerr, AJ; Dokla, EME; Domiciano, D; Domingo, N; Dong, C; Dong, J; Dong, Q; Dong, S; Dong, X; Dong, Z; Douair, I; Douglas, TA; Doyle, SM; Drain, PK; Du, K; Du, L; Du, Q; Du, S; Duan, C; Duan, H; Duan, J; Duan, S; Duan, W; Dueluzeau, R; Dukic, L; Dunmire, BL; Duvauchelle, T; Dymek, B; Dzwonek, K; Earnest, A; Eckardt, KU; El Ghadraoui, L; El Massoudi, S; Elloumi, F; Elnour, IE; Embarak, S; Ende, M; England, K; Enikeev, D; Enyedy, I; Epple, R; Erickson, GE; Eriksson, J; Erndt-Marino, J; Errachidi, F; Etxeberria, I; Evan, AP; Fairlamb, AH; Falahi, E; Fan, CC; Fan, H; Fan, M; Fan, MZ; Fan, S; Fan, Y; Fang, CS; Fang, J; Fang, X; Fang, Z; Farmany, A; Farooqi, A; Farouk, HO; Fazelipour, S; Feng, D; Feng, J; Feng, JX; Feng, YL; Ferraz, SL; Ferreira, CR; Figenshau, RS; Finn, AV; Fiseha, T; Fleischer, AS; Fogleman, AD; Fontaine, O; Ford, CR; Fouladvand, F; Four, M; Fousteri, G; Francis, JR; Fraser, JF; Frazier, RP; Fu, H; Fu, P; Fu, YJ; Fujishima, A; Fuster, V; Gabilan, JC; Gagliani, N; Gai, QY; Galán-Arriola, C; Gale, P; Galimova, GR; Galkin, A; Gallo, A; Gallo, AA; Gang, DD; Ganschow, S; Gao, C; Gao, F; Gao, GP; Gao, H; Gao, K; Gao, M; Gao, MY; Gao, P; Gao, R; Gao, S; Gao, WJ; Gao, Y; Garbacz, P; García Ruiz, L; Garcia, EM; Garofoli, F; Gasbarrini, A; Gattinoni, L; Gaudig, M; Gbureck, U; Ge, X; Genko, N; Gentile, GL; George, MW; Gerety, GF; Gestwicki, JE; Geusens, PP; Ghassemi, M; Giardina, JD; Giebultowicz, JM; Gifford, CA; Gijsen, FJH; Gilfillan, R; Gilson, E; Gingl, K; Giuliano, C; Glybochko, P; Goessler, W; Gofflot, S; Golab, J; Goldstein, A; Golebiowski, A; Gómez, L; Gómez-Carballo, J; Gonçalves, PEO; Gonzales, R; Gonzalez-Cotto, M; González-Fernández, D; Gonzalez-Lopez de Turiso, F; Goodman, JM; Govinda Raju, S; Grimm, J; Gross, AJ; Gruenheid, S; Gu, C; Gu, FF; Gu, S; Gu, Z; Guest, RL; Gui, C; Gui, J; Guillem, A; Guo, G; Guo, L; Guo, Q; Guo, S; Guo, SW; Guo, W; Guo, Y; Guo, YG; Guo, Z; Guretzky, JA; Haenggi, M; Hahn, MS; Hakkola, J; Halim, AA; Hampel, D; Han, B; Han, BH; Han, D; Han, G; Han, J; Han, LZ; Han, R; Han, S; Han, X; Han, Z; Handley, MA; Hanke, I; Hannongbua, S; Hao, P; Happ, JT; Hara, M; Haraux, F; Hare, JL; Harper, JD; Hartley, AM; Harvey, E; Hashimoto, K; Hassan, HM; Hautajärvi, H; Hayton, TW; He, C; He, H; He, HJ; He, WP; He, Y; He, Z; Hedrick, V; Heffernan, JK; Hegrová, J; Heidarimoghadam, R; Helms, K; Hengphasatporn, K; Henry, D; Herrmann, TRW; Hesson, T; Himmelbauer, MK; Hindle, A; Hoffmann, R; Hogg, N; Hong, KB; Hong, SK; Honjol, Y; Hood, C; Hsi, RS; Hsu, JL; Hu, B; Hu, BC; Hu, D; Hu, H; Hu, J; Hu, K; Hu, M; Hu, MK; Hu, T; Hu, W; Hu, Y; Hu, Z; Hua, S; Huang, H; Huang, J; Huang, L; Huang, M; Huang, P; Huang, X; Huang, Y; Huang, Z; Hukkanen, J; Hung, MC; Huo, X; Hyötyläinen, T; Ianiro, G; Ibanez, B; Imran, M; Ireland, S; Irwin, MS; Ishiguro, H; Jackowski, K; Jackson, C; Jacob, SI; Jahromy, MH; Jakob, SM; Jang, J; Javvaji, PK; Jefferson, KK; Jena, P; Ji, H; Jiang, F; Jiang, GH; Jiang, H; Jiang, J; Jiang, X; Jiang, Z; Jiao, J; Jiménez, A; Jin, X; Jincai, W; Jintao, X; Jo, K; Jofra, T; Johari, Y; Johnson, ACM; Jones, JH; Josephine Fauci, A; Juhl, AK; Jun, S; Kaiser, RI; Kajioka, J; Kajiyama, H; Kalliyil, A; Kalthur, SG; Kamalanathan, M; Kamaldinov, T; Kanaani, L; Kang, D; Kang, J; Kang, S; Känsäkoski, P; Kaplan, DL; Karwan, M; Kasibhatla, S; Kaur, A; Kawazoe, Y; Ke, C; Keyser, J; Khalique, A; Khan, IT; Kharshoum, RM; Kher, R; Kherani, J; Ki, KK; Kikkawa, F; Kikkawa, R; Kim, BT; Kim, EH; Kim, GA; Kim, GD; Kim, HB; Kim, HG; Kim, JS; Kim, MJ; Kim, SI; Kim, SJ; Kim, Y; King, K; Kinyamu-Akunda, J; Kirkkala, T; Kjaer-Sorensen, K; Kleppinger, EL; Kloner, RA; Klopfenstein, TJ; Knappe, D; Knezevic, P; Kobos, LM; Kohli, M; Kolano, L; Kolodgie, FD; Kolte, AP; Koneru, B; Kong, D; Kong, F; Kong, X; Konggidinata, MI; Köpke, M; Koski, KG; Kotsis, F; Köttgen, A; Kouakou-Kouamé, CA; Kraemer, US; Krane, V; Krehbiel, CR; Krenning, BJ; Kretzschmar, D; Ku, KB; Kubota, Y; Kulich, P; Kumar, NG; Kupiec-Weglinski, JW; Lalani, SS; Lan, X; Landfeldt, E; Langenberg, E; Lapauw, B; Larkin, J; Lassoued, MA; Laukhtina, E; Laura Martinez, J; Laveillé, A; Lavela, P; Law, AD; Lazraq, A; Le Foll, B; Lee, BK; Lee, C; Lee, CS; Lee, EJ; Lee, EY; Lee, G; Lee, HY; Lee, JH; Lee, JJ; Lee, JO; Lee, JS; Lee, R; Lei, H; Lei, P; Lellouche, F; Lennerz, JK; Leong, W; Leslie, I; Lessem, E; Levin, M; Levinger, I; Li, C; Li, CW; Li, CX; Li, CY; Li, D; Li, H; Li, HM; Li, J; Li, L; Li, LM; Li, N; Li, S; Li, W; Li, X; Li, XX; Li, Y; Li, Z; Li, ZL; Li, ZX; Lian, Q; Liang, C; Liang, GH; Liang, H; Liang, J; Liang, X; Liao, CX; Liao, R; Ličbinský, R; Lim, YS; Lima, HK; Lin, JG; Lin, L; Lin, S; Lin, WP; Lin, Z; Liso, M; Liu, BX; Liu, C; Liu, H; Liu, J; Liu, M; Liu, Q; Liu, S; Liu, SF; Liu, SL; Liu, T; Liu, W; Liu, X; Liu, XB; Liu, Y; Liu, YY; Liu, Z; Liu, ZQ; Lobo, M; Loitzenbauer, M; López, F; Lopez, G; López, GJ; Lou, Z; Lu, IC; Lu, J; Lu, M; Lu, W; Lu, X; Lu, Y; Luhovyy, BL; Luna-Abanto, J; Luo, J; Luo, K; Luo, L; Luo, M; Luo, W; Luo, X; Luo, XM; Lv, Y; Lv, YQ; Lyu, HD; Lyu, J; Ma, C; Ma, G; Ma, L; Ma, Q; Ma, X; Ma, Y; Macha, SJ; MacLean, E; Mahalapbutr, P; Maina, T; Malfait, F; Malfertheiner, MV; Malzert-Fréon, A; Mansouri, E; Mao, C; Marcellin, E; Marchiori, PER; Marcotte, DJ; Maréchal, A; Maric, N; Maris, JM; Maron, L; Marti, CN; Martínez-Milla, J; Mateo, J; Mather, K; Mathison, CJN; Matthay, MA; Maxwell, CL; Mazier, D; Mazumder, D; Mazurkiewicz, M; Mazzucchelli, TG; McAuley, DF; Mccoy, K; McVicar, DW; Mebel, AM; Mech, A; Meester, EJ; Meiselbach, H; Melero, I; Ménard, G; Meng, X; Mengya, Y; Merle, G; Meunier, B; Mfarrej, B; Mi, K; Migueliz, I; Mikuška, P; Miladi, K; Miletich, R; Millar, JE; Mills, MR; Milne, R; Minute, L; Misiak, M; Mo, F; Modi, A; Mok, F; Molina, C; Mollen, CJ; Molteni, V; Montalto, M; Montet, D; Monti, MC; Moor, MB; Moravec, P; Morsiani, C; Murillo, E; Murugan, P; Muslem, R; Myers, RK; N'guessan, FK; Nabil, H; Nadal, J; Nadeem, M; Nafady, MM; Nafie, MS; Nair, HP; Nakano, R; Nance, J; Naren, N; Neil, CJ; Nelson, J; Nery, FC; Netsch, C; Nguyen, TH; Ni, L; Ni, YX; Nie, W; Nielsen, LK; Nigam, K; Nikolayev, AA; Nishiyama, M; Niu, LL; Niu, PP; Nock, BA; Noer, PR; Noll, G; Noll, S; Norenberg, JP; Nowicka, J; Nutho, B; O'Connor, M; Obonyo, NG; Ochiai, T; Ochoa, MC; Oh, BL; Oh, S; Olczak, J; Olivares, X; Ommurugan, B; Oosthuizen, MC; Operario, D; Orešič, M; Oshima, K; Otano, I; Ou, Y; Owen, TW; Oxvig, C; Pacey, V; Pai, M; Paik, H; Paiva, R; Palmieri, EM; Palpant, N; Pan, L; Pan, Q; Panahi, S; Pang, B; Pang, ZC; Pannecouque, C; Paris, L; Park, D; Park, DJ; Park, E; Park, EC; Park, IH; Park, JH; Park, JI; Park, S; Passmore, MR; Pattaranggoon, NC; Paun, M; Pedersen, S; Pedron, J; Peng, M; Peng, X; Penzhorn, BL; Pérez-Camargo, D; Perez-Maldonado, R; Pérez-Vicente, C; Pham, TD; Pickering, L; Pickersgill, NA; Pinault, E; Pinotsis, N; Plan, M; Pocino, K; Poh, CL; Pons, EDC; Popoff, MR; Porri, D; Pourmand, A; Pratviel, G; Prudente, DO; Qi, H; Qi, N; Qian, LY; Qiao, L; Qiao, Q; Qin, QP; Qiu, N; Qiu, SW; Qu, F; Quan, M; 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| Damgé, C; Neufeld, RJ; Reis, CP; Ribeiro, AJ; Veiga, F | 1 |
| Amidi, M; Crommelin, DJ; Della Pasqua, OE; Hennink, WE; Jiskoot, W; Krudys, KM; Snel, CJ | 1 |
| Ishida, H; Miura, T; Seino, Y; Tsuura, Y; Usami, M | 1 |
| Hayashi, K; Ito, M; Kondo, Y; Nakatani, A | 1 |
| Huang, H; Li, X; Tian, H; Zhao, G | 1 |
4 review(s) available for chitosan and Alloxan Diabetes
| Article | Year |
|---|---|
Antidiabetic Properties of Chitosan and Its Derivatives.
Topics: Animals; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Gluconeogenesis; Glucose; Hypoglycemic Agents; Insulin Resistance; Liver; Rats | 2022 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; Circadian Rhythm; Circular Dichroism; Cisplatin; Citric Acid; Clinical Competence; Clinical Laboratory Techniques; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clostridioides difficile; Clostridium Infections; Coculture Techniques; Cohort Studies; Cold Temperature; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type XI; Color; Connective Tissue Diseases; Copper; Coronary Angiography; Coronavirus 3C Proteases; Coronavirus Infections; Cost of Illness; Counselors; COVID-19; COVID-19 Testing; Creatine Kinase; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Cryoelectron Microscopy; Cryosurgery; Crystallography, X-Ray; Cues; Cultural Competency; Cultural Diversity; Curriculum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cycloparaffins; Cysteine Endopeptidases; Cytokines; Cytoplasm; Cytoprotection; Databases, Factual; Denitrification; Deoxycytidine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diatoms; Diet; Diet, High-Fat; Dietary Exposure; Diffusion Magnetic Resonance Imaging; Diketopiperazines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Disease-Free Survival; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; DNA, Bacterial; DNA, Viral; Docetaxel; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drosophila; Drosophila melanogaster; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Repositioning; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Edema; Edible Grain; Education, Graduate; Education, Medical, Graduate; Education, Pharmacy; Ehlers-Danlos Syndrome; Electron Transport Complex III; Electron Transport Complex IV; Electronic Nicotine Delivery Systems; Emergency Service, Hospital; Empathy; Emulsions; Endothelial Cells; Endurance Training; Energy Intake; Enterovirus A, Human; Environment; Environmental Monitoring; Enzyme Assays; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Epoxide Hydrolases; Epoxy Compounds; Erythrocyte Count; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Estrogens; Etanercept; Ethiopia; Ethnicity; Ethylenes; Exanthema; Exercise; Exercise Test; Exercise Tolerance; Extracellular Matrix; Extracorporeal Membrane Oxygenation; Eye Infections, Fungal; False Negative Reactions; Fatty Acids; Fecal Microbiota Transplantation; Feces; Female; Femur Neck; Fermentation; Ferritins; Fetal Development; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibroins; Fish Proteins; Flavanones; Flavonoids; Focus Groups; Follow-Up Studies; Food Handling; Food Supply; Food, Formulated; Forced Expiratory Volume; Forests; Fractures, Bone; Fruit and Vegetable Juices; Fusobacteria; G1 Phase Cell Cycle Checkpoints; G2 Phase Cell Cycle Checkpoints; Gamma Rays; Gastrectomy; Gastrointestinal Microbiome; Gastrointestinal Stromal Tumors; Gefitinib; Gels; Gemcitabine; Gene Amplification; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Gene-Environment Interaction; Genotype; Germany; Glioma; Glomerular Filtration Rate; Glucagon; Glucocorticoids; Glycemic Control; Glycerol; Glycogen Synthase Kinase 3 beta; Glycolipids; Glycolysis; Goblet Cells; Gram-Negative Bacterial Infections; Granulocyte Colony-Stimulating Factor; Graphite; Greenhouse Effect; Guanidines; Haemophilus influenzae; HCT116 Cells; Health Knowledge, Attitudes, Practice; Health Personnel; Health Services Accessibility; Health Services Needs and Demand; Health Status Disparities; Healthy Volunteers; Heart Failure; Heart Rate; Heart Transplantation; Heart-Assist Devices; HEK293 Cells; Heme; Heme Oxygenase-1; Hemolysis; Hemorrhage; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Hexoses; High-Throughput Nucleotide Sequencing; Hippo Signaling Pathway; Histamine; Histamine Agonists; Histidine; Histone Deacetylase 2; HIV Infections; HIV Reverse Transcriptase; HIV-1; Homebound Persons; Homeodomain Proteins; Homosexuality, Male; Hospice and Palliative Care Nursing; HSP70 Heat-Shock Proteins; Humans; Hyaluronan Receptors; Hydrogen; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemia; Hypoglycemic Agents; Hypoxia; Idiopathic Interstitial Pneumonias; Imaging, Three-Dimensional; Imatinib Mesylate; Immunotherapy; Implementation Science; Incidence; INDEL Mutation; Induced Pluripotent Stem Cells; Industrial Waste; Infant; Infant, Newborn; Inflammation; Inflammation Mediators; Infliximab; Infusions, Intravenous; Inhibitory Concentration 50; Injections; Insecticides; Insulin-Like Growth Factor Binding Protein 5; Insulin-Secreting Cells; Interleukin-1; Interleukin-17; Interleukin-8; Internship and Residency; Intestines; Intracellular Signaling Peptides and Proteins; Ion Transport; Iridaceae; Iridoid Glucosides; Islets of Langerhans Transplantation; Isodon; Isoflurane; Isotopes; Italy; Joint Instability; Ketamine; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Kidney Neoplasms; Kinetics; Klebsiella pneumoniae; Knee Joint; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lactate Dehydrogenase 5; Laparoscopy; Laser Therapy; Lasers, Semiconductor; Lasers, Solid-State; Laurates; Lead; Leukocyte L1 Antigen Complex; Leukocytes, Mononuclear; Light; Lipid Peroxidation; Lipopolysaccharides; Liposomes; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Locomotion; Longitudinal Studies; Lopinavir; Lower Urinary Tract Symptoms; Lubricants; Lung; Lung Diseases, Interstitial; Lung Neoplasms; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating; Lymphoma, Mantle-Cell; Lysosomes; Macrophages; Male; Manganese Compounds; MAP Kinase Kinase 4; Mass Screening; Maternal Health; Medicine, Chinese Traditional; Melanoma, Experimental; Memantine; Membrane Glycoproteins; Membrane Proteins; Mesenchymal Stem Cell Transplantation; Metal Nanoparticles; Metalloendopeptidases; Metalloporphyrins; Methadone; Methane; Methicillin-Resistant Staphylococcus aureus; Mexico; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Nude; Mice, SCID; Mice, Transgenic; Microarray Analysis; Microbial Sensitivity Tests; Microbiota; Micronutrients; MicroRNAs; Microscopy, Confocal; Microsomes, Liver; Middle Aged; Milk; Milk, Human; Minority Groups; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Models, Animal; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Epidemiology; Molecular Structure; Molecular Weight; Multilocus Sequence Typing; Multimodal Imaging; Muscle Strength; Muscle, Skeletal; Muscular Diseases; Mutation; Mycobacterium tuberculosis; Myocardial Stunning; Myristates; NAD(P)H Dehydrogenase (Quinone); Nanocomposites; Nanogels; Nanoparticles; Nanotechnology; Naphthalenes; Nasal Cavity; National Health Programs; Necrosis; Needs Assessment; Neoadjuvant Therapy; Neonicotinoids; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm Transplantation; Neoplasms; Neoplastic Stem Cells; Netherlands; Neuroblastoma; Neuroprotective Agents; Neutrophils; NF-kappa B; NFATC Transcription Factors; Nicotiana; Nicotine; Nitrates; Nitrification; Nitrites; Nitro Compounds; Nitrogen; Nitrogen Dioxide; North Carolina; Nuclear Magnetic Resonance, Biomolecular; Nuclear Proteins; Nucleic Acid Hybridization; Nucleosomes; Nutrients; Obesity; Obesity, Morbid; Oceans and Seas; Oncogene Protein v-akt; Oncogenes; Oocytes; Open Reading Frames; Osteoclasts; Osteogenesis; Osteoporosis; Osteoporosis, Postmenopausal; Outpatients; Ovarian Neoplasms; Ovariectomy; Overweight; Oxazines; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxides; Oxidoreductases; Oxygen; Oxygen Inhalation Therapy; Oxygenators, Membrane; Ozone; Paclitaxel; Paenibacillus; Pain Measurement; Palliative Care; Pancreatic Neoplasms; Pandemics; Parasympathetic Nervous System; Particulate Matter; Pasteurization; Patient Preference; Patient Satisfaction; Pediatric Obesity; Permeability; Peroxiredoxins; Peroxynitrous Acid; Pharmaceutical Services; Pharmacists; Pharmacy; Phaseolus; Phenotype; Phoeniceae; Phosphates; Phosphatidylinositol 3-Kinases; Phospholipid Transfer Proteins; Phospholipids; Phosphorus; Phosphorylation; Photoperiod; Photosynthesis; Phylogeny; Physical Endurance; Physicians; Pilot Projects; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Plant Extracts; Plant Leaves; Plant Proteins; Plant Roots; Plaque, Atherosclerotic; Pneumonia; Pneumonia, Viral; Point-of-Care Testing; Polyethylene Glycols; Polymers; Polysorbates; Pore Forming Cytotoxic Proteins; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Postprandial Period; Poverty; Pre-Exposure Prophylaxis; Prediabetic State; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, First; Pregnancy, High-Risk; Prenatal Exposure Delayed Effects; Pressure; Prevalence; Primary Graft Dysfunction; Primary Health Care; Professional Role; Professionalism; Prognosis; Progression-Free Survival; Prolactin; Promoter Regions, Genetic; Proof of Concept Study; Proportional Hazards Models; Propylene Glycol; Prospective Studies; Prostate; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Kinase Inhibitors; Protein Phosphatase 2; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Proteoglycans; Proteome; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Proton Pumps; Protons; Protoporphyrins; Pseudomonas aeruginosa; Pseudomonas fluorescens; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pulmonary Gas Exchange; Pulmonary Veins; Pyrazoles; Pyridines; Pyrimidines; Qualitative Research; Quinoxalines; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Histamine H3; Receptors, Immunologic; Receptors, Transferrin; Recombinant Proteins; Recurrence; Reference Values; Referral and Consultation; Regional Blood Flow; Registries; Regulon; Renal Insufficiency, Chronic; Reperfusion Injury; Repressor Proteins; Reproducibility of Results; Republic of Korea; Research Design; Resistance Training; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Insufficiency; Resuscitation; Retinal Dehydrogenase; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Ribosomal Proteins; Ribosomes; Risk Assessment; Risk Factors; Ritonavir; Rivers; RNA Interference; RNA-Seq; RNA, Messenger; RNA, Ribosomal, 16S; RNA, Small Interfering; Rosuvastatin Calcium; Rural Population; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salivary Ducts; Salivary Gland Neoplasms; San Francisco; SARS-CoV-2; Satiation; Satiety Response; Schools; Schools, Pharmacy; Seasons; Seawater; Selection, Genetic; Sequence Analysis, DNA; Serine-Threonine Kinase 3; Sewage; Sheep; Sheep, Domestic; Shock, Hemorrhagic; Signal Transduction; Silver; Silymarin; Single Photon Emission Computed Tomography Computed Tomography; Sirolimus; Sirtuin 1; Skin; Skin Neoplasms; Skin Physiological Phenomena; Sleep Initiation and Maintenance Disorders; Social Class; Social Participation; Social Support; Soil; Soil Microbiology; Solutions; Somatomedins; Soot; Specimen Handling; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spinal Fractures; Spirometry; Staphylococcus aureus; STAT1 Transcription Factor; STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus | 2016 |
Efficacy of alginate-and chitosan-based scaffolds on the healing of diabetic skin wounds in animal experimental models and cell studies: A systematic review.
Topics: Alginates; Animals; Biocompatible Materials; Cells, Cultured; Chitosan; Diabetes Mellitus, Experimental; Diabetic Foot; Drug Combinations; Tissue Scaffolds; Wound Healing | 2020 |
The role of polysaccharides from natural resources to design oral insulin micro- and nanoparticles intended for the treatment of Diabetes mellitus: A review.
Topics: Administration, Oral; Alginates; Animals; Chitosan; Dextrans; Diabetes Mellitus; Diabetes Mellitus, Experimental; Drug Compounding; Drug Delivery Systems; Drug Liberation; Humans; Hypoglycemic Agents; Insulin; Intestinal Mucosa; Nanoparticles; Pectins; Permeability; Starch | 2021 |
1 trial(s) available for chitosan and Alloxan Diabetes
220 other study(ies) available for chitosan and Alloxan Diabetes
| Article | Year |
|---|---|
Mucoadhesive versus mucopenetrating nanoparticles for oral delivery of insulin.
Topics: Administration, Oral; Animals; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Insulin; Nanoparticles; Rats | 2021 |
Conductive dual hydrogen bonding hydrogels for the electrical stimulation of infected chronic wounds.
Topics: Aniline Compounds; Animals; Biofilms; Cell Survival; Chitosan; Compressive Strength; Diabetes Mellitus, Experimental; Electric Conductivity; Electric Stimulation; Glycine; Hydrogels; Hydrogen Bonding; Male; Mice; Platelet Aggregation; Pseudomonas aeruginosa; Rats; Staphylococcus aureus; Wound Healing | 2021 |
Formulation and Characterization of Rutin Loaded Chitosan-alginate Nanoparticles: Antidiabetic and Cytotoxicity Studies.
Topics: Alginates; Animals; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Glucose; Hypoglycemic Agents; Nanoparticles; Particle Size; Rats; Rutin; Spectroscopy, Fourier Transform Infrared | 2022 |
A thermoreversible antibacterial zeolite-based nanoparticles loaded hydrogel promotes diabetic wound healing via detrimental factor neutralization and ROS scavenging.
Topics: Animals; Anti-Bacterial Agents; Cells, Cultured; Chitosan; Diabetes Mellitus, Experimental; Free Radical Scavengers; Human Umbilical Vein Endothelial Cells; Humans; Hydrogels; Male; Mice; Nanoparticles; Poloxamer; Rats, Sprague-Dawley; RAW 264.7 Cells; Reactive Oxygen Species; Temperature; Wound Healing; Zeolites | 2021 |
Facile formation of injectable quaternized chitosan/tannic acid hydrogels with antibacterial and ROS scavenging capabilities for diabetic wound healing.
Topics: Animals; Anti-Bacterial Agents; Bandages; Chitosan; Collagen; Diabetes Mellitus, Experimental; Escherichia coli; Hydrogels; Injections; Male; Microbial Viability; Rats; Reactive Oxygen Species; Staphylococcus aureus; Streptozocin; Tannins; Treatment Outcome; Wound Healing | 2022 |
Electrospun multifunctional nanofibrous mats loaded with bioactive anemoside B4 for accelerated wound healing in diabetic mice.
Topics: Animals; Biomimetics; Cell Survival; Chitosan; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Liberation; Inflammation Mediators; Macrophages; Mice; Nanofibers; Polyvinyl Alcohol; RAW 264.7 Cells; Saponins; Wound Healing; Wounds and Injuries | 2022 |
Potential Use of Tailored Citicoline Chitosan-Coated Liposomes for Effective Wound Healing in Diabetic Rat Model.
Topics: Animals; Chitosan; Cytidine Diphosphate Choline; Diabetes Mellitus, Experimental; Humans; Liposomes; Rats; Wound Healing | 2022 |
Chitosan-Encapsulated Nano-selenium Targeting TCF7L2, PPARγ, and CAPN10 Genes in Diabetic Rats.
Topics: Animals; Antioxidants; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic Agents; Insulin; Insulin-Like Growth Factor I; Male; Oxidative Stress; PPAR gamma; Rats; Rats, Wistar; Selenium; Streptozocin | 2023 |
Functional thermosensitive hydrogels based on chitin as RIN-m5F cell carrier for the treatment of diabetes.
Topics: Animals; Chitin; Chitosan; Diabetes Mellitus, Experimental; Hydrogels; Insulin Secretion; Mice; Rats; Rats, Sprague-Dawley | 2022 |
An oxygen-sensitive probe and a hydrogel for optical imaging and photodynamic antimicrobial chemotherapy of chronic wounds.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Chitosan; Diabetes Mellitus, Experimental; Hydrogels; Hypoxia; Mice; Molecular Probes; Optical Imaging; Oxygen | 2022 |
Phenytoin-loaded bioactive nanoparticles for the treatment of diabetic pressure ulcers: formulation and in vitro/in vivo evaluation.
Topics: Animals; Chitosan; Collagen; Diabetes Mellitus, Experimental; Nanoparticles; Phenytoin; Pressure Ulcer; Rats; Suspensions | 2022 |
Self-assembled polyelectrolyte complexes of chitosan and fucoidan for sustained growth factor release from PRP enhance proliferation and collagen deposition in diabetic mice.
Topics: Animals; Cell Proliferation; Chitosan; Collagen; Diabetes Mellitus, Experimental; Intercellular Signaling Peptides and Proteins; Keratins; Ki-67 Antigen; Mice; Platelet-Rich Plasma; Polyelectrolytes; Polysaccharides; Spectroscopy, Fourier Transform Infrared; Wound Healing | 2022 |
Preparation and in-vitro, in-vivo characterisation of pioglitazone loaded chitosan/PEG blended PLGA biocompatible nanoparticles.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Carriers; Nanoparticles; Particle Size; Pioglitazone; Rats; Spectroscopy, Fourier Transform Infrared | 2022 |
Controlled synthesis of in-situ gold nanoparticles onto chitosan functionalized PLGA nanoparticles for oral insulin delivery.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Glycols; Gold; Insulin; Lactic Acid; Metal Nanoparticles; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats | 2022 |
Antioxidative Stress and Antiapoptosis Effect of Chitosan Nanoparticles to Protect Cardiac Cell Damage on Streptozotocin-Induced Diabetic Rat.
Topics: Animals; Caspase 3; Chitosan; Diabetes Mellitus, Experimental; Glutathione Peroxidase; Nanoparticles; Necrosis; NF-E2-Related Factor 2; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Streptozocin; Superoxide Dismutase | 2022 |
A multifunctional antibacterial and self-healing hydrogel laden with bone marrow mesenchymal stem cell-derived exosomes for accelerating diabetic wound healing.
Topics: Animals; Anti-Bacterial Agents; Chitosan; Diabetes Mellitus, Experimental; Exosomes; Hydrogels; Inflammation; Mesenchymal Stem Cells; Rats; Wound Healing | 2022 |
Electrical signals regulate the release of insulin from electrodeposited chitosan composite hydrogel: An in vitro and in vivo study.
Topics: Animals; Blood Glucose; Chitosan; Copper; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Drug Delivery Systems; Hydrogels; Hydroxides; Insulin; Rats | 2022 |
A hybrid hydrogel encapsulating human umbilical cord mesenchymal stem cells enhances diabetic wound healing.
Topics: Animals; Catechols; Chitosan; Collagen; Diabetes Mellitus, Experimental; Gelatin; Humans; Hydrogels; Mesenchymal Stem Cells; Methacrylates; Mice; Tumor Necrosis Factor-alpha; Umbilical Cord; Wound Healing | 2022 |
The Effects of Chitosan-PEG Nanoparticles Based on Channa striata Protein Hydrolyzate on Decreasing Diabetes Mellitus in Diabetic Rats.
Topics: Acarbose; Animals; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Male; Nanoparticles; Protein Hydrolysates; Rats; Rats, Sprague-Dawley; Streptozocin | 2022 |
Preparation and characterization of vaccarin, hypaphorine and chitosan nanoparticles and their promoting effects on chronic wounds healing.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Chitosan; Diabetes Mellitus, Experimental; Humans; Nanoparticles; Rats | 2022 |
A self-healing hydrogel based on crosslinked hyaluronic acid and chitosan to facilitate diabetic wound healing.
Topics: Animals; Anti-Inflammatory Agents; Chitosan; Cytokines; Diabetes Mellitus, Experimental; Hyaluronic Acid; Hydrogels; Rats; Schiff Bases; Taurine; Wound Healing | 2022 |
Therapeutic significance of thymoquinone-loaded chitosan nanoparticles on streptozotocin/nicotinamide-induced diabetic rats: In vitro and in vivo functional analysis.
Topics: Animals; Benzoquinones; Chitosan; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Nanoparticles; Niacinamide; Rats; Streptozocin | 2022 |
The effect of insulin-loaded gold and carboxymethyl chitosan nanoparticles on gene expression of glucokinase and pyruvate kinase in rats with diabetes type 1.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Gene Expression; Glucokinase; Glucose; Gold; Insulin; Male; Metal Nanoparticles; Pyruvate Kinase; Rats; Rats, Wistar | 2022 |
Hydrogel patch with pretreated stem cells accelerates wound closure in diabetic rats.
Topics: Animals; Biocompatible Materials; Chitosan; Diabetes Mellitus, Experimental; Hydrogels; Polyethylene Glycols; Quality of Life; Rats; Stem Cells; Wound Healing | 2022 |
pH-sensitive O-carboxymethyl chitosan/sodium alginate nanohydrogel for enhanced oral delivery of insulin.
Topics: Administration, Oral; Alginates; Animals; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Drug Delivery Systems; Hydrogen-Ion Concentration; Insulin; Rats | 2022 |
Phosphorylated chitosan accelerates dermal wound healing in diabetic wistar rats.
Topics: Animals; Antioxidants; Chitosan; Diabetes Mellitus, Experimental; Rats; Rats, Wistar; Spectroscopy, Fourier Transform Infrared; Wound Healing | 2023 |
Histopathological investigation of the effect of chitosan on oral mucous wound healing in experimentally established diabetic rats.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Fibrosis; Foreign-Body Reaction; Inflammation; Male; Rats; Rats, Sprague-Dawley; Wound Healing | 2023 |
Injectable self-healing chitosan-based POSS-PEG hybrid hydrogel as wound dressing to promote diabetic wound healing.
Topics: Animals; Bandages; Biocompatible Materials; Chitosan; Diabetes Mellitus, Experimental; Hydrogels; Mice; Wound Healing | 2023 |
In situ rearranged multifunctional lipid nanoparticles via synergistic potentiation for oral insulin delivery.
Topics: Administration, Oral; Animals; Caco-2 Cells; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Drug Delivery Systems; Humans; Insulin; Micelles; Nanoparticles; Rats | 2023 |
Preparation of nanocomposite membranes loaded with taxifolin liposome and its mechanism of wound healing in diabetic mice.
Topics: Animals; Anti-Bacterial Agents; Chitosan; Diabetes Mellitus, Experimental; Liposomes; Mice; Nanocomposites; Polyvinyl Alcohol; Wound Healing | 2023 |
A nano-delivery system based on preventing degradation and promoting absorption to improve the oral bioavailability of insulin.
Topics: Administration, Oral; Animals; Biological Availability; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Insulin; Mice; Nanoparticle Drug Delivery System; Nanoparticles | 2023 |
Preparation of Ultra-Small Copper Nanoparticles-Loaded Self-Healing Hydrogels with Antibacterial, Inflammation-Suppressing and Angiogenesis-Enhancing Properties for Promoting Diabetic Wound Healing.
Topics: Animals; Anti-Bacterial Agents; Chitosan; Copper; Diabetes Mellitus, Experimental; Hydrogels; Nanoparticles; Rats; Wound Healing | 2023 |
Therapeutic effect of melatonin-loaded chitosan/lecithin nanoparticles on hyperglycemia and pancreatic beta cells regeneration in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Humans; Hyperglycemia; Insulin; Insulin-Secreting Cells; Lecithins; Melatonin; Rats; Streptozocin | 2023 |
Enhance the oral insulin delivery route using a modified chitosan-based formulation fabricated by microwave.
Topics: Administration, Oral; Animals; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Insulin; Microwaves; Nanoparticles; Particle Size; Rats | 2023 |
Carboxymethyl chitosan-TK resistant starch complex ameliorates type 2 diabetes by regulating the gut microbiota.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gastrointestinal Microbiome; Mice; Resistant Starch; Starch | 2023 |
Fast disintegrating dosage forms of mucoadhesive-based nanoparticles for oral insulin delivery: Optimization to in vivo evaluation.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Drug Delivery Systems; Hypoglycemic Agents; Insulin; Mice; Nanoparticles; Tablets | 2023 |
LC-MS based metabolic profiling and wound healing activity of a chitosan nanoparticle-loaded formula of Teucrium polium in diabetic rats.
Topics: Animals; Chitosan; Chromatography, Liquid; Diabetes Mellitus, Experimental; Hydrogels; Nanogels; Plant Extracts; Rats; Tandem Mass Spectrometry; Teucrium; Wound Healing | 2023 |
Engineering superstable islets-laden chitosan microgels with carboxymethyl cellulose coating for long-term blood glucose regulation in vivo.
Topics: Animals; Blood Glucose; Carboxymethylcellulose Sodium; Chitosan; Diabetes Mellitus, Experimental; Islets of Langerhans; Maleimides; Mice; Microgels; Sulfhydryl Compounds | 2024 |
Pioglitazone-loaded three-dimensional composite polymeric scaffolds: A proof of concept study in wounded diabetic rats.
Topics: Animals; Bandages; Chitosan; Diabetes Mellitus, Experimental; Drug Liberation; Hypromellose Derivatives; Male; Pioglitazone; Polymers; Porosity; Proof of Concept Study; Rats; Rats, Wistar; Skin; Tissue Scaffolds; Wound Healing | 2019 |
Electrospun chitosan/PVA/bioglass Nanofibrous membrane with spatially designed structure for accelerating chronic wound healing.
Topics: Animals; Bandages; Cell Line; Ceramics; Chitosan; Chronic Disease; Diabetes Complications; Diabetes Mellitus, Experimental; Male; Membranes, Artificial; Mice; Nanofibers; Polyvinyl Alcohol; Rats; Rats, Sprague-Dawley; Wound Healing; Wounds and Injuries | 2019 |
Preparation of a novel asymmetric wettable chitosan-based sponge and its role in promoting chronic wound healing.
Topics: Animals; Anti-Bacterial Agents; Bandages; Cell Line; Cell Survival; Chitosan; Diabetes Mellitus, Experimental; Drug Delivery Systems; Escherichia coli; Male; Mice; Nanoparticles; Quaternary Ammonium Compounds; Staphylococcus aureus; Wound Healing | 2020 |
Chitosan-based nitric oxide-releasing dressing for anti-biofilm and in vivo healing activities in MRSA biofilm-infected wounds.
Topics: Animals; Anti-Bacterial Agents; Bandages; Biofilms; Cell Line; Cell Survival; Chitosan; Collagen; Diabetes Mellitus, Experimental; Drug Delivery Systems; Drug Liberation; Hydrogels; Male; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred ICR; Nitric Oxide; Wound Healing | 2020 |
Preparation, in vitro and in vivo evaluation of PLGA/Chitosan based nano-complex as a novel insulin delivery formulation.
Topics: Animals; Blood Glucose; Cell Line; Cell Survival; Chitosan; Diabetes Mellitus, Experimental; Drug Compounding; Drug Delivery Systems; Drug Liberation; Glucose Oxidase; Hypoglycemic Agents; Insulin; Male; Mice; Nanoparticles; Polylactic Acid-Polyglycolic Acid Copolymer; Rats, Wistar | 2019 |
The fabrication of a highly efficient self-healing hydrogel from natural biopolymers loaded with exosomes for the synergistic promotion of severe wound healing.
Topics: Animals; Biocompatible Materials; Biopolymers; Cell Proliferation; Cells, Cultured; Chitosan; Diabetes Mellitus, Experimental; Exosomes; Hydrogels; Methylcellulose; Mice; Nanoparticles; Neovascularization, Physiologic; Receptors, Leptin; Wound Healing | 2019 |
Biofabrication of microcapsules encapsulating beta-TC-6 cells via scalable device and in-vivo evaluation in type 1 diabetic mice.
Topics: Alginates; Animals; Blood Glucose; Capsules; Chitosan; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Immune Tolerance; Immunity, Humoral; Insulin-Secreting Cells; Mice; Streptozocin; Time Factors | 2019 |
Synergistic effect of novel chitosan combined metformin drug on streptozotocin-induced diabetes mellitus rat.
Topics: alpha-Amylases; Animals; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Drug Synergism; Insulin; Male; Metformin; Rats; Rats, Wistar | 2020 |
Development of a chitosan hydrogel containing flavonoids extracted from Passiflora edulis leaves and the evaluation of its antioxidant and wound healing properties for the treatment of skin lesions in diabetic mice.
Topics: Animals; Antioxidants; Chitosan; Diabetes Mellitus, Experimental; Drug Delivery Systems; Flavonoids; Hydrogels; Passiflora; Rats, Wistar; Wound Healing | 2020 |
Effect of insulin-loaded trimethyl chitosan nanoparticles on genes expression in the hippocampus of diabetic rats.
Topics: Administration, Oral; Animals; Chitosan; Diabetes Mellitus, Experimental; Gene Expression Regulation; Hippocampus; Hypoglycemic Agents; Insulin; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Male; Nanoparticles; Particle Size; Rats; Rats, Wistar | 2019 |
Thiolated Nanoparticles Overcome the Mucus Barrier and Epithelial Barrier for Oral Delivery of Insulin.
Topics: Acrylic Resins; Administration, Oral; Animals; Biological Availability; Cell Line, Tumor; Chitosan; Cysteine; Diabetes Mellitus, Experimental; Drug Carriers; Epithelial Cells; Humans; Insulin; Microscopy, Electron, Transmission; Mucus; Nanoparticles; Nicotinic Acids; Picolinic Acids; Rats; Sulfhydryl Compounds; Tight Junctions | 2020 |
Enhancement of cellular activity in hyperglycemic mice dermal wounds dressed with chitosan-alginate membranes.
Topics: Alginates; Animals; Bandages; Biocompatible Materials; Biomarkers; Cell Proliferation; Chitosan; Collagen; Diabetes Mellitus, Experimental; Inflammation; Male; Mice; Mice, Inbred C57BL; Time Factors; Wound Healing | 2020 |
Retinoic acid-loaded solid lipid nanoparticles surrounded by chitosan film support diabetic wound healing in in vivo study.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Disease Models, Animal; Drug Carriers; Lipids; Male; Mice; Mice, Inbred C57BL; Nanoparticles; Particle Size; Surface Properties; Tretinoin; Wound Healing | 2020 |
Preparation and characterization of epigallocatechin gallate, ascorbic acid, gelatin, chitosan nanoparticles and their beneficial effect on wound healing of diabetic mice.
Topics: Animals; Ascorbic Acid; Catechin; Chitosan; Collagen; Diabetes Mellitus, Experimental; Gelatin; Male; Mice; Mice, Inbred ICR; Nanoparticles; Streptozocin; Wound Healing | 2020 |
Wound healing treatment using insulin within polymeric nanoparticles in the diabetes animal model.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Female; Hypoglycemic Agents; Insulin; Nanoparticles; Rats, Wistar; Skin; Wound Healing | 2020 |
Long-term glycemic control and prevention of diabetes complications in vivo using oleic acid-grafted-chitosan‑zinc-insulin complexes incorporated in thermosensitive copolymer.
Topics: Animals; Blood Glucose; Chitosan; Diabetes Complications; Diabetes Mellitus, Experimental; Glycemic Control; Humans; Hypoglycemic Agents; Insulin; Oleic Acid; Polymers; Rats; Zinc | 2020 |
Treatment of insulin resistance in obesity-associated type 2 diabetes mellitus through adiponectin gene therapy.
Topics: 3T3-L1 Cells; Adiponectin; Animals; Chitosan; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Genetic Therapy; Insulin Resistance; Male; Mice; Nanoparticles; Obesity; Oleic Acid; Peptides; Plasmids; Rats, Wistar | 2020 |
Cholesterol moieties as building blocks for assembling nanoparticles to achieve effective oral delivery of insulin.
Topics: Administration, Oral; Animals; Caco-2 Cells; Chitosan; Cholesterol; Diabetes Mellitus, Experimental; Drug Carriers; Humans; Insulin; Nanoparticles; Rats | 2020 |
Eudragit L-100 Capsules Aromatize and Quaternerize Chitosan for Insulin Nanoparticle Oral Delivery During Toxic Oxidative Stress in Rat Liver and Kidney.
Topics: Administration, Oral; Animals; Capsules; Chitosan; Diabetes Mellitus, Experimental; Drug Delivery Systems; Insulin; Kidney; Liver; Male; Nanoparticles; Oxidative Stress; Polymethacrylic Acids; Rats; Rats, Wistar | 2020 |
PPAR-Gamma as putative gene target involved in Butein mediated anti-diabetic effect.
Topics: Animals; Chalcones; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Hypoglycemic Agents; Kidney; Liver; Male; Pancreas; PPAR gamma; Rats; Rats, Wistar | 2020 |
Carboxymethyl β-cyclodextrin grafted carboxymethyl chitosan hydrogel-based microparticles for oral insulin delivery.
Topics: Administration, Oral; Animals; beta-Cyclodextrins; Blood Glucose; Caco-2 Cells; Chitosan; Cross-Linking Reagents; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Drug Carriers; Humans; Hydrogels; Hydrogen-Ion Concentration; Hypoglycemic Agents; Insulin; Male; Mice; Protein Structure, Secondary; Streptozocin; Succinimides | 2020 |
Overcoming Multiple Absorption Barrier for Insulin Oral Delivery Using Multifunctional Nanoparticles Based on Chitosan Derivatives and Hyaluronic Acid.
Topics: Administration, Oral; Animals; Biological Transport; Caco-2 Cells; Cell Death; Chitosan; Diabetes Mellitus, Experimental; Electric Impedance; Endocytosis; Guanidines; Humans; Hyaluronic Acid; Hypoglycemic Agents; Insulin; Intestinal Absorption; Male; Mucus; Multifunctional Nanoparticles; Nanoparticles; Rats; Solubility; Swine | 2020 |
Optimization of phytic acid-crosslinked chitosan microspheres for oral insulin delivery using response surface methodology.
Topics: Administration, Oral; Animals; Caco-2 Cells; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Humans; Hypoglycemic Agents; Insulin; Microspheres; Particle Size; Phytic Acid; Rats | 2020 |
Chitosan hydrogels functionalized with either unfractionated heparin or bemiparin improve diabetic wound healing.
Topics: Animals; Bandages, Hydrocolloid; Chitosan; Collagen Type I; Collagen Type III; Diabetes Mellitus, Experimental; Female; Heparin, Low-Molecular-Weight; Hydrogels; Macrophages; Myofibroblasts; Rats, Wistar; Skin; Surgical Wound; Time Factors; Transforming Growth Factor beta1; Wound Healing | 2020 |
Melatonin loaded lecithin-chitosan nanoparticles improved the wound healing in diabetic rats.
Topics: Animals; Biocompatible Materials; Biopsy; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Drug Liberation; Fibroblasts; Lecithins; Melatonin; Nanoparticles; Particle Size; Rats; Skin Ulcer; Wound Healing | 2020 |
Carbon nanodot decorated acellular dermal matrix hydrogel augments chronic wound closure.
Topics: Acellular Dermis; Amnion; Animals; Anti-Bacterial Agents; Carbon; Chitosan; Diabetes Mellitus, Experimental; Escherichia coli; Free Radical Scavengers; Human Embryonic Stem Cells; Humans; Hydrogels; Male; Microbial Sensitivity Tests; Neovascularization, Physiologic; Quantum Dots; Rats, Wistar; Re-Epithelialization; Staphylococcus aureus; Wound Healing | 2020 |
Sulfated chitosan rescues dysfunctional macrophages and accelerates wound healing in diabetic mice.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Macrophages; Mice; Sulfates; Wound Healing | 2020 |
Chitosan-stabilized selenium nanoparticles alleviate cardio-hepatic damage in type 2 diabetes mellitus model via regulation of caspase, Bax/Bcl-2, and Fas/FasL-pathway.
Topics: Animals; Antioxidants; bcl-2-Associated X Protein; Blood Glucose; Caspases; Chitosan; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Fas Ligand Protein; fas Receptor; Heart Diseases; Hypoglycemic Agents; Insulin Resistance; Liver; Liver Diseases; Male; Nanoparticles; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Selenium; Signal Transduction; Streptozocin | 2021 |
Novel silver and nanoparticle-encapsulated growth factor co-loaded chitosan composite hydrogel with sustained antimicrobility and promoted biological properties for diabetic wound healing.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Hydrogels; Nanoparticles; Rats; Silver; Wound Healing | 2021 |
Chitosan-sodium alginate-fatty acid nanocarrier system: Lutein bioavailability, absorption pharmacokinetics in diabetic rat and protection of retinal cells against H
Topics: Alginates; Animals; Biological Availability; Cell Line; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Fatty Acids; Gastrointestinal Absorption; Half-Life; Humans; Hydrogen Peroxide; Lutein; Male; Micelles; Mitochondria; Nanoparticles; Oxidative Stress; Protective Agents; Rats; Rats, Wistar; Retinal Pigment Epithelium | 2021 |
Polydatin and polydatin-loaded chitosan nanoparticles attenuate diabetic cardiomyopathy in rats.
Topics: Animals; Antioxidants; Chitosan; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Glucosides; Glycated Hemoglobin; Immunohistochemistry; Male; Nanoparticles; Oxidative Stress; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Stilbenes | 2021 |
Improved insulin sensitivity in obese-diabetic mice via chitosan Nanomicelles mediated silencing of pro-inflammatory Adipocytokines.
Topics: Adipocytes; Adipokines; Adiponectin; Adipose Tissue; Animals; Biocompatible Materials; Chitosan; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose Tolerance Test; Inflammation Mediators; Insulin; Insulin Resistance; Macrophages; Male; Mice; Mice, Inbred C57BL; Micelles; Nanoparticles; Obesity; RAW 264.7 Cells; RNA Interference; Tumor Necrosis Factor-alpha | 2021 |
Scar free healing of full thickness diabetic wounds: A unique combination of silver nanoparticles as antimicrobial agent, calcium alginate nanoparticles as hemostatic agent, fresh blood as nutrient/growth factor supplier and chitosan as base matrix.
Topics: Alginates; Animals; Anti-Bacterial Agents; Bandages; Chitosan; Diabetes Mellitus, Experimental; Female; Hemostatics; Hydrogels; Metal Nanoparticles; Rats; Rats, Sprague-Dawley; Silver; Wound Healing | 2021 |
Suppression of Fibrotic Reactions of Chitosan-Alginate Microcapsules Containing Porcine Islets by Dexamethasone Surface Coating.
Topics: Alginates; Animals; Capsules; Chitosan; Dexamethasone; Diabetes Mellitus, Experimental; Fibrosis; Islets of Langerhans; Islets of Langerhans Transplantation; Mice; Swine | 2021 |
Microfluidic-based synthesized carboxymethyl chitosan nanoparticles containing metformin for diabetes therapy: In vitro and in vivo assessments.
Topics: Animals; Blood Glucose; Chitosan; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Drug Carriers; Drug Liberation; Metformin; Microfluidics; Nanoparticles; Particle Size; Rats; Rats, Wistar | 2021 |
Hepatoprotective Effects of Polydatin-Loaded Chitosan Nanoparticles in Diabetic Rats: Modulation of Glucose Metabolism, Oxidative Stress, and Inflammation Biomarkers.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Glucose; Glucosides; Inflammation; Lipid Peroxidation; Liver; Male; Metformin; Nanoparticles; Niacinamide; Oxidative Stress; Protective Agents; Rats; Rats, Wistar; Stilbenes; Streptozocin | 2021 |
Stabilized-chitosan selenium nanoparticles efficiently reduce renal tissue injury and regulate the expression pattern of aldose reductase in the diabetic-nephropathy rat model.
Topics: Aldehyde Reductase; Animals; Chitosan; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Gene Expression Regulation; Kidney; Kidney Function Tests; Male; Nanoparticles; Rats; Rats, Sprague-Dawley; Selenium | 2021 |
Assessment of Exenatide loaded Biotinylated Trimethylated Chitosan/HP- 55 Nanoparticles.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Carriers; Exenatide; Humans; Methylcellulose; Mice; Nanoparticles; Particle Size; Spectroscopy, Fourier Transform Infrared; Tissue Distribution | 2022 |
Chitosan Oligosaccharide Alleviates Abnormal Glucose Metabolism without Inhibition of Hepatic Lipid Accumulation in a High-Fat Diet/Streptozotocin-Induced Diabetic Rat Model.
Topics: Animals; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Dietary Fats; Gluconeogenesis; Liver; Male; Models, Animal; Oligosaccharides; Rats; Rats, Wistar; Streptozocin | 2021 |
Chitosan alginate nanoparticles as a platform for the treatment of diabetic and non-diabetic pressure ulcers: Formulation and in vitro/in vivo evaluation.
Topics: Alginates; Animals; Chitosan; Diabetes Mellitus, Experimental; Nanoparticles; Particle Size; Pressure Ulcer; Rats | 2021 |
pH-sensitive chitosan-deoxycholic acid/alginate nanoparticles for oral insulin delivery.
Topics: Administration, Oral; Alginates; Animals; Caco-2 Cells; Cell Survival; Chitosan; Deoxycholic Acid; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Delivery Systems; Humans; Hydrogen-Ion Concentration; Insulin; Male; Nanoparticles; Rats; Rats, Sprague-Dawley | 2021 |
Influence of Dietary Chitosan Feeding Duration on Glucose and Lipid Metabolism in a Diabetic Rat Model.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Dietary Carbohydrates; Disease Models, Animal; Glucose; Lipid Metabolism; Male; Rats; Rats, Sprague-Dawley; Time Factors | 2021 |
Scalable fabrication of size-controlled chitosan nanoparticles for oral delivery of insulin.
Topics: Administration, Oral; Animals; Biological Transport; Blood Glucose; Caco-2 Cells; Chitosan; Diabetes Mellitus, Experimental; Disease Models, Animal; Drug Delivery Systems; Electric Impedance; Freeze Drying; Humans; Hydrogen-Ion Concentration; Insulin; Male; Nanoparticles; Particle Size; Polyphosphates; Rats, Sprague-Dawley; Sus scrofa; Tight Junctions | 2017 |
Co-microencapsulation of BMSCs and mouse pancreatic β cells for improving the efficacy of type I diabetes therapy.
Topics: Alginates; Animals; Blood Glucose; Capsules; Chitosan; Coculture Techniques; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Insulin; Insulin-Secreting Cells; Islets of Langerhans Transplantation; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice | 2017 |
Alginate coated chitosan core-shell nanoparticles for efficient oral delivery of naringenin in diabetic animals-An in vitro and in vivo approach.
Topics: Administration, Oral; Alginates; Animals; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Flavanones; Glucuronic Acid; Hexuronic Acids; Nanoparticles; Particle Size; Rats | 2017 |
Preparation of poly(lactic-co-glycolic acid) and chitosan composite nanocarriers via electrostatic self assembly for oral delivery of insulin.
Topics: Administration, Oral; Animals; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Insulin; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats | 2017 |
A cell-penetrating peptide mediated chitosan nanocarriers for improving intestinal insulin delivery.
Topics: Administration, Oral; Animals; Cell-Penetrating Peptides; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Insulin; Nanoparticles; Rats | 2017 |
Synthesis of a novel structure for the oral delivery of insulin and the study of its effect on diabetic rats.
Topics: Administration, Oral; Animals; Blood Glucose; Cell Survival; Cells, Cultured; Chitosan; Dendrimers; Diabetes Mellitus, Experimental; Dietary Fiber; Drug Carriers; Drug Delivery Systems; Drug Liberation; Gelatin; Hypoglycemic Agents; Insulin; Nanoparticles; Oryza; Porosity; Rats; Silicon Dioxide; Spectroscopy, Fourier Transform Infrared; Tissue Distribution | 2017 |
Surface-modified PLGA nanoparticles with chitosan for oral delivery of tolbutamide.
Topics: Administration, Oral; Animals; Blood Glucose; Cell Survival; Chitosan; Diabetes Mellitus, Experimental; Drug Liberation; Hep G2 Cells; Humans; Hypoglycemic Agents; Lactic Acid; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats, Sprague-Dawley; Surface Properties; Tolbutamide | 2018 |
Functional nanoparticles exploit the bile acid pathway to overcome multiple barriers of the intestinal epithelium for oral insulin delivery.
Topics: Administration, Oral; Animals; Bile Acids and Salts; Biological Availability; Caco-2 Cells; Cardiovascular System; Carrier Proteins; Chitosan; Deoxycholic Acid; Diabetes Mellitus, Experimental; Drug Carriers; Drug Liberation; Drug Trafficking; Humans; Insulin; Intestinal Mucosa; Male; Membrane Glycoproteins; Mucus; Nanoparticles; Organic Anion Transporters, Sodium-Dependent; Particle Size; Permeability; Rats, Sprague-Dawley; Surface Properties; Symporters | 2018 |
The effect of insulin-loaded trimethylchitosan nanoparticles on rats with diabetes type I.
Topics: Animals; Antioxidants; Biological Availability; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Drug Carriers; Gene Expression Regulation; Glucokinase; Hypoglycemic Agents; Inflammation; Insulin; Liver; Male; Nanoparticles; Oxidative Stress; Rats; Rats, Wistar | 2018 |
A composite hydrogel of chitosan/heparin/poly (γ-glutamic acid) loaded with superoxide dismutase for wound healing.
Topics: 3T3 Cells; Animals; Bandages, Hydrocolloid; Chitosan; Diabetes Mellitus, Experimental; Diabetic Foot; Elasticity; Heparin; Hydrogels; Male; Mice; Polyglutamic Acid; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Viscosity; Wound Healing | 2018 |
Preparation, characterization and in vivo evaluation of pH sensitive, safe quercetin-succinylated chitosan-alginate core-shell-corona nanoparticle for diabetes treatment.
Topics: Administration, Oral; Alginates; Animals; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Drug Delivery Systems; Glucuronic Acid; Hexuronic Acids; HT29 Cells; Humans; Hydrogen-Ion Concentration; Hypoglycemic Agents; Male; Nanoparticles; Particle Size; Quercetin; Rats; Rats, Wistar; Succinic Acid | 2018 |
Experimental Study on Effects of Adipose-Derived Stem Cell-Seeded Silk Fibroin Chitosan Film on Wound Healing of a Diabetic Rat Model.
Topics: Adipocytes; Animals; Cell Culture Techniques; Chitosan; Diabetes Mellitus, Experimental; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Fibroins; Flow Cytometry; Immunophenotyping; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Stem Cells; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A; Wound Healing | 2018 |
Targeted delivery of antigen to intestinal dendritic cells induces oral tolerance and prevents autoimmune diabetes in NOD mice.
Topics: Animals; Antigen Presentation; Antigens; Chitosan; Dendritic Cells; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Female; Glucose Tolerance Test; Immune Tolerance; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Nanoparticles; T-Lymphocytes, Regulatory | 2018 |
Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice.
Topics: Animals; Blood Glucose; Body Composition; Chitosan; Diabetes Mellitus, Experimental; Dysbiosis; Dyslipidemias; Enzyme Activation; Gastrointestinal Microbiome; Male; Mice; Mice, Inbred C57BL; Oligosaccharides; p38 Mitogen-Activated Protein Kinases | 2018 |
Bioadhesive Chitosan-Coated Cationic Nanoliposomes With Improved Insulin Encapsulation and Prolonged Oral Hypoglycemic Effect in Diabetic Mice.
Topics: Adhesives; Animals; Blood Glucose; Cations; Chitosan; Diabetes Mellitus, Experimental; Female; Hypoglycemic Agents; Insulin; Liposomes; Male; Mice | 2018 |
Endogenous ornithine decarboxylase/polyamine system mediated the antagonist role of insulin/PEG-CMCS preconditioning against heart ischemia/reperfusion injury in diabetes mellitus.
Topics: Animals; Apoptosis; Cardiotonic Agents; Chitosan; Coronary Vessels; Diabetes Mellitus, Experimental; Drug Carriers; Insulin; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Nanoparticles; Ornithine Decarboxylase; Polyamines; Polyethylene Glycols; Rats, Sprague-Dawley | 2018 |
Wound healing effects of a Curcuma zedoaria polysaccharide with platelet-rich plasma exosomes assembled on chitosan/silk hydrogel sponge in a diabetic rat model.
Topics: Animals; Bandages; Blood Glucose; Chitosan; Curcuma; Diabetes Mellitus, Experimental; Exosomes; Female; Hydrogels; Molecular Weight; Monosaccharides; Plant Extracts; Platelet-Rich Plasma; Polysaccharides; Rats; Silk; Skin Ulcer; Wound Healing | 2018 |
Liver-targeted delivery of insulin-loaded nanoparticles via enterohepatic circulation of bile acids.
Topics: Animals; Bile Acids and Salts; Blood Glucose; Caco-2 Cells; Cell Line, Tumor; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Drug Delivery Systems; Enterohepatic Circulation; Female; Hep G2 Cells; Humans; Hypoglycemic Agents; Insulin; Liver; Male; Methylcellulose; Mice, Inbred ICR; Nanoparticles | 2018 |
Effect of insulin-coated trimethyl chitosan nanoparticles on IGF-1, IGF-2, and apoptosis in the hippocampus of diabetic male rats.
Topics: Animals; Anticholesteremic Agents; Apoptosis; Chitosan; Diabetes Mellitus, Experimental; Disease Models, Animal; Drug Delivery Systems; Hippocampus; Hypoglycemic Agents; In Situ Nick-End Labeling; Insulin; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Male; Nanoparticles; Rats; Rats, Wistar | 2018 |
Synthesis and antidiabetic properties of chitosan-stabilized selenium nanoparticles.
Topics: Administration, Oral; Animals; Chitosan; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Male; Mice; Mice, Inbred ICR; Nanoparticles; Particle Size; Selenium Compounds; Streptozocin; Surface Properties | 2018 |
Fatty acid and quaternary ammonium modified chitosan nanoparticles for insulin delivery.
Topics: Absorption, Physiological; Administration, Oral; Animals; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Drug Delivery Systems; Fatty Acids; Hep G2 Cells; Hepatocytes; Humans; Hydrophobic and Hydrophilic Interactions; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred ICR; Nanoparticles; Particle Size; Quaternary Ammonium Compounds; Surface Properties | 2018 |
Alginate-C18 Conjugate Nanoparticles Loaded in Tripolyphosphate-Cross-Linked Chitosan-Oleic Acid Conjugate-Coated Calcium Alginate Beads as Oral Insulin Carrier.
Topics: Administration, Oral; Alginates; Animals; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Drug Liberation; Gastrointestinal Absorption; HT29 Cells; Humans; Hypoglycemic Agents; Insulin; Intestinal Mucosa; Male; Models, Animal; Nanoconjugates; Oleic Acid; Particle Size; Polyphosphates; Rats; Rats, Sprague-Dawley; Streptozocin | 2018 |
An Antifouling Hydrogel Containing Silver Nanoparticles for Modulating the Therapeutic Immune Response in Chronic Wound Healing.
Topics: Animals; Anti-Bacterial Agents; Chitosan; Chronic Disease; Dermis; Dextrans; Diabetes Mellitus, Experimental; Hydrogels; Male; Metal Nanoparticles; Mice; NIH 3T3 Cells; Pseudomonas aeruginosa; Rats, Sprague-Dawley; Silver; Skin Ulcer; Staphylococcus aureus; T-Lymphocytes; Wound Healing | 2019 |
3D-printed chitosan-based scaffolds: An in vitro study of human skin cell growth and an in-vivo wound healing evaluation in experimental diabetes in rats.
Topics: Animals; Bandages; Biocompatible Materials; Cell Line; Cell Survival; Chitosan; Diabetes Mellitus, Experimental; Elastic Modulus; Female; Fibroblasts; Humans; Keratinocytes; Porosity; Printing, Three-Dimensional; Rats, Wistar; Skin; Tissue Scaffolds; Wound Closure Techniques; Wound Healing | 2018 |
Synthesis and characterization of a novel peptide-grafted Cs and evaluation of its nanoparticles for the oral delivery of insulin, in vitro, and in vivo study.
Topics: Administration, Oral; Amino Acid Sequence; Animals; Blood Glucose; Cell-Penetrating Peptides; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Drug Delivery Systems; Drug Liberation; Humans; Hypoglycemia; Insulin; Male; Nanoparticles; Particle Size; Polyphosphates; Proton Magnetic Resonance Spectroscopy; Rats, Wistar; Spectroscopy, Fourier Transform Infrared; Static Electricity | 2018 |
Oral insulin delivery by carboxymethyl-β-cyclodextrin-grafted chitosan nanoparticles for improving diabetic treatment.
Topics: Administration, Oral; Animals; beta-Cyclodextrins; Caco-2 Cells; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Drug Liberation; Humans; Insulin; Male; Mice | 2018 |
The safety profile of new antidiabetic xanthine derivatives and their chitosan based formulations.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Hematologic Tests; Hypoglycemic Agents; Kidney; Lipid Metabolism; Liver; Rats; Thiazolidines; Xanthines | 2019 |
Therapeutic potential of human mesenchymal stem cells derived beta cell precursors on a nanofibrous scaffold: An approach to treat diabetes mellitus.
Topics: Animals; Cell Differentiation; Chitosan; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Homeobox Protein Nkx-2.2; Homeodomain Proteins; Humans; Insulin-Secreting Cells; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Nanofibers; Nuclear Proteins; Polyesters; Tissue Engineering; Tissue Scaffolds; Transcription Factors | 2019 |
Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus.
Topics: Animals; Blood Glucose; Chitosan; Cyclooxygenase 2; Diabetes Mellitus, Experimental; Drug Compounding; Drug Liberation; Insulin; Male; Mesenteric Arteries; Microcirculation; Rats, Sprague-Dawley; Vascular Cell Adhesion Molecule-1 | 2018 |
Combined synergetic potential of metformin loaded pectin-chitosan biohybrids nanoparticle for NIDDM.
Topics: Animals; Cell Line; Chemical Phenomena; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Drug Compounding; Drug Liberation; Glucose; Humans; Metformin; Muscle Fibers, Skeletal; Nanoparticles; Particle Size; Pectins; Rats | 2019 |
A Delivery System for Oral Administration of Proteins/Peptides Through Bile Acid Transport Channels.
Topics: Administration, Oral; Animals; Biological Availability; Caco-2 Cells; Chitosan; Deoxycholic Acid; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Drug Liberation; Humans; Hypoglycemic Agents; Insulin; Intestinal Absorption; Intestinal Mucosa; Liposomes; Male; Nanoconjugates; Nanoparticles; Organic Anion Transporters, Sodium-Dependent; Particle Size; Rats; Streptozocin; Symporters | 2019 |
Polyglutamic Acid Functionalization of Chitosan Nanoparticles Enhances the Therapeutic Efficacy of Insulin Following Oral Administration.
Topics: Administration, Oral; Animals; Blood Glucose; Caco-2 Cells; Chitosan; Cross-Linking Reagents; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Drug Carriers; Humans; Hydrogen-Ion Concentration; Hypoglycemic Agents; Insulin; Intestinal Absorption; Intestinal Mucosa; Male; Nanoparticles; Particle Size; Polyglutamic Acid; Rats; Rats, Sprague-Dawley | 2019 |
Inhibiting hepatic gluconeogenesis by chitosan lactate nanoparticles containing CRTC2 siRNA targeted by poly(ethylene glycol)-glycyrrhetinic acid.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Gene Expression; Gluconeogenesis; Glycyrrhetinic Acid; Hep G2 Cells; Humans; Lactic Acid; Liver; Male; Nanoparticles; Polyethylene Glycols; Rats, Wistar; RNA, Small Interfering; Tissue Distribution; Transcription Factors | 2019 |
Self-assembly pH-sensitive chitosan/alginate coated polyelectrolyte complexes for oral delivery of insulin.
Topics: Administration, Oral; Alginates; Animals; Caco-2 Cells; Chitosan; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Humans; Hydrogen-Ion Concentration; Hypoglycemic Agents; Insulin; Male; Polyelectrolytes; Rats, Sprague-Dawley | 2019 |
Prospective insulin-based ophthalmic delivery systems for the treatment of dry eye syndrome and corneal injuries.
Topics: Administration, Topical; Animals; Chitosan; Cornea; Corneal Injuries; Diabetes Mellitus, Experimental; Dry Eye Syndromes; Epithelium, Corneal; Humans; Insulin; Lacrimal Apparatus; Male; Ophthalmic Solutions; Poloxamer; Prospective Studies; Rats; Rats, Wistar; Tears | 2019 |
Preparation and characterization of insulin chitosan-nanoparticles loaded in buccal films.
Topics: Adhesives; Administration, Buccal; Animals; Chitosan; Diabetes Mellitus, Experimental; Dosage Forms; Drug Carriers; Drug Delivery Systems; Insulin; Male; Mouth Mucosa; Nanoparticles; Particle Size; Rats; Rats, Wistar | 2019 |
Curcumin-loaded chitosan nanoparticles promote diabetic wound healing via attenuating inflammation in a diabetic rat model.
Topics: Angiogenesis Inducing Agents; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chitosan; Curcumin; Diabetes Mellitus, Experimental; Drug Carriers; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Nanoparticles; Rats; Rats, Sprague-Dawley; Wound Healing | 2019 |
Accelerated healing of diabetic wound using artificial dermis constructed with adipose stem cells and poly (L-glutamic acid)/chitosan scaffold.
Topics: Adipose Tissue; Animals; Chitosan; Diabetes Mellitus, Experimental; Male; Mice; Mice, Inbred BALB C; Polyglutamic Acid; Skin, Artificial; Stem Cells; Streptozocin; Tissue Scaffolds; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A; Wound Healing | 2013 |
In vitro cell culture evaluation and in vivo efficacy of amphiphilic chitosan for oral insulin delivery.
Topics: Administration, Oral; Animals; Biological Transport; Blood Glucose; Body Weight; Caco-2 Cells; Cell Culture Techniques; Cell Death; Cell Membrane Permeability; Chitosan; Dextrans; Diabetes Mellitus, Experimental; Drug Delivery Systems; Electric Impedance; Epithelial Cells; Fluorescein-5-isothiocyanate; Fluoresceins; Humans; Insulin; Male; Microscopy, Fluorescence; Particle Size; Rats; Rats, Sprague-Dawley; Surface-Active Agents; Tissue Distribution; Treatment Outcome; Zonula Occludens-1 Protein | 2013 |
Effect of chitosan-gluconic acid conjugate/poly(vinyl alcohol) cryogels as wound dressing on partial-thickness wounds in diabetic rats.
Topics: Animals; Bandages, Hydrocolloid; Chitosan; Cryogels; Diabetes Mellitus, Experimental; Fibroblast Growth Factor 2; Gluconates; Male; Materials Testing; Microscopy, Electron, Scanning; Muramidase; Polyvinyl Alcohol; Rats; Rats, Wistar; Stress, Mechanical; Water; Wound Healing | 2013 |
[The production of mouse model of slowly progressive diabetes mellitus and the preventive effect of low molecular weight chitosan on the progression of the diabetes mellitus].
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Disease Models, Animal; Disease Progression; Male; Mice; Molecular Weight; Streptozocin | 2013 |
Combination therapy via oral co-administration of insulin- and exendin-4-loaded nanoparticles to treat type 2 diabetic rats undergoing OGTT.
Topics: Administration, Oral; Animals; Cattle; Chitosan; Diabetes Mellitus, Experimental; Drug Combinations; Drug Delivery Systems; Exenatide; Glucose Tolerance Test; Hypoglycemic Agents; Insulin; Intestinal Absorption; Nanoparticles; Particle Size; Peptides; Polyglutamic Acid; Rats; Rats, Wistar; Venoms | 2013 |
Intestinal mucosa permeability following oral insulin delivery using core shell corona nanolipoparticles.
Topics: Administration, Oral; Animals; Caco-2 Cells; Chitosan; Diabetes Mellitus, Experimental; Drug Delivery Systems; Humans; Hypoglycemic Agents; Insulin; Intestinal Absorption; Intestinal Mucosa; Male; Nanoparticles; Permeability; Poloxamer; Polyethylene Glycols; Rats; Rats, Sprague-Dawley | 2013 |
Decanoic acid-modified glycol chitosan hydrogels containing tightly adsorbed palmityl-acylated exendin-4 as a long-acting sustained-release anti-diabetic system.
Topics: Adsorption; Animals; Cell Death; Chitosan; Decanoic Acids; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Exenatide; Fasting; Hydrogels; Hypoglycemic Agents; Magnetic Resonance Spectroscopy; Male; Melanoma, Experimental; Mice; Microscopy, Electron, Scanning; Molecular Weight; Peptides; Tissue Distribution; Venoms | 2014 |
Repair of nerve defect with chitosan graft supplemented by uncultured characterized stromal vascular fraction in streptozotocin induced diabetic rats.
Topics: Animals; Biocompatible Materials; Chitosan; Diabetes Mellitus, Experimental; Immunohistochemistry; Male; Nerve Regeneration; Rats; Rats, Wistar; Sciatic Nerve; Stromal Cells | 2014 |
Ultrasound-triggered regulation of blood glucose levels using injectable nano-network.
Topics: Alginates; Animals; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Glucuronic Acid; Hexuronic Acids; Hypoglycemic Agents; Insulin; Lactic Acid; Male; Mice; Mice, Inbred C57BL; Nanostructures; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Ultrasonic Therapy | 2014 |
Accelerated wound healing and anti-inflammatory effects of physically cross linked polyvinyl alcohol-chitosan hydrogel containing honey bee venom in diabetic rats.
Topics: Alloxan; Animals; Anti-Inflammatory Agents; Apamin; Bacterial Infections; Chemical Phenomena; Chemistry, Pharmaceutical; Chitosan; Cross-Linking Reagents; Diabetes Mellitus, Experimental; Drug Carriers; Drug Compounding; Hydrogels; Male; Polyvinyl Alcohol; Rats, Wistar; Skin; Wound Healing; Wounds, Penetrating | 2014 |
Influence of magnesium stearate on the physicochemical and pharmacodynamic characteristics of insulin-loaded Eudragit entrapped mucoadhesive microspheres.
Topics: Administration, Oral; Animals; Blood Glucose; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Chitosan; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Carriers; Drug Liberation; Female; Hypoglycemic Agents; Insulin; Lubricants; Male; Microspheres; Particle Size; Polymethacrylic Acids; Rats; Rats, Wistar; Stearic Acids; Surface Properties | 2015 |
Nanolayer encapsulation of insulin-chitosan complexes improves efficiency of oral insulin delivery.
Topics: Administration, Oral; Animals; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Diffusion; Hypoglycemic Agents; Insulin; Male; Mice, Inbred ICR; Nanocapsules; Nanocomposites; Oral Mucosal Absorption; Streptozocin; Treatment Outcome | 2014 |
Engineered silybin nanoparticles educe efficient control in experimental diabetes.
Topics: Animals; Biocompatible Materials; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Liver; Male; Nanoparticles; Particle Size; Rats; Rats, Wistar; Silybin; Silymarin; Streptozocin | 2014 |
In vitro and in vivo evaluation of thermosensitive chitosan hydrogel for sustained release of insulin.
Topics: Animals; Chemistry, Pharmaceutical; Chitosan; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Drug Delivery Systems; Glycerophosphates; Hydrogel, Polyethylene Glycol Dimethacrylate; Hypoglycemic Agents; Insulin; Mice; Pharmaceutical Solutions; Temperature | 2016 |
Effect of long-term supplementation of low molecular weight chitosan oligosaccharide (GO2KA1) on fasting blood glucose and HbA1c in db/db mice model and elucidation of mechanism of action.
Topics: Animals; Blood Glucose; Body Weight; Chitosan; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Eating; Glycated Hemoglobin; Glycoside Hydrolases; Hyperglycemia; Intestines; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oligosaccharides; Prediabetic State | 2014 |
pH sensitive N-succinyl chitosan grafted polyacrylamide hydrogel for oral insulin delivery.
Topics: Acrylic Resins; Administration, Oral; Animals; Biological Availability; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Hydrogel, Polyethylene Glycol Dimethacrylate; Hydrogen-Ion Concentration; Insulin; Liver Function Tests; Male; Mice; Microscopy, Electron, Scanning; Toxicity Tests | 2014 |
pH-sensitive chitosan/alginate core-shell nanoparticles for efficient and safe oral insulin delivery.
Topics: Administration, Oral; Alginates; Animals; Biological Availability; Chitosan; Diabetes Mellitus, Experimental; Drug Delivery Systems; Glucuronic Acid; Hexuronic Acids; Insulin; Nanoparticles | 2015 |
Osseointegration of chitosan coated porous titanium alloy implant by reactive oxygen species-mediated activation of the PI3K/AKT pathway under diabetic conditions.
Topics: Alloys; Animals; Cell Adhesion; Cell Proliferation; Cells, Cultured; Chitosan; Coated Materials, Biocompatible; Diabetes Mellitus, Experimental; Osseointegration; Osteoblasts; Phosphatidylinositol 3-Kinases; Porosity; Prostheses and Implants; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sheep; Signal Transduction; Titanium | 2015 |
Oral insulin delivery by self-assembled chitosan nanoparticles: in vitro and in vivo studies in diabetic animal model.
Topics: Administration, Oral; Alloxan; Animals; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Disease Models, Animal; Drug Carriers; Hydrogen-Ion Concentration; Insulin; Mice; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Nanoparticles; Particle Size; Spectroscopy, Fourier Transform Infrared | 2013 |
Influence of molecular weight and degree of deacetylation of low molecular weight chitosan on the bioactivity of oral insulin preparations.
Topics: Acetylation; Administration, Oral; Animals; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Drug Compounding; Drug Delivery Systems; Electrolytes; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin, Regular, Human; Male; Molecular Weight; Nanoparticles; Particle Size; Random Allocation; Rats, Sprague-Dawley; Recombinant Proteins; Surface Properties; Viscosity | 2015 |
Low molecular weight chitosan-insulin polyelectrolyte complex: characterization and stability studies.
Topics: Administration, Oral; Animals; Biological Availability; Biotransformation; Chitin; Chitosan; Diabetes Mellitus, Experimental; Drug Delivery Systems; Drug Liberation; Drug Stability; Drug Storage; Electrolytes; Excipients; Hyperglycemia; Hypoglycemic Agents; Insulin; Male; Micelles; Molecular Weight; Oligosaccharides; Particle Size; Random Allocation; Rats, Sprague-Dawley | 2015 |
Antidiabetic activity of differently regioselective chitosan sulfates in alloxan-induced diabetic rats.
Topics: Alloxan; Animals; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Female; Hypoglycemic Agents; Insulin; Male; Rats; Rats, Wistar | 2015 |
N-trimethyl chitosan chloride-coated PLGA nanoparticles overcoming multiple barriers to oral insulin absorption.
Topics: Administration, Oral; Animals; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Drug Delivery Systems; Humans; Insulin; Lactic Acid; Male; Mice; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Wistar | 2015 |
Green Synthesis of Oxovanadium(IV)/chitosan Nanocomposites and Its Ameliorative Effect on Hyperglycemia, Insulin Resistance, and Oxidative Stress.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Stability; Glucose Tolerance Test; Green Chemistry Technology; Hyperglycemia; Insulin Resistance; Liver; Male; Mice, Inbred C57BL; Nanocomposites; Oxidative Stress; Vanadates | 2016 |
A novel ligand conjugated nanoparticles for oral insulin delivery.
Topics: Administration, Oral; Animals; Caco-2 Cells; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Drug Delivery Systems; Humans; Hydrogen-Ion Concentration; Insulin; Ligands; Micelles; Nanoparticles; Polyethylene Glycols; Polyglactin 910; Rats | 2016 |
Preparation of hydrogel embedded polymer-growth factor conjugated nanoparticles as a diabetic wound dressing.
Topics: Administration, Topical; alpha-Amylases; Animals; Bandages; Cell Proliferation; Cells, Cultured; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Epidermal Growth Factor; Fibroblasts; Humans; Hydrogels; Male; Mice; Nanoparticles; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Serine Endopeptidases; Wound Healing | 2016 |
Preparation of hydrogel embedded polymer-growth factor conjugated nanoparticles as a diabetic wound dressing.
Topics: Animals; Bandages; Cell Line; Cell Proliferation; Chitosan; Diabetes Mellitus, Experimental; Epidermal Growth Factor; Fibroblasts; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate; Male; Mice; Nanoparticles; Polymers; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Wound Healing | 2016 |
Simultaneous Effect of Thiolation and Carboxylation of Chitosan Particles Towards Mucoadhesive Oral Insulin Delivery Applications: An In Vitro and In Vivo Evaluation.
Topics: Administration, Oral; Animals; Blood Glucose; Caco-2 Cells; Chitosan; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Diffusion; Gastric Mucins; Humans; Insulin; Male; Nanocapsules; Particle Size; Rats; Rats, Wistar; Streptozocin; Thiomalates; Treatment Outcome | 2015 |
Chitosan-Modified Cationic Amino Acid Nanoparticles as a Novel Oral Delivery System for Insulin.
Topics: Administration, Oral; Amino Acids; Animals; Blood Glucose; Caco-2 Cells; Cations; Chitosan; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diffusion; Humans; Insulin; Nanocapsules; Nanoconjugates; Rats; Treatment Outcome | 2015 |
Long-term Efficacy and Biocompatibility of Encapsulated Islet Transplantation With Chitosan-Coated Alginate Capsules in Mice and Canine Models of Diabetes.
Topics: Alginates; Animals; Barium Compounds; Blood Glucose; Cell Adhesion; Chitosan; Chlorides; Coated Materials, Biocompatible; Cross-Linking Reagents; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Dogs; Female; Fibrosis; Galactosyltransferases; Glucuronic Acid; Graft Survival; Heterografts; Hexuronic Acids; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Mice; Mice, Knockout; Porosity; RAW 264.7 Cells; Swine; Swine, Miniature; Time Factors; Transplantation, Homologous | 2016 |
Investigation of Chitosan for Prevention of Diabetic Progression Through Gut Microbiota Alteration in Sugar Rich Diet Induced Diabetic Rats.
Topics: Animal Feed; Animals; Carbohydrates; Chitosan; Diabetes Mellitus, Experimental; Diet; Disease Progression; Gastrointestinal Microbiome; Inflammation; Insulin; Insulin Resistance; Male; Rats; Rats, Wistar; Toll-Like Receptors | 2015 |
Hydrogel Dressing with a Nano-Formula against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa Diabetic Foot Bacteria.
Topics: Amikacin; Animals; Anti-Bacterial Agents; Artemia; Bacteria; Bandages, Hydrocolloid; Chitosan; Coinfection; Diabetes Mellitus, Experimental; Diabetic Foot; Drug Resistance, Multiple, Bacterial; Metal Nanoparticles; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Rats; Silver; Staphylococcus aureus; Wound Healing | 2016 |
Influence of glucosamine on the bioactivity of insulin delivered subcutaneously and in an oral nanodelivery system.
Topics: Administration, Oral; Animals; Biomarkers; Blood Glucose; Chemistry, Pharmaceutical; Chitosan; Diabetes Mellitus, Experimental; Drug Administration Schedule; Drug Carriers; Glucosamine; Hypoglycemic Agents; Injections, Subcutaneous; Insulin; Male; Micelles; Nanoparticles; Rats, Sprague-Dawley; Time Factors | 2015 |
Vitamin B12 functionalized layer by layer calcium phosphate nanoparticles: A mucoadhesive and pH responsive carrier for improved oral delivery of insulin.
Topics: Administration, Oral; Alginates; Animals; Caco-2 Cells; Calcium Phosphates; Carbodiimides; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Electrolytes; Endocytosis; Flow Cytometry; Fluorescein-5-isothiocyanate; Glucuronic Acid; Hexuronic Acids; Humans; Hydrogen-Ion Concentration; Insulin; Male; Microscopy, Confocal; Microscopy, Fluorescence; Nanoparticles; Particle Size; Rats; Rats, Wistar; Vitamin B 12 | 2016 |
Efficient mucus permeation and tight junction opening by dissociable "mucus-inert" agent coated trimethyl chitosan nanoparticles for oral insulin delivery.
Topics: Acrylamides; Administration, Oral; Animals; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Drug Liberation; Epithelial Cells; Female; Humans; Hypoglycemic Agents; Insulin; Male; Mucus; Nanoparticles; Permeability; Rats, Sprague-Dawley; Tight Junctions | 2016 |
Injectable insulin-lysozyme-loaded nanogels with enzymatically-controlled degradation and release for basal insulin treatment: In vitro characterization and in vivo observation.
Topics: Acrylic Resins; Algorithms; Animals; Anti-Infective Agents; Blood Glucose; Cell Line; Cell Survival; Chitosan; Diabetes Mellitus, Experimental; Gels; Humans; Hypoglycemic Agents; Insulin; Mice; Mice, Inbred ICR; Muramidase; Nanostructures | 2016 |
Effect of novel blend nanofibrous scaffolds on diabetic wounds healing.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Diabetic Foot; Male; Nanofibers; Polyesters; Polyvinyl Alcohol; Rats; Tissue Scaffolds; Wound Healing | 2016 |
Upregulating Hif-1α by Hydrogel Nanofibrous Scaffolds for Rapidly Recruiting Angiogenesis Relative Cells in Diabetic Wound.
Topics: Animals; Biocompatible Materials; Chitosan; Deferoxamine; Dermis; Diabetes Mellitus, Experimental; Drug Liberation; Fibroblasts; Fluorescence; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Male; Nanofibers; Neovascularization, Physiologic; Polyvinyl Alcohol; Rats, Sprague-Dawley; Signal Transduction; Tissue Scaffolds; Up-Regulation; Vascular Endothelial Growth Factor A; Wound Healing | 2016 |
Self-assembled lecithin/chitosan nanoparticles for oral insulin delivery: preparation and functional evaluation.
Topics: Administration, Oral; Animals; Biological Availability; Chitosan; Diabetes Mellitus, Experimental; Hydrophobic and Hydrophilic Interactions; Hypoglycemic Agents; Insulin; Lecithins; Male; Microscopy, Electron, Transmission; Nanoparticles; Phospholipids; Rats; Rats, Sprague-Dawley | 2016 |
Oral hypoglycaemic effect of GLP-1 and DPP4 inhibitor based nanocomposites in a diabetic animal model.
Topics: Administration, Oral; Animals; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Glucagon-Like Peptide 1; Intestine, Small; Methylcellulose; Nanocomposites; Nanoparticles; Rats, Wistar; Silicon | 2016 |
Enhancing insulin oral absorption by using mucoadhesive nanoparticles loaded with LMWP-linked insulin conjugates.
Topics: Adhesiveness; Administration, Oral; Animals; Blood Glucose; Cell Line, Tumor; Cell-Penetrating Peptides; Chitosan; Diabetes Mellitus, Experimental; Drug Liberation; Humans; Hypoglycemic Agents; Insulin; Intestinal Absorption; Intestinal Mucosa; Lactic Acid; Male; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Protamines; Rats, Wistar | 2016 |
Curcumin loaded chitosan nanoparticles impregnated into collagen-alginate scaffolds for diabetic wound healing.
Topics: 3T3-L1 Cells; Alginates; Animals; Anti-Inflammatory Agents; Biocompatible Materials; Chitosan; Collagen; Curcumin; Diabetes Mellitus, Experimental; Drug Carriers; Drug Evaluation, Preclinical; Hydrogels; Male; Materials Testing; Mice; Nanoparticles; Rats, Wistar; Tissue Scaffolds; Wound Healing | 2016 |
Effective Enhancement of Hypoglycemic Effect of Insulin by Liver-Targeted Nanoparticles Containing Cholic Acid-Modified Chitosan Derivative.
Topics: Animals; Chitosan; Cholic Acid; Diabetes Mellitus, Experimental; HEK293 Cells; Humans; Hypoglycemic Agents; Insulin; Liver; Male; Nanoparticles; Rats; Rats, Sprague-Dawley; Spectroscopy, Fourier Transform Infrared | 2016 |
Antidiabetic potential of bioactive molecules coated chitosan nanoparticles in experimental rats.
Topics: Animals; Chitosan; Coated Materials, Biocompatible; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Male; Nanoparticles; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Stevia | 2016 |
Chitosan/lecithin liposomal nanovesicles as an oral insulin delivery system.
Topics: Administration, Oral; Animals; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Drug Stability; Hypoglycemic Agents; Insulin; Lecithins; Liposomes; Male; Nanoparticles; Rats, Wistar; Surface Properties | 2017 |
Eudragit S100-Coated Chitosan Nanoparticles Co-loading Tat for Enhanced Oral Colon Absorption of Insulin.
Topics: Administration, Oral; Animals; Biological Availability; Caco-2 Cells; Cell-Penetrating Peptides; Chitosan; Colon; Diabetes Mellitus, Experimental; Drug Carriers; Drug Liberation; Humans; Hypoglycemic Agents; Insulin; Intestinal Absorption; Male; Nanoparticles; Polymethacrylic Acids; Rats; Rats, Wistar; Swine; tat Gene Products, Human Immunodeficiency Virus | 2017 |
Application of Chitosan/PVA Nano fiber as a potential wound dressing for streptozotocin-induced diabetic rats.
Topics: Administration, Cutaneous; Animals; Bandages, Hydrocolloid; Biological Transport; Chitosan; Diabetes Mellitus, Experimental; Nanofibers; Polyvinyl Alcohol; Rats; Rats, Wistar; Skin Ulcer; Streptozocin; Water | 2016 |
Diabetic wound regeneration using peptide-modified hydrogels to target re-epithelialization.
Topics: Amino Acid Sequence; Animals; Cell Adhesion; Cell Death; Cell Movement; Cell Survival; Cells, Cultured; Chitosan; Collagen; Diabetes Mellitus, Experimental; Humans; Hydrogels; Hydrogen Peroxide; Immobilized Proteins; Keratinocytes; Male; MAP Kinase Signaling System; Mice; Peptides; Proto-Oncogene Proteins c-akt; Re-Epithelialization | 2016 |
Preparation of chitosan-based multifunctional nanocarriers overcoming multiple barriers for oral delivery of insulin.
Topics: Administration, Oral; Animals; Cell Death; Cell Survival; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Drug Delivery Systems; Drug Liberation; Dynamic Light Scattering; Endocytosis; Flow Cytometry; HT29 Cells; Humans; Hypoglycemic Agents; Insulin; Nanoparticles; Rats, Sprague-Dawley | 2017 |
Hepatic and skeletal muscle mitochondrial toxicity of chitosan oligosaccharides of normal and diabetic rats.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Energy Metabolism; Hypoglycemic Agents; Liver; Male; Membrane Potential, Mitochondrial; Mitochondria, Liver; Mitochondria, Muscle; Muscle, Skeletal; Rats, Wistar | 2016 |
Mechanism of surface charge triggered intestinal epithelial tight junction opening upon chitosan nanoparticles for insulin oral delivery.
Topics: Administration, Oral; Animals; Biological Availability; Chitosan; Claudin-4; Diabetes Mellitus, Experimental; Drug Carriers; Drug Liberation; Insulin; Intestinal Absorption; Nanoparticles; Rats; Tight Junctions; Tissue Distribution | 2017 |
The Influence of Chitosan Cross-linking on the Properties of Alginate Microparticles with Metformin Hydrochloride-In Vitro and In Vivo Evaluation.
Topics: Alginates; Animals; Blood Glucose; Chemistry, Pharmaceutical; Chitosan; Cross-Linking Reagents; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Drug Carriers; Drug Compounding; Glucuronic Acid; Hexuronic Acids; Kidney; Liver; Male; Metformin; Pancreas; Particle Size; Rats; Rats, Wistar; Streptozocin | 2017 |
Chitosan Wound Dressings Incorporating Exosomes Derived from MicroRNA-126-Overexpressing Synovium Mesenchymal Stem Cells Provide Sustained Release of Exosomes and Heal Full-Thickness Skin Defects in a Diabetic Rat Model.
Topics: Animals; Bandages; Cell Proliferation; Chitosan; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Disease Models, Animal; Endothelial Cells; Exosomes; Fibroblasts; Humans; Male; Mesenchymal Stem Cells; MicroRNAs; Rats, Sprague-Dawley; Skin; Synovial Membrane; Wound Healing; X-Ray Microtomography | 2017 |
Prolonged antidiabetic effect of zinc-crystallized insulin loaded glycol chitosan nanoparticles in type 1 diabetic rats.
Topics: Animals; Area Under Curve; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Drug Carriers; Glycols; Hypoglycemic Agents; Insulin; Male; Nanoparticles; Rats; Rats, Sprague-Dawley; Solubility | 2008 |
Expression of human insulin gene wrapped with chitosan nanoparticles in NIH3T3 cells and diabetic rats.
Topics: Animals; Chitosan; Cytomegalovirus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Humans; Insulin; Male; Mice; Nanoparticles; NIH 3T3 Cells; Plasmids; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction | 2008 |
Applying the Taguchi design for optimized formulation of sustained release gliclazide chitosan beads: an in vitro/in vivo study.
Topics: Animals; Blood Glucose; Chemistry, Pharmaceutical; Chitosan; Cross-Linking Reagents; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Drug Carriers; Drug Compounding; Gels; Gliclazide; Hydrogen-Ion Concentration; Hypoglycemic Agents; Kinetics; Male; Models, Statistical; Molecular Weight; Particle Size; Polyphosphates; Rats; Rats, Wistar; Solubility; Technology, Pharmaceutical | 2009 |
Preparation, characterization, and oral delivery of insulin loaded carboxylated chitosan grafted poly(methyl methacrylate) nanoparticles.
Topics: Administration, Oral; Animals; Biocompatible Materials; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Carriers; Drug Delivery Systems; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Insulin; Materials Testing; Nanoparticles; Particle Size; Polymethyl Methacrylate; Rats; Surface Properties; Time Factors | 2009 |
Antioxidant activity of chito-oligosaccharides on pancreatic islet cells in streptozotocin-induced diabetes in rats.
Topics: Animals; Antioxidants; Cell Line; Chitin; Chitosan; Diabetes Mellitus, Experimental; Glutathione Peroxidase; Insulin-Secreting Cells; Islets of Langerhans; Male; Malondialdehyde; Metformin; Mice; Mice, Inbred NOD; Oligosaccharides; Rats; Rats, Wistar; Streptozocin; Superoxide Dismutase | 2009 |
Synthesis and evaluation of lauryl succinyl chitosan particles towards oral insulin delivery and absorption.
Topics: Administration, Oral; Animals; Blood Glucose; Caco-2 Cells; Chitosan; Diabetes Mellitus, Experimental; Drug Delivery Systems; Drug Evaluation, Preclinical; Electric Impedance; Fluorescein-5-isothiocyanate; Humans; Hydrogen-Ion Concentration; Hypoglycemic Agents; Insulin; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Nanoparticles; Particle Size; Rats; Rats, Wistar; Streptozocin; Time Factors | 2009 |
Formulation and characterization of an oily-based system for oral delivery of insulin.
Topics: Administration, Oral; Animals; Blood Glucose; Chemistry, Pharmaceutical; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Drug Compounding; Drug Stability; Emulsions; Gastric Juice; Hydrogen-Ion Concentration; Hypoglycemic Agents; Injections, Subcutaneous; Insulin; Male; Molecular Weight; Nanoparticles; Oils; Protein Stability; Rats; Rats, Wistar; Recombinant Proteins; Temperature; Time Factors | 2009 |
Chitosan iron(III) reduces phosphorus levels in alloxan diabetes-induced rats with signs of renal failure development.
Topics: Alloxan; Animals; Chitosan; Chlorides; Cross-Linking Reagents; Diabetes Mellitus, Experimental; Female; Ferric Compounds; Intestinal Absorption; Iron; Male; Phosphates; Phosphorus; Rats; Rats, Wistar; Renal Insufficiency; Sex Factors | 2010 |
Enteric-coated capsules filled with freeze-dried chitosan/poly(gamma-glutamic acid) nanoparticles for oral insulin delivery.
Topics: Administration, Oral; Animals; Chitosan; Diabetes Mellitus, Experimental; Electrophoresis, Polyacrylamide Gel; Freeze Drying; Insulin; Male; Nanoparticles; Rats; Rats, Wistar; Scattering, Radiation; Solubility | 2010 |
The cytoprotection of chitosan based hydrogels in xenogeneic islet transplantation: An in vivo study in streptozotocin-induced diabetic mouse.
Topics: Animals; Capsules; Cell Survival; Chitosan; Cytoprotection; Diabetes Mellitus, Experimental; Hydrogels; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Mice; Mice, Inbred C57BL; Rats; Rats, Wistar; Transplantation, Heterologous | 2010 |
Chitosan reduces gluconeogenesis and increases glucose uptake in skeletal muscle in streptozotocin-induced diabetic rats.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Gluconeogenesis; Glucose; Glucose Transporter Type 4; Male; Muscle, Skeletal; Phosphoenolpyruvate Carboxykinase (ATP); Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Streptozocin | 2010 |
Cyclodextrin complexed insulin encapsulated hydrogel microparticles: An oral delivery system for insulin.
Topics: Administration, Oral; Animals; beta-Cyclodextrins; Blood Glucose; Caco-2 Cells; Chemistry, Pharmaceutical; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Drug Compounding; Humans; Hydrogels; Hypoglycemic Agents; Insulin; Kinetics; Male; Methacrylates; Particle Size; Permeability; Polyethylene Glycols; Rats; Rats, Wistar; Solubility; Technology, Pharmaceutical | 2010 |
Antidiabetic effect and mechanism of chitooligosaccharides.
Topics: Animals; Apoptosis; Cells, Cultured; Chitosan; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Insulin-Secreting Cells; Male; Oligosaccharides; Random Allocation; Rats; Rats, Sprague-Dawley | 2010 |
Preparation and evaluation of alginate-chitosan microspheres for oral delivery of insulin.
Topics: Administration, Oral; Alginates; Animals; Blood Glucose; Chitosan; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Drug Carriers; Drug Stability; Gastric Juice; Glucuronic Acid; Hexuronic Acids; Hydrogen-Ion Concentration; Hypoglycemic Agents; Insulin; Male; Microspheres; Particle Size; Rats; Rats, Sprague-Dawley; Solubility; Surface Properties; Tissue Distribution | 2011 |
Design and development of gliclazide-loaded chitosan for oral sustained drug delivery: in vitro/in vivo evaluation.
Topics: Administration, Oral; Animals; Chitosan; Diabetes Mellitus, Experimental; Drug Delivery Systems; Gliclazide; Glutaral; Hydrogen-Ion Concentration; Hypoglycemic Agents; Male; Particle Size; Rats | 2011 |
Design and development of gliclazide-loaded chitosan microparticles for oral sustained drug delivery: in-vitro/in-vivo evaluation.
Topics: Administration, Oral; Animals; Blood Glucose; Calorimetry, Differential Scanning; Chitosan; Cross-Linking Reagents; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Drug Carriers; Drug Design; Gliclazide; Glutaral; Hydrogen-Ion Concentration; Hypoglycemic Agents; Male; Microspheres; Particle Size; Pectins; Polyphosphates; Powders; Rabbits; Spectroscopy, Fourier Transform Infrared; Tablets | 2011 |
Effective and safe gene-based delivery of GLP-1 using chitosan/plasmid-DNA therapeutic nanocomplexes in an animal model of type 2 diabetes.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Genetic Therapy; Genetic Vectors; Glucagon-Like Peptide 1; Insulin; Nanoconjugates; Plasmids; Rats; Rats, Zucker | 2011 |
Oral delivery of insulin using chitosan capsules cross-linked with phytic acid.
Topics: Administration, Oral; Animals; Capsules; Chitosan; Cross-Linking Reagents; Diabetes Mellitus, Experimental; Drug Carriers; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred BALB C; Phytic Acid | 2011 |
Chitosan-sodium lauryl sulfate nanoparticles as a carrier system for the in vivo delivery of oral insulin.
Topics: Administration, Oral; Animals; Biological Availability; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Drug Delivery Systems; Insulin; Male; Nanoparticles; Particle Size; Rats; Rats, Wistar; Sodium Dodecyl Sulfate; Spectroscopy, Fourier Transform Infrared; Technology, Pharmaceutical | 2011 |
Efficacy of chitooligosaccharides for the management of diabetes in alloxan induced mice: a correlative study with antihyperlipidemic and antioxidative activity.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Blood Glucose; Body Weight; Catalase; Chitin; Chitosan; Cholesterol; Creatinine; Diabetes Mellitus, Experimental; Glycogen; Hypolipidemic Agents; Lipoproteins; Liver; Male; Mice; Mice, Inbred Strains; Oligosaccharides; Papain; Spectroscopy, Fourier Transform Infrared; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Triglycerides; Urea | 2011 |
The role of apurinic/apyrimidinic endonuclease on the progression of streptozotocin-induced diabetic nephropathy in rats.
Topics: Animals; Blood Urea Nitrogen; Caspase 3; Chitosan; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; DNA Damage; DNA-(Apurinic or Apyrimidinic Site) Lyase; Enzyme Activators; Male; Nephrons; Organ Size; Rats; Rats, Sprague-Dawley; Streptozocin; Tumor Suppressor Protein p53 | 2012 |
Protease inhibition and absorption enhancement by functional nanoparticles for effective oral insulin delivery.
Topics: Absorption; Administration, Oral; Animals; Biological Availability; Blood Glucose; Cell Adhesion; Chitosan; Diabetes Mellitus, Experimental; Drug Delivery Systems; Electric Impedance; Injections, Subcutaneous; Insulin; Molecular Dynamics Simulation; Nanoparticles; Particle Size; Pentetic Acid; Polyglutamic Acid; Protease Inhibitors; Protective Agents; Rats; Rats, Wistar; Spectroscopy, Fourier Transform Infrared; Static Electricity; Tissue Distribution; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed | 2012 |
Chitosan reduces plasma adipocytokines and lipid accumulation in liver and adipose tissues and ameliorates insulin resistance in diabetic rats.
Topics: Adiponectin; Adipose Tissue; Animals; Biological Products; Blood Glucose; Chitosan; Cholesterol; Diabetes Mellitus, Experimental; Glucagon-Like Peptide 1; Hypoglycemic Agents; Inflammation; Insulin; Insulin Resistance; Interleukin-6; Lipid Metabolism; Liver; Male; PPAR alpha; Rats; Rats, Sprague-Dawley; Triglycerides; Tumor Necrosis Factor-alpha | 2012 |
Chitosan-coated solid lipid nanoparticles for insulin delivery.
Topics: Animals; Chitosan; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Insulin; Lipids; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nanoparticles; Spectrophotometry, Ultraviolet | 2012 |
Controlled synthesis, characterization, and application of iron oxide nanoparticles for oral delivery of insulin.
Topics: Animals; Blood Glucose; Chemistry Techniques, Synthetic; Chitosan; Colloids; Diabetes Mellitus, Experimental; Female; Ferric Compounds; Insulin; Laser Therapy; Male; Metal Nanoparticles; Rats; Rats, Wistar; Spectrophotometry, Ultraviolet | 2013 |
Chitosan-zinc-insulin complex incorporated thermosensitive polymer for controlled delivery of basal insulin in vivo.
Topics: Animals; Blood Glucose; Cell Survival; Chitosan; Collagen; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Drug Delivery Systems; HEK293 Cells; Hot Temperature; Humans; Insulin; Male; Polyesters; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Skin; Zinc | 2012 |
Calcium depletion-mediated protease inhibition and apical-junctional-complex disassembly via an EGTA-conjugated carrier for oral insulin delivery.
Topics: Administration, Oral; Animals; Caco-2 Cells; Calcium; Chelating Agents; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Egtazic Acid; Humans; Hypoglycemic Agents; Insulin; Models, Molecular; Nanoparticles; Peptide Hydrolases; Polyglutamic Acid; Rats; Rats, Wistar | 2013 |
Preparation of amphiphilic hollow carbon nanosphere loaded insulin for oral delivery.
Topics: Administration, Oral; Animals; Buffers; Carbon; Chitosan; Circular Dichroism; Diabetes Mellitus, Experimental; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Female; Hydrogen-Ion Concentration; Hypoglycemia; Insulin; Kinetics; Male; Nanospheres; Particle Size; Polymethacrylic Acids; Rats; Rats, Wistar; Solubility; Spectroscopy, Fourier Transform Infrared; Surface-Active Agents; Zebrafish | 2013 |
Nanoemulsions coated with alginate/chitosan as oral insulin delivery systems: preparation, characterization, and hypoglycemic effect in rats.
Topics: Administration, Oral; Alginates; Analysis of Variance; Animals; Blood Glucose; Chitosan; Circular Dichroism; Diabetes Mellitus, Experimental; Drug Carriers; Drug Stability; Emulsions; Gastric Juice; Glucuronic Acid; Hexuronic Acids; Hypoglycemic Agents; Insulin; Male; Models, Biological; Nanoparticles; Particle Size; Rats; Rats, Wistar | 2013 |
Relationship between drug effects and particle size of insulin-loaded bioadhesive microspheres.
Topics: Animals; Biological Availability; Blood Glucose; Chitin; Chitosan; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Drug Carriers; Hypoglycemic Agents; Insulin; Microspheres; Particle Size; Rats; Rats, Wistar | 2002 |
Effect of chitosan film containing basic fibroblast growth factor on wound healing in genetically diabetic mice.
Topics: Animals; Chitin; Chitosan; Diabetes Mellitus, Experimental; Female; Fibroblast Growth Factor 2; Humans; Mice; Mice, Inbred C57BL; Recombinant Proteins; Wound Healing | 2003 |
Antidiabetic effects of chitosan oligosaccharides in neonatal streptozotocin-induced noninsulin-dependent diabetes mellitus in rats.
Topics: Animals; Animals, Newborn; Blood Glucose; Chitin; Chitosan; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Oligosaccharides; Rats; Rats, Sprague-Dawley | 2003 |
[Enhancement of gastrointestinal absorption of chitosan-coated insulin-loaded poly (lactic-co-glycolic acid) nanoparticles].
Topics: Animals; Blood Glucose; Chitin; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Drug Delivery Systems; Hypoglycemic Agents; Insulin; Intestinal Absorption; Lactic Acid; Male; Nanotechnology; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Random Allocation; Rats; Rats, Wistar | 2003 |
Pharmacological activity of peroral chitosan-insulin nanoparticles in diabetic rats.
Topics: Administration, Oral; Animals; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Insulin; Male; Nanostructures; Rats; Rats, Wistar | 2005 |
Nasal delivery of insulin using chitosan microspheres.
Topics: Administration, Intranasal; Animals; Ascorbic Acid; Biological Availability; Blood Glucose; Chitosan; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Drug Compounding; Hypoglycemic Agents; Insulin; Male; Microspheres; Particle Size; Rats; Rats, Wistar; Surface Properties | 2004 |
The controlled release of insulin-mimetic metal ions by the multifunction of chitosan.
Topics: Adsorption; Animals; Blood Glucose; Chitosan; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Drug Implants; Gels; Humans; Hydrogen-Ion Concentration; Insulin; Male; Mice; Molecular Mimicry; Vanadium | 2005 |
Sustained insulin release with biodegradation of chitosan gel beads prepared by copper ions.
Topics: Animals; Biodegradation, Environmental; Cations, Divalent; Chitosan; Copper; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Drug Delivery Systems; Drug Stability; Gels; Hypoglycemic Agents; Insulin; Male; Mice; Microspheres; Solubility | 2005 |
Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery.
Topics: Administration, Oral; Animals; Blood Glucose; Caco-2 Cells; Cell Membrane Permeability; Chitosan; Diabetes Mellitus, Experimental; Drug Delivery Systems; Humans; Hydrogen-Ion Concentration; Insulin; Nanoparticles; Polyglutamic Acid; Rats; X-Ray Diffraction | 2007 |
Antidiabetic effects of chitooligosaccharides on pancreatic islet cells in streptozotocin-induced diabetic rats.
Topics: Animals; Cell Division; Cells, Cultured; Chitosan; Diabetes Mellitus, Experimental; Insulin; Insulin Secretion; Islets of Langerhans; Male; Oligosaccharides; Rats; Rats, Wistar | 2007 |
Chitosan reduced gold nanoparticles as novel carriers for transmucosal delivery of insulin.
Topics: Administration, Intranasal; Administration, Oral; Animals; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Diffusion; Drug Carriers; Gold; Insulin; Male; Metal Nanoparticles; Microscopy, Electron, Transmission; Nasal Mucosa; Oxidation-Reduction; Particle Size; Rats; Rats, Wistar; Spectrometry, Fluorescence; Static Electricity; Viscosity | 2007 |
Alginate/chitosan nanoparticles are effective for oral insulin delivery.
Topics: Administration, Oral; Alginates; Animals; Biological Availability; Blood Glucose; Chemistry, Pharmaceutical; Chitosan; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Fluorescein-5-isothiocyanate; Glucuronic Acid; Hexuronic Acids; Hydrogen-Ion Concentration; Hypoglycemic Agents; Insulin; Intestinal Absorption; Intestinal Mucosa; Male; Microscopy, Confocal; Nanoparticles; Particle Size; Rats; Rats, Wistar; Solubility | 2007 |
Development and in-vivo evaluation of insulin-loaded chitosan phthalate microspheres for oral delivery.
Topics: Administration, Oral; Animals; Blood Glucose; Chitosan; Cross-Linking Reagents; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Drug Carriers; Emulsions; Gastric Juice; Hydrogen-Ion Concentration; Hypoglycemic Agents; Insulin; Intestinal Absorption; Intestinal Secretions; Male; Microspheres; Particle Size; Rats; Rats, Wistar; Streptozocin | 2007 |
Acceleration of diabetic wound healing with chitosan-crosslinked collagen sponge containing recombinant human acidic fibroblast growth factor in healing-impaired STZ diabetic rats.
Topics: Animals; Chitosan; Collagen; Cross-Linking Reagents; Diabetes Mellitus, Experimental; Fibroblast Growth Factor 1; Humans; Male; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Surgical Sponges; Time Factors; Wound Healing; Wounds and Injuries | 2008 |
A comparative study on hypoglycemic and hypocholesterolemic effects of high and low molecular weight chitosan in streptozotocin-induced diabetic rats.
Topics: Animals; Anticholesteremic Agents; Blood Glucose; Body Weight; Cecum; Chitosan; Cholesterol; Diabetes Mellitus, Experimental; Diet; Disaccharidases; Drinking; Eating; Fatty Acids; Feces; Fructosamine; Hexokinase; Hypoglycemic Agents; Insulin; Lipids; Liver; Male; Molecular Weight; Organ Size; Rats; Rats, Sprague-Dawley | 2008 |
Nanoparticles of quaternized chitosan derivatives as a carrier for colon delivery of insulin: ex vivo and in vivo studies.
Topics: Animals; Chitosan; Colon; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Drug Delivery Systems; Electrolytes; Hypoglycemic Agents; Insulin; Light; Male; Microscopy, Electron, Transmission; Nanoparticles; Particle Size; Rats; Rats, Wistar; Scattering, Radiation | 2008 |
Polyelectrolyte biomaterial interactions provide nanoparticulate carrier for oral insulin delivery.
Topics: Albumins; Alginates; Animals; Biocompatible Materials; Calorimetry, Differential Scanning; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Drug Compounding; Drug Delivery Systems; Electrolytes; Excipients; Hypoglycemic Agents; Insulin; Male; Nanoparticles; Particle Size; Pepsin A; Polymers; Rats; Rats, Wistar; Solubility; Spectroscopy, Fourier Transform Infrared; Viscosity | 2008 |
Efficacy of pulmonary insulin delivery in diabetic rats: use of a model-based approach in the evaluation of insulin powder formulations.
Topics: Animals; Blood Glucose; Chitosan; Dextrans; Diabetes Mellitus, Experimental; Drug Administration Routes; Hypoglycemic Agents; Insulin; Lung; Male; Models, Biological; Powders; Rats; Rats, Sprague-Dawley | 2008 |
Hypoglycemic and hypolipidemic effect of chitosan in normal and neonatal streptozotocin-induced diabetic mice.
Topics: Animals; Animals, Newborn; Anticholesteremic Agents; Blood Glucose; Chitin; Chitosan; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hyperinsulinism; Hypoglycemic Agents; Male; Mice; Mice, Inbred Strains; Obesity; Triglycerides | 1995 |
Low molecular weight chitosan prevents the progression of low dose streptozotocin-induced slowly progressive diabetes mellitus in mice.
Topics: Administration, Oral; Animals; Blood Glucose; Chitin; Chitosan; Diabetes Mellitus, Experimental; Disease Progression; Dose-Response Relationship, Drug; Glucosamine; Lactic Acid; Male; Mice; Mice, Inbred ICR; Molecular Weight; Substance Withdrawal Syndrome | 2000 |
[Hypoglycemic effect of chitosan-microcapsulated insulin on the blood glucose level of streptozotocin-diabetic Wistar rats].
Topics: Animals; Blood Glucose; Chitin; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Hypoglycemic Agents; In Vitro Techniques; Insulin; Male; Rats; Rats, Wistar | 2001 |