chiniofon and Urinary-Tract-Infections

Topics: Bacteria; Clinical Trials as Topic; Drug Evaluation; Humans; Hydroxyquinolines; Microbial Sensitivity Tests; Nitro Compounds; Oxyquinoline; Urinary Tract Infections

A new commercial agar (Uricult-Trio) with 8-hydroxyquinoline-beta-glucuronide was used to assess 2,536 uropathogens for beta-glucuronidase activity typical of Escherichia coli. Included in the study were 1,807 strains of the family Enterobacteriaceae, 284 strains of nonfermentative bacilli, 345 strains of gram-positive cocci, and 100 yeast strains. In identifying E. coli, the test agar gave a sensitivity of 95.5% and a specificity of 97.2%. Fifty E. coli isolates gave negative reactions; 31 non-E. coli strains produced black colonies characteristic of E. coli. No growth of gram-positive cocci and no false-positive reactions from yeasts were observed. The recovery rate for E. coli on this agar was at least 10% higher than that on blood agar.

Topics: Agar; Bacteriological Techniques; Bacteriuria; Diagnostic Errors; Escherichia coli; Escherichia coli Infections; Evaluation Studies as Topic; Humans; Hydroxyquinolines; Quinolines; Sensitivity and Specificity; Urinary Tract Infections; Urine

Topics: Drug Evaluation; Humans; Hydroxyquinolines; Nalidixic Acid; Oxolinic Acid; Oxyquinoline; Urinary Tract Infections

In vitro studies on the antibacterial activity of nitroxoline and sulphamethizole, alone and in combination, were undertaken and minimal inhibitory concentrations (MICs) determined on a range of urinary pathogens. Eighty per cent of the strains tested were sensitive to less than or equal to 16 mg/l of nitroxoline, and all strains, including Pseudomonas aeruginosa and Streptococcus faecalis, were sensitive to less than or equal to 64 mg/l of nitroxoline. No synergism could be demonstrated with sulphamethizole, but the combination was antagonistic when tested against strains of Ps. aeruginosa and Strep. faecalis. An in vivo study on 10 volunteers showed excellent urinary levels of nitroxoline and sulphamethizole after an oral dose of 160 mg of each agent, and 6-hour urinary nitroxoline levels were greater than or equal to 64 mg/l in 9 of the 10 subjects, and sulphamethizole levels were greater than or equal to 64 mg/l in all 10 subjects. Laboratory findings suggest that nitroxoline and sulphamethizole are both suitable agents for use in urinary tract infections caused by organisms sensitive to these agents, but there appears to be litte advantage in using them in combination.

Topics: Drug Combinations; Enterococcus faecalis; Escherichia coli; Humans; Hydroxyquinolines; Nitro Compounds; Nitroquinolines; Oxyquinoline; Sulfamethizole; Sulfathiazoles; Urinary Tract Infections

Topics: Adult; Bacterial Infections; Chronic Disease; Drug Evaluation; Female; Humans; Hydroxyquinolines; Male; Oxyquinoline; Prostatitis; Pyelonephritis; Urinary Tract Infections