chenodeoxycholic acid has been researched along with Cancer of Colon in 43 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (51.16) | 18.7374 |
| 1990's | 8 (18.60) | 18.2507 |
| 2000's | 6 (13.95) | 29.6817 |
| 2010's | 3 (6.98) | 24.3611 |
| 2020's | 4 (9.30) | 2.80 |
| Authors | Studies |
|---|---|
| Bazin, MA; Clément, M; Descamps, G; El Kihel, L; Khalid, M; Rault, S | 1 |
| Brossard, D; Clément, M; El Kihel, L; Khalid, M; Rault, S; Roussakis, C; Sebbahi, W | 1 |
| Ahuja, N; Cai, Y; Gaule, P; Huang, H; Johnson, CH; Khan, SA; Lu, J; Lu, L; Muca, E; Paty, PB; Rattray, NJW; Rattray, Z; Shen, X; Theriot, CM; Yan, H; Zhang, Y | 1 |
| Choi, BH; Jang, H; Lee, EY; Lee, YJ; Myung, JK; You, HJ | 1 |
| Sun, X; Yang, K; Yu, J; Zhao, W; Zheng, J | 1 |
| Byun, Y; Chang, KY; Choi, JU; Jha, SK; Kang, SH; Kweon, S; Pangeni, R; Park, JW; Subedi, L | 1 |
| Alrefai, WA; Ao, M; Domingue, J; Rao, MC; Sarathy, J | 1 |
| Antonia Lizarbe, M; Ignacio Barrasa, J; Lecona, E; Olmo, N; Pérez-Ramos, P; Santiago-Gómez, A; Turnay, J | 1 |
| Kramer, PM; Pereira, MA; Tao, L; Wang, W | 1 |
| Fleckl, E; Jurek, D; Marian, B | 1 |
| Bresalier, RS; Byrd, JC; Koo, JS; Song, S | 1 |
| Ikawa, S; Ikeguchi, M; Kaibara, N; Koga, S; Sasaki, T | 1 |
| Leuschner, U | 1 |
| Makino, T | 1 |
| Mamianetti, A | 1 |
| Gelb, AM; McSherry, CK; Mosbach, EH; Sadowsky, JR | 1 |
| Cohen, BI; Raicht, RF | 1 |
| Deser, HJ; Edenharder, R | 1 |
| Mitschke, H; Sauer, HD; Thoma, G; Winkler, R | 1 |
| Bird, RP; Sutherland, LA | 1 |
| Fiander, H; Latta, RK; Ross, NW; Schneider, H; Simpson, C | 1 |
| Fiander, H; Latta, RK; Ross, NW; Schneider, H | 1 |
| Handa, H; Hiramoto, M; Hirano, F; Makino, I; Makino, Y; Okamoto, K; Tanada, H | 1 |
| Andresen, MS; Garagozlian, S; Halvorsen, B; Kase, BF; Kolset, SO; Prydz, K | 1 |
| Dannenberg, AJ; DeLellis, RA; Golijanin, D; Jakobsson, PJ; Paty, PB; Soslow, RA; Subbaramaiah, K; Yoshimatsu, K | 1 |
| Allgayer, H; Kolb, M; Kruis, W; Stuber, V | 1 |
| Hofmann, AF; van Berge Henegouwen, GP | 1 |
| de Heer, K; Mitschke, H; Sauer, HD | 1 |
| Schmack, B | 1 |
| Jeannin, JF; Martin, F; Martin, MS | 1 |
| Cohen, BI; Fazzini, E; Raicht, RF; Sarwal, AN; Takahashi, M | 1 |
| Chessebeuf, M; Jeannin, JF; Lagneau, A; Martin, MS | 1 |
| Reddy, BS; Watanabe, K; Weisburger, JH; Wynder, EL | 1 |
| Edenharder, R; Slemrova, J | 1 |
| Core, SK; Watne, AL | 1 |
| Fadden, K; Owen, RW | 1 |
| Biasco, G; Hill, MJ; Owen, RW; Paganelli, GM | 1 |
| Bernstein, H; Cheah, PY | 1 |
| Story, JA | 1 |
| Campbell, GR; Donaldson, JD; McKelvey, ST; Moorehead, RJ | 1 |
| Hikasa, Y; Setchell, KD; Shimoyama, T; Tanida, N | 1 |
| Breuer, NF; Dommes, P; Goebell, H; Jaekel, S | 1 |
| Classen, M; Kurtz, WJ; Leuschner, U; Strohm, WD | 1 |
3 review(s) available for chenodeoxycholic acid and Cancer of Colon
| Article | Year |
|---|---|
Current problem of chemical gallstone dissolution.
Topics: Animals; Calcinosis; Chenodeoxycholic Acid; Cholelithiasis; Cholesterol; Colonic Neoplasms; Cost-Benefit Analysis; Deoxycholic Acid; Diarrhea; Female; Humans; Liver; Macaca mulatta; Male; Transaminases; Ursodeoxycholic Acid | 1983 |
Clinical aspects of disturbances in the enterohepatic circulation of bile acids in man: the cholanopathies.
Topics: Bile Acids and Salts; Biliary Tract Diseases; Celiac Disease; Chenodeoxycholic Acid; Cholelithiasis; Cholestasis; Cholic Acids; Colonic Neoplasms; Deoxycholic Acid; Diarrhea; Humans; Intestinal Diseases; Intestine, Small; Lipid Metabolism; Lithocholic Acid; Liver; Liver Circulation; Malabsorption Syndromes; Portal System | 1978 |
Dietary fiber and lipid metabolism.
Topics: Adsorption; Animals; Bile Acids and Salts; Cellulose; Chenodeoxycholic Acid; Cholesterol; Cholesterol, Dietary; Colonic Neoplasms; Coronary Disease; Dietary Fats; Dietary Fiber; Edible Grain; Feces; Female; Humans; Intestinal Absorption; Lignin; Lipid Metabolism; Liver; Medicago sativa; Polysaccharides; Steroids; Triticum | 1985 |
40 other study(ies) available for chenodeoxycholic acid and Cancer of Colon
| Article | Year |
|---|---|
New lithocholic and chenodeoxycholic piperazinylcarboxamides with antiproliferative and pro-apoptotic effects on human cancer cell lines.
Topics: Amides; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Chenodeoxycholic Acid; Colonic Neoplasms; DNA Fragmentation; Glioblastoma; Humans; Lithocholic Acid; Multiple Myeloma; Neoplasms; NF-kappa B; Piperazines; Signal Transduction | 2008 |
Synthesis of bile acid derivatives and in vitro cytotoxic activity with pro-apoptotic process on multiple myeloma (KMS-11), glioblastoma multiforme (GBM), and colonic carcinoma (HCT-116) human cell lines.
Topics: Apoptosis; Bile Acids and Salts; Cell Line, Tumor; Colonic Neoplasms; Glioblastoma; Humans; Multiple Myeloma; Piperazine; Piperazines | 2010 |
Bile acid distributions, sex-specificity, and prognosis in colorectal cancer.
Topics: Bile Acids and Salts; Chenodeoxycholic Acid; Colonic Neoplasms; Colorectal Neoplasms; Female; Forkhead Transcription Factors; Glycochenodeoxycholic Acid; Humans; Lithocholic Acid; Male; Sex Distribution; Ursodeoxycholic Acid | 2022 |
The Role of Nuclear Receptor Subfamily 1 Group H Member 4 (NR1H4) in Colon Cancer Cell Survival through the Regulation of c-Myc Stability.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chenodeoxycholic Acid; Clustered Regularly Interspaced Short Palindromic Repeats; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Molecular Targeted Therapy; Protein Stability; Proto-Oncogene Proteins c-myc; Receptors, Cytoplasmic and Nuclear; Signal Transduction | 2020 |
Synergistic tumor inhibition of colon cancer cells by nitazoxanide and obeticholic acid, a farnesoid X receptor ligand.
Topics: Animals; beta Catenin; Carcinogenesis; Cell Proliferation; Chenodeoxycholic Acid; Colonic Neoplasms; Drug Synergism; Gene Expression Regulation, Neoplastic; HCT116 Cells; Heterografts; Humans; Ligands; Liver; Mice; Molecular Targeted Therapy; Nitro Compounds; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles | 2021 |
Improvements in the Oral Absorption and Anticancer Efficacy of an Oxaliplatin-Loaded Solid Formulation: Pharmacokinetic Properties in Rats and Nonhuman Primates and the Effects of Oral Metronomic Dosing on Colorectal Cancer.
Topics: Administration, Metronomic; Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Caco-2 Cells; Cell Membrane Permeability; Chenodeoxycholic Acid; Colonic Neoplasms; Drug Carriers; Female; Glycerides; Humans; Intestinal Absorption; Lysine; Macaca fascicularis; Male; Mice, Inbred BALB C; Oxaliplatin; Poloxamer; Rats, Sprague-Dawley | 2020 |
Chenodeoxycholic acid stimulates Cl(-) secretion via cAMP signaling and increases cystic fibrosis transmembrane conductance regulator phosphorylation in T84 cells.
Topics: Cell Line, Tumor; Cell Membrane; Cell Membrane Permeability; Cell Polarity; Chenodeoxycholic Acid; Chlorides; Colonic Neoplasms; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis Transmembrane Conductance Regulator; Cytokines; Humans; Inflammation Mediators; Intestinal Mucosa; Membrane Potentials; Microtubules; Phosphorylation; Second Messenger Systems; Time Factors; Up-Regulation | 2013 |
Deoxycholic and chenodeoxycholic bile acids induce apoptosis via oxidative stress in human colon adenocarcinoma cells.
Topics: Adenocarcinoma; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Survival; Chenodeoxycholic Acid; Colonic Neoplasms; Deoxycholic Acid; Humans; Membrane Potential, Mitochondrial; Mitochondria; Necrosis; Oxidative Stress; Reactive Oxygen Species | 2011 |
DNA hypomethylation induced by non-genotoxic carcinogens in mouse and rat colon.
Topics: Animals; Azacitidine; Carcinogens; Chenodeoxycholic Acid; Cholic Acid; Colon; Colonic Neoplasms; Decitabine; Deoxycholic Acid; DNA; DNA Methylation; Dose-Response Relationship, Drug; Female; Lithocholic Acid; Male; Mice; Rats; Rats, Inbred F344; Rutin; Time Factors | 2004 |
Bile acid induced gene expression in LT97 colonic adenoma cells.
Topics: Adenoma; Bile Acids and Salts; Biomarkers, Tumor; Cell Line, Tumor; Chenodeoxycholic Acid; Colonic Neoplasms; Cyclooxygenase 2; Deoxycholic Acid; Dose-Response Relationship, Drug; Gene Amplification; Gene Expression Regulation, Neoplastic; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Isoenzymes; Membrane Proteins; Polymerase Chain Reaction; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins c-fos; RNA; Taurodeoxycholic Acid; Time Factors; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Endothelial Growth Factor A | 2005 |
Bile acids induce MUC2 overexpression in human colon carcinoma cells.
Topics: Antineoplastic Agents; Chenodeoxycholic Acid; Cholagogues and Choleretics; Cholic Acids; Colonic Neoplasms; Curcumin; Deoxycholic Acid; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Mitogen-Activated Protein Kinases; Mucin-2; Mucins; Naphthalenes; Promoter Regions, Genetic; Protein Kinase C; RNA, Messenger; Transcription Factor AP-1; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured; Up-Regulation; Ursodeoxycholic Acid | 2005 |
Fecal bile acids and neutral sterols in Japanese with large bowel carcinoma.
Topics: Aged; Bile; Chenodeoxycholic Acid; Cholestanol; Cholesterol; Cholic Acids; Colonic Neoplasms; Feces; Female; Humans; Japan; Lithocholic Acid; Male; Middle Aged; Rectal Neoplasms | 1983 |
Fecal bile acid excretion in patients with colon cancer, colon polyp and peptic ulcer.
Topics: Adenoma; Adult; Aged; Bile Acids and Salts; Chenodeoxycholic Acid; Cholic Acid; Cholic Acids; Colon; Colonic Neoplasms; Colonic Polyps; Diet; Feces; Humans; Middle Aged; Peptic Ulcer | 1984 |
[Current treatment of gallbladder calculi].
Topics: Animals; Chenodeoxycholic Acid; Cholecystectomy; Cholelithiasis; Cholesterol; Colonic Neoplasms; Deoxycholic Acid; Female; Humans; Male; Risk; Ursodeoxycholic Acid | 1984 |
Tissue bile acids in patients with colon cancer and colonic polyps.
Topics: Adenocarcinoma; Adenoma; Adult; Aged; Bile Acids and Salts; Biopsy; Carcinoma; Carcinoma in Situ; Chenodeoxycholic Acid; Colon; Colonic Neoplasms; Female; Humans; Intestinal Polyps; Liver; Male; Middle Aged | 1982 |
Effects of bile acids on colon carcinogenesis in rats treated with carcinogens.
Topics: Animals; Chenodeoxycholic Acid; Cholic Acids; Cocarcinogenesis; Colonic Neoplasms; Diet; Feces; Methods; Methylnitrosourea; Neoplasms, Experimental; Rats; Steroids | 1981 |
[The significance of the bacterial steroid degradation for the etiology of large bowel cancer. VIII. Transformation of cholic-, chenodeoxycholic-, and deoxycholic acid by lecithinase-lipase-negative clostridia].
Topics: Bile Acids and Salts; Biotransformation; Chenodeoxycholic Acid; Cholic Acid; Cholic Acids; Clostridium; Colonic Neoplasms; Deoxycholic Acid; Feces; Humans; Lipase; Phospholipases | 1981 |
[Promotion of adenocarcinomas at the preternatural anus by bile acids in rats (author's transl)].
Topics: Adenocarcinoma; Animals; Bile Acids and Salts; Chenodeoxycholic Acid; Cocarcinogenesis; Colon; Colonic Neoplasms; Colostomy; Disease Models, Animal; Intestinal Polyps; Neoplasms, Experimental; Rats; Time Factors | 1980 |
The effect of chenodeoxycholic acid on the development of aberrant crypt foci in the rat colon.
Topics: Animals; Antigens, Neoplasm; Body Weight; Bromodeoxyuridine; Cell Division; Chenodeoxycholic Acid; Colon; Colonic Neoplasms; Dose-Response Relationship, Drug; Eating; Male; Nuclear Proteins; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley | 1994 |
Toxicity of bile acids to colon cancer cell lines.
Topics: Bile Acids and Salts; Cell Survival; Chenodeoxycholic Acid; Colonic Neoplasms; Deoxycholic Acid; Dose-Response Relationship, Drug; Feces; Humans; Least-Squares Analysis; Lithocholic Acid; Serum Albumin, Bovine; Time Factors; Tumor Cells, Cultured | 1993 |
Bile acid inhibition of xenobiotic-metabolizing enzymes is a factor in the mechanism of colon carcinogenesis: tests of aspects of the concept with glucuronosyltransferase.
Topics: Bile Acids and Salts; Chenodeoxycholic Acid; Colon; Colonic Neoplasms; Deoxycholic Acid; Dose-Response Relationship, Drug; Fluoresceins; Fluorescence; Fluorescent Dyes; Glucuronates; Glucuronic Acid; Glucuronosyltransferase; Glutathione Transferase; Humans; Hymecromone; Lithocholic Acid; Permeability; Tumor Cells, Cultured; Xenobiotics | 1993 |
Induction of the transcription factor AP-1 in cultured human colon adenocarcinoma cells following exposure to bile acids.
Topics: Activating Transcription Factor 1; Adenocarcinoma; Base Sequence; Bile Acids and Salts; Chenodeoxycholic Acid; Cholagogues and Choleretics; Cholic Acid; Cholic Acids; Colonic Neoplasms; Deoxycholic Acid; DNA Primers; DNA-Binding Proteins; DNA, Neoplasm; Enzyme Activation; Gene Expression Regulation; Genetic Vectors; Humans; Lithocholic Acid; Molecular Sequence Data; NF-kappa B; Podophyllin; Podophyllotoxin; Protein Kinase C; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription Factors; Tumor Cells, Cultured; Ursodeoxycholic Acid | 1996 |
Sulphation of lithocholic acid in the colon-carcinoma cell line CaCo-2.
Topics: Bile Acids and Salts; Caco-2 Cells; Chenodeoxycholic Acid; Cholic Acid; Chromatography, High Pressure Liquid; Colonic Neoplasms; Deoxycholic Acid; Electrophoresis, Polyacrylamide Gel; Humans; Kinetics; Lithocholic Acid; Radioisotope Dilution Technique; Sulfates; Sulfur Radioisotopes | 1999 |
Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer.
Topics: Adenocarcinoma; Adenoma; Blotting, Western; Cell Line; Chenodeoxycholic Acid; Colonic Neoplasms; Colorectal Neoplasms; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Gene Expression Regulation, Enzymologic; Humans; Intestinal Mucosa; Intramolecular Oxidoreductases; Isoenzymes; Membrane Proteins; Prostaglandin-E Synthases; Prostaglandin-Endoperoxide Synthases; Recombinant Proteins; Transfection; Tumor Necrosis Factor-alpha | 2001 |
Effects of bile acids on base hydroxylation in a model of human colonic mucosal DNA.
Topics: Adenine; Animals; Cattle; Chenodeoxycholic Acid; Colon; Colonic Neoplasms; Deoxycholic Acid; DNA; DNA Damage; Gas Chromatography-Mass Spectrometry; Gastrointestinal Agents; Guanine; Humans; Hydroxylation; Intestinal Mucosa; Models, Chemical; Reactive Oxygen Species; Salicylates; Thymus Gland | 2002 |
[Chenodeoxycholic acid therapy and colorectal carcinoma--an experimental approach (author's transl)].
Topics: Animals; Carcinoma; Chenodeoxycholic Acid; Colonic Neoplasms; Dimethylhydrazines; Drug Synergism; Male; Neoplasms, Experimental; Rats; Rectal Neoplasms; Time Factors | 1979 |
[Clinical significance of bile acids].
Topics: Bile Acids and Salts; Chenodeoxycholic Acid; Cholelithiasis; Colonic Neoplasms; Deoxycholic Acid; Gastritis; Humans; Intestinal Absorption; Liver Diseases; Oxalates; Stomach Ulcer | 1979 |
[Bile acids and experimental carcinogenesis].
Topics: Animals; Bile Acids and Salts; Carcinogens; Chenodeoxycholic Acid; Colonic Neoplasms; Drug Synergism; Humans; Lithocholic Acid; Mice; Neoplasms, Experimental; Rats; Rectal Neoplasms | 1979 |
Effects of dietary administration of chenodeoxycholic acid on N-methyl-N-nitrosourea-induced colon cancer in rats.
Topics: Animals; Chenodeoxycholic Acid; Colonic Neoplasms; Feces; In Vitro Techniques; Male; Methylnitrosourea; Rats; Sterols | 1979 |
[Effects of bile acids on the growth of cell cultures obtained from rat liver and intestinal cancer (author's transl)].
Topics: Animals; Bile Acids and Salts; Cell Division; Cells, Cultured; Chenodeoxycholic Acid; Cholic Acids; Colonic Neoplasms; Deoxycholic Acid; Lithocholic Acid; Liver; Rats | 1978 |
Promoting effect of bile acids in colon carcinogenesis in germ-free and conventional F344 rats.
Topics: Adenocarcinoma; Adenoma; Animals; Chenodeoxycholic Acid; Cholic Acids; Colonic Neoplasms; Drug Synergism; Female; Germ-Free Life; Methylnitronitrosoguanidine; Neoplasms, Experimental; Rats; Rats, Inbred F344 | 1977 |
[Significance of the bacterial steroid degradation for the etiology of large bowel cancer. VII. Methodology of the identification of degradation products of bile acids].
Topics: Bacteroides; Bile Acids and Salts; Biodegradation, Environmental; Chemical Phenomena; Chemistry; Chenodeoxycholic Acid; Cholic Acids; Chromatography, Gas; Chromatography, Thin Layer; Colonic Neoplasms; Deoxycholic Acid; Evaluation Studies as Topic; Humans; Humidity; Mass Spectrometry; Steroids; Temperature | 1977 |
Fecal steroids in polyposis coli and ileorectostomy patients.
Topics: Bile Acids and Salts; Chenodeoxycholic Acid; Cholestanol; Cholesterol; Cholic Acids; Colectomy; Colonic Neoplasms; Deoxycholic Acid; Feces; Humans; Ileum; Intestinal Polyps; Lithocholic Acid; Neoplasms, Multiple Primary; Rectum; Sterols; Syndrome | 1975 |
Faecal steroids and colorectal cancer: the effect of lactulose on faecal bacterial metabolism in a continuous culture model of the large intestine.
Topics: Amino Acids; Bacteria; Bile Acids and Salts; Biomarkers, Tumor; Chenodeoxycholic Acid; Colon; Colonic Neoplasms; Fatty Acids, Volatile; Feces; Fermentation; Humans; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Lactulose; Lithocholic Acid; Models, Biological; Oxidation-Reduction; Rectal Neoplasms; Steroids | 1992 |
Faecal bile acids and colorectal cell proliferation. The ECP Colon Cancer Working Group.
Topics: Adenoma; Adult; Aged; Aged, 80 and over; Bile Acids and Salts; Cell Cycle; Cell Division; Chenodeoxycholic Acid; Cholesterol; Cholic Acid; Cholic Acids; Colon; Colonic Neoplasms; Colonic Polyps; Deoxycholic Acid; Feces; Female; Humans; Lithocholic Acid; Male; Middle Aged; Phytosterols; Rectum; Sterols | 1991 |
Colon cancer and dietary fiber: cellulose inhibits the DNA-damaging ability of bile acids.
Topics: Cellulose; Chenodeoxycholic Acid; Coliphages; Colonic Neoplasms; Deoxycholic Acid; Dietary Fiber; DNA Damage; Transfection | 1990 |
Relationship between duodenal bile acids and colorectal neoplasia.
Topics: Adenoma; Adult; Aged; Bile; Bile Acids and Salts; Chenodeoxycholic Acid; Colonic Neoplasms; Duodenum; Female; Humans; Male; Rectal Neoplasms | 1987 |
Fecal bile acid profiles of Japanese patients with adenomatous polyps of the large bowel: special reference to distribution, multiplicity, size and degree of dysplasia of the polyps.
Topics: Adult; Aged; Bile Acids and Salts; Chenodeoxycholic Acid; Cholic Acid; Cholic Acids; Colon; Colonic Neoplasms; Deoxycholic Acid; Feces; Female; Humans; Intestinal Polyps; Intestine, Large; Japan; Lithocholic Acid; Male; Middle Aged; Neoplasms, Multiple Primary; Rectal Neoplasms; Rectum; Statistics as Topic | 1985 |
Fecal bile acid excretion pattern in colonic cancer patients.
Topics: Bile Acids and Salts; Chenodeoxycholic Acid; Cholic Acid; Cholic Acids; Colonic Neoplasms; Deoxycholic Acid; Feces; Female; Humans; Intestinal Mucosa; Lithocholic Acid; Male; Middle Aged; Ursodeoxycholic Acid | 1985 |
Ileal and colonic mucosal bile acids in Crohn's disease and right colonic carcinoma.
Topics: Adolescent; Adult; Aged; Bile Acids and Salts; Chenodeoxycholic Acid; Cholic Acids; Colon; Colonic Neoplasms; Crohn Disease; Deoxycholic Acid; Female; Humans; Ileitis; Ileum; Intestinal Mucosa; Lithocholic Acid; Male; Middle Aged; Ursodeoxycholic Acid | 1985 |