chiniofon and Liver-Abscess

To utilize 111In leukocytes in a routine work, simplified procedure for sterile leukocytes preparation and labeling with water soluble oxine sulfate was performed. Viability and chemotaxis of leukocytes were maintained during separation and labeling. Chelated rate of 111In with oxine sulfate was 93.5%. Labeling efficiency of 111In leukocytes was 93.8%. Obvious blood pool images due to remained erythrocytes were not observed. 111In labeled leukocytes showed good migration into inflammatory focci.

Topics: Humans; Hydroxyquinolines; Indium Radioisotopes; Isotope Labeling; Leukapheresis; Leukocytes; Liver Abscess; Organometallic Compounds; Oxyquinoline; Radionuclide Imaging

The use of In-111 labeled leukocytes for abscess localization is becoming well established. The first report of In-111 imaging following hepatic embolization is presented. A 45-year-old man with adenocarcinoma of the colon and metastatic liver disease was treated for intractable pain using particulate embolization of the hepatic artery. In-111 leukocyte imaging was performed to rule out abscess formation. The distribution of the labeled leukocytes demonstrated hepatic uptake commensurate with Tc-99m sulfur colloid (SC) images. Areas of embolization did not accumulate tracer. Pathologic examination at autopsy correlated with the distribution of the labeled leukocytes. Thus, therapeutic embolization did not alter the normal distribution of this tracer in functional hepatic tissue.

Topics: Adenocarcinoma; Colonic Neoplasms; Embolization, Therapeutic; Hepatic Artery; Humans; Hydroxyquinolines; Indium; Leukocytes; Liver Abscess; Liver Neoplasms; Male; Middle Aged; Organometallic Compounds; Oxyquinoline; Pain, Intractable; Radioisotopes; Radionuclide Imaging