chiniofon and Intestinal-Diseases

Ciprofloxacin (Bayer, FRG), a derivative of hydroxyquinolone acid, was used for the treatment of patients with shigellosis and salmonellosis and for the sanitation of Salmonella carriers. The drug turned out to exert a positive effect on bacteriological sanitation of the body. In order to treat patients with food toxinfection of unknown etiology, use was made of intetrix (Farmacos, Socialist Federal Republic of Yugoslavia). Inclusion of the drug into combined treatment of patients with food toxinfections did not show any material advantages.

Topics: Acute Disease; Adult; Anti-Infective Agents, Local; Carrier State; Ciprofloxacin; Drug Combinations; Drug Evaluation; Dysentery, Bacillary; Female; Humans; Hydroxyquinolines; Intestinal Diseases; Middle Aged; Oxyquinoline; Salmonella Food Poisoning; Shigella dysenteriae; Shigella flexneri; Shigella sonnei

A five months old infant is described with acrodermatitis enteropathica. The aetiology, pathogenesis and the clinical course of the disease is reported. It will be discussed the side effects of the oxychinolin therapy, the advantages and benefits of the substitution with zinc.

Topics: Acrodermatitis; Eye Diseases; Female; Humans; Hydroxyquinolines; Infant; Intestinal Diseases; Optic Nerve; Zinc Oxide

Topics: Acute Disease; Adolescent; Adult; Bacterial Infections; Diagnosis, Differential; Dysentery; Humans; Hydroxyquinolines; Intestinal Diseases; Middle Aged; Precipitin Tests

In 3 cases of acrodermatitis enteropathica duodenal biopsy performed at the outset of treatment showed a similar abnormality of the intestinal mucosa. Further biopsies taken during treatment showed progressive improvement of the intestinal mucosa with subsequent complete restoration of the normal cellular and villous pattern. The initial treatment was with expressed human breast milk and oral di-iodohydroxyquinoline. The latter was continued alone and later replaced by zinc sulphate. Changes in the intestinal epithelial cells and inflammatory cell infiltration of the lamina propria still detectable on di-iodohydroxyquinoline therapy reverted to normal with oral zinc.

Topics: Acrodermatitis; Biopsy; Child; Child, Preschool; Duodenum; Humans; Hydroxyquinolines; Infant; Intestinal Diseases; Intestinal Mucosa; Male; Milk, Human; Zinc