chir-99021 and Colorectal-Neoplasms

chir-99021 has been researched along with Colorectal-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for chir-99021 and Colorectal-Neoplasms

Article	Year
The Tissue-Reconstructing Ability of Colon CSCs Is Enhanced by FK506 and Suppressed by GSK3 Inhibition. Molecular cancer research : MCR, 2017, Volume: 15, Issue:10 Cancer stem cells (CSC) are capable of reconstructing cancer tissues, are involved in both recurrence and metastasis, and contribute to therapeutic resistance. Therefore, elucidating the molecular mechanism in CSCs is important to successfully treat unresectable cancers. Previously, we observed that colon cancer stem-like cells can be induced from human colon cancer cell lines by retrovirally introducing OCT3/4, SOX2, and KLF4, and we have designated such cells as induced cancer stem cells (iCSC). In the current study, we used iCSCs to evaluate the molecular mechanism of colon CSCs and developed new methods to control them. The spheres that were derived Topics: Cell Line, Tumor; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3; Human Umbilical Vein Endothelial Cells; Humans; Kruppel-Like Factor 4; Neoplastic Stem Cells; NFATC Transcription Factors; Pyridines; Pyrimidines; Spheroids, Cellular; Tacrolimus; Tumor Cells, Cultured; Valproic Acid	2017

Article

Year

The Tissue-Reconstructing Ability of Colon CSCs Is Enhanced by FK506 and Suppressed by GSK3 Inhibition.

Molecular cancer research : MCR, 2017, Volume: 15, Issue:10

Cancer stem cells (CSC) are capable of reconstructing cancer tissues, are involved in both recurrence and metastasis, and contribute to therapeutic resistance. Therefore, elucidating the molecular mechanism in CSCs is important to successfully treat unresectable cancers. Previously, we observed that colon cancer stem-like cells can be induced from human colon cancer cell lines by retrovirally introducing OCT3/4, SOX2, and KLF4, and we have designated such cells as induced cancer stem cells (iCSC). In the current study, we used iCSCs to evaluate the molecular mechanism of colon CSCs and developed new methods to control them. The spheres that were derived

Topics: Cell Line, Tumor; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3; Human Umbilical Vein Endothelial Cells; Humans; Kruppel-Like Factor 4; Neoplastic Stem Cells; NFATC Transcription Factors; Pyridines; Pyrimidines; Spheroids, Cellular; Tacrolimus; Tumor Cells, Cultured; Valproic Acid

2017