chelerythrine has been researched along with Myocardial Infarction in 51 studies
chelerythrine : A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae.
Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
Excerpt | Relevance | Reference |
---|---|---|
"Previous results from our laboratory have suggested that morphine can attenuate neutrophil activation in patients with acute myocardial infarction." | 7.70 | Morphine preconditioning attenuates neutrophil activation in rat models of myocardial infarction. ( Chang, H; Hung, CR; Tseng, YZ; Wang, TL, 1998) |
" Preconditioning with 10 microM adenosine limited necrosis (10." | 3.72 | Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effects. ( Headrick, JP; Peart, J, 2003) |
"Previous results from our laboratory have suggested that morphine can attenuate neutrophil activation in patients with acute myocardial infarction." | 3.70 | Morphine preconditioning attenuates neutrophil activation in rat models of myocardial infarction. ( Chang, H; Hung, CR; Tseng, YZ; Wang, TL, 1998) |
"In chelerythrine-treated hearts, however, alternate mechanisms appear to maintain cardiac function." | 1.46 | Angiotensin II-preconditioning is associated with increased PKCε/PKCδ ratio and prosurvival kinases in mitochondria. ( Escobales, N; Javadov, S; Nuñez, RE, 2017) |
"Wortmannin treatment increased apoptosis in the remote myocardium both at baseline and after MI, together with an activation of the PKC-δ/p38-MAPK-pathway." | 1.39 | Inhibition of anti-apoptotic signals by Wortmannin induces apoptosis in the remote myocardium after LAD ligation: evidence for a protein kinase C-δ-dependent pathway. ( Ebner, B; Jercke, M; Joachim, D; Schwarz, K; Simonis, G; Strasser, RH; Wessela, T; Wiedemann, S, 2013) |
"Pretreatment with Zaprinast neither induced HSP72 expression nor reduced infarct size ((55." | 1.35 | Nitric oxide induces heat shock protein 72 production and delayed protection against myocardial ischemia in rabbits via activating protein kinase C. ( Guo, WY; Hori, M; Jia, GL; Kitakaze, M; Li, F; Li, WJ; Liu, B; Wang, HC; Zhang, DX; Zhao, ZJ, 2008) |
"Treatment with chelerythrine alone or the PKCepsilon antagonist KIE1-1 alone at reperfusion had no effect on infarct size compared to control." | 1.33 | Infarct-sparing effect of myocardial postconditioning is dependent on protein kinase C signalling. ( Guyton, RA; Jiang, R; Kin, H; Lee, G; Lust, R; Mykytenko, J; Reeves, JG; Vinten-Johansen, J; Wang, N; Zatta, AJ; Zhao, ZQ, 2006) |
"Chelerythrine pretreatment alone did not have any effect on infarct size (I/R 51." | 1.31 | Exercise directly enhances myocardial tolerance to ischaemia-reperfusion injury in the rat through a protein kinase C mediated mechanism. ( Baxter, GF; Yamashita, N; Yellon, DM, 2001) |
"Pretreatment with chelerythrine alone (group IV, n = 5) did not alter stunning." | 1.30 | Nitroglycerin induces late preconditioning against myocardial stunning via a PKC-dependent pathway. ( Banerjee, S; Bolli, R; Dawn, B; Manchikalapudi, S; Qiu, Y; Shirk, G; Takano, H; Tang, XL, 1999) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 16 (31.37) | 18.2507 |
2000's | 31 (60.78) | 29.6817 |
2010's | 4 (7.84) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Nuñez, RE | 1 |
Javadov, S | 1 |
Escobales, N | 1 |
Gao, Q | 1 |
Hu, J | 2 |
Yu, Y | 1 |
Ye, H | 1 |
Li, Z | 1 |
Guan, S | 1 |
Baharvand, B | 1 |
Dehaj, ME | 1 |
Rasoulian, B | 1 |
Namdari, M | 1 |
Shikhani, Y | 1 |
Kiani, AA | 1 |
Li, WJ | 1 |
Zhao, ZJ | 1 |
Liu, B | 1 |
Zhang, DX | 1 |
Li, F | 1 |
Wang, HC | 1 |
Guo, WY | 1 |
Jia, GL | 1 |
Kitakaze, M | 1 |
Hori, M | 1 |
Edwards, AG | 1 |
Rees, ML | 1 |
Gioscia, RA | 1 |
Zachman, DK | 1 |
Lynch, JM | 1 |
Browder, JC | 1 |
Chicco, AJ | 1 |
Moore, RL | 1 |
Zhou, W | 1 |
Ko, Y | 1 |
Benharash, P | 1 |
Yamakawa, K | 1 |
Patel, S | 1 |
Ajijola, OA | 1 |
Mahajan, A | 1 |
Wiedemann, S | 2 |
Wessela, T | 1 |
Schwarz, K | 2 |
Joachim, D | 1 |
Jercke, M | 1 |
Strasser, RH | 2 |
Ebner, B | 1 |
Simonis, G | 2 |
Wolfrum, S | 1 |
Schneider, K | 1 |
Heidbreder, M | 2 |
Nienstedt, J | 1 |
Dominiak, P | 2 |
Dendorfer, A | 2 |
Shimizu, Y | 1 |
Minatoguchi, S | 1 |
Hashimoto, K | 1 |
Uno, Y | 1 |
Arai, M | 1 |
Wang, N | 2 |
Chen, X | 2 |
Lu, C | 1 |
Takemura, G | 1 |
Shimomura, M | 1 |
Fujiwara, T | 1 |
Fujiwara, H | 1 |
Zhao, TC | 1 |
Kukreja, RC | 2 |
Peart, J | 1 |
Headrick, JP | 1 |
Przyklenk, K | 2 |
Li, G | 1 |
Simkhovich, BZ | 1 |
Kloner, RA | 1 |
Okubo, S | 1 |
Tanabe, Y | 1 |
Fujioka, N | 1 |
Takeda, K | 1 |
Takekoshi, N | 1 |
Das, A | 1 |
Ockaili, R | 1 |
Salloum, F | 1 |
Hilfiker-Kleiner, D | 1 |
Kaminski, K | 1 |
Kaminska, A | 1 |
Fuchs, M | 1 |
Klein, G | 1 |
Podewski, E | 1 |
Grote, K | 1 |
Kiian, I | 1 |
Wollert, KC | 1 |
Hilfiker, A | 1 |
Drexler, H | 1 |
Hellwig-Bürgel, T | 1 |
Jöhren, O | 1 |
Qadri, F | 1 |
Zhang, Y | 1 |
Chen, ZW | 1 |
Girwin, M | 1 |
Wong, TM | 1 |
Hanlon, PR | 1 |
Fu, P | 1 |
Wright, GL | 1 |
Steenbergen, C | 1 |
Arcasoy, MO | 1 |
Murphy, E | 1 |
Bae, S | 1 |
Zhang, L | 1 |
Maynard, M | 1 |
Whittaker, P | 1 |
Bell, RM | 1 |
Cave, AC | 1 |
Johar, S | 1 |
Hearse, DJ | 1 |
Shah, AM | 1 |
Shattock, MJ | 1 |
Zatta, AJ | 1 |
Kin, H | 1 |
Lee, G | 1 |
Jiang, R | 1 |
Lust, R | 1 |
Reeves, JG | 1 |
Mykytenko, J | 1 |
Guyton, RA | 1 |
Zhao, ZQ | 1 |
Vinten-Johansen, J | 1 |
Philipp, S | 2 |
Yang, XM | 4 |
Cui, L | 2 |
Davis, AM | 1 |
Downey, JM | 9 |
Cohen, MV | 9 |
Sovershaev, MA | 1 |
Egorina, EM | 1 |
Andreasen, TV | 1 |
Jonassen, AK | 1 |
Ytrehus, K | 3 |
Serejo, FC | 1 |
Rodrigues, LF | 1 |
da Silva Tavares, KC | 1 |
de Carvalho, AC | 1 |
Nascimento, JH | 1 |
Hausenloy, DJ | 1 |
Wynne, AM | 1 |
Yellon, DM | 4 |
Kuno, A | 1 |
Critz, SD | 2 |
Solodushko, V | 1 |
Krahn, T | 1 |
Albrecht, B | 1 |
Hu, Y | 1 |
Pan, TT | 1 |
Neo, KL | 1 |
Lee, SW | 1 |
Khin, ES | 1 |
Moore, PK | 1 |
Bian, JS | 1 |
Christ, T | 1 |
Sedding, DG | 1 |
Yu, X | 1 |
Marquetant, R | 1 |
Braun-Dullaeus, RC | 1 |
Ravens, U | 1 |
Liu, Y | 1 |
Bugge, E | 2 |
Speechly-Dick, ME | 1 |
Mocanu, MM | 1 |
Wang, P | 1 |
Gallagher, KP | 1 |
Joyeux, M | 1 |
Baxter, GF | 2 |
Thomas, DL | 1 |
Ribuot, C | 1 |
Lasley, RD | 1 |
Noble, MA | 1 |
Mentzer, RM | 1 |
Baines, CP | 2 |
Wang, L | 1 |
Miki, T | 1 |
Wang, TL | 1 |
Chang, H | 1 |
Hung, CR | 1 |
Tseng, YZ | 1 |
Zacharowski, K | 1 |
Olbrich, A | 1 |
Thiemermann, C | 1 |
Ping, P | 1 |
Takano, H | 2 |
Zhang, J | 1 |
Tang, XL | 2 |
Qiu, Y | 2 |
Li, RC | 1 |
Banerjee, S | 2 |
Dawn, B | 2 |
Balafonova, Z | 1 |
Bolli, R | 2 |
Fryer, RM | 3 |
Schultz, JE | 1 |
Hsu, AK | 3 |
Gross, GJ | 3 |
Diaz, RJ | 1 |
Losito, VA | 1 |
Mao, GD | 1 |
Ford, MK | 1 |
Backx, PH | 1 |
Wilson, GJ | 1 |
Manchikalapudi, S | 1 |
Shirk, G | 1 |
Falck, G | 1 |
Schjott, J | 1 |
Jynge, P | 1 |
Pain, T | 1 |
Yue, Y | 1 |
Nakano, A | 1 |
Liu, GS | 1 |
Heusch, G | 2 |
Wang, Y | 2 |
Yamashita, N | 1 |
Krenz, M | 1 |
Henry, M | 1 |
Eells, J | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Randomised Controlled Trial of the Effect of Remote Ischaemic Conditioning on Coronary Endothelial Function in Patients With Angina.[NCT02666235] | Phase 2 | 60 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
Sodium Bicarbonate to Treat Severe Acidosis in the Critically Ill : A Multiple Center Randomized Clinical Trial (BICAR-ICU)[NCT02476253] | Phase 3 | 400 participants (Anticipated) | Interventional | 2015-05-05 | Recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
51 other studies available for chelerythrine and Myocardial Infarction
Article | Year |
---|---|
Angiotensin II-preconditioning is associated with increased PKCε/PKCδ ratio and prosurvival kinases in mitochondria.
Topics: Angiotensin II; Animals; Benzophenanthridines; In Vitro Techniques; Ischemic Preconditioning, Myocar | 2017 |
Calcium activated potassium channel and protein kinase C participate in the cardiac protection of remote post conditioning.
Topics: Animals; Arrhythmias, Cardiac; Benzophenanthridines; Disease Models, Animal; Enzyme Activation; Femo | 2013 |
Delayed anti-arrhythmic effect of nitroglycerin in anesthetized rats: involvement of CGRP, PKC and mK ATP channels.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzophenanthridines; Calcitonin | 2009 |
Nitric oxide induces heat shock protein 72 production and delayed protection against myocardial ischemia in rabbits via activating protein kinase C.
Topics: Animals; Benzophenanthridines; Cyclic GMP; Hemodynamics; HSP72 Heat-Shock Proteins; Male; Myocardial | 2008 |
PKC-permitted elevation of sarcolemmal KATP concentration may explain female-specific resistance to myocardial infarction.
Topics: Animals; ATP-Binding Cassette Transporters; Benzophenanthridines; Blotting, Western; Coronary Circul | 2009 |
Cardioprotection of electroacupuncture against myocardial ischemia-reperfusion injury by modulation of cardiac norepinephrine release.
Topics: Animals; Arrhythmias, Cardiac; Benzophenanthridines; Electroacupuncture; Models, Animal; Myocardial | 2012 |
Inhibition of anti-apoptotic signals by Wortmannin induces apoptosis in the remote myocardium after LAD ligation: evidence for a protein kinase C-δ-dependent pathway.
Topics: Androstadienes; Animals; Apoptosis; Atrial Natriuretic Factor; Benzophenanthridines; Biphenyl Compou | 2013 |
Remote preconditioning protects the heart by activating myocardial PKCepsilon-isoform.
Topics: Adrenergic beta-Antagonists; Alkaloids; Animals; Benzophenanthridines; Bradykinin; Enzyme Activation | 2002 |
The role of serotonin in ischemic cellular damage and the infarct size-reducing effect of sarpogrelate, a 5-hydroxytryptamine-2 receptor blocker, in rabbit hearts.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Benzophenanthridines; Decanoic Acids; Disease Models, An | 2002 |
Protein kinase C-delta mediates adenosine A3 receptor-induced delayed cardioprotection in mouse.
Topics: Adenosine; Alkaloids; Animals; Benzophenanthridines; Blotting, Western; Cell Nucleus; Cytosol; Dihyd | 2003 |
Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effects.
Topics: Adenosine; Adenosine Diphosphate; Alkaloids; Animals; Benzophenanthridines; Calcium Channel Blockers | 2003 |
Mechanisms of myocardial ischemic preconditioning are age related: PKC-epsilon does not play a requisite role in old rabbits.
Topics: Aging; Alkaloids; Animals; Benzophenanthridines; Blotting, Western; Enzyme Inhibitors; Female; Hemod | 2003 |
Differential activation of protein kinase C between ischemic and pharmacological preconditioning in the rabbit heart.
Topics: Alkaloids; Animals; Benzophenanthridines; Cardiotonic Agents; Conditioning, Psychological; Diazoxide | 2003 |
Protein kinase C plays an essential role in sildenafil-induced cardioprotection in rabbits.
Topics: Alkaloids; Animals; Benzophenanthridines; Cytosol; Enzyme Inhibitors; Hemodynamics; Isoenzymes; Male | 2004 |
Regulation of proangiogenic factor CCN1 in cardiac muscle: impact of ischemia, pressure overload, and neurohumoral activation.
Topics: Alkaloids; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoat | 2004 |
Deferoxamine induces prolonged cardiac preconditioning via accumulation of oxygen radicals.
Topics: Aldehyde Reductase; Alkaloids; Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Basic Helix- | 2005 |
Remifentanil mimics cardioprotective effect of ischemic preconditioning via protein kinase C activation in open chest of rats.
Topics: Alkaloids; Animals; Benzophenanthridines; Cardiotonic Agents; Hemodynamics; Indoles; Ischemic Precon | 2005 |
Mechanisms of erythropoietin-mediated cardioprotection during ischemia-reperfusion injury: role of protein kinase C and phosphatidylinositol 3-kinase signaling.
Topics: Alkaloids; Androstadienes; Animals; Benzophenanthridines; Chromones; Erythropoietin; Extracellular S | 2005 |
Gender differences in cardioprotection against ischemia/reperfusion injury in adult rat hearts: focus on Akt and protein kinase C signaling.
Topics: Alkaloids; Androstadienes; Animals; Benzophenanthridines; Blotting, Western; Enzyme Activation; Fema | 2005 |
Reduction of infarct size with D-myo-inositol trisphosphate: role of PI3-kinase and mitochondrial K(ATP) channels.
Topics: Alkaloids; Animals; Benzamides; Benzophenanthridines; Cardiotonic Agents; Chromones; Decanoic Acids; | 2006 |
Pivotal role of NOX-2-containing NADPH oxidase in early ischemic preconditioning.
Topics: Acridines; Alkaloids; Animals; Benzophenanthridines; Coloring Agents; Heart; Ischemia; Ischemic Prec | 2005 |
Infarct-sparing effect of myocardial postconditioning is dependent on protein kinase C signalling.
Topics: Acetophenones; Alkaloids; Animals; Benzophenanthridines; Benzopyrans; Blotting, Western; Cytosol; Ma | 2006 |
Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade.
Topics: Acetamides; Adenosine; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Alkaloi | 2006 |
Preconditioning by 17beta-estradiol in isolated rat heart depends on PI3-K/PKB pathway, PKC, and ROS.
Topics: Alkaloids; Androstadienes; Animals; Benzophenanthridines; Dose-Response Relationship, Drug; Enzyme I | 2006 |
The pH hypothesis of postconditioning: staccato reperfusion reintroduces oxygen and perpetuates myocardial acidosis.
Topics: Acidosis; Alkaloids; Animals; Apoptosis; Benzophenanthridines; Buffers; Carbon Dioxide; Catheterizat | 2007 |
Cardioprotective properties of humoral factors released from rat hearts subject to ischemic preconditioning.
Topics: Alkaloids; Analysis of Variance; Animals; Benzophenanthridines; Cardiotonic Agents; Coronary Circula | 2007 |
Ischemic preconditioning targets the reperfusion phase.
Topics: Alkaloids; Animals; Antineoplastic Agents; Benzophenanthridines; In Vitro Techniques; Ischemic Preco | 2007 |
Protein kinase C protects preconditioned rabbit hearts by increasing sensitivity of adenosine A2b-dependent signaling during early reperfusion.
Topics: Acetamides; Adenosine A2 Receptor Agonists; Adenosine-5'-(N-ethylcarboxamide); Alkaloids; Aminopyrid | 2007 |
Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways.
Topics: Animals; Benzophenanthridines; Cardiotonic Agents; Cell Survival; Chromones; Disease Models, Animal; | 2008 |
Chelerythrine treatment influences the balance of pro- and anti-apoptotic signaling pathways in the remote myocardium after infarction.
Topics: Animals; Apoptosis; Apoptosis Inducing Factor; Atrial Natriuretic Factor; bcl-Associated Death Prote | 2008 |
Chelerythrine, a highly selective protein kinase C inhibitor, blocks the anti-infarct effect of ischemic preconditioning in rabbit hearts.
Topics: Alkaloids; Animals; Benzophenanthridines; Female; Male; Myocardial Infarction; Myocardial Ischemia; | 1994 |
Ischaemic preconditioning is protein kinase C dependent but not through stimulation of alpha adrenergic or adenosine receptors in the isolated rat heart.
Topics: Alkaloids; Animals; Benzophenanthridines; In Vitro Techniques; Male; Myocardial Infarction; Myocardi | 1995 |
Protein kinase C. Its role in ischemic preconditioning in the rat.
Topics: Alkaloids; Analysis of Variance; Animals; Arrhythmias, Cardiac; Benzophenanthridines; Blood Pressure | 1994 |
Endothelin-1 can reduce infarct size through protein kinase C and KATP channels in the isolated rat heart.
Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Benzophenanthridines; Bosentan; Coronary Circulation; De | 1996 |
Pretreatment with endothelin-1 mimics ischemic preconditioning against infarction in isolated rabbit heart.
Topics: Alkaloids; Animals; Benzophenanthridines; Coronary Vessels; Dioxoles; Endothelin Receptor Antagonist | 1996 |
Protein kinase C is involved in resistance to myocardial infarction induced by heat stress.
Topics: Alkaloids; Animals; Benzophenanthridines; Enzyme Activation; Enzyme Inhibitors; Genistein; Heart; He | 1997 |
Effects of protein kinase C inhibitors in in situ and isolated ischemic rabbit myocardium.
Topics: Alkaloids; Animals; Benzophenanthridines; Enzyme Inhibitors; Female; In Vitro Techniques; Indoles; I | 1997 |
Protein tyrosine kinase is downstream of protein kinase C for ischemic preconditioning's anti-infarct effect in the rabbit heart.
Topics: Alkaloids; Animals; Anisomycin; Benzophenanthridines; Enzyme Activation; Enzyme Inhibitors; Female; | 1998 |
Opioid receptor contributes to ischemic preconditioning through protein kinase C activation in rabbits.
Topics: Alkaloids; Animals; Benzophenanthridines; Enzyme Activation; Enzyme Inhibitors; Female; In Vitro Tec | 1998 |
Morphine preconditioning attenuates neutrophil activation in rat models of myocardial infarction.
Topics: Alkaloids; Animals; Benzophenanthridines; Glyburide; Glycopeptides; Hypoglycemic Agents; Intercellul | 1998 |
Reduction of myocardial injury by the EP3 receptor agonist TEI-3356. Role of protein kinase C and of K(ATP)-channels.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Anti-Arrhythmia Agents; Benzophenanthridines; Decanoic A | 1999 |
Isoform-selective activation of protein kinase C by nitric oxide in the heart of conscious rabbits: a signaling mechanism for both nitric oxide-induced and ischemia-induced preconditioning.
Topics: Alkaloids; Animals; Benzophenanthridines; Enzyme Activation; Enzyme Inhibitors; Hemodynamics; Ischem | 1999 |
Importance of PKC and tyrosine kinase in single or multiple cycles of preconditioning in rat hearts.
Topics: Alkaloids; Animals; Benzophenanthridines; Drug Combinations; Enzyme Inhibitors; Genistein; Heart; He | 1999 |
Chloride channel inhibition blocks the protection of ischemic preconditioning and hypo-osmotic stress in rabbit ventricular myocardium.
Topics: Alkaloids; Animals; Benzophenanthridines; Cells, Cultured; Chloride Channels; Electrophysiology; Enz | 1999 |
Nitroglycerin induces late preconditioning against myocardial stunning via a PKC-dependent pathway.
Topics: Alkaloids; Animals; Benzophenanthridines; Cardiotonic Agents; Enzyme Inhibitors; Ischemic Preconditi | 1999 |
Hyperosmotic pretreatment reduces infarct size in the rat heart.
Topics: Alkaloids; Animals; Benzophenanthridines; Fluorescent Dyes; Gadolinium; Guanidines; In Vitro Techniq | 1999 |
Opening of mitochondrial K(ATP) channels triggers the preconditioned state by generating free radicals.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Benzophenanthridines; Blotting, Western; Decanoic Acids; | 2000 |
Essential activation of PKC-delta in opioid-initiated cardioprotection.
Topics: Acetophenones; Alkaloids; Analgesics; Animals; Benzophenanthridines; Benzopyrans; Benzylidene Compou | 2001 |
Exercise directly enhances myocardial tolerance to ischaemia-reperfusion injury in the rat through a protein kinase C mediated mechanism.
Topics: Alkaloids; Animals; Benzophenanthridines; Hemodynamics; Myocardial Infarction; Myocardial Reperfusio | 2001 |
Acute alcohol-induced protection against infarction in rabbit hearts: differences from and similarities to ischemic preconditioning.
Topics: Adenosine Triphosphate; Alcohols; Alkaloids; Analysis of Variance; Animals; Anti-Arrhythmia Agents; | 2001 |
PKC-delta inhibition does not block preconditioning-induced preservation in mitochondrial ATP synthesis and infarct size reduction in rats.
Topics: Acetophenones; Adenosine Triphosphate; Alkaloids; Animals; Benzophenanthridines; Benzopyrans; Enzyme | 2002 |