Page last updated: 2024-08-21

chenodeoxycholic acid and Carcinoma, Hepatocellular

chenodeoxycholic acid has been researched along with Carcinoma, Hepatocellular in 30 studies

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19903 (10.00)18.7374
1990's8 (26.67)18.2507
2000's9 (30.00)29.6817
2010's6 (20.00)24.3611
2020's4 (13.33)2.80

Authors

AuthorsStudies
Arias, IM; Fantappié, O; Gatmaitan, Z; Gentilini, P; Kamimoto, Y; Mazzanti, R1
Choi, HS; Fan, Y; Jung, YS; Kim, HJ; Na, SY; Radhakrishnan, K1
Chen, W; Ding, M; Guo, Y; Huang, M; Ji, L; Jin, X; Lin, Y; Liu, Z; Lu, L; Shen, Q; Wang, Y; Yan, W; Yao, J; Yu, S; Zheng, Y1
Chen, H; Dai, Y; Gan, Q; Lai, L; Liao, S; Liu, F; Ou, M; Sui, W; Wang, B; Yang, M1
Ali, AA; Attia, YM; Elmazar, MM; Gibriel, AA; Hammam, OA; Kassem, DH; Tawfiq, RA1
Chan, HL; Chan, WK; Chawla, Y; Chitturi, S; Dan, YY; Duseja, A; Fan, J; Farrell, G; Goh, KL; Hamaguchi, M; Hashimoto, E; Kim, SU; Lesmana, LA; Lin, YC; Liu, CJ; Ni, YH; Sollano, J; Wong, GL; Wong, SK; Wong, VW1
Kainuma, M; Makishima, M; Sano, K; Takada, I1
Rinella, ME; Sanyal, AJ1
Buchmann, B; Ciesek, S; Döhner, K; Manns, MP; Pinto Marques Souza de Oliveira, C; Sandmann, L; Sarrazin, C; Schlaphoff, V; Sodeik, B; Sprinzl, K; Veloso Alves Pereira, I; von Hahn, T; Vondran, F1
Ahn, EY; Choi, YH; Hossain, MA; Kim, GY; Kim, MN; Kim, MY; Kim, ND; Lee, SW; Park, SE; Park, YC; Suh, H1
Han, GQ; Liu, H; Qin, CK; Qin, CY; Ren, WH; Xu, HW1
Abe, T; Egawa, S; Fukase, K; Ii, T; Katayose, Y; Motoi, F; Mutoh, M; Ohtsuka, H; Oikawa, M; Onogawa, T; Oshio, H; Rikiyama, T; Unno, M1
Chiang, JY; Li, T; Owsley, E; Song, KH; Strom, S1
Baller, JF; Faber, KN; Geuken, M; Heegsma, J; Hoeke, MO; Jansen, PL; Kuipers, F; Moshage, H; Plass, JR; van Rijsbergen, D1
Chang, KO; Kim, Y1
Gao, M; Gong, W; He, F; Huang, G; Pan, Z; Xu, Z; Zeng, Y; Zhang, Y; Zhao, Y; Zhou, P1
Jung, D; Kullak-Ublick, GA1
Blevins, RA; Cui, J; de Pedro, N; Hrywna, Y; Huang, L; Lew, JL; Peláez, F; Thompson, JR; Wright, SD; Yu, J; Zhang, T; Zhao, A1
Daitoku, H; Fujii, H; Fukamizu, A; Hirota, K; Ishida, J; Kato, H; Matsuoka, T; Nangaku, M; Saito, T; Shimamoto, Y; Takeda, J; Yamagata, K1
Amuro, Y; Endo, T; Hayashi, E; Higashino, K; Kishimoto, S; Nakabayashi, H; Sato, J; Tanaka, M1
Hirano, F; Inaba, M; Makino, I; Makino, Y; Miura, T; Okamoto, K; Tanaka, H1
Cooper, AD; Craig, WY; Everson, GT; Taniguchi, T1
Hirano, F; Makino, I; Tanaka, H1
Hirano, F; Makino, I; Makino, Y; Okamoto, K; Tanaka, H1
Kato, Y; Khan, KN; Nagataki, S; Nakao, K; Nakata, K; Tsutsumi, T1
Calmus, Y; Conti, F; Meier, PJ; Podevin, P; Poupon, R; Rosmorduc, O1
Amborade, E; Deschatrette, J; Le Goascogne, C; Ng, KH; Stieger, B1
Axelson, M; Everson, GT; Mörk, B1
Budai, K; Javitt, NB1
Everson, GT; Polokoff, MA1

Reviews

2 review(s) available for chenodeoxycholic acid and Carcinoma, Hepatocellular

ArticleYear
The Asia-Pacific Working Party on Non-alcoholic Fatty Liver Disease guidelines 2017-Part 2: Management and special groups.
    Journal of gastroenterology and hepatology, 2018, Volume: 33, Issue:1

    Topics: Adolescent; Asia; Bariatric Surgery; Carcinoma, Hepatocellular; Chenodeoxycholic Acid; Child; Diet; Exercise; Fatty Acids, Omega-3; Gastroenterology; Humans; Liver Neoplasms; Liver Transplantation; Non-alcoholic Fatty Liver Disease; Obesity; Pacific Islands; Practice Guidelines as Topic; Risk; Systematic Reviews as Topic; Thiazolidinediones; Vitamin E

2018
NAFLD in 2014: Genetics, diagnostics and therapeutic advances in NAFLD.
    Nature reviews. Gastroenterology & hepatology, 2015, Volume: 12, Issue:2

    Topics: Anticholesteremic Agents; Carcinoma, Hepatocellular; Chenodeoxycholic Acid; Genetic Predisposition to Disease; Humans; Liver Neoplasms; Membrane Proteins; Non-alcoholic Fatty Liver Disease

2015

Other Studies

28 other study(ies) available for chenodeoxycholic acid and Carcinoma, Hepatocellular

ArticleYear
Bile acid inhibition of P-glycoprotein-mediated transport in multidrug-resistant cells and rat liver canalicular membrane vesicles.
    Hepatology (Baltimore, Md.), 1994, Volume: 20, Issue:1 Pt 1

    Topics: Animals; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile Acids and Salts; Bile Canaliculi; Biological Transport; Carcinoma, Hepatocellular; Carrier Proteins; Cell Membrane; Daunorubicin; Depression, Chemical; Doxorubicin; Drug Resistance; Liver Neoplasms; Male; Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Rhodamine 123; Rhodamines; Tumor Cells, Cultured

1994
Chenodeoxycholic acid regulates fibroblast growth factor 23 gene expression via estrogen-related receptor γ in human hepatoma Huh7 cells.
    Steroids, 2023, Volume: 197

    Topics: Bile Acids and Salts; Carcinoma, Hepatocellular; Chenodeoxycholic Acid; Drug Inverse Agonism; Estrogens; Fibroblast Growth Factor-23; Gene Expression; Humans; Liver Neoplasms; RNA, Messenger

2023
Bile acids promote the development of HCC by activating inflammasome.
    Hepatology communications, 2023, 09-01, Volume: 7, Issue:9

    Topics: Animals; Bile Acids and Salts; Carcinoma, Hepatocellular; Cells, Cultured; Chenodeoxycholic Acid; Inflammasomes; Inflammation; Liver Neoplasms; Mice; Molecular Docking Simulation; Reactive Oxygen Species

2023
Dynamic Metabolomics Study of the Bile Acid Pathway During Perioperative Primary Hepatic Carcinoma Following Liver Transplantation.
    Annals of transplantation, 2020, Jun-23, Volume: 25

    Topics: Adult; Bile Acids and Salts; Biomarkers; Carcinoma, Hepatocellular; Chenodeoxycholic Acid; Chromatography, Liquid; Female; Glycocholic Acid; Graft Survival; Humans; Liver; Liver Neoplasms; Liver Transplantation; Male; Metabolomics; Middle Aged; Tandem Mass Spectrometry; Taurochenodeoxycholic Acid; Taurocholic Acid; Treatment Outcome

2020
Activation of FXR modulates SOCS3/Jak2/STAT3 signaling axis in a NASH-dependent hepatocellular carcinoma animal model.
    Biochemical pharmacology, 2021, Volume: 186

    Topics: Animals; Carcinoma, Hepatocellular; Chenodeoxycholic Acid; Janus Kinase 2; Liver Neoplasms; Male; Mice; Non-alcoholic Fatty Liver Disease; Receptors, Cytoplasmic and Nuclear; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein

2021
Farnesoid X Receptor Activation Enhances Transforming Growth Factor β-Induced Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma Cells.
    International journal of molecular sciences, 2018, 06-28, Volume: 19, Issue:7

    Topics: Bile Acids and Salts; Cadherins; Carcinoma, Hepatocellular; Cell Line, Tumor; Chenodeoxycholic Acid; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Isoxazoles; Liver; Liver Neoplasms; Receptors, Cytoplasmic and Nuclear; Transforming Growth Factor beta1

2018
Primary biliary acids inhibit hepatitis D virus (HDV) entry into human hepatoma cells expressing the sodium-taurocholate cotransporting polypeptide (NTCP).
    PloS one, 2015, Volume: 10, Issue:2

    Topics: Adult; Bile Acids and Salts; Carcinoma, Hepatocellular; Cell Line, Tumor; Chenodeoxycholic Acid; Coinfection; Extracellular Space; Female; Gene Expression Regulation, Neoplastic; Hepatitis B, Chronic; Hepatitis D, Chronic; Hepatitis Delta Virus; Humans; Liver Neoplasms; Male; Middle Aged; Organic Anion Transporters, Sodium-Dependent; Sodium; Symporters; Virus Internalization; Virus Replication

2015
A chenodeoxycholic derivative, HS-1200, induces apoptosis and cell cycle modulation via Egr-1 gene expression control on human hepatoma cells.
    Cancer letters, 2008, Oct-18, Volume: 270, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Chenodeoxycholic Acid; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclooxygenase 2; Early Growth Response Protein 1; G1 Phase; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; Tumor Suppressor Protein p53

2008
Synthetic chenodeoxycholic acid derivative, HS-1200, induces apoptosis of human hepatoma cells via a mitochondrial pathway.
    Cancer letters, 2008, Nov-08, Volume: 270, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspase 8; Caspase 9; Caspase Inhibitors; Cell Proliferation; Chenodeoxycholic Acid; Cysteine Proteinase Inhibitors; Cytochromes c; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2

2008
Bile acids repress E-cadherin through the induction of Snail and increase cancer invasiveness in human hepatobiliary carcinoma.
    Cancer science, 2008, Volume: 99, Issue:9

    Topics: Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cadherins; Carcinoma, Hepatocellular; Cell Line, Tumor; Chenodeoxycholic Acid; Cholangiocarcinoma; Down-Regulation; Female; Gastrointestinal Agents; Humans; Lithocholic Acid; Liver Neoplasms; Male; Neoplasm Invasiveness; Snail Family Transcription Factors; Transcription Factors

2008
Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression.
    Hepatology (Baltimore, Md.), 2009, Volume: 49, Issue:1

    Topics: Butadienes; Carcinoma, Hepatocellular; Cell Line, Tumor; Chenodeoxycholic Acid; Cholesterol 7-alpha-Hydroxylase; DNA-Binding Proteins; Fibroblast Growth Factors; Gene Expression; Hepatocytes; Humans; Isoxazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Receptor, Fibroblast Growth Factor, Type 4; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Transcription Factors

2009
Low retinol levels differentially modulate bile salt-induced expression of human and mouse hepatic bile salt transporters.
    Hepatology (Baltimore, Md.), 2009, Volume: 49, Issue:1

    Topics: Alitretinoin; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Carcinoma, Hepatocellular; Cell Line, Tumor; Chenodeoxycholic Acid; Cholic Acid; DNA-Binding Proteins; Gene Expression Regulation; Humans; Male; Mice; Mice, Inbred C57BL; Organic Anion Transporters, Sodium-Dependent; Receptors, Cytoplasmic and Nuclear; Response Elements; Retinoid X Receptor alpha; Symporters; Transcription Factors; Tretinoin; Vitamin A; Vitamin A Deficiency

2009
Inhibitory effects of bile acids and synthetic farnesoid X receptor agonists on rotavirus replication.
    Journal of virology, 2011, Volume: 85, Issue:23

    Topics: Animals; Blotting, Western; Caco-2 Cells; Carcinoma, Hepatocellular; Chenodeoxycholic Acid; Female; Gastrointestinal Agents; Humans; Isoxazoles; Liver Neoplasms; Mice; Mice, Inbred BALB C; Real-Time Polymerase Chain Reaction; RNA-Binding Proteins; RNA, Messenger; Rotavirus; Rotavirus Infections; Triglycerides; Tumor Cells, Cultured; Virus Replication

2011
FXR ligands protect against hepatocellular inflammation via SOCS3 induction.
    Cellular signalling, 2012, Volume: 24, Issue:8

    Topics: Animals; Carcinoma, Hepatocellular; Cells, Cultured; Chenodeoxycholic Acid; Hep G2 Cells; Humans; Inflammation; Ligands; Lipopolysaccharides; Liver Neoplasms; Mice; Mice, Inbred C57BL; Receptors, Cytoplasmic and Nuclear; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins

2012
Hepatocyte nuclear factor 1 alpha: a key mediator of the effect of bile acids on gene expression.
    Hepatology (Baltimore, Md.), 2003, Volume: 37, Issue:3

    Topics: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Bile Acids and Salts; Carcinoma, Hepatocellular; Cell Nucleus; Chenodeoxycholic Acid; DNA-Binding Proteins; Gene Expression Regulation; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 1-beta; Hepatocyte Nuclear Factor 4; Humans; Liver Neoplasms; Liver-Specific Organic Anion Transporter 1; Mutagenesis; Nuclear Proteins; Phosphoproteins; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Response Elements; Transcription Factors; Transcriptional Activation; Transfection; Tumor Cells, Cultured

2003
Human kininogen gene is transactivated by the farnesoid X receptor.
    The Journal of biological chemistry, 2003, Aug-01, Volume: 278, Issue:31

    Topics: Binding Sites; Blotting, Northern; Carcinoma, Hepatocellular; Chenodeoxycholic Acid; DNA; DNA-Binding Proteins; Gene Deletion; Gene Expression Regulation; Hepatocytes; Humans; Isoxazoles; Kininogens; Liver Neoplasms; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Repetitive Sequences, Nucleic Acid; Retinoid X Receptors; RNA, Messenger; Transcription Factors; Transcriptional Activation; Transfection; Tumor Cells, Cultured

2003
Inhibitory effect of the small heterodimer partner on hepatocyte nuclear factor-4 mediates bile acid-induced repression of the human angiotensinogen gene.
    The Journal of biological chemistry, 2004, Feb-27, Volume: 279, Issue:9

    Topics: Angiotensinogen; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Bile Acids and Salts; Binding Sites; Carcinoma, Hepatocellular; Chenodeoxycholic Acid; Cholic Acid; DNA; DNA-Binding Proteins; Female; Gene Expression; Gene Expression Regulation; HeLa Cells; Hepatocyte Nuclear Factor 4; Humans; Liver; Luciferases; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutagenesis; Phosphoproteins; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Recombinant Proteins; RNA, Messenger; Transcription Factors; Transfection; Tumor Cells, Cultured

2004
Bile acid synthesis by long-term cultured cell line established from human hepatoblastoma.
    The Journal of clinical investigation, 1982, Volume: 70, Issue:5

    Topics: Animals; Bile Acids and Salts; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Chenodeoxycholic Acid; Chromatography, Gas; Deoxycholic Acid; Humans; Liver Neoplasms; Rats; Time Factors

1982
Regulation of the major histocompatibility complex class I mRNA expression by bile acids in cultured human hepatoma cells.
    Biochemical and biophysical research communications, 1995, Mar-28, Volume: 208, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bile Acids and Salts; Carcinoma, Hepatocellular; Cell Line; Cell Membrane; Chenodeoxycholic Acid; Cytosol; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Genes, MHC Class I; Histocompatibility Antigens Class I; Humans; Isoquinolines; Kinetics; Liver Neoplasms; Piperazines; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1995
Characteristics and regulation of bile salt synthesis and secretion by human hepatoma HepG2 cells.
    Hepatology (Baltimore, Md.), 1994, Volume: 20, Issue:6

    Topics: Bile Acids and Salts; Biological Transport; Blotting, Northern; Carcinoma, Hepatocellular; Chenodeoxycholic Acid; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Cholic Acid; Cholic Acids; Gas Chromatography-Mass Spectrometry; Humans; Hydroxycholesterols; Liver Neoplasms; Microsomes, Liver; Progesterone; RNA, Messenger; Tumor Cells, Cultured

1994
Chenodeoxycholic acid-dependent induction of major histocompatibility complex class I mRNA expression in a human hepatoma cell line.
    Biochemical and biophysical research communications, 1993, Sep-30, Volume: 195, Issue:3

    Topics: Carcinoma, Hepatocellular; Chenodeoxycholic Acid; Gene Expression Regulation, Neoplastic; Genes, MHC Class I; Liver Cirrhosis, Biliary; Liver Neoplasms; RNA, Messenger; Tumor Cells, Cultured

1993
Effects of ursodeoxycholic acid and chenodeoxycholic acid on major histocompatibility complex class I gene expression.
    Journal of gastroenterology, 1996, Volume: 31, Issue:1

    Topics: Blotting, Northern; Carcinoma, Hepatocellular; Chenodeoxycholic Acid; Gene Expression; Histocompatibility Antigens Class I; Humans; Liver Neoplasms; RNA, Messenger; Tumor Cells, Cultured; Ursodeoxycholic Acid

1996
Regulation of alkaline phosphatase gene expression in human hepatoma cells by bile acids.
    Journal of gastroenterology and hepatology, 1998, Volume: 13, Issue:6

    Topics: Alkaline Phosphatase; Bile Acids and Salts; Carcinoma, Hepatocellular; Chenodeoxycholic Acid; Cholic Acid; Dose-Response Relationship, Drug; Gene Expression; Humans; Liver Neoplasms; RNA, Messenger; Tumor Cells, Cultured; Ursodeoxycholic Acid

1998
Bile acids modulate the interferon signalling pathway.
    Hepatology (Baltimore, Md.), 1999, Volume: 29, Issue:6

    Topics: 2',5'-Oligoadenylate Synthetase; Animals; Antiviral Agents; Bile Acids and Salts; Carcinoma, Hepatocellular; Carrier Proteins; Cell Survival; Chenodeoxycholic Acid; CHO Cells; Cricetinae; DNA Fragmentation; Gene Expression Regulation; GTP-Binding Proteins; Humans; Interferon alpha-2; Interferon-alpha; Kinetics; Liver Neoplasms; Models, Biological; Myxovirus Resistance Proteins; Organic Anion Transporters, Sodium-Dependent; Promoter Regions, Genetic; Proteins; Recombinant Proteins; Signal Transduction; Symporters; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured

1999
Reversible induction of rat hepatoma cell polarity with bile acids.
    Journal of cell science, 2000, Volume: 113 Pt 23

    Topics: Animals; Carcinoma, Hepatocellular; CD13 Antigens; Cell Differentiation; Cell Division; Cell Polarity; Chenodeoxycholic Acid; Fluoresceins; gamma-Glutamyltransferase; Gastrointestinal Agents; Membrane Proteins; Microscopy, Electron; Mitochondrial Proteins; Phosphoproteins; Rats; Ribosomal Proteins; Saccharomyces cerevisiae Proteins; Tight Junctions; Tumor Cells, Cultured; Zonula Occludens-1 Protein

2000
Bile acid synthesis in cultured human hepatoblastoma cells.
    The Journal of biological chemistry, 1991, Sep-25, Volume: 266, Issue:27

    Topics: Bile Acids and Salts; Carcinoma, Hepatocellular; Chenodeoxycholic Acid; Cholesterol; Cholic Acid; Cholic Acids; Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Humans; Liver Neoplasms; Mass Spectrometry; Methylation; Steroids; Tumor Cells, Cultured

1991
Cholesterol and bile acid synthesis in Hep G2 cells. Metabolic effects of 26- and 7 alpha-hydroxycholesterol.
    The Biochemical journal, 1989, Sep-15, Volume: 262, Issue:3

    Topics: Bile Acids and Salts; Carcinoma, Hepatocellular; Cell Line; Chenodeoxycholic Acid; Cholesterol; Cholic Acids; Humans; Hydroxycholesterols; Liver Neoplasms

1989
HepG2. A human hepatoblastoma cell line exhibiting defects in bile acid synthesis and conjugation.
    The Journal of biological chemistry, 1986, Feb-15, Volume: 261, Issue:5

    Topics: Bile Acids and Salts; Carcinoma, Hepatocellular; Cell Line; Chenodeoxycholic Acid; Cholestanols; Cholic Acid; Cholic Acids; Gas Chromatography-Mass Spectrometry; Humans; Liver Neoplasms

1986