chiniofon and Acrodermatitis

Topics: Acrodermatitis; Adolescent; Clioquinol; Feces; Female; Humans; Hydroxyquinolines; Sulfates; Zinc; Zinc Sulfate

The effect of picolinic acid and hydroxyquinolines in intestinal zinc absorption of cattle was studied. In contrast to reports of the absorption in rat and in man, picolinic acid did not enhance zinc absorption in cattle. In two calves suffering from Adema disease, the bovine parallel to Acrodermatitis enteropathica, hydroxyquinoline supplementation resulted in an increase in intestinal 65Zn absorption, while picolinic acid had no such effect. The results may indicate a difference in the zinc absorption mechanism between cattle and other species.

Topics: Acrodermatitis; Animals; Cattle; Cattle Diseases; Diet; Hydroxyquinolines; Intestinal Absorption; Male; Picolinic Acids; Zinc

Acrodermatitis enteropathica, a heritable disease of zinc deficiency, was formerly amenable to treatment only with dihaloquinolinol drugs. A few cases of optic atrophy were reported in surviving patients and were proposed as examples of ocular drug toxicity, principally because of the association between iodochlorhydroxyquin and subacute myelo-optic neuropathy (SMON) in Japan. An alternate hypothesis is now offered: that the optic atrophy was secondary to the zinc deficiency, which is consistent with diverse evidence cited from the literature. Therefore, it would seem worthwhile to investigate zinc in cases of disk pallor described as idiopathic or drug associated, and to investigate visual function in cases of severe malnourishment.

Topics: Acrodermatitis; Clioquinol; Humans; Hydroxyquinolines; Myelitis; Optic Atrophy; Optic Neuritis; Oxyquinoline; Syndrome; Time Factors; Zinc

A meanwhile 13 years old boy had to be treated by hydroxychinolines for a severe acrodermatitis enteropathica since his 1st year of life. At the age of 5 years he showed visual deterioration by atrophia optici. Dose reduction and application of different halogen substitutions were tried. Finally, it was daily oral zinc application and continuous control of the serum zinc level which made disappear all cutaneous and mucous symptoms. At an unchanged ophthalmoscopic status, there occurred a slight raise of vision, an enlargement of peripheric campus and a normalization of the electroretinographic potentials.

Topics: Acrodermatitis; Administration, Oral; Adolescent; Electroretinography; Humans; Hydroxyquinolines; Male; Optic Atrophy; Zinc

In connection with the clinical observation of their five patients suffering from AE the authors summarize current questions related to this disease. They examined the function of the cellular immunity in this disease. They call attention to dangers of oxychinoline treatment, and to benefits of zinc administration. They established that the introduction of zinc therapy indicates a progress in the treatment of AE.

Topics: Acrodermatitis; Adolescent; Child; Female; Humans; Hydroxyquinolines; Immunity, Cellular; Immunologic Deficiency Syndromes; Infant; Malabsorption Syndromes; Male; Zinc

A five months old infant is described with acrodermatitis enteropathica. The aetiology, pathogenesis and the clinical course of the disease is reported. It will be discussed the side effects of the oxychinolin therapy, the advantages and benefits of the substitution with zinc.

Topics: Acrodermatitis; Eye Diseases; Female; Humans; Hydroxyquinolines; Infant; Intestinal Diseases; Optic Nerve; Zinc Oxide

Topics: Acrodermatitis; Gastrointestinal Diseases; Humans; Hydroxyquinolines; Optic Nerve; Oxyquinoline; Vestibulocochlear Nerve; Zinc

In 3 cases of acrodermatitis enteropathica duodenal biopsy performed at the outset of treatment showed a similar abnormality of the intestinal mucosa. Further biopsies taken during treatment showed progressive improvement of the intestinal mucosa with subsequent complete restoration of the normal cellular and villous pattern. The initial treatment was with expressed human breast milk and oral di-iodohydroxyquinoline. The latter was continued alone and later replaced by zinc sulphate. Changes in the intestinal epithelial cells and inflammatory cell infiltration of the lamina propria still detectable on di-iodohydroxyquinoline therapy reverted to normal with oral zinc.

Topics: Acrodermatitis; Biopsy; Child; Child, Preschool; Duodenum; Humans; Hydroxyquinolines; Infant; Intestinal Diseases; Intestinal Mucosa; Male; Milk, Human; Zinc

A 24-year-old patient treated with hydroxychinoline preparations without cure for acrodermatitis enteropathica since he was nine years old was given zinc oxide orally, at first 50 mg three times, later twice daily. Zinc concentrations in blood plasma, whole blood and sputum were serially determined. At the start of treatment they were significantly below that in four healthy controls. One week after starting zinc therapy the blood level had returned to normal and with it the changes in skin, hair and nails had regressed, as had the emotional disturbances.

Topics: Acrodermatitis; Adult; Humans; Hydroxyquinolines; Male; Saliva; Zinc; Zinc Oxide