chiniofon and Fever-of-Unknown-Origin

Radiolabeled blood cells are widely used for both clinical and research studies. In vitro and in vivo studies have shown the tagging process does not significantly affect function. The labeling techniques and clinical uses of labeled leukocytes and platelets are reviewed.

Topics: Abscess; Blood Platelets; Cerebrovascular Disorders; Chromium Radioisotopes; Eosinophils; Fever of Unknown Origin; Graft Rejection; Humans; Hydroxyquinolines; Indium; Isotope Labeling; Leukocyte Count; Leukocytes; Lymphocytes; Organometallic Compounds; Oxyquinoline; Pulmonary Embolism; Radioisotopes; Radionuclide Imaging; Thrombophlebitis; Tropolone

In three patients with fever of unknown etiology, an Indium-111-Oxine WBC (White blood cell) scan was performed, in order to detect occult sites of inflammation. An intra-abdominal abscess was located in two cases, while in the third the negative result of the scan directed the diagnosis to other systemic pathologies.

Topics: Abscess; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Colonic Neoplasms; Connective Tissue Diseases; Female; Fever of Unknown Origin; Humans; Hydroxyquinolines; Male; Middle Aged; Organometallic Compounds; Oxyquinoline; Radionuclide Imaging; Rectal Diseases

Indium-111 leukocyte scanning is a reliable means of locating acute infection in adults, but its use in the pediatric population has not been extensively documented. The results of scans on 30 children retrospectively reviewed are presented. Acute infections were detected in 15 of 16 patients (94% sensitivity) with one false negative scan. There were 8 truly negative and 6 falsely positive studies (57% specificity).

Topics: Adolescent; Child; Child, Preschool; Fever of Unknown Origin; Humans; Hydroxyquinolines; Indium; Infant; Infections; Leukocytes; Organometallic Compounds; Oxyquinoline; Radionuclide Imaging