Compounds > chalcone
Page last updated: 2024-08-18

chalcone and Neoplasms

chalcone has been researched along with Neoplasms in 39 studies

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.56)18.7374
1990's1 (2.56)18.2507
2000's3 (7.69)29.6817
2010's21 (53.85)24.3611
2020's13 (33.33)2.80

Authors

AuthorsStudies
Bracke, ME; De Ryck, T; Roman, BI; Stevens, CV; Verhasselt, S1
Amawi, H; Fetcenko, A; Hussein, N; Karthikeyan, C; Manivannan, E; Narayana Moorthy, NSH; Tiwari, AK; Trivedi, P1
Pi, C; Wei, Y; Ye, Y; Zhao, L; Zhao, S1
Bhandari, S; Patil, S1
Aguilar, LF; Coddou, C; Jara-Gutierrez, C; Mellado, M; Reyna-Jeldes, M; Villena, J; Weinstein-Oppenheimer, C1
Constantinescu, T; Lungu, CN1
Bibá, GCC; de Souza, PS; Melo, EDDN; Muzitano, MF1
Abdelhamid, IA; El-Shorbagy, HM; Ibrahim, SA; Sabet, S; WalyEldeen, AA1
Ganesan, R; Gunasekaran, V; Gurusamy, H; Palapetta, SC; Yuvakkumar, R1
Cheng, S; Huo, D; Jing, T; Lv, J; Ma, X; Meng, T; Wen, R; Yang, J1
Borges, ID; Kenari, F; Molnár, S; Napolitano, HB; Perjési, P1
Gao, F; Huang, G; Xiao, J1
Du, Z; Jiang, ZH; Peng, Y; Zhang, L; Zhang, W; Zhou, W1
Goyal, K; Gulati, S; Guliya, N; Kumar, S; Sharma, V; Shukla, S; Singh, A; Sood, AK1
Chen, X; Fu, X; Li, J; Ouyang, Y; Sun, S; Wu, Q1
Luo, B; Song, X1
Qiao, Z; Yang, F; Zhang, J; Zhou, H; Zhu, M1
Chen, C; Geng, C; Hidru, TH; Li, H; Liu, Y; Tao, M; Zhang, Y; Zhi, L; Zou, L1
Brandão, P; Carvalho, S; Cidade, H; Cravo, S; Hamadou, MH; Loureiro, JB; Moreira, J; Palmeira, A; Pereira, D; Pinto, M; Saraiva, L1
Fu, L; He, H; Jin, C; Liang, YJ1
Chovolou, Y; Kubbutat, MH; Limper, C; Lou, Y; Proksch, P; Ruhl, S; Totzke, F; Wang, Y; Wang, Z; Wätjen, W1
Bernades, A; da Silva, JA; de Moraes, MO; Demetrius, G; Dos Santos, CY; Mousinho, KC; Noda-Perez, C; Ramalho, SD; Vieira, PC1
Ajiboye, TO; Oladiji, AT; Yakubu, MT1
Jadala, C; Kamal, A; Nagesh, N; Nekkanti, S; Ramakrishna, S; Sathish, M; Senwar, KR; Shankaraiah, N; Sharma, P; Siraj, KP; Srinivasulu, V; Vishnuvardhan, MV1
Cao, Q; Chen, GL; Fang, WH; Jiang, XR; Li, HH; Li, M; Li, Y; Liu, X; Ping, GF; Wang, LH; Wang, S; Wu, CF; Yang, JY1
Duan, YT; Liang, XY; Makawana, JA; Man, RJ; Tang, DJ; Tao, XX; Wang, ZC; Yao, YF; Yu, C; Zhu, HL; Zou, MJ1
Bousbaa, H; Brandão, P; Cidade, H; Fonseca, J; Marques, S; Pinto, MM; Silva, PM1
Budak, Y; Ceylan, M; Ertürk, F; Gülçin, İ; Gürdere, MB; Kocyigit, UM; Köprülü, TK; Özcan, K; Tekin, Ş1
Ahmad, A; Oswal, N; Padhye, S; Sarkar, FH1
Balakishan, G; Kamal, A; Pal-Bhadra, M; Raju, P; Ramaiah, MJ; Ramakrishna, G; Viswanath, A1
Liu, C; Meng, H; Ren, L; Xie, L; Zhai, X; Zhao, Y; Zhu, W1
Chan, HH; Chen, SS; Kuo, PC; Lin, ML; Reddy, MV; Wu, TS1
Abdelwahab, SI; Abdul, AB; Ahmad, S; Cheah, SCh; Isa, NM; Mohan, S; Mustafa, MR; Narrima, P; Sukari, MA; Syam, S; Taha, MM1
Charlson, AT; Solberg, EL; Srinivasan, B; Warmka, JK; Wattenberg, EV; Xing, C; Zeliadt, NA1
Czuba, ZP; Jaworska, D; Król, W; Ksek, M; Szliszka, E1
OWEN, TY; SUN, HL1
Bhat, BA; Dhar, KL; Puri, SC; Qazi, GN; Saxena, AK; Shanmugavel, M1
Byung-Zun, A; Nam, NH1
Satomi, Y1

Reviews

12 review(s) available for chalcone and Neoplasms

ArticleYear
Recent advances of analogues of curcumin for treatment of cancer.
    European journal of medicinal chemistry, 2019, Oct-15, Volume: 180

    Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Proliferation; Curcumin; Humans; Neoplasms

2019
A Review: Discovering 1,3,4-oxadiazole and Chalcone Nucleus for Cytotoxicity / EGFR Inhibitory Anticancer Activity.
    Mini reviews in medicinal chemistry, 2022, Volume: 22, Issue:5

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chalcone; Drug Design; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Molecular Structure; Neoplasms; Oxadiazoles; Structure-Activity Relationship

2022
Anticancer Activity of Natural and Synthetic Chalcones.
    International journal of molecular sciences, 2021, Oct-20, Volume: 22, Issue:21

    Topics: Antineoplastic Agents; Chalcone; Chalcones; Drug Screening Assays, Antitumor; Flavonoids; Humans; Molecular Structure; Neoplasms; Structure-Activity Relationship

2021
Chalcones against the hallmarks of cancer: a mini-review.
    Natural product research, 2022, Volume: 36, Issue:18

    Topics: Antineoplastic Agents; Chalcone; Chalcones; Flavonoids; Humans; Neoplasms; Tumor Microenvironment

2022
Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer.
    Chemico-biological interactions, 2023, Jan-05, Volume: 369

    Topics: Antineoplastic Agents; Chalcone; Chalcones; Humans; Neoplasms; Signal Transduction

2023
Recent Progresses in Chalcone Derivatives as Potential Anticancer Agents.
    Anti-cancer agents in medicinal chemistry, 2023, Volume: 23, Issue:11

    Topics: Antineoplastic Agents; Chalcone; Chalcones; Humans; Neoplasms; Structure-Activity Relationship

2023
Chalcone hybrids as potential anticancer agents: Current development, mechanism of action, and structure-activity relationship.
    Medicinal research reviews, 2020, Volume: 40, Issue:5

    Topics: Antineoplastic Agents; Chalcone; Chalcones; Humans; Molecular Structure; Neoplasms; Structure-Activity Relationship

2020
Chalcone Scaffolds as Anticancer Drugs: A Review on Molecular Insight in Action of Mechanisms and Anticancer Properties.
    Anti-cancer agents in medicinal chemistry, 2021, Volume: 21, Issue:13

    Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Chalcone; Humans; Molecular Structure; Neoplasms

2021
Chalcone Derivatives: Role in Anticancer Therapy.
    Biomolecules, 2021, 06-16, Volume: 11, Issue:6

    Topics: Antineoplastic Agents; Cell Cycle; Chalcone; Chalcones; Humans; Molecular Structure; Neoplasms; Structure-Activity Relationship

2021
A comprehensive overview of β-carbolines and its derivatives as anticancer agents.
    European journal of medicinal chemistry, 2021, Nov-15, Volume: 224

    Topics: Alkaloids; Antineoplastic Agents; Carbolines; Chalcone; Coordination Complexes; DNA; DNA Topoisomerases; Humans; Indoles; Neoplasms

2021
Sonodynamic therapy: A potential treatment for atherosclerosis.
    Life sciences, 2018, Aug-15, Volume: 207

    Topics: Animals; Anthracenes; Antineoplastic Agents; Apoptosis; Atherosclerosis; Berberine; Cell Death; Chalcone; Curcumin; Emodin; Humans; Inflammation; Macrophages; Matrix Metalloproteinases; Mice; Neoplasms; Perylene; Photochemotherapy; Plaque, Atherosclerotic; Quinones; Reactive Oxygen Species; THP-1 Cells; Ultrasonic Therapy

2018
Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs.
    Journal of hematology & oncology, 2009, Sep-02, Volume: 2

    Topics: Animals; Antineoplastic Agents; Antioxidants; Chalcone; Chalcones; Garcinia; HIV Infections; Humans; Inflammation; Models, Biological; Neoplasms; Terpenes

2009

Other Studies

27 other study(ies) available for chalcone and Neoplasms

ArticleYear
Further studies on anti-invasive chemotypes: An excursion from chalcones to curcuminoids.
    Bioorganic & medicinal chemistry letters, 2015, Mar-01, Volume: 25, Issue:5

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Chalcones; Chickens; Curcumin; Halogenation; Heart; Humans; Neoplasm Invasiveness; Neoplasms; Structure-Activity Relationship

2015
Design and discovery of silybin analogues as antiproliferative compounds using a ring disjunctive - Based, natural product lead optimization approach.
    European journal of medicinal chemistry, 2017, Jun-16, Volume: 133

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Humans; Membrane Potential, Mitochondrial; Molecular Docking Simulation; Neoplasms; Silybin; Silymarin; Tubulin; Tubulin Modulators

2017
Inhibition of Caco-2 and MCF-7 cancer cells using chalcones: synthesis, biological evaluation and computational study.
    Natural product research, 2022, Volume: 36, Issue:17

    Topics: Antineoplastic Agents; Caco-2 Cells; Cell Proliferation; Chalcone; Chalcones; Daunorubicin; Humans; MCF-7 Cells; Molecular Structure; Neoplasms; Structure-Activity Relationship

2022
Biological evaluation of polycyclic chalcone based acrylamides in human MCF-7 and HeLa cancer cell lines.
    Environmental research, 2023, Apr-01, Volume: 222

    Topics: Acrylamides; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chalcone; Chalcones; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; HeLa Cells; Humans; MCF-7 Cells; Molecular Structure; Naphthalenes; Neoplasms; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship

2023
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    International journal of molecular sciences, 2023, May-10, Volume: 24, Issue:10

    Topics: Acetylcysteine; Antineoplastic Agents; Chalcone; Chalcones; Chromatography, High Pressure Liquid; Glutathione; Neoplasms; Sulfhydryl Compounds

2023
Design, Synthesis and Anti-Tumor Activity of Novel Benzimidazole-Chalcone Hybrids as Non-Intercalative Topoisomerase II Catalytic Inhibitors.
    Molecules (Basel, Switzerland), 2020, Jul-12, Volume: 25, Issue:14

    Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Benzimidazoles; Cell Proliferation; Chalcone; Drug Design; Drug Evaluation, Preclinical; Humans; Molecular Docking Simulation; Neoplasms; Structure-Activity Relationship; Topoisomerase II Inhibitors

2020
Chalcone-benzoxaborole hybrids as novel anticancer agents.
    Bioorganic & medicinal chemistry letters, 2016, 12-01, Volume: 26, Issue:23

    Topics: Antineoplastic Agents; Boron Compounds; Cell Line, Tumor; Cell Proliferation; Chalcone; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Neoplasms; Structure-Activity Relationship

2016
Targeting the MDM2-p53 protein-protein interaction with prenylchalcones: Synthesis of a small library and evaluation of potential antitumor activity.
    European journal of medicinal chemistry, 2018, Aug-05, Volume: 156

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Chalcone; HCT116 Cells; Humans; Models, Molecular; Molecular Docking Simulation; Neoplasms; Protein Interaction Maps; Proto-Oncogene Proteins c-mdm2; Small Molecule Libraries; Tumor Suppressor Protein p53

2018
Synthesis and antitumor activity of novel chalcone derivatives.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2013, Volume: 67, Issue:3

    Topics: Antineoplastic Agents; Cell Line, Tumor; Chalcone; Curcumin; Drug Screening Assays, Antitumor; Humans; K562 Cells; MCF-7 Cells; Neoplasms; Structure-Activity Relationship

2013
Compounds isolated from Psoralea corylifolia seeds inhibit protein kinase activity and induce apoptotic cell death in mammalian cells.
    The Journal of pharmacy and pharmacology, 2013, Volume: 65, Issue:9

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Chalcone; ErbB Receptors; HCT116 Cells; Humans; Inhibitory Concentration 50; Mitogen-Activated Protein Kinases; Neoplasms; Phytotherapy; Plant Extracts; Protein Kinase Inhibitors; Psoralea; Rats; Seeds

2013
Synthetic chalcone derivatives as inhibitors of cathepsins K and B, and their cytotoxic evaluation.
    Chemistry & biodiversity, 2013, Volume: 10, Issue:11

    Topics: Antineoplastic Agents; Cathepsin B; Cathepsin K; Cell Line, Tumor; Chalcone; Enzyme Inhibitors; Humans; Neoplasms

2013
Cytotoxic, antimutagenic, and antioxidant activities of methanolic extract and chalcone dimers (lophirones B and C) derived from Lophira alata (Van Tiegh. Ex Keay) stem bark.
    Journal of evidence-based complementary & alternative medicine, 2014, Volume: 19, Issue:1

    Topics: Antimutagenic Agents; Antineoplastic Agents; Antioxidants; Cell Line, Tumor; Chalcone; Drug Evaluation, Preclinical; Humans; Mutation; Neoplasms; Ochnaceae; Plant Bark; Plant Extracts; Salmonella typhimurium

2014
DNA-binding affinity and anticancer activity of β-carboline-chalcone conjugates as potential DNA intercalators: Molecular modelling and synthesis.
    Bioorganic chemistry, 2015, Volume: 59

    Topics: Antineoplastic Agents; Carbolines; Cell Line, Tumor; Cell Proliferation; Chalcone; DNA; Drug Screening Assays, Antitumor; Humans; Intercalating Agents; Models, Molecular; Neoplasms; Structure-Activity Relationship

2015
SL4, a chalcone-based compound, induces apoptosis in human cancer cells by activation of the ROS/MAPK signalling pathway.
    Cell proliferation, 2015, Volume: 48, Issue:6

    Topics: Animals; Anthracenes; Apoptosis; bcl-X Protein; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Cell Proliferation; Chalcone; Chalcones; Enzyme Activation; Female; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1; Imidazoles; Inhibitor of Apoptosis Proteins; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mice, Nude; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neoplasms; Neovascularization, Pathologic; Pyridines; Reactive Oxygen Species; Survivin; X-Linked Inhibitor of Apoptosis Protein

2015
Design, Synthesis and Antitumor Activity of Novel link-bridge and B-Ring Modified Combretastatin A-4 (CA-4) Analogues as Potent Antitubulin Agents.
    Scientific reports, 2016, 05-03, Volume: 6

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chalcone; Drug Screening Assays, Antitumor; Humans; Hydrazones; Mice; Neoplasms; Stilbenes; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Xenograft Model Antitumor Assays

2016
Prenylated Chalcone 2 Acts as an Antimitotic Agent and Enhances the Chemosensitivity of Tumor Cells to Paclitaxel.
    Molecules (Basel, Switzerland), 2016, Jul-29, Volume: 21, Issue:8

    Topics: Chalcone; Drug Screening Assays, Antitumor; Humans; MCF-7 Cells; Mitosis; Neoplasms; Paclitaxel; Prenylation; Spindle Apparatus

2016
Synthesis, characterization, anticancer, antimicrobial and carbonic anhydrase inhibition profiles of novel (3aR,4S,7R,7aS)-2-(4-((E)-3-(3-aryl)acryloyl) phenyl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione derivatives.
    Bioorganic chemistry, 2017, Volume: 70

    Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; Bacteria; Bacterial Infections; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Cell Line, Tumor; Chalcone; Fungi; Humans; Isoindoles; Mycoses; Neoplasms; Rats; Structure-Activity Relationship

2017
Synthesis and anti-cancer activity of chalcone linked imidazolones.
    Bioorganic & medicinal chemistry letters, 2010, Aug-15, Volume: 20, Issue:16

    Topics: Antineoplastic Agents; Cell Line, Tumor; Chalcone; Drug Screening Assays, Antitumor; Humans; Imidazoles; Neoplasms

2010
Design, synthesis and antitumor activity of novel artemisinin derivatives using hybrid approach.
    Chemical & pharmaceutical bulletin, 2011, Volume: 59, Issue:8

    Topics: Antineoplastic Agents, Phytogenic; Artemisia; Artemisinins; Cell Line, Tumor; Chalcone; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Neoplasms; Structure-Activity Relationship

2011
Preparation of a series of novel bichalcones linked with a 1,4-dimethylenepiperazine moiety and examination of their cytotoxicity.
    Chemical & pharmaceutical bulletin, 2011, Volume: 59, Issue:12

    Topics: Antineoplastic Agents; Cell Line, Tumor; Chalcone; Drug Screening Assays, Antitumor; Humans; Neoplasms; Piperazines; Structure-Activity Relationship

2011
In vitro anti-inflammatory, cytotoxic and antioxidant activities of boesenbergin A, a chalcone isolated from Boesenbergia rotunda (L.) (fingerroot).
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2012, Volume: 45, Issue:6

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Cell Line, Tumor; Chalcone; Chromatography; Drug Screening Assays, Antitumor; Humans; In Vitro Techniques; Mice; Neoplasms; Phytotherapy; Rhizome; Zingiberaceae

2012
Inhibition of mitogen activated protein kinases increases the sensitivity of A549 lung cancer cells to the cytotoxicity induced by a kava chalcone analog.
    Biochemical and biophysical research communications, 2012, Aug-03, Volume: 424, Issue:3

    Topics: Cell Survival; Chalcone; Chalcones; Drug Resistance, Neoplasm; Humans; Kava; Lung Neoplasms; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasms

2012
Targeting death receptor TRAIL-R2 by chalcones for TRAIL-induced apoptosis in cancer cells.
    International journal of molecular sciences, 2012, Nov-20, Volume: 13, Issue:11

    Topics: Apoptosis; Cell Line, Tumor; Chalcone; Drug Synergism; HeLa Cells; Humans; Neoplasms; Receptors, TNF-Related Apoptosis-Inducing Ligand; Recombinant Proteins; TNF-Related Apoptosis-Inducing Ligand

2012
[TUMOUR CHEMOTHERAPY. XVIII. PREPARATION OF SEVERAL SUBSTITUTED CHALCONES].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1963, Volume: 10

    Topics: Acetophenones; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Chalcone; Chalcones; Mice; Neoplasms; Pharmacology; Pigments, Biological; Research

1963
Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents.
    Bioorganic & medicinal chemistry letters, 2005, Jun-15, Volume: 15, Issue:12

    Topics: Antineoplastic Agents; Chalcone; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Neoplasms; Pyrazoles; Tumor Cells, Cultured

2005
Combretastatin-chalcone hybrids: synthesis and cytotoxicity.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2007, Volume: 3, Issue:4

    Topics: Bibenzyls; Cell Line; Cell Survival; Chalcone; Humans; Molecular Structure; Neoplasms; Stilbenes; Structure-Activity Relationship

2007
Inhibitory effects of 3'-methyl-3-hydroxy-chalcone on proliferation of human malignant tumor cells and on skin carcinogenesis.
    International journal of cancer, 1993, Sep-30, Volume: 55, Issue:3

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Chalcone; Chalcones; Dose-Response Relationship, Drug; HeLa Cells; Humans; Mice; Neoplasm Proteins; Neoplasms; Papilloma; Phosphorylation; Skin Neoplasms; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured

1993