chelerythrine has been researched along with Morphine Dependence in 2 studies
chelerythrine : A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae.
Morphine Dependence: Strong dependence, both physiological and emotional, upon morphine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of morphine dependence and withdrawal, phosphorylated CREB (pCREB), corticotrophin-releasing factor (CRF) expression in the PVN and HPA axis activity were measured using immunoblotting, immunohistochemistry and radioimmunoassay in controls and in morphine-dependent rats, withdrawn with naloxone and pretreated with vehicle, calphostin C, chelerythrine (inhibitors of protein kinase C (PKC) or SL-327 [inhibitor of extracellular signal regulated kinase (ERK) kinase]." | 3.77 | Protein kinase C phosphorylates the cAMP response element binding protein in the hypothalamic paraventricular nucleus during morphine withdrawal. ( Laorden, M; Martín, F; Milanés, M; Mora, L, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Martín, F | 1 |
| Mora, L | 1 |
| Laorden, M | 1 |
| Milanés, M | 1 |
| Fundytus, ME | 1 |
| Coderre, TJ | 1 |
2 other studies available for chelerythrine and Morphine Dependence
| Article | Year |
|---|---|
Protein kinase C phosphorylates the cAMP response element binding protein in the hypothalamic paraventricular nucleus during morphine withdrawal.
Topics: Animals; Benzophenanthridines; Corticotropin-Releasing Hormone; Cyclic AMP Response Element-Binding | 2011 |
Chronic inhibition of intracellular Ca2+ release or protein kinase C activation significantly reduces the development of morphine dependence.
Topics: Alkaloids; Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Benzophenanthridines | 1996 |