chiniofon and Infections

Indium-111-labeled leukocyte scans were performed on 39 patients with suspected musculoskeletal infections to assess the usefulness of this study in detecting bone and joint infections. Results of these scans, as well as results of technetium-99m bone scans, were correlated with the patients' final diagnoses. The indium scan had an overall sensitivity of 77%, a specificity of 69%, and an accuracy of 72%. In 10 patients with a duration of symptoms of six weeks or less, the sensitivity was 100% and the specificity was 75%. In 29 patients with symptoms of greater than six weeks, the sensitivity and specificity were lower at 50% and 71% respectively. Technetium-99m bone scans were performed on 23 patients; sensitivity for infection was 100% while specificity was 60%. Our results suggest that the indium-111 leukocyte scan is a useful adjunct in the diagnosis of acute musculoskeletal infections, but may be inconclusive in chronic infections.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bone Diseases; Child; Female; Humans; Hydroxyquinolines; Indium Radioisotopes; Infections; Leukocytes; Male; Middle Aged; Muscular Diseases; Organometallic Compounds; Oxyquinoline; Radionuclide Imaging

Indium-111 leukocyte scanning is a reliable means of locating acute infection in adults, but its use in the pediatric population has not been extensively documented. The results of scans on 30 children retrospectively reviewed are presented. Acute infections were detected in 15 of 16 patients (94% sensitivity) with one false negative scan. There were 8 truly negative and 6 falsely positive studies (57% specificity).

Topics: Adolescent; Child; Child, Preschool; Fever of Unknown Origin; Humans; Hydroxyquinolines; Indium; Infant; Infections; Leukocytes; Organometallic Compounds; Oxyquinoline; Radionuclide Imaging

There is considerable disagreement as to whether oxine or tropolone is the best labeling agent for indium leukocytes. We have previously looked at the sensitivity of oxine-labeled 111In leukocyte scans for occult infections and now present a similar group of patients imaged with tropolone-labeled 111In leukocytes. Thirty-four patients (38 studies) with possible occult infection were prospectively studied. Patients were imaged 1-4 hr after injection and again at 24 hr postinjection. The early tropolone images had a sensitivity of 53% while the delayed images at 24 hr had a sensitivity of 93%. Based on a previous study, oxine-labeled leukocyte scans have an early sensitivity of 33% and a delayed sensitivity (at 24 hr) of 95%. The differences in sensitivity between oxine and tropolone when imaged early and at 24 hr were not statistically significant. We conclude that there is no significant difference in the ability to detect infection between oxine- and tropolone-labeled leukocytes, both early at 1-4 hr, and on delayed imaging 24 hr after injection.

Topics: Abscess; Adult; Cycloheptanes; False Negative Reactions; Female; Humans; Hydroxyquinolines; Indium; Infections; Leukocytes; Male; Organometallic Compounds; Oxyquinoline; Prospective Studies; Radioisotopes; Radionuclide Imaging; Surgical Wound Infection; Time Factors; Tropolone

Topics: Animals; Blood Platelets; Blood Vessel Prosthesis; Dogs; Hydroxyquinolines; Indium; Infections; Organometallic Compounds; Oxyquinoline; Radioisotopes

Topics: Humans; Hydroxyquinolines; Indium; Infections; Leukocytes; Organometallic Compounds; Oxyquinoline; Radioisotopes; Radionuclide Imaging

Topics: Bismuth; Cardiovascular Diseases; Diazepam; Drug Therapy; Endocrine System Diseases; Gastrointestinal Diseases; Glafenine; Hepatitis; Humans; Hydroxyquinolines; Hypersensitivity; Infections; Kidney Diseases; Metabolic Diseases; Neoplasms; Nervous System Diseases; Practolol; Respiratory Tract Diseases; Rheumatic Diseases

Topics: Amebiasis; Animals; Arsanilic Acid; Clioquinol; Entamoeba histolytica; Eukaryota; Heterozygote; Hydroxyquinolines; Infections; Intestines; Parasites