chalcone has been researched along with Innate Inflammatory Response in 52 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (1.92) | 18.2507 |
| 2000's | 12 (23.08) | 29.6817 |
| 2010's | 26 (50.00) | 24.3611 |
| 2020's | 13 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arenzana-Seisdedos, F; Balabanian, K; Baleux, F; Bonnet, D; Chow, KY; Dagher, R; Didier, B; Franchet, C; Frossard, N; Galzi, JL; Gizzi, P; Hachet-Haas, M; Haiech, J; Hibert, M; Kellenberger, E; Lagane, B; Lecat, S; Parmentier, M; Pons, F; Rohmer, F | 1 |
| Edwards, BS; Graves, SW; Saunders, MJ; Sklar, LA; Zhu, J | 1 |
| Bailly, C | 1 |
| Chen, QY; He, Y; Li, C; Liu, MM; Liu, YH; Meng, XM | 1 |
| Guohua, F; Juan, X; Wei, W; Zhongyin, Z | 1 |
| Fu, R; Hu, M; Hu, X; Huang, F; Li, X; Tan, W; Tong, X; Wei, Y; Yang, Z | 1 |
| Borghi, SM; Casagrande, R; Verri, WA | 1 |
| Chang, CH; Chang, FR; Chang, WH; Fang, WY; Huang, YC; Lin, CL; Lo, YC; Tsai, YH | 1 |
| Almutairi, BO; Arockiaraj, J; Arokiyaraj, S; Dhivya, LS; Kathiravan, MK; Nayak, SPRR; R, R | 1 |
| Chen, Z; Ding, W; Liu, Y; Lu, T; Yang, X | 1 |
| Liu, Y; Xu, R; Xu, X; Zhang, S | 1 |
| Fan, RY; He, MF; He, ZH; Li, CY; Liu, YY; Wu, JQ | 1 |
| Chen, LW; Chen, SJ; Chern, CY; Lin, CS; Lin, FY; Lin, WS; Liu, YW; Lu, HJ; Tsai, CS; Tsai, MC; Tsao, TP; Tsui, PF; Wu, WL | 1 |
| Chen, L; Li, Y; Nel, D; Sun, B; Wu, J; Xu, M; Yang, X; Zhang, P | 1 |
| Chen, K; Huang, X; Huang, YK; Ren, P; Xu, J; Zhan, T; Zhang, XH; Zheng, W | 1 |
| Bao, C; Chen, D; Guo, H; Li, J; Li, Y; Tang, P; Zhu, L | 1 |
| Baracat, MM; Casagrande, R; Georgetti, SR; Martinez, RM; Pinho-Ribeiro, FA; Steffen, VS; Vale, DL; Verri, WA; Vicentini, FTMC; Vignoli, JA | 1 |
| Baracat, MM; Bottura, C; Bussmann, AJC; Casagrande, R; Caviglione, CV; Fattori, V; Fonseca, MJV; Georgetti, SR; Martinez, RM; Pinho-Ribeiro, FA; Steffen, VS; Verri, WA; Vignoli, JA | 1 |
| Deng, L; He, Y; Wan, H; Yu, L; Zhou, H | 1 |
| Chew, EH; Chui, WK; Gan, FF; Hadadi, E; Karuppasamy, M; Ng, HL; Ong, SM; Seah, W; Wong, SC; Yeap, WH; Zhang, R | 1 |
| Gong, Z; He, L; Li, X; Pan, J; Peng, Y; Wang, H | 1 |
| Ding, YX; Han, B; He, J; Ma, CJ; Wang, T; Wang, ZH; Zhao, Y | 1 |
| Chen, C; Geng, C; Hidru, TH; Li, H; Liu, Y; Tao, M; Zhang, Y; Zhi, L; Zou, L | 1 |
| Dong, F; Jin, M; Peng, YY; Tan, L; Wang, Y; Xue, CJ; Zang, BX; Zhang, YD | 1 |
| Chen, C; Huang, L; Lin, Y; Qiu, D; Song, C; Wang, B; Wu, J; Zhang, S | 1 |
| Chen, JJ; Geng, CA; Hou, B; Huang, XY; Ma, YB; Peng, H; Yan, DX; Yang, TH; Zhang, XM | 1 |
| Ashida, H; Kawabata, K; Miyashita, M; Ohigashi, H; Okumura, M; Takahashi, M; Yamamoto, N; Yasuda, M | 1 |
| Hui, X; Pan, J; Wu, Z; Xu, Y; Zhang, Z; Zhu, X | 1 |
| Hui, XC; Wu, ZZ; Xu, Y; Yang, H; Yin, KL; Yu, LJ; Zhang, ZH | 1 |
| Jin, M; Sun, CY; Zang, BX | 1 |
| Chen, G; Fang, Q; Jiang, L; Liang, G; Liu, X; Shan, X; Wang, J; Wang, Y; Wang, Z; Wu, W; Zhang, Y | 1 |
| Abdullah, MP; Abu, N; Akhtar, MN; Alitheen, NB; Kee, BB; Lim, KL; Mohamed, NE; Omar, AR; Yeap, SK; Zulfadli, AJ | 1 |
| Han, X; Long, Y; Zhang, X; Zhang, Y; Zhou, Z | 1 |
| Baba, K; Goto, T; Ikutani, R; Jheng, HF; Kawada, T; Li, Y; Lin, S; Murakami, S; Takahashi, H; Takahashi, N; Taniguchi, M; Yu, R | 1 |
| Dong, F; Jin, M; Peng, Y; Wang, Y; Xue, C; Zang, B; Zhang, Y | 1 |
| Gao, WY; Ye, SY | 1 |
| Jang, S; Jung, JC; Jung, M; Kim, DH; Lee, Y; Oh, S; Ryu, JH | 1 |
| Ecker, GF; Kim, HP; Park, H; Thai, KM; Tran, TD | 1 |
| Amirabadi, A; Azimzadeh, BS; Eskandarizadeh, A; Foroumadi, A; Heidari, MR; Samzadeh-Kermani, A | 1 |
| Ahmad, A; Oswal, N; Padhye, S; Sarkar, FH | 1 |
| Feng, ZM; He, J; Jiang, JS; Zhang, PC | 1 |
| Qu, S; Sun, X; Wei, X; Zhang, X; Zhao, Y | 1 |
| Jia, MM; Li, XJ; Li, YS; Liu, M; Tang, HB; Wang, JX | 1 |
| Bukhari, SN; Jantan, I; Jasamai, M | 1 |
| Jin, M; Song, L; Zang, B; Zhu, Y | 1 |
| Lee, SH; Seo, GS; Sohn, DH | 1 |
| Abuarqoub, H; Foresti, R; Green, CJ; Motterlini, R | 1 |
| Choi, SC; Jin, XY; Kim, SW; Lee, SH; Seo, GS; Sohn, DH | 1 |
| Cechinel-Filho, V; Corrêa, R; de Campos-Buzzi, F; Meira, AV; Nunes, RJ; Padaratz, P | 1 |
| Hsieh, HK; Lin, CN; Tsao, LT; Wang, JP | 1 |
| Alcaraz, MJ; Charris, JE; Dominguez, JN; Ferrándiz, ML; Guillén, I; Herencia, F; Lobo, GM; Ubeda, A | 1 |
| Hirota, M; Irie, R; Koshimizu, K; Murakami, A; Ohigashi, H; Takeda, N; Tanaka, S; Tatematsu, A | 1 |
5 review(s) available for chalcone and Innate Inflammatory Response
| Article | Year |
|---|---|
Toward the use of Boesenbergia rotunda extracts and the chalcone panduratin A to treat periodontitis.
Topics: Anti-Inflammatory Agents; Chalcone; Chalcones; Humans; Inflammation; Periodontitis; Plant Extracts; Zingiberaceae | 2022 |
Isoliquiritigenin, a potential therapeutic agent for treatment of inflammation-associated diseases.
Topics: Biological Availability; Chalcone; Chalcones; Glycyrrhiza; Inflammation | 2024 |
Sonodynamic therapy: A potential treatment for atherosclerosis.
Topics: Animals; Anthracenes; Antineoplastic Agents; Apoptosis; Atherosclerosis; Berberine; Cell Death; Chalcone; Curcumin; Emodin; Humans; Inflammation; Macrophages; Matrix Metalloproteinases; Mice; Neoplasms; Perylene; Photochemotherapy; Plaque, Atherosclerotic; Quinones; Reactive Oxygen Species; THP-1 Cells; Ultrasonic Therapy | 2018 |
Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs.
Topics: Animals; Antineoplastic Agents; Antioxidants; Chalcone; Chalcones; Garcinia; HIV Infections; Humans; Inflammation; Models, Biological; Neoplasms; Terpenes | 2009 |
Anti-inflammatory trends of 1, 3-diphenyl-2-propen-1-one derivatives.
Topics: Animals; Anti-Inflammatory Agents; Chalcone; Cyclooxygenase Inhibitors; Enzyme Induction; Humans; Inflammation | 2013 |
47 other study(ies) available for chalcone and Innate Inflammatory Response
| Article | Year |
|---|---|
Small neutralizing molecules to inhibit actions of the chemokine CXCL12.
Topics: Calcium; Calorimetry; Cell Line; Cell Proliferation; Chalcones; Chemokine CCL5; Chemokine CXCL12; Gene Expression Regulation; Humans; Inflammation; Ligands; Protein Binding; Receptors, CXCR; Receptors, CXCR4; Spectrometry, Fluorescence | 2008 |
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Proteins; High-Throughput Screening Assays; Humans; Inflammation; Kinetics; Microspheres; Peptide Hydrolases; Peptides; Reproducibility of Results; Temperature | 2010 |
Discovery of a chalcone derivative as potent necroptosis inhibitor for the treatment of acute kidney injury.
Topics: Acute Kidney Injury; Animals; Apoptosis; Chalcone; Chalcones; Cisplatin; Inflammation; Mice; Mice, Inbred C57BL | 2022 |
Isoliquiritin apioside relieves intestinal ischemia/reperfusion-induced acute lung injury by blocking Hif-1α-mediated ferroptosis.
Topics: Acute Lung Injury; Animals; Chalcone; Ferroptosis; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Mice; Reperfusion Injury; RNA, Messenger | 2022 |
Therapeutic Effect of Renifolin F on Airway Allergy in an Ovalbumin-Induced Asthma Mouse Model In Vivo.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Chalcone; Cytokines; Disease Models, Animal; Hypersensitivity; Immunity, Innate; Inflammation; Lung; Lymphocytes; Mice; MicroRNAs; Ovalbumin | 2022 |
Hesperidin Methyl Chalcone: An Emerging Compound for the Treatment of Inflammation and Pain.
Topics: Chalcone; Chalcones; Hesperidin; Humans; Inflammation; Pain | 2023 |
Protective Effects of the Chalcone-Based Derivative AN07 on Inflammation-Associated Myotube Atrophy Induced by Lipopolysaccharide.
Topics: Chalcone; Chalcones; Humans; Inflammation; Lipopolysaccharides; Muscle Fibers, Skeletal; Muscular Atrophy; Phosphatidylinositol 3-Kinases; PPAR gamma | 2022 |
Furan based synthetic chalcone derivative functions against gut inflammation and oxidative stress demonstrated in in-vivo zebrafish model.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Chalcone; Chalcones; Colitis; Dextran Sulfate; Inflammation; Inflammatory Bowel Diseases; Oxidative Stress; Zebrafish | 2023 |
Renoprotective Effects Of Isoliquiritin Against Cationic Bovine Serum Albumin-Induced Membranous Glomerulonephritis In Experimental Rat Model Through Its Anti-Oxidative And Anti-Inflammatory Properties.
Topics: Animals; Biomarkers; Cations; Chalcone; Disease Models, Animal; Dose-Response Relationship, Drug; Glomerulonephritis, Membranous; Glucosides; Inflammation; Injections, Intravenous; Male; Molecular Structure; Oxidative Stress; Protective Agents; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Structure-Activity Relationship | 2019 |
Isoliquiritin promote angiogenesis by recruiting macrophages to improve the healing of zebrafish wounds.
Topics: Animals; Chalcone; Glucosides; Inflammation; Macrophages; Neovascularization, Physiologic; Plant Extracts; Plants, Medicinal; Skin; Wound Healing; Zebrafish | 2020 |
A chalcone derivative, 1m-6, exhibits atheroprotective effects by increasing cholesterol efflux and reducing inflammation-induced endothelial dysfunction.
Topics: Animals; Atherosclerosis; ATP Binding Cassette Transporter 1; Chalcone; Chalcones; Cholesterol; Inflammation; Mice; Mice, Knockout | 2020 |
Protective effect of hydroxysafflor yellow A on dopaminergic neurons against 6-hydroxydopamine, activating anti-apoptotic and anti-neuroinflammatory pathways.
Topics: Animals; Apoptosis; Chalcone; Corpus Striatum; Dopamine; Dopaminergic Neurons; Dose-Response Relationship, Drug; Inflammation; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Quinones; Signal Transduction | 2020 |
Hydroxysafflor yellow A acutely attenuates blood-brain barrier permeability, oxidative stress, inflammation and apoptosis in traumatic brain injury in rats1.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Brain Injuries, Traumatic; Chalcone; Inflammation; Oxidative Stress; Permeability; Quinones; Rats | 2021 |
Carthamin yellow improves cerebral ischemia‑reperfusion injury by attenuating inflammation and ferroptosis in rats.
Topics: Animals; Chalcone; Ferroptosis; Fluorescent Antibody Technique; Glucosides; Inflammation; Interleukin-6; Male; Malondialdehyde; Molecular Structure; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2021 |
Trans-chalcone added in topical formulation inhibits skin inflammation and oxidative stress in a model of ultraviolet B radiation skin damage in hairless mice.
Topics: Administration, Topical; Animals; Catalase; Chalcone; Cyclooxygenase 2; Disease Models, Animal; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Glutathione Reductase; Heme Oxygenase-1; Inflammation; Isomerism; Lipid Peroxidation; Matrix Metalloproteinase 9; Mice; Mice, Hairless; NF-E2-Related Factor 2; Oxidative Stress; Peroxidase; Skin; Tumor Necrosis Factor-alpha; Ultraviolet Rays | 2017 |
trans-Chalcone, a flavonoid precursor, inhibits UV-induced skin inflammation and oxidative stress in mice by targeting NADPH oxidase and cytokine production.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chalcone; Cytokines; Dose-Response Relationship, Drug; Edema; Enzyme-Linked Immunosorbent Assay; Inflammation; Male; Mice; Mice, Hairless; Molecular Structure; NADPH Oxidases; Oxidative Stress; Skin; Structure-Activity Relationship; Ultraviolet Rays | 2017 |
Protective effect of hydroxysafflor yellow A alone or in combination with acetylglutamine on cerebral ischemia reperfusion injury in rat: A PET study using
Topics: Animals; Apoptosis; Brain Ischemia; Chalcone; Fluorine Radioisotopes; Glutamine; Infarction, Middle Cerebral Artery; Inflammation; Male; Neuroprotective Agents; Positron-Emission Tomography; Quinones; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Up-Regulation | 2018 |
Novel dual-targeting anti-proliferative dihydrotriazine-chalcone derivatives display suppression of cancer cell invasion and inflammation by inhibiting the NF-κB signaling pathway.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chalcone; Cyclooxygenase 2; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Humans; Inflammation; Inflammation Mediators; Lipopolysaccharides; Matrix Metalloproteinase 9; Mice; Monocytes; Neoplasm Invasiveness; NF-kappa B; Nitric Oxide Synthase Type II; RAW 264.7 Cells; Signal Transduction; Tetradecanoylphorbol Acetate; Triazines | 2018 |
Hydroxysafflor Yellow A Reprograms TLR9 Signalling Pathway in Ischaemic Cortex after Cerebral Ischaemia and Reperfusion.
Topics: Animals; Animals, Newborn; Brain; Brain Infarction; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Chalcone; Disease Models, Animal; Dose-Response Relationship, Drug; Functional Laterality; Gene Expression Regulation; Glucose; In Situ Nick-End Labeling; Inflammation; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Neurologic Examination; Quinones; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion; RNA Interference; RNA, Messenger; Signal Transduction; Time Factors; Toll-Like Receptor 9; Transfection | 2018 |
Hydroxysafflor Yellow A Attenuates Lipopolysaccharide-Induced Neurotoxicity and Neuroinflammation in Primary Mesencephalic Cultures.
Topics: Animals; Carthamus tinctorius; Cell Survival; Cells, Cultured; Chalcone; Cytokines; Humans; Inflammation; Lipopolysaccharides; Mesencephalon; Mice, Inbred C57BL; Neurons; Nitrogen Oxides; Primary Cell Culture; Quinones; Signal Transduction; Tissue Distribution; Transcription Factor RelA | 2018 |
Protective Effect of Hydroxysafflor Yellow A on Inflammatory Injury in Chronic Obstructive Pulmonary Disease Rats.
Topics: Animals; Chalcone; Cytokines; Disease Models, Animal; Inflammation; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pulmonary Disease, Chronic Obstructive; Quinones; Rats; Transcription Factor RelA | 2019 |
A novel chalcone derivative, L2H17, ameliorates lipopolysaccharide-induced acute lung injury via upregulating HO-1 activity.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Chalcone; Chalcones; Disease Models, Animal; Gene Expression Regulation; Heme Oxygenase-1; Humans; Inflammation; Lipopolysaccharides; Lung; Macrophages; Male; Membrane Proteins; Metalloporphyrins; Mice; Mice, Inbred C57BL; Protoporphyrins; RAW 264.7 Cells | 2019 |
Termipaniculatones A-F, chalcone-flavonone heterodimers from Terminthia paniculata, and their protective effects on hyperuricemia and acute gouty arthritis.
Topics: Anacardiaceae; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Chalcone; Dose-Response Relationship, Drug; Edema; Enzyme Inhibitors; Flavanones; Hyperuricemia; Inflammation; Male; Mice; Mice, Inbred Strains; Molecular Structure; Oxonic Acid; Structure-Activity Relationship; Uric Acid; Xanthine Oxidase | 2019 |
Inhibitory effects of 4-hydroxyderricin and xanthoangelol on lipopolysaccharide-induced inflammatory responses in RAW264 macrophages.
Topics: Angelica; Animals; Cell Line; Chalcone; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Gene Expression; Inflammation; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2014 |
Hydroxy-safflor yellow A inhibits neuroinflammation mediated by Aβ₁₋₄₂ in BV-2 cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Apoptosis; Cell Line; Chalcone; Humans; Inflammation; Microglia; Neurons; Neuroprotective Agents; Quinones; Signal Transduction | 2014 |
Hydroxy-safflor yellow A attenuates Aβ₁₋₄₂-induced inflammation by modulating the JAK2/STAT3/NF-κB pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cells, Cultured; Chalcone; Inflammation; Janus Kinase 2; Male; Mice; Mice, Inbred ICR; Microglia; NF-kappa B; Peptide Fragments; Quinones; Signal Transduction; Spatial Learning; STAT3 Transcription Factor | 2014 |
Hydroxysafflor yellow A attenuate lipopolysaccharide-induced endothelium inflammatory injury.
Topics: Cell Adhesion; Cell Nucleus; Cell Survival; Chalcone; E-Selectin; Endothelium, Vascular; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; I-kappa B Proteins; Inflammation; Intercellular Adhesion Molecule-1; Leukocytes; Lipopolysaccharides; MAP Kinase Signaling System; NF-KappaB Inhibitor alpha; Phosphorylation; Protective Agents; Protein Binding; Quinones; RNA, Messenger | 2016 |
MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsis.
Topics: Animals; Cell Line; Chalcone; Dose-Response Relationship, Drug; Drug Delivery Systems; Humans; Inflammation; Inflammation Mediators; Lipopolysaccharides; Lymphocyte Antigen 96; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Structure, Secondary; Protein Structure, Tertiary; Sepsis | 2015 |
In Vivo Anti-Tumor Effects of Flavokawain A in 4T1 Breast Cancer Cell-Challenged Mice.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chalcone; Female; Immunologic Factors; Inflammation; Interferon-gamma; Interleukin-2; Killer Cells, Natural; Mammary Neoplasms, Animal; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Nitric Oxide; T-Lymphocytes; Tumor Burden | 2015 |
Hydroxysafflor yellow A improves established monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Chalcone; Deoxyguanosine; Gene Expression Regulation; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation; Male; Malondialdehyde; Monocrotaline; Oxidative Stress; Quinones; Rats, Wistar; RNA, Messenger; Superoxide Dismutase; Vascular Remodeling | 2016 |
Xanthoangelol and 4-hydroxyderrcin suppress obesity-induced inflammatory responses.
Topics: Adipocytes; Angelica; Animals; Cell Differentiation; Chalcone; Coculture Techniques; Culture Media, Conditioned; Diet, High-Fat; Inflammation; JNK Mitogen-Activated Protein Kinases; Macrophages; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Obesity; Phosphorylation; Phytotherapy; Plant Extracts; Transcription Factor AP-1 | 2016 |
Hydroxysafflor yellow A attenuates the expression of inflammatory cytokines in acute soft tissue injury.
Topics: Acute Disease; Animals; Chalcone; Cytokines; Enzyme Activation; Gene Expression Regulation; Inflammation; Intercellular Adhesion Molecule-1; Male; Muscles; p38 Mitogen-Activated Protein Kinases; Quinones; Rats, Wistar; RNA, Messenger; Soft Tissue Injuries; Transcription Factor RelA; Vascular Cell Adhesion Molecule-1 | 2017 |
Hydroxysafflor yellow A protects neuron against hypoxia injury and suppresses inflammatory responses following focal ischemia reperfusion in rats.
Topics: Animals; Behavior, Animal; Blotting, Western; Brain Edema; Cell Hypoxia; Cells, Cultured; Chalcone; Female; Glucose; Indicators and Reagents; Inflammation; Interleukin-1beta; Ischemic Attack, Transient; L-Lactate Dehydrogenase; Neurons; Neuroprotective Agents; Nitric Oxide; Pregnancy; Quinones; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha | 2008 |
The neuroprotective effects of benzylideneacetophenone derivatives on excitotoxicity and inflammation via phosphorylated Janus tyrosine kinase 2/phosphorylated signal transducer and activator of transcription 3 and mitogen-activated protein K pathways.
Topics: Animals; Brain Ischemia; Chalcone; Disease Models, Animal; DNA-Binding Proteins; Glutamic Acid; Hydrogen Peroxide; Inflammation; Janus Kinase 2; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Microglia; Mitogen-Activated Protein Kinases; Neuroprotective Agents; Neurotoxicity Syndromes; Nitric Oxide; Phosphorylation; Propiophenones; Signal Transduction; Transcription Factors | 2009 |
Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study.
Topics: Animals; Cell Line; Chalcone; Chalcones; Chemistry, Pharmaceutical; Cyclooxygenase 2; Dinoprostone; Drug Design; Inflammation; Inhibitory Concentration 50; Lipopolysaccharides; Mice; Models, Chemical; Structure-Activity Relationship; Time Factors | 2009 |
Evaluation of anti-inflammatory and analgesic activity of a novel rigid 3, 4-dihydroxy chalcone in mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Aspirin; Chalcone; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Formaldehyde; Hot Temperature; Inflammation; Male; Mice; Molecular Structure; Morphine; Naloxone; Narcotic Antagonists; Pain; Pain Measurement | 2009 |
Two new quinochalcones from the florets of Carthamus tinctorius.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carthamus tinctorius; Chalcone; Enzyme Inhibitors; Flowers; Glucosides; Glucuronidase; Inflammation; Molecular Conformation; Neutrophils; Rats; Stereoisomerism; Structure-Activity Relationship | 2010 |
Hydroxysafflor Yellow A suppresses thrombin generation and inflammatory responses following focal cerebral ischemia-reperfusion in rats.
Topics: Animals; Brain Ischemia; Chalcone; Inflammation; Male; Quinones; Rats; Rats, Wistar; Reperfusion Injury; Thrombin | 2010 |
Dragon's blood inhibits chronic inflammatory and neuropathic pain responses by blocking the synthesis and release of substance P in rats.
Topics: Analgesics, Non-Narcotic; Animals; Bradykinin; Capsaicin; Carrageenan; Chalcone; Cyclooxygenase 2; Drugs, Chinese Herbal; Ganglia, Spinal; Inflammation; Male; Pain; Plant Extracts; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Sciatic Nerve; Substance P; Tachykinins | 2012 |
Hydroxysafflor yellow a inhibits lipopolysaccharide-induced inflammatory signal transduction in human alveolar epithelial A549 cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Cell Line, Tumor; Chalcone; Cytokines; Epithelial Cells; Gene Expression Regulation; Humans; Inflammation; Leukocytes; Lipopolysaccharides; Molecular Structure; Myeloid Differentiation Factor 88; Quinones; Signal Transduction; Toll-Like Receptor 4; Transcription Factor RelA | 2013 |
Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by butein in RAW 264.7 cells.
Topics: Animals; Blotting, Northern; Blotting, Western; Cell Line; Cell Nucleus; Chalcone; Chalcones; Cyclooxygenase 2; Cytosol; Dose-Response Relationship, Drug; Flow Cytometry; Inflammation; Integrin alphaVbeta3; Isoenzymes; Lipopolysaccharides; Macrophages; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Osteopontin; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Sialoglycoproteins | 2004 |
Heme oxygenase-1 mediates the anti-inflammatory actions of 2'-hydroxychalcone in RAW 264.7 murine macrophages.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cell Survival; Chalcone; Chalcones; Enzyme Activation; Heme Oxygenase-1; Inflammation; Lipopolysaccharides; Macrophages; Membrane Proteins; Mice; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide Synthase Type II; Nitrites; Phosphatidylinositol 3-Kinases; Signal Transduction; Tumor Necrosis Factor-alpha | 2006 |
2',4',6'-tris(methoxymethoxy) chalcone protects against trinitrobenzene sulfonic acid-induced colitis and blocks tumor necrosis factor-alpha-induced intestinal epithelial inflammation via heme oxygenase 1-dependent and independent pathways.
Topics: Animals; Cell Line; Chalcone; Colitis; Epithelium; Heme Oxygenase-1; Inflammation; Intestines; Mice; Mucous Membrane; Protective Agents; Signal Transduction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2007 |
4'-Acetamidochalcone derivatives as potential antinociceptive agents.
Topics: Acetamides; Acetaminophen; Analgesics; Animals; Aspirin; Chalcone; Chalcones; Chromatography, Thin Layer; Drug Design; Drug Evaluation, Preclinical; Formaldehyde; Inflammation; Infusions, Parenteral; Magnetic Resonance Spectroscopy; Mice; Models, Chemical | 2007 |
Synthesis and anti-inflammatory effect of chalcones.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chalcone; Glucuronidase; Inflammation; Inflammation Mediators; Macrophages; Mast Cells; Neutrophils; Nitric Oxide; Rats | 2000 |
4-dimethylamino-3',4'-dimethoxychalcone downregulates iNOS expression and exerts anti-inflammatory effects.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Animals; Anti-Inflammatory Agents; Carrageenan; Chalcone; Chalcones; Edema; Enzyme Inhibitors; Female; Free Radical Scavengers; Gene Expression Regulation, Enzymologic; Inflammation; Luminescent Measurements; Macrophages, Peritoneal; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; Respiratory Burst; Superoxides; Zymosan | 2001 |
Chalcone tetramers, lophirachalcone and alatachalcone, from Lophira alata as possible anti-tumor promoters.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antiviral Agents; Chalcone; Chalcones; Female; Herpesvirus 4, Human; Inflammation; Irritants; Lyngbya Toxins; Macromolecular Substances; Mice; Mice, Inbred ICR; Phenols; Plant Extracts; Plants, Medicinal; Skin Neoplasms | 1992 |