chebulagic-acid and Inflammation

chebulagic-acid has been researched along with Inflammation* in 1 studies

Other Studies

1 other study(ies) available for chebulagic-acid and Inflammation

Article	Year
Chebulagic acid (CA) attenuates LPS-induced inflammation by suppressing NF-kappaB and MAPK activation in RAW 264.7 macrophages. Biochemical and biophysical research communications, 2009, Mar-27, Volume: 381, Issue:1 Chebulagic acid (CA), a natural anti-oxidant, showed potent anti-inflammatory effects in LPS-stimulated RAW 264.7, a mouse macrophage cell line. These effects were exerted via inhibition of NO and PGE2 production and down-regulation of iNOS, COX-2, 5-LOX, TNF-alpha and IL-6. CA inhibited NF-kappaB activation by LPS, and this was associated with the abrogation of IkappaB-alpha phosphorylation and subsequent decreases in nuclear p50 and p65 protein levels. Further, the phosphorylation of p38, ERK 1/2 and JNK in LPS-stimulated RAW 264.7 cells was suppressed by CA in a concentration-dependent manner. LPS-induced generation of reactive oxygen species (ROS) was also effectively inhibited by CA. These results suggest that CA exerts anti-inflammatory effects in LPS-stimulated RAW 264.7 macrophages by inhibition of NF-kappaB activation and MAP kinase phosphorylation. Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Benzopyrans; Cell Line; Cyclooxygenase 2; Glucosides; Inflammation; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinases; NADP; NF-kappa B; Nitric Oxide Synthase Type II; Phosphorylation; Reactive Oxygen Species	2009

Article

Year

Chebulagic acid (CA) attenuates LPS-induced inflammation by suppressing NF-kappaB and MAPK activation in RAW 264.7 macrophages.

Biochemical and biophysical research communications, 2009, Mar-27, Volume: 381, Issue:1

Chebulagic acid (CA), a natural anti-oxidant, showed potent anti-inflammatory effects in LPS-stimulated RAW 264.7, a mouse macrophage cell line. These effects were exerted via inhibition of NO and PGE2 production and down-regulation of iNOS, COX-2, 5-LOX, TNF-alpha and IL-6. CA inhibited NF-kappaB activation by LPS, and this was associated with the abrogation of IkappaB-alpha phosphorylation and subsequent decreases in nuclear p50 and p65 protein levels. Further, the phosphorylation of p38, ERK 1/2 and JNK in LPS-stimulated RAW 264.7 cells was suppressed by CA in a concentration-dependent manner. LPS-induced generation of reactive oxygen species (ROS) was also effectively inhibited by CA. These results suggest that CA exerts anti-inflammatory effects in LPS-stimulated RAW 264.7 macrophages by inhibition of NF-kappaB activation and MAP kinase phosphorylation.

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Benzopyrans; Cell Line; Cyclooxygenase 2; Glucosides; Inflammation; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinases; NADP; NF-kappa B; Nitric Oxide Synthase Type II; Phosphorylation; Reactive Oxygen Species

2009