chelerythrine has been researched along with Myocardial Ischemia in 51 studies
chelerythrine : A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
Excerpt | Relevance | Reference |
---|---|---|
"Landiolol, a highly cardioselective beta1-blocker, has cardioprotective effects against ischemia-reperfusion injury, although the precise mechanism is still unclear." | 7.74 | Landiolol has cardioprotective effects against reperfusion injury in the rat heart via the PKCepsilon signaling pathway. ( Hirai, H; Minamiyama, Y; Sakaguchi, M; Sasaki, Y; Shibata, T; Suehiro, S; Takahashi, Y; Takemura, S, 2007) |
"Landiolol, a highly cardioselective beta1-blocker, has cardioprotective effects against ischemia-reperfusion injury, although the precise mechanism is still unclear." | 3.74 | Landiolol has cardioprotective effects against reperfusion injury in the rat heart via the PKCepsilon signaling pathway. ( Hirai, H; Minamiyama, Y; Sakaguchi, M; Sasaki, Y; Shibata, T; Suehiro, S; Takahashi, Y; Takemura, S, 2007) |
" Intravenous injection of protein kinase C inhibitors chelerythrine (5 mg/kg) and staurosporine (50 microg/kg) or a specific mitochondrial K(ATP) channel inhibitor 5-hydroxydecanoate (5 mg/kg) 5 min before sustained myocardial ischemia abolished the preconditioning afforded by intestinal ischemia." | 3.71 | Intestinal ischemia preconditions myocardium: role of protein kinase C and mitochondrial K(ATP) channel. ( Maeta, H; Mizoguchi, K; Oe, M; Suzuki, T; Wang, YP; Yamashita, Y, 2002) |
"Chelerythrine (5 mg/kg) was injected before EP to investigate the role of PKC in EP." | 1.40 | Exercise preconditioning-induced early and late phase of cardioprotection is associated with protein kinase C epsilon translocation. ( Ge, J; Hao, Z; Pan, SS; Shen, YJ, 2014) |
"Pretreatment with Zaprinast neither induced HSP72 expression nor reduced infarct size ((55." | 1.35 | Nitric oxide induces heat shock protein 72 production and delayed protection against myocardial ischemia in rabbits via activating protein kinase C. ( Guo, WY; Hori, M; Jia, GL; Kitakaze, M; Li, F; Li, WJ; Liu, B; Wang, HC; Zhang, DX; Zhao, ZJ, 2008) |
"Treatment with adenosine only at the onset of prolonged ischemia afforded a dose-dependent protection." | 1.30 | Preconditioning of isolated rabbit cardiomyocytes: no evident separation of induction, memory and protection. ( Armstrong, SC; Ganote, CE; Hoover, DB; Shivell, LC, 1997) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 21 (41.18) | 18.2507 |
2000's | 25 (49.02) | 29.6817 |
2010's | 5 (9.80) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Hao, Z | 3 |
Pan, SS | 4 |
Shen, YJ | 4 |
Ge, J | 3 |
Zhong, B | 1 |
Wang, DH | 1 |
Baharvand, B | 1 |
Dehaj, ME | 1 |
Rasoulian, B | 1 |
Namdari, M | 1 |
Shikhani, Y | 1 |
Kiani, AA | 1 |
Li, WJ | 1 |
Zhao, ZJ | 1 |
Liu, B | 1 |
Zhang, DX | 1 |
Li, F | 1 |
Wang, HC | 1 |
Guo, WY | 1 |
Jia, GL | 1 |
Kitakaze, M | 1 |
Hori, M | 1 |
Edwards, AG | 1 |
Rees, ML | 1 |
Gioscia, RA | 1 |
Zachman, DK | 1 |
Lynch, JM | 1 |
Browder, JC | 1 |
Chicco, AJ | 1 |
Moore, RL | 1 |
Zhuang, T | 1 |
Wang, FJ | 1 |
Mao, HJ | 1 |
Chen, BP | 1 |
Wang, HP | 1 |
Gao, YF | 1 |
Xia, Q | 1 |
Wang, YP | 1 |
Maeta, H | 1 |
Mizoguchi, K | 1 |
Suzuki, T | 1 |
Yamashita, Y | 1 |
Oe, M | 1 |
Yamamoto, S | 1 |
Yang, G | 1 |
Zablocki, D | 1 |
Liu, J | 1 |
Hong, C | 1 |
Kim, SJ | 1 |
Soler, S | 1 |
Odashima, M | 1 |
Thaisz, J | 1 |
Yehia, G | 1 |
Molina, CA | 1 |
Yatani, A | 1 |
Vatner, DE | 1 |
Vatner, SF | 1 |
Sadoshima, J | 1 |
Wang, QD | 1 |
Nygren, E | 1 |
Okawa, H | 1 |
Horimoto, H | 1 |
Mieno, S | 1 |
Nomura, Y | 1 |
Yoshida, M | 1 |
Shinjiro, S | 1 |
Loubani, M | 1 |
Hassouna, A | 1 |
Galiñanes, M | 2 |
Hilfiker-Kleiner, D | 1 |
Kaminski, K | 1 |
Kaminska, A | 1 |
Fuchs, M | 1 |
Klein, G | 1 |
Podewski, E | 1 |
Grote, K | 1 |
Kiian, I | 1 |
Wollert, KC | 1 |
Hilfiker, A | 1 |
Drexler, H | 1 |
Ding, HL | 1 |
Zhu, HF | 1 |
Dong, JW | 1 |
Zhu, WZ | 1 |
Zhou, ZN | 1 |
Xu, P | 1 |
Wang, J | 1 |
Kodavatiganti, R | 1 |
Zeng, Y | 1 |
Kass, IS | 1 |
Rorabaugh, BR | 1 |
Ross, SA | 1 |
Gaivin, RJ | 1 |
Papay, RS | 1 |
McCune, DF | 1 |
Simpson, PC | 1 |
Perez, DM | 1 |
Hatanaka, K | 1 |
Kawata, H | 1 |
Toyofuku, T | 1 |
Yoshida, K | 1 |
Ritchie, RH | 1 |
Gordon, JM | 1 |
Woodman, OL | 1 |
Cao, AH | 1 |
Dusting, GJ | 1 |
Bae, S | 1 |
Zhang, L | 1 |
Kubal, C | 1 |
Sheth, K | 1 |
Nadal-Ginard, B | 1 |
Takahashi, Y | 1 |
Takemura, S | 1 |
Minamiyama, Y | 1 |
Shibata, T | 1 |
Hirai, H | 1 |
Sasaki, Y | 1 |
Sakaguchi, M | 1 |
Suehiro, S | 1 |
Baxter, GF | 1 |
Goma, FM | 1 |
Yellon, DM | 3 |
Speechly-Dick, ME | 2 |
Grover, GJ | 1 |
Liu, Y | 1 |
Cohen, MV | 3 |
Downey, JM | 3 |
Bugge, E | 1 |
Ytrehus, K | 1 |
Mocanu, MM | 1 |
Rehring, TF | 1 |
Friese, RS | 1 |
Cleveland, JC | 2 |
Meng, X | 1 |
Robertson, FG | 1 |
Harken, AH | 2 |
Bannerjee, A | 1 |
Moolman, JA | 1 |
Genade, S | 1 |
Tromp, E | 1 |
Lochner, A | 1 |
Meldrum, DR | 1 |
Mitchell, MB | 1 |
Sheridan, BC | 1 |
Gamboni-Robertson, F | 1 |
Banerjee, A | 1 |
Cope, DK | 1 |
Impastato, WK | 1 |
Armstrong, SC | 1 |
Hoover, DB | 1 |
Shivell, LC | 1 |
Ganote, CE | 1 |
Kremastinos, DT | 1 |
Rohs, TJ | 1 |
Kilgore, KS | 1 |
Georges, AJ | 1 |
Bolling, SF | 1 |
Miyawaki, H | 1 |
Wang, Y | 3 |
Ashraf, M | 2 |
Miki, T | 1 |
Diaz, RJ | 1 |
Losito, VA | 1 |
Mao, GD | 1 |
Ford, MK | 1 |
Backx, PH | 1 |
Wilson, GJ | 1 |
Ping, P | 2 |
Zhang, J | 2 |
Cao, X | 2 |
Li, RC | 2 |
Kong, D | 1 |
Tang, XL | 2 |
Qiu, Y | 2 |
Manchikalapudi, S | 1 |
Auchampach, JA | 1 |
Black, RG | 1 |
Bolli, R | 2 |
Lundmark, JL | 1 |
Ramasamy, R | 1 |
Vulliet, PR | 1 |
Schaefer, S | 1 |
Vinokurov, AA | 1 |
Boldyrev, AA | 1 |
Chesnokov, DN | 1 |
Dmitrashchuk, AI | 1 |
Alabovskiĭ, VV | 1 |
Huang, S | 1 |
Zheng, YT | 1 |
Clerk, A | 1 |
Sugden, P | 1 |
Han, J | 1 |
Falck, G | 1 |
Schjott, J | 1 |
Jynge, P | 1 |
Maczewski, M | 1 |
Beresewicz, A | 1 |
Rakhit, RD | 1 |
Edwards, RJ | 1 |
Mockridge, JW | 1 |
Baydoun, AR | 1 |
Wyatt, AW | 1 |
Mann, GE | 1 |
Marber, MS | 1 |
Ito, K | 1 |
Shigematsu, S | 1 |
Sato, T | 1 |
Abe, T | 1 |
Li, Y | 1 |
Arita, M | 1 |
Fryer, RM | 1 |
Hsu, AK | 1 |
Gross, GJ | 1 |
Munakata, M | 1 |
Stamm, C | 1 |
Friehs, I | 1 |
Zurakowski, D | 1 |
Cowan, DB | 1 |
Cao-Danh, H | 1 |
McGowan, FX | 1 |
del Nido, PJ | 1 |
Jin, ZQ | 1 |
Zhou, HZ | 2 |
Zhu, P | 1 |
Honbo, N | 1 |
Mochly-Rosen, D | 1 |
Messing, RO | 1 |
Goetzl, EJ | 1 |
Karliner, JS | 2 |
Gray, MO | 2 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
The Effect of Eplerenone on Ischemia Reperfusion Injury in Human Myocardium (EPLICARD Study)[NCT02118753] | 24 participants (Actual) | Interventional | 2014-03-31 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
1 review available for chelerythrine and Myocardial Ischemia
Article | Year |
---|---|
Ischemic preconditioning of the heart.
Topics: Adenosine; Alkaloids; Animals; Benzophenanthridines; Cardiovascular Agents; Drug Therapy, Combinatio | 1997 |
50 other studies available for chelerythrine and Myocardial Ischemia
Article | Year |
---|---|
Exercise preconditioning-induced early and late phase of cardioprotection is associated with protein kinase C epsilon translocation.
Topics: Animals; Antineoplastic Agents; Benzophenanthridines; Cytoplasm; Enzyme Activation; Male; Myocardial | 2014 |
Exercise preconditioning-induced late phase of cardioprotection against exhaustive exercise: possible role of protein kinase C delta.
Topics: Animals; Benzophenanthridines; Cardiotonic Agents; Heart Ventricles; Male; Myocardial Ischemia; Myoc | 2014 |
N-oleoyldopamine, a novel endogenous capsaicin-like lipid, protects the heart against ischemia-reperfusion injury via activation of TRPV1.
Topics: Animals; Benzophenanthridines; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Rece | 2008 |
Delayed anti-arrhythmic effect of nitroglycerin in anesthetized rats: involvement of CGRP, PKC and mK ATP channels.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzophenanthridines; Calcitonin | 2009 |
Nitric oxide induces heat shock protein 72 production and delayed protection against myocardial ischemia in rabbits via activating protein kinase C.
Topics: Animals; Benzophenanthridines; Cyclic GMP; Hemodynamics; HSP72 Heat-Shock Proteins; Male; Myocardial | 2008 |
PKC-permitted elevation of sarcolemmal KATP concentration may explain female-specific resistance to myocardial infarction.
Topics: Animals; ATP-Binding Cassette Transporters; Benzophenanthridines; Blotting, Western; Coronary Circul | 2009 |
Exercise preconditioning initiates late cardioprotection against isoproterenol-induced myocardial injury in rats independent of protein kinase C.
Topics: Animals; Benzophenanthridines; Isoproterenol; Male; Microscopy, Electron, Transmission; Myocardial I | 2011 |
[The study of effects and mechanism of U50, 488H on electrical coupling during ischemia in the perfused isolated rat heart].
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; B | 2010 |
Exercise preconditioning provides early cardioprotection against exhaustive exercise in rats: potential involvement of protein kinase C delta translocation.
Topics: Animals; Antineoplastic Agents; Benzophenanthridines; Enzyme Activation; Male; Muscle Proteins; Myoc | 2012 |
Intestinal ischemia preconditions myocardium: role of protein kinase C and mitochondrial K(ATP) channel.
Topics: Alkaloids; Analysis of Variance; Animals; Benzophenanthridines; Blood Pressure; Decanoic Acids; Enzy | 2002 |
Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy.
Topics: Alkaloids; Animals; Apoptosis; Benzophenanthridines; Cardiomegaly; Cardiomyopathy, Dilated; Caspase | 2003 |
Various inotropic effects of angiotensin II in post-ischaemic rat hearts depending on ischaemic time with possible involvement of protein kinase C.
Topics: Alkaloids; Angiotensin II; Animals; Benzophenanthridines; Blood Pressure; Cardiotonic Agents; Heart; | 2003 |
Preischemic infusion of alpha-human atrial natriuretic peptide elicits myoprotective effects against ischemia reperfusion in isolated rat hearts.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Atrial Natriuretic Factor; Benzophenanthridines; Cyclic | 2003 |
Delayed preconditioning of the human myocardium: signal transduction and clinical implications.
Topics: Acetylcholine; Aged; Alkaloids; Anisomycin; Antihypertensive Agents; Benzophenanthridines; Culture T | 2004 |
Regulation of proangiogenic factor CCN1 in cardiac muscle: impact of ischemia, pressure overload, and neurohumoral activation.
Topics: Alkaloids; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoat | 2004 |
Intermittent hypoxia protects the rat heart against ischemia/reperfusion injury by activating protein kinase C.
Topics: Alkaloids; Animals; Benzophenanthridines; Calcium; Cells, Cultured; Coronary Circulation; Heart Vent | 2004 |
Activation of protein kinase C contributes to the isoflurane-induced improvement of functional and metabolic recovery in isolated ischemic rat hearts.
Topics: Adenosine Triphosphate; Alkaloids; Anesthetics, Inhalation; Animals; Benzophenanthridines; Energy Me | 2004 |
alpha1A- but not alpha1B-adrenergic receptors precondition the ischemic heart by a staurosporine-sensitive, chelerythrine-insensitive mechanism.
Topics: Alkaloids; Animals; Benzophenanthridines; Enzyme Inhibitors; Female; Ischemic Preconditioning, Myoca | 2005 |
Down-regulation of connexin43 in early myocardial ischemia and protective effect by ischemic preconditioning in rat hearts in vivo.
Topics: Alkaloids; Animals; Benzophenanthridines; Blotting, Northern; Connexin 43; Down-Regulation; Immunohi | 2004 |
Annexin-1 peptide Anx-1(2-26) protects adult rat cardiac myocytes from cellular injury induced by simulated ischaemia.
Topics: Alkaloids; Analysis of Variance; Animals; Annexin A1; Benzophenanthridines; Cells, Cultured; Creatin | 2005 |
Gender differences in cardioprotection against ischemia/reperfusion injury in adult rat hearts: focus on Akt and protein kinase C signaling.
Topics: Alkaloids; Androstadienes; Animals; Benzophenanthridines; Blotting, Western; Enzyme Activation; Fema | 2005 |
Bone marrow cells have a potent anti-ischemic effect against myocardial cell death in humans.
Topics: Alkaloids; Apoptosis; Benzophenanthridines; Bone Marrow Cells; Cell Death; Heart; Heart Atria; Human | 2006 |
Landiolol has cardioprotective effects against reperfusion injury in the rat heart via the PKCepsilon signaling pathway.
Topics: Adrenergic beta-Antagonists; Alkaloids; Animals; Benzophenanthridines; Cardiotonic Agents; Glyburide | 2007 |
Involvement of protein kinase C in the delayed cytoprotection following sublethal ischaemia in rabbit myocardium.
Topics: Alkaloids; Analysis of Variance; Animals; Benzophenanthridines; Blood Pressure; Cadmium; Cadmium Com | 1995 |
Does ischemic preconditioning in the human involve protein kinase C and the ATP-dependent K+ channel? Studies of contractile function after simulated ischemia in an atrial in vitro model.
Topics: Adenosine Triphosphate; Adult; Aged; Alkaloids; Benzophenanthridines; Benzopyrans; Cromakalim; Digly | 1995 |
Chelerythrine, a highly selective protein kinase C inhibitor, blocks the anti-infarct effect of ischemic preconditioning in rabbit hearts.
Topics: Alkaloids; Animals; Benzophenanthridines; Female; Male; Myocardial Infarction; Myocardial Ischemia; | 1994 |
Ischaemic preconditioning is protein kinase C dependent but not through stimulation of alpha adrenergic or adenosine receptors in the isolated rat heart.
Topics: Alkaloids; Animals; Benzophenanthridines; In Vitro Techniques; Male; Myocardial Infarction; Myocardi | 1995 |
Protein kinase C. Its role in ischemic preconditioning in the rat.
Topics: Alkaloids; Analysis of Variance; Animals; Arrhythmias, Cardiac; Benzophenanthridines; Blood Pressure | 1994 |
Alpha-adrenergic preservation of myocardial pH during ischemia is PKC isoform dependent.
Topics: Alkaloids; Analysis of Variance; Animals; Benzophenanthridines; Calcium; Diglycerides; Enzyme Inhibi | 1996 |
No evidence for mediation of ischemic preconditioning by alpha 1-adrenergic signal transduction pathway or protein kinase C in the isolated rat heart.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Alkaloids; Animals; Benzophenanthridines; Card | 1996 |
Protein kinase C mediates Ca2(+)-induced cardioadaptation to ischemia-reperfusion injury.
Topics: Adaptation, Physiological; Alkaloids; Animals; Benzophenanthridines; Biological Transport; Calcium; | 1996 |
Volatile anesthetics protect the ischemic rabbit myocardium from infarction.
Topics: Adenosine; Alkaloids; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Benzophenanthridin | 1997 |
Preconditioning of isolated rabbit cardiomyocytes: no evident separation of induction, memory and protection.
Topics: Adenosine; Alkaloids; Animals; Benzophenanthridines; Cardiovascular Agents; Cells, Cultured; Enzyme | 1997 |
Postischemic function and protein kinase C signal transduction.
Topics: Acetylcholine; Alkaloids; Animals; Benzophenanthridines; Bicarbonates; Calcium Chloride; Cardioplegi | 1998 |
Oxidant stress with hydrogen peroxide attenuates calcium paradox injury: role of protein kinase C and ATP-sensitive potassium channel.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Anti-Arrhythmia Agents; Benzophenanthridines; Calcium; C | 1998 |
Opioid receptor contributes to ischemic preconditioning through protein kinase C activation in rabbits.
Topics: Alkaloids; Animals; Benzophenanthridines; Enzyme Activation; Enzyme Inhibitors; Female; In Vitro Tec | 1998 |
Chloride channel inhibition blocks the protection of ischemic preconditioning and hypo-osmotic stress in rabbit ventricular myocardium.
Topics: Alkaloids; Animals; Benzophenanthridines; Cells, Cultured; Chloride Channels; Electrophysiology; Enz | 1999 |
PKC-dependent activation of p44/p42 MAPKs during myocardial ischemia-reperfusion in conscious rabbits.
Topics: Alkaloids; Amino Acid Sequence; Animals; Benzophenanthridines; Calcium-Calmodulin-Dependent Protein | 1999 |
Role of protein kinase C in mitochondrial KATP channel-mediated protection against Ca2+ overload injury in rat myocardium.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Benzophenanthridines; Calcium; Calcium Channel Blockers; | 1999 |
Chelerythrine increases Na-K-ATPase activity and limits ischemic injury in isolated rat hearts.
Topics: Alkaloids; Animals; Benzophenanthridines; Enzyme Activation; Enzyme Inhibitors; Male; Myocardial Isc | 1999 |
[Protein kinase C inhibitors block contractions of the ischemic myocardium caused by acetylcarnosine].
Topics: Adenine Nucleotides; Alkaloids; Animals; Benzophenanthridines; Carnosine; Enzyme Inhibitors; Indoles | 1999 |
PKC-dependent activation of p46/p54 JNKs during ischemic preconditioning in conscious rabbits.
Topics: Alkaloids; Animals; Benzophenanthridines; Enzyme Activation; Enzyme Inhibitors; Ischemic Preconditio | 1999 |
Hyperosmotic pretreatment reduces infarct size in the rat heart.
Topics: Alkaloids; Animals; Benzophenanthridines; Fluorescent Dyes; Gadolinium; Guanidines; In Vitro Techniq | 1999 |
The role of endothelin, protein kinase C and free radicals in the mechanism of the post-ischemic endothelial dysfunction in guinea-pig hearts.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Alkaloids; Angiotensin-Converting Enzyme Inhibitors; An | 2000 |
Nitric oxide-induced cardioprotection in cultured rat ventricular myocytes.
Topics: Alkaloids; Animals; Animals, Newborn; Anti-Infective Agents; Benzophenanthridines; Cells, Cultured; | 2000 |
JTV-519, a novel cardioprotective agent, improves the contractile recovery after ischaemia-reperfusion in coronary perfused guinea-pig ventricular muscles.
Topics: Action Potentials; Adenosine Triphosphate; Alkaloids; Animals; Benzophenanthridines; Calcium Channel | 2000 |
Essential activation of PKC-delta in opioid-initiated cardioprotection.
Topics: Acetophenones; Alkaloids; Analgesics; Animals; Benzophenanthridines; Benzopyrans; Benzylidene Compou | 2001 |
Protective effects of protein kinase C during myocardial ischemia require activation of phosphatidyl-inositol specific phospholipase C.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Benzophenanthridines; Blotting, Western; Calcium; Corona | 2002 |
Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts.
Topics: Alkaloids; Animals; Animals, Newborn; Benzophenanthridines; Blotting, Western; Cells, Cultured; Crea | 2002 |
Moderate alcohol consumption induces sustained cardiac protection by activating PKC-epsilon and Akt.
Topics: Alkaloids; Animals; Benzophenanthridines; Body Weight; Creatine Kinase; Enzyme Activation; Enzyme In | 2002 |