chiniofon and Sarcoma

The preparation of chiral tetrahydroquinolines using Ir-catalysed asymmetric hydrogenation and their possible cytotoxic potential anti-cancer activity were reported. Both of the in vitro cytotoxicity assay on a series of human cancer cell lines including A549 small cell lung cancer, MDA-MB-231 breast cancer, SaoS2 sacroma, SKHep-1 hepatoma and Hep3B hepatocellular carcinoma as well as in vivo animal model using Hep3B hepatocellular tumour xenograft on athymic nude mice suggest that 1,2,3,4-tetrahydroquin-8-ol is a potential anti-tumour alkaloid which may be further developed as a novel cancer chemotherapeutic agent.

Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Female; Humans; Hydroxyquinolines; Liver Neoplasms, Experimental; Mice; Mice, Nude; Plant Extracts; Rutaceae; Sarcoma; Small Cell Lung Carcinoma

The preparation is given of an 111indium-oxine complex that is non toxic and can label reproductively various types of cells. They retain the label for long periods (24 hours and more). This method gives parallel results for cell-mediated cytotoxicity measurements to Chromium-51 labelling and is found to have wider uses. It can label cells that release 51Cr too fast, makes possible long term measurements of cytotoxicity and accurate counts on small numbers of target cells.

Topics: Animals; Cell Line; Chromium Radioisotopes; Cytotoxicity Tests, Immunologic; Hydroxyquinolines; Indium; Lymphocyte Culture Test, Mixed; Mice; Mice, Inbred Strains; Organometallic Compounds; Oxyquinoline; Radioisotopes; Sarcoma; Spleen; T-Lymphocytes, Cytotoxic; Time Factors