chiniofon and Dermatomycoses

In this multicentre, between-patient trial the efficacy and tolerability of a cream, containing 0.05% halometasone and 1% triclosan, was compared with those of Nerisona C cream, containing 0.1% diflucortolone valerate and 1% chlorquinaldol, in 183 patients with acute dermatomycoses. Halometasone/triclosan cream and the comparative cream showed closely similar results with respect to good to very good therapeutic effects (60% versus 57%). However, halometasone/triclosan cream proved superior to the comparative preparation with regard to very good (cured) results (53% versus 46%), an early cure in less than 30 days (41% versus 34%) and onset of action within 3 days of starting the treatment (32% versus 18%). Mycological findings were positive on direct microscopy in 36% and 43% and in culture in 19% and 17% of the patients following treatment with halometasone/triclosan cream and the comparative cream preparation, respectively. Adverse effects were reported in seven out of 108 patients treated with halometasone/triclosan cream and in five out of 107 patients treated with the comparative preparation.

Topics: Acute Disease; Administration, Topical; Adolescent; Adult; Anti-Inflammatory Agents; Betamethasone; Chlorquinaldol; Clinical Trials as Topic; Dermatomycoses; Diflucortolone; Drug Combinations; Female; Fluocortolone; Humans; Hydroxyquinolines; Male; Middle Aged; Phenyl Ethers; Triclosan

Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chloroquinolinols; Dermatomycoses; Dose-Response Relationship, Drug; Drug Evaluation; Emulsions; Ethylene Glycols; Female; Humans; Hydroxyquinolines; Infant; Male; Middle Aged; Ointments

Topics: Animals; Antifungal Agents; Dermatomycoses; Female; Hydroxyquinolines; Male; Mice; Oxyquinoline

This paper reports on the clinical trials of an antimycoticum using 5-chlorine-8-hydroxychinolin as an antimycotic agent. 142 patients with surface dermatomycoses were treated locally with the preparation for 5 to 6 weeks. Clinical and mycological healing was achieved in 68% of the cases. The results of the treatment, the epicutaneous tests and the additional UV exposition are discussed. The best results of treatment were obtained in the case of superficial dermatomycoses, in particular Trichophytia inguinalis.

Topics: 1-Propanol; Adult; Antifungal Agents; Benzoates; Dermatomycoses; Drug Combinations; Female; Humans; Hydroxyquinolines; Male; Oxyquinoline; Salicylates; Skin Tests; Ultraviolet Therapy