chalcone has been researched along with Disease Models, Animal in 76 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (17.11) | 29.6817 |
| 2010's | 51 (67.11) | 24.3611 |
| 2020's | 12 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| Bracke, ME; De Ryck, T; Katritzky, AR; Patronov, A; Roman, BI; Slavov, SH; Stevens, CV; Vanhoecke, BW | 1 |
| He, M; Liu, Z; Qu, X; Xu, L; Yang, P; Zou, Y | 1 |
| Feng, Z; Wu, X; Zhang, J; Zhang, M; Zhou, P | 1 |
| Fu, R; Hu, M; Hu, X; Huang, F; Li, X; Tan, W; Tong, X; Wei, Y; Yang, Z | 1 |
| Baracat, MM; Casagrande, R; Colombo, BB; Fattori, V; Georgetti, SR; Guazelli, CFS; Ludwig, IS; Martinez, RM; Urbano, A; Verri, WA; Vicente, LG | 1 |
| Byeon, SR; Cheong, E; Choi, JW; Jang, BK; Kim, HJ; Lee, YS; Pae, AN; Park, JH; Park, KD; Park, SJ | 1 |
| Liu, Y; Xu, R; Xu, X; Zhang, S | 1 |
| Hou, J; Hu, Y; Mo, Y; Pang, J; Qu, Z; Ren, M; Yang, G; Zhou, Z | 1 |
| Gao, KX; Gong, MZ; Ren, P; Sun, HT; Yu, C; Zhang, Y; Zhao, X | 1 |
| Ahmad, N; Gao, H; Gao, Y; Guo, H; Li, H; Liu, X; Min, F; Sun, H; Wang, B | 1 |
| He, MF; Hua, Y; Li, CY; Li, K; Wei, P; Zhang, XH; Zhou, CC | 1 |
| Bao, H; Fang, J; He, S; Liu, Z; Wang, X; Xue, J; Zhang, W | 1 |
| Chen, H; Ding, L; Gong, J; Guo, W; Li, S; Xu, P; Zhang, M; Zhang, W; Zhang, Y | 1 |
| Chen, J; Jiang, ZX; Luo, Y; Tang, N; Wang, Q; Wang, Y; Yao, LH | 1 |
| Baracat, MM; Casagrande, R; Georgetti, SR; Martinez, RM; Pinho-Ribeiro, FA; Steffen, VS; Vale, DL; Verri, WA; Vicentini, FTMC; Vignoli, JA | 1 |
| Dong, H; Fu, D; Jin, CY; Li, L; Li, T; Li, Y; Liu, HM; Wang, X; Xu, H; Zhang, L; Zhang, S; Zhang, Y; Zi, X | 1 |
| Ahn, B; Cho, WJ; Han, SB; Hong, JT; Hwang, BY; Jung, SH; Kim, Y; Kwak, JA; Na, CS; Park, SH; Yun, CY | 1 |
| Gong, Z; He, L; Li, X; Pan, J; Peng, Y; Wang, H | 1 |
| Feng, W; Liu, J; Meng, X; Peng, C; Wang, A; Wang, C; Yan, D; Yang, Z; Yue, S | 1 |
| Jing, Y; Liu, S; Ni, B; Zhou, D | 1 |
| Cao, J; Che, D; Ding, Y; Gao, Z; Liu, R; Lv, Y; Ma, P; Wang, J; Wang, N; Wang, X; Zhang, T; Zhao, T | 1 |
| Dong, X; Liao, W; Liu, K; Tan, G; Wang, X; Wu, H | 1 |
| Dong, F; Jin, M; Peng, YY; Tan, L; Wang, Y; Xue, CJ; Zang, BX; Zhang, YD | 1 |
| Chittiboyina, A; Liu, Y; Pandey, PR; Sharma, S; Tyagi, A; Watabe, K; Wu, K; Wu, SY; Xing, F | 1 |
| Cao, J; Chen, S; Liu, W; Luo, X; Qiao, Y; Sun, M; Wen, A; Yang, Z; Zhao, X | 1 |
| Chen, C; Huang, L; Lin, Y; Qiu, D; Song, C; Wang, B; Wu, J; Zhang, S | 1 |
| Ahmad, O; An, XH; Hua, YR; Lai, YF; Shang, J; Zhang, R; Zhang, Y; Zhong, H; Zhou, J | 1 |
| Duan, YY; Li, B; Lu, QY; Ma, JQ; Sun, Y; Yu, S; Zhang, GM | 1 |
| Akhtar, MN; Akira, A; Israf, DA; Kamaldin, MN; Lajis, N; Ming-Tatt, L; Mohamad, AS; Perimal, EK; Sulaiman, MR | 1 |
| Cheng, Y; Liang, H; Shi, F; Wang, Y; Xing, M; Yang, Z; Zhang, N | 1 |
| Aguilar-Mariscal, H; Gómez-Rivera, A; Lobato-García, CE; Roa-de la Fuente, LF; Romero-Ceronio, N | 1 |
| Mei, X; Wang, J; Zhang, Q; Zhang, X | 1 |
| Chen, HX; Guo, WZ; Jin, ZL; Li, YF; Qiu, ZK; Xue, R; Yang, RF; Zhang, LM; Zhang, YZ; Zhao, N | 1 |
| He, F; Li, X; Liu, S; Liu, Z; Simoneau, AR; Wu, XR; Xu, X; Zi, X | 1 |
| Dezfulian, M; Ebrahim-Habibi, A; Haeri-Rohani, A; Kheirbakhsh, R; Larijani, B; Yaghmaei, P | 1 |
| Kushwaha, V; Modukuri, RK; Murthy, PK; Rao, KB; Sashidhara, KV; Verma, R | 1 |
| Bhatia, G; Dodda, RP; Palnati, GR; Sashidhara, KV; Sonkar, R | 1 |
| Bai, X; Jiang, S; Li, C; Ma, C; Shi, Z; Wang, C | 1 |
| Dong, F; Jin, M; Peng, Y; Tan, L; Wang, Y; Xue, C; Zang, B; Zhang, Y | 1 |
| Dodda, RP; Haque, R; Jadiya, P; Kumar, M; Kumar, V; Modukuri, RK; Nazir, A; Sashidhara, KV; Siddiqi, MI; Sridhar, B | 1 |
| Avula, SR; Bhatta, RS; Chhonker, YS; Mishra, V; Palit, G; Palnati, GR; Sashidhara, KV; Singh, LR; Singh, N; Swami, P | 1 |
| Hao, YY; Li, XS; Liu, Q; Liu, SH; Liu, Y; Liu, YJ; Liu, YL; Pan, YG; Zhang, J | 1 |
| Duan, SJ; Han, B; Lu, Y; Wang, LJ; Wang, SY; Wang, T; Zhu, Q | 1 |
| Baba, K; Kimura, Y; Sumiyoshi, M; Taniguchi, M | 1 |
| Ramagiri, S; Taliyan, R | 1 |
| Ding, L; Li, X; Lilly, MB; Liu, HM; Mercola, D; Yokoyama, NN; Zhang, S; Zi, X | 1 |
| Hu, YL; Ma, Q; Ruan, YY; Shi, XM; Wang, ZX; Xu, H | 1 |
| Cao, Y; Cui, X; Duan, JA; Jin, Y; Li, S; Qu, C; Shan, C; Shen, J; Tang, Y; Wu, L; Yue, S; Zhang, L | 1 |
| Cheng, Y; Sun, Q; Wang, Y; Xing, M; Zhang, N | 1 |
| Chu, J; Duan, J; Hu, N; Li, H; Liu, M; Lu, C; Sun, J; Wang, C; Wang, F; Wang, Y; Wen, A | 1 |
| Chen, G; Dai, Y; Huang, L; Liang, G; Liu, X; Liu, Z; Shan, X; Wu, B; Wu, J; Xu, T; Ying, S; Zhang, Y | 1 |
| Fan, R; Gan, P; Huang, W; Peng, W; Shi, Y; Wang, Y; Xia, Z; Zhang, C | 1 |
| Fu, H; Li, Y; Shou, Q; Tang, X; Tu, J; Wang, J; Wu, R; Zhang, L; Zhou, W | 1 |
| Dube, A; Jaiswal, AK; Joshi, S; Khare, P; Kushwaha, P; Mishra, S; Modukuri, RK; Rai, A; Rao, KB; Rawat, K; Sashidhara, KV | 1 |
| Chen, N; Chen, T; Deng, X; Li, R; Li, Y; Luo, M; Pang, N; Ren, M; Wang, L; Wu, J; Xiao, L | 1 |
| He, H; Li, L; Liu, Q; Shi, M; Wu, L; Yang, J; Zeng, X | 1 |
| Jang, S; Jung, JC; Jung, M; Kim, DH; Lee, Y; Oh, S; Ryu, JH | 1 |
| Bie, XD; Dai, HB; Han, J | 1 |
| Fan, H; Li, L; Liu, J; Liu, X; Lu, W; Niu, Y; Sun, L; Zhu, H | 1 |
| Pratap, R; Rawat, AK; Shukla, P; Srivastava, AK; Srivastava, R; Srivastava, SP | 1 |
| Duan, JA; Guo, J; Liu, L; Ma, H; Shi, X; Tang, Y; Yang, N | 1 |
| Jin, M; Wang, L; Wu, Y; Zang, BX | 1 |
| Cheng, Y; Han, J; Liang, H; Sun, L; Xu, YW; Yang, L; Zhao, RJ | 1 |
| Kase, Y; Kobayashi, H; Lee, KK; Omiya, Y; Yuzurihara, M | 1 |
| Chen, Y; Li, Q; Pan, Y; Wang, J; Yu, X; Zheng, J | 1 |
| Jia, M; Jiang, Y; Mei, Q; Wen, A; Yang, Z; Zhang, S | 1 |
| Fu, F; Guo, D; Li, C; Liu, K; Ma, C; Roeder, E; Tian, J; Wang, Z; Zhu, H | 1 |
| Liu, JW; Lu, YH; Qian, F; Wei, DZ; Ye, CL | 1 |
| An, J; Ding, H; Fu, F; Liu, H; Sun, X; Wang, J; Wei, X; Zhang, X | 1 |
| Yang, J; Zhan, C | 1 |
| Butler, PC; Gescher, AJ; Potter, GA; Ruparelia, KC; Sale, S; Steward, WP; Tunstall, RG | 1 |
| Cuendet, M; Moon, RC; Oteham, CP; Pezzuto, JM | 1 |
| He, H; Li, L; Shi, M; Wu, L; Yang, J; Yang, X; Zeng, X | 1 |
| Alberton, EH; Cazarolli, LH; Chiaradia, LD; Damazio, RG; Leal, PC; Nunes, RJ; Silva, FR; Yunes, RA | 1 |
| Aiba, Y; Igarashi, M; Kabir, AM; Koga, Y; Shimizu, K; Takagi, A | 1 |
| Chen, X; Cheng, M; Coetzer, TH; Cohen, FE; Flaherty, TM; Hua, H; Kenyon, GL; Lonsdale-Eccles, JD; McKerrow, JH; Morty, RE; Springer, C; Troeberg, L | 1 |
1 review(s) available for chalcone and Disease Models, Animal
| Article | Year |
|---|---|
Quinone reductase induction as a biomarker for cancer chemoprevention.
Topics: Animals; Anticarcinogenic Agents; Biomarkers; Chalcone; Chalcones; Disease Models, Animal; Enzyme Induction; Molecular Structure; NAD(P)H Dehydrogenase (Quinone); Plants, Medicinal; Rats | 2006 |
1 trial(s) available for chalcone and Disease Models, Animal
| Article | Year |
|---|---|
Indole and trans-chalcone attenuate amyloid β plaque accumulation in male Wistar rat: in vivo effectiveness of two anti-amyloid scaffolds.
Topics: Amyloid beta-Peptides; Animals; Antipsychotic Agents; Avoidance Learning; CA1 Region, Hippocampal; Chalcone; Disease Models, Animal; Dose-Response Relationship, Drug; Frontal Lobe; Indoles; Male; Peptide Fragments; Plaque, Amyloid; Rats; Rats, Wistar; Time Factors | 2013 |
74 other study(ies) available for chalcone and Disease Models, Animal
| Article | Year |
|---|---|
4-Fluoro-3',4',5'-trimethoxychalcone as a new anti-invasive agent. From discovery to initial validation in an in vivo metastasis model.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biological Products; Cell Line, Tumor; Cell Movement; Cell Survival; Chalcones; Chick Embryo; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Female; Humans; Mice; Mice, Nude; Molecular Structure; Myocardium; Neoplasm Invasiveness; Neoplasm Metastasis; Quantitative Structure-Activity Relationship | 2015 |
Hydroxysafflor yellow A can improve depressive behavior by inhibiting hippocampal inflammation and oxidative stress through regulating HPA axis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chalcone; Cytokines; Depressive Disorder; Disease Models, Animal; Encephalitis; Hippocampus; Hypothalamo-Hypophyseal System; Male; NF-kappa B; Oxidative Stress; Quinones; Rats, Wistar; Toll-Like Receptor 4 | 2022 |
Hydroxysafflor yellow A protects against ulcerative colitis via suppressing TLR4/NF-κB signaling pathway.
Topics: Animals; Body Weight; Chalcone; Colitis, Ulcerative; Colon; Disease Models, Animal; Lipopolysaccharides; NF-kappa B; Quinones; Rats; Rats, Sprague-Dawley; Signal Transduction; Toll-Like Receptor 4 | 2022 |
Therapeutic Effect of Renifolin F on Airway Allergy in an Ovalbumin-Induced Asthma Mouse Model In Vivo.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Chalcone; Cytokines; Disease Models, Animal; Hypersensitivity; Immunity, Innate; Inflammation; Lung; Lymphocytes; Mice; MicroRNAs; Ovalbumin | 2022 |
Development of trans-Chalcone loaded pectin/casein biodegradable microcapsules: Efficacy improvement in the management of experimental colitis.
Topics: Animals; Capsules; Caseins; Chalcone; Chalcones; Colitis; Colon; Disease Models, Animal; Mice; NF-kappa B; Pectins | 2023 |
A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Cells, Cultured; Chalcone; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrogen Peroxide; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Microglia; Molecular Structure; NF-E2-Related Factor 2; Oxidative Stress; Scopolamine; Structure-Activity Relationship | 2020 |
Renoprotective Effects Of Isoliquiritin Against Cationic Bovine Serum Albumin-Induced Membranous Glomerulonephritis In Experimental Rat Model Through Its Anti-Oxidative And Anti-Inflammatory Properties.
Topics: Animals; Biomarkers; Cations; Chalcone; Disease Models, Animal; Dose-Response Relationship, Drug; Glomerulonephritis, Membranous; Glucosides; Inflammation; Injections, Intravenous; Male; Molecular Structure; Oxidative Stress; Protective Agents; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Structure-Activity Relationship | 2019 |
Safflower Yellow Improves Synaptic Plasticity in APP/PS1 Mice by Regulating Microglia Activation Phenotypes and BDNF/TrkB/ERK Signaling Pathway.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Arginase; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Chalcone; Dendritic Spines; Disease Models, Animal; Donepezil; Drugs, Chinese Herbal; Enzyme Induction; Escape Reaction; Female; Hippocampus; Male; MAP Kinase Signaling System; Membrane Glycoproteins; Memory, Long-Term; Memory, Short-Term; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Morris Water Maze Test; Nerve Tissue Proteins; Neuronal Plasticity; Nitric Oxide Synthase Type II; Phytotherapy; Presenilin-1; Protein-Tyrosine Kinases; Random Allocation | 2020 |
Serotonergically dependent antihyperalgesic and antiallodynic effects of isoliquiritin in a mouse model of neuropathic pain.
Topics: Analgesics; Animals; Behavior, Animal; Brain; Chalcone; Disease Models, Animal; Glucosides; Hyperalgesia; Male; Mice, Inbred C57BL; Neuralgia; Pain Threshold; Receptor, Serotonin, 5-HT1A; Serotonin; Serotonin 5-HT1 Receptor Agonists; Spinal Cord | 2020 |
Hepatoprotective effects of hydroxysafflor yellow A in D-galactose-treated aging mice.
Topics: Age Factors; Animals; Antioxidants; Cellular Senescence; Chalcone; Chemical and Drug Induced Liver Injury; Cyclin-Dependent Kinase Inhibitor p16; Cytoprotection; Disease Models, Animal; Galactose; Gene Expression Regulation; Liver; Male; Mice, Inbred C57BL; Oxidative Stress; Phosphorylation; Quinones; Retinoblastoma Protein; Signal Transduction | 2020 |
Isoliquiritin exert protective effect on telencephalon infarction injury by regulating multi-pathways in zebrafish model of ischemic stroke.
Topics: Animals; Antioxidants; Apoptosis; Brain Ischemia; Chalcone; Disease Models, Animal; Enzymes; Female; Glucosides; Ischemic Stroke; Male; Oxidative Stress; Protective Agents; Signal Transduction; Telencephalon; Zebrafish; Zebrafish Proteins | 2021 |
Hydroxysafflor Yellow A Inhibits Staphylococcus aureus-Induced Mouse Endometrial Inflammation via TLR2-Mediated NF-kB and MAPK Pathway.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Chalcone; Cytokines; Disease Models, Animal; Endometritis; Endometrium; Female; Host-Pathogen Interactions; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Quinones; Signal Transduction; Staphylococcal Infections; Staphylococcus aureus; Toll-Like Receptor 2 | 2021 |
Trojan Horse Delivery of 4,4'-Dimethoxychalcone for Parkinsonian Neuroprotection.
Topics: Animals; Blood-Brain Barrier; Chalcone; Disease Models, Animal; Drug Delivery Systems; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Parkinson Disease; Substantia Nigra | 2021 |
Protective Effect of Hydroxysafflor Yellow A against Chronic Mild Stress-induced Memory Impairments by Suppressing Tau Phosphorylation in Mice.
Topics: Alzheimer Disease; Animals; Brain-Derived Neurotrophic Factor; Calcium-Binding Proteins; Chalcone; Disease Models, Animal; Gene Expression Regulation; Glycogen Synthase Kinase 3; Humans; Learning Disabilities; Membrane Glycoproteins; Memory Disorders; Mice; Muscle Proteins; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Quinones; TOR Serine-Threonine Kinases | 2021 |
Trans-chalcone added in topical formulation inhibits skin inflammation and oxidative stress in a model of ultraviolet B radiation skin damage in hairless mice.
Topics: Administration, Topical; Animals; Catalase; Chalcone; Cyclooxygenase 2; Disease Models, Animal; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Glutathione Reductase; Heme Oxygenase-1; Inflammation; Isomerism; Lipid Peroxidation; Matrix Metalloproteinase 9; Mice; Mice, Hairless; NF-E2-Related Factor 2; Oxidative Stress; Peroxidase; Skin; Tumor Necrosis Factor-alpha; Ultraviolet Rays | 2017 |
A novel chalcone derivative S17 induces apoptosis through ROS dependent DR5 up-regulation in gastric cancer cells.
Topics: Animals; Apoptosis; Biomarkers; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chalcone; Disease Models, Animal; Humans; Membrane Potential, Mitochondrial; Mice; Mitochondria; Reactive Oxygen Species; Receptors, TNF-Related Apoptosis-Inducing Ligand; Signal Transduction; Stomach Neoplasms; Xenograft Model Antitumor Assays | 2017 |
Piperidylmethyloxychalcone improves immune-mediated acute liver failure via inhibiting TAK1 activity.
Topics: Animals; Chalcone; Disease Models, Animal; Gene Expression Regulation; Hepatocytes; Immune System Diseases; Liver Failure, Acute; Macrophages; MAP Kinase Kinase Kinases; Mice; Models, Molecular; Molecular Conformation; NF-kappa B; Phosphorylation; Protective Agents; Protein Binding; Structure-Activity Relationship | 2017 |
Hydroxysafflor Yellow A Reprograms TLR9 Signalling Pathway in Ischaemic Cortex after Cerebral Ischaemia and Reperfusion.
Topics: Animals; Animals, Newborn; Brain; Brain Infarction; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Chalcone; Disease Models, Animal; Dose-Response Relationship, Drug; Functional Laterality; Gene Expression Regulation; Glucose; In Situ Nick-End Labeling; Inflammation; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Neurologic Examination; Quinones; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion; RNA Interference; RNA, Messenger; Signal Transduction; Time Factors; Toll-Like Receptor 9; Transfection | 2018 |
Oral hydroxysafflor yellow A reduces obesity in mice by modulating the gut microbiota and serum metabolism.
Topics: Adiposity; Administration, Oral; Animals; Anti-Obesity Agents; Bacteria; Biomarkers; Blood Glucose; Chalcone; Diet, High-Fat; Disease Models, Animal; Energy Metabolism; Fatty Acids, Volatile; Gastrointestinal Microbiome; Insulin; Insulin Resistance; Intestines; Male; Metabolomics; Mice, Inbred C57BL; Obesity; Quinones; Weight Loss | 2018 |
Hydroxysafflor yellow A protects against angiotensin II‑induced hypertrophy.
Topics: Angiotensin II; Animals; Cardiomegaly; Cell Line; Chalcone; Disease Models, Animal; Heme Oxygenase-1; Male; Myocardial Infarction; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Protective Agents; Quinones; Rats; Rats, Sprague-Dawley; Signal Transduction | 2018 |
The anti-anaphylactoid effects of hydroxysafflor yellow A on the suppression of mast cell Ca
Topics: Anaphylaxis; Animals; Calcium; Carthamus tinctorius; Cell Degranulation; Cells, Cultured; Chalcone; Cytokines; Disease Models, Animal; Mast Cells; Mice; Mice, Inbred C57BL; Quinones; Signal Transduction | 2018 |
Correlation of drug-induced and drug-related ultra-high performance liquid chromatography-mass spectrometry serum metabolomic profiles yields discovery of effective constituents of Sini decoction against myocardial ischemia in rats.
Topics: Aconitine; Alkaloids; Animals; Aspartate Aminotransferases; Catechols; Chalcone; Chromatography, High Pressure Liquid; Creatine Kinase; Disease Models, Animal; Drugs, Chinese Herbal; Fatty Alcohols; Flavanones; Glucosides; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Malondialdehyde; Mass Spectrometry; Metabolome; Myocardial Ischemia; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2018 |
Protective Effect of Hydroxysafflor Yellow A on Inflammatory Injury in Chronic Obstructive Pulmonary Disease Rats.
Topics: Animals; Chalcone; Cytokines; Disease Models, Animal; Inflammation; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pulmonary Disease, Chronic Obstructive; Quinones; Rats; Transcription Factor RelA | 2019 |
ID2 and GJB2 promote early-stage breast cancer progression by regulating cancer stemness.
Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Cell Proliferation; Chalcone; Connexin 26; Connexins; Disease Models, Animal; Disease Progression; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Inhibitor of Differentiation Protein 2; Mice; Neoplasm Staging; Neoplastic Stem Cells; Prognosis; Promoter Regions, Genetic | 2019 |
Neuroprotection of hydroxysafflor yellow A in experimental cerebral ischemia/reperfusion injury via metabolic inhibition of phenylalanine and mitochondrial biogenesis.
Topics: Animals; Behavior, Animal; Brain Ischemia; Chalcone; Disease Models, Animal; Energy Metabolism; Gene Expression Regulation, Enzymologic; Mice; Mitochondria; Neurons; Neuroprotective Agents; Organelle Biogenesis; Oxidative Stress; PC12 Cells; Phenylalanine; Quinones; Rats; Reperfusion Injury; Treatment Outcome | 2019 |
A novel chalcone derivative, L2H17, ameliorates lipopolysaccharide-induced acute lung injury via upregulating HO-1 activity.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Chalcone; Chalcones; Disease Models, Animal; Gene Expression Regulation; Heme Oxygenase-1; Humans; Inflammation; Lipopolysaccharides; Lung; Macrophages; Male; Membrane Proteins; Metalloporphyrins; Mice; Mice, Inbred C57BL; Protoporphyrins; RAW 264.7 Cells | 2019 |
Natural product-based design, synthesis and biological evaluation of 2',3,4,4'-tetrahydrochalcone analogues as antivitiligo agents.
Topics: Animals; Biological Products; Cell Line, Tumor; Cell Survival; Chalcone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Molecular Structure; Oxidative Stress; Structure-Activity Relationship; Vernonia; Vitiligo; Zebrafish | 2019 |
Carthamin Yellow Protects the Heart Against Ischemia/Reperfusion Injury With Reduced Reactive Oxygen Species Release and Inflammatory Response.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Caspase 1; Cell Hypoxia; Cell Line; Chalcone; Cytokines; Disease Models, Animal; Inflammation Mediators; Isolated Heart Preparation; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Rats, Wistar; Reactive Oxygen Species; Signal Transduction | 2019 |
Peripheral antinociception of a chalcone, flavokawin B and possible involvement of the nitric oxide/cyclic guanosine monophosphate/potassium channels pathway.
Topics: Analgesics; Animals; Arginine; Carrageenan; Chalcone; Cyclic GMP; Disease Models, Animal; Flavonoids; Hyperalgesia; Male; Nitric Oxide; Potassium Channel Blockers; Potassium Channels; Rats; Signal Transduction | 2013 |
Hydroxysafflor yellow A improves learning and memory in a rat model of vascular dementia by increasing VEGF and NR1 in the hippocampus.
Topics: Animals; Carotid Artery Diseases; Chalcone; Dementia, Vascular; Disease Models, Animal; Electric Stimulation; Gene Expression Regulation; Hippocampus; Learning Disabilities; Long-Term Potentiation; Male; Maze Learning; Memory Disorders; Quinones; Random Allocation; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Time Factors; Vascular Endothelial Growth Factor A | 2014 |
Synthesis and anti-inflammatory activity of three nitro chalcones.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Area Under Curve; Chalcone; Disease Models, Animal; Edema; Rats; ROC Curve | 2013 |
Hydroxysafflor yellow A attenuates left ventricular remodeling after pressure overload-induced cardiac hypertrophy in rats.
Topics: Animals; Apoptosis; Captopril; Cardiomegaly; Carthamus tinctorius; Chalcone; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Hypertension; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Medicine, Chinese Traditional; Myocytes, Cardiac; Quinones; Rats; Rats, Wistar; Ventricular Remodeling | 2014 |
Antidepressant-like and anxiolytic-like effects of YL-IPA08, a potent ligand for the translocator protein (18 kDa).
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Chalcone; Conditioning, Psychological; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Mice; Mice, Inbred ICR; Motor Activity; Protein Binding; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Swimming | 2014 |
Kava chalcone, flavokawain A, inhibits urothelial tumorigenesis in the UPII-SV40T transgenic mouse model.
Topics: Animals; Antigens, Polyomavirus Transforming; Apoptosis; Blotting, Southern; Blotting, Western; Cell Proliferation; Cell Transformation, Neoplastic; Chalcone; Chromatography, Liquid; Disease Models, Animal; Female; Humans; Immunoenzyme Techniques; Kava; Male; Mice; Mice, Transgenic; Tandem Mass Spectrometry; Urinary Bladder Neoplasms; Uroplakin II | 2013 |
Synthesis and antifilarial activity of chalcone-thiazole derivatives against a human lymphatic filarial parasite, Brugia malayi.
Topics: Animals; Brugia malayi; Chalcone; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Filariasis; Filaricides; Gerbillinae; Male; Molecular Structure; Murinae; Parasitic Sensitivity Tests; Structure-Activity Relationship; Thiazoles | 2014 |
Design and synthesis of novel indole-chalcone fibrates as lipid lowering agents.
Topics: Animals; Antioxidants; Chalcone; Disease Models, Animal; Drug Design; Hyperlipidemias; Hypolipidemic Agents; Indoles; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Male; Molecular Structure; Polyethylene Glycols; Rats | 2014 |
Hydroxysafflor yellow A attenuates ischemia/reperfusion-induced liver injury by suppressing macrophage activation.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Chalcone; Chemotaxis; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation Mediators; Liver; Liver Diseases; Macrophage Activation; Macrophages; Male; Matrix Metalloproteinase 9; Mice, Inbred C57BL; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Quinones; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction; Time Factors | 2014 |
Hydroxysafflor yellow a attenuates small airway remodeling in a rat model of chronic obstructive pulmonary disease.
Topics: Airway Remodeling; Animals; Chalcone; Disease Models, Animal; Male; Pulmonary Disease, Chronic Obstructive; Quinones; Rats; Rats, Wistar | 2014 |
Benzofuran-chalcone hybrids as potential multifunctional agents against Alzheimer's disease: synthesis and in vivo studies with transgenic Caenorhabditis elegans.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Antioxidants; Benzofurans; Binding Sites; Caenorhabditis elegans; Chalcone; Chalcones; Crystallography, X-Ray; Disease Models, Animal; Humans; Microscopy, Fluorescence; Molecular Conformation; Molecular Docking Simulation; Oxidative Stress; Protein Structure, Tertiary; Structure-Activity Relationship; Thiophenes | 2014 |
Identification of quinoline-chalcone hybrids as potential antiulcer agents.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Aspirin; Chalcone; Disease Models, Animal; Dose-Response Relationship, Drug; Molecular Structure; Quinolones; Rats; Rats, Sprague-Dawley; Stomach Ulcer | 2015 |
Hydroxysafflor yellow A ameliorates lipopolysaccharide-induced acute lung injury in mice via modulating toll-like receptor 4 signaling pathways.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Blotting, Western; Bronchoalveolar Lavage Fluid; Chalcone; Cytokines; Disease Models, Animal; Endotoxins; Enzyme-Linked Immunosorbent Assay; Male; Medicine, Chinese Traditional; Mice, Inbred ICR; Molecular Structure; Quinones; Signal Transduction; Toll-Like Receptor 4 | 2014 |
Coadministration of hydroxysafflor yellow A with levodopa attenuates the dyskinesia.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Antiparkinson Agents; Apomorphine; Chalcone; Disease Models, Animal; Levodopa; Male; Motor Activity; Olfaction Disorders; Oxidopamine; Parkinson Disease; Quinones; Rats; Receptors, Dopamine D3; Time Factors | 2015 |
Antitumor and antimetastatic actions of xanthoangelol and 4-hydroxyderricin isolated from Angelica keiskei roots through the inhibited activation and differentiation of M2 macrophages.
Topics: Angelica; Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Cell Differentiation; Cell Line; Chalcone; Chemokine CCL2; Disease Models, Animal; Humans; Interleukin-10; Macrophage Activation; Macrophages; Male; Mice, Inbred C3H; Osteosarcoma; Plant Roots; STAT3 Transcription Factor | 2015 |
Neuroprotective effect of hydroxy safflor yellow A against cerebral ischemia-reperfusion injury in rats: putative role of mPTP.
Topics: Animals; Brain Ischemia; Chalcone; Cognition Disorders; Disease Models, Animal; Free Radical Scavengers; Infarction, Middle Cerebral Artery; Male; Maze Learning; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Neuroprotective Agents; Oxidative Stress; Quinones; Rats; Rats, Wistar; Reperfusion Injury; Tumor Necrosis Factor-alpha | 2016 |
Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Apoptosis; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Chalcone; Cullin Proteins; Disease Models, Animal; Dose-Response Relationship, Drug; Genetic Predisposition to Disease; Humans; Male; Mice, Inbred C57BL; Mice, Transgenic; Molecular Docking Simulation; NEDD8 Protein; Phenotype; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Protein Binding; Protein Processing, Post-Translational; Proteolysis; Retinoblastoma Protein; S-Phase Kinase-Associated Proteins; Time Factors; Transfection; Ubiquitin-Conjugating Enzymes; Ubiquitination; Ubiquitins | 2015 |
Safflower yellow reduces lipid peroxidation, neuropathology, tau phosphorylation and ameliorates amyloid β-induced impairment of learning and memory in rats.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Chalcone; Disease Models, Animal; Hippocampus; Lipid Peroxidation; Male; Maze Learning; Memory Disorders; Neurons; Peptide Fragments; Phosphorylation; Rats; Rats, Wistar; tau Proteins | 2015 |
UFLC-Q-TOF/MS based screening and identification of the metabolites in plasma, bile, urine and feces of normal and blood stasis rats after oral administration of hydroxysafflor yellow A.
Topics: Administration, Oral; Animals; Bile; Carthamus tinctorius; Chalcone; Chromatography, High Pressure Liquid; Disease Models, Animal; Drugs, Chinese Herbal; Feces; Female; Hematologic Diseases; Quinones; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization | 2016 |
Hydroxysafflor yellow A increases BDNF and NMDARs in the hippocampus in a vascular dementia rat model.
Topics: Angiogenesis Inducing Agents; Animals; Brain-Derived Neurotrophic Factor; Chalcone; Dementia, Vascular; Disease Models, Animal; Drug Evaluation, Preclinical; Hippocampus; Long-Term Potentiation; Male; Maze Learning; Neuroprotective Agents; Nootropic Agents; Quinones; Random Allocation; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spatial Memory; Up-Regulation | 2016 |
Hydroxysafflor Yellow A Ameliorates Renal Fibrosis by Suppressing TGF-β1-Induced Epithelial-to-Mesenchymal Transition.
Topics: Animals; Apoptosis; Blood Urea Nitrogen; Cell Proliferation; Chalcone; Creatinine; Disease Models, Animal; Epithelial-Mesenchymal Transition; Fibrosis; Kidney; Kidney Diseases; Male; Mice, Inbred C57BL; Quinones; Smad3 Protein; Transforming Growth Factor beta1; Ureteral Obstruction | 2016 |
Discovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Chalcone; Cytokines; Disease Models, Animal; Gene Expression Regulation; Hydrogen Bonding; Lipopolysaccharides; Lymphocyte Antigen 96; MAP Kinase Signaling System; Mice; Molecular Docking Simulation; NF-kappa B; Rats; RAW 264.7 Cells | 2016 |
Hydroxysafflor yellow A exerts antioxidant effects in a rat model of traumatic brain injury.
Topics: Animals; Antioxidants; Brain; Brain Injuries, Traumatic; Carthamus tinctorius; Catalase; Chalcone; Disease Models, Animal; Male; Malondialdehyde; Oxidative Stress; Quinones; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2016 |
Safflower Yellow Prevents Pulmonary Metastasis of Breast Cancer by Inhibiting Tumor Cell Invadopodia.
Topics: Animals; Breast Neoplasms; Carthamus tinctorius; Chalcone; Chlorocebus aethiops; COS Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Epidermal Growth Factor; Female; Humans; Lung Neoplasms; Matrix Metalloproteinase 9; MCF-7 Cells; Mice; Mice, Inbred BALB C; Phytotherapy; Podosomes; Proto-Oncogene Proteins pp60(c-src) | 2016 |
Development of Leishmania donovani stably expressing DsRed for flow cytometry-based drug screening using chalcone thiazolyl-hydrazone as a new antileishmanial target.
Topics: Animals; Antiprotozoal Agents; Cell Line; Chalcone; Cricetinae; Disease Models, Animal; DNA, Protozoan; DNA, Ribosomal; Drug Evaluation, Preclinical; Female; Flow Cytometry; Genes, Reporter; Hydrazones; Leishmania donovani; Leishmaniasis, Visceral; Luminescent Proteins; Macrophages; Male; Mice; Recombination, Genetic; RNA, Ribosomal, 18S; Staining and Labeling; Treatment Outcome | 2016 |
Hydroxysafflor Yellow A Promotes Angiogenesis via the Angiopoietin 1/ Tie-2 Signaling Pathway.
Topics: Angiogenesis Inducing Agents; Angiopoietin-1; Animals; Blood Flow Velocity; Cell Movement; Cells, Cultured; Chalcone; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Hindlimb; Human Umbilical Vein Endothelial Cells; Humans; Ischemia; Male; Mice, Inbred C57BL; Muscle, Skeletal; Neovascularization, Physiologic; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinones; Receptor, TIE-2; Regional Blood Flow; Signal Transduction; Time Factors | 2016 |
Cardioprotective effects of hydroxysafflor yellow A on diabetic cardiac insufficiency attributed to up-regulation of the expression of intracellular calcium handling proteins of sarcoplasmic reticulum in rats.
Topics: Administration, Oral; Animals; Calcium Signaling; Calcium-Binding Proteins; Cardiomyopathies; Cardiotonic Agents; Chalcone; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal; Electrocardiography; Gene Expression Regulation; Hemodynamics; Male; Pigments, Biological; Quinones; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sarcoplasmic Reticulum Calcium-Transporting ATPases | 2008 |
The neuroprotective effects of benzylideneacetophenone derivatives on excitotoxicity and inflammation via phosphorylated Janus tyrosine kinase 2/phosphorylated signal transducer and activator of transcription 3 and mitogen-activated protein K pathways.
Topics: Animals; Brain Ischemia; Chalcone; Disease Models, Animal; DNA-Binding Proteins; Glutamic Acid; Hydrogen Peroxide; Inflammation; Janus Kinase 2; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Microglia; Mitogen-Activated Protein Kinases; Neuroprotective Agents; Neurotoxicity Syndromes; Nitric Oxide; Phosphorylation; Propiophenones; Signal Transduction; Transcription Factors | 2009 |
Effects of hydroxysafflor yellow A on the experimental traumatic brain injury in rats.
Topics: Adenosine Triphosphatases; Animals; Brain; Brain Injuries; Chalcone; Disease Models, Animal; Malondialdehyde; Mitochondria; Molecular Structure; Nimodipine; Plasminogen Activator Inhibitor 1; Quinones; Rats; Rats, Sprague-Dawley; Tissue Plasminogen Activator | 2010 |
3,5,2',4'-Tetrahydroxychalcone, a new non-purine xanthine oxidase inhibitor.
Topics: Animals; Chalcone; Chalcones; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydroxylation; Hyperuricemia; Kinetics; Mice; Uric Acid; Xanthine Oxidase | 2011 |
Synthesis and antidyslipidemic activity of chalcone fibrates.
Topics: Animals; Chalcone; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dyslipidemias; Fibric Acids; Humans; Hypolipidemic Agents; Lipid Metabolism; Molecular Structure; Structure-Activity Relationship | 2011 |
Taoren-Honghua herb pair and its main components promoting blood circulation through influencing on hemorheology, plasma coagulation and platelet aggregation.
Topics: Amygdalin; Animals; Anticoagulants; Blood Coagulation; Blood Coagulation Tests; Blood Sedimentation; Blood Viscosity; Chalcone; Chromatography, High Pressure Liquid; Disease Models, Animal; Drugs, Chinese Herbal; Female; Hemorheology; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinones; Rabbits; Rats; Rats, Sprague-Dawley; Thrombosis; Time Factors | 2012 |
Hydroxysafflor yellow A alleviates early inflammatory response of bleomycin-induced mice lung injury.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Bleomycin; Carthamus; Chalcone; Cytokines; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; p38 Mitogen-Activated Protein Kinases; Peroxidase; Phytotherapy; Plant Extracts; Quinones; RNA, Messenger; Transcription Factor RelA | 2012 |
Neuroprotection of hydroxysafflor yellow A in the transient focal ischemia: inhibition of protein oxidation/nitration, 12/15-lipoxygenase and blood-brain barrier disruption.
Topics: Animals; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Blood-Brain Barrier; Blotting, Western; Chalcone; Disease Models, Animal; Fluorescent Antibody Technique; Ischemic Attack, Transient; Male; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Quinones; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2012 |
Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix.
Topics: Animals; Animals, Outbred Strains; Chalcone; Chalcones; Coumarins; Dantrolene; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drugs, Chinese Herbal; Electric Stimulation; Flavanones; Glucosides; Glycyrrhetinic Acid; Glycyrrhiza; Male; Mice; Muscle Contraction; Muscle Cramp; Muscle, Skeletal; Paeonia; Parasympatholytics; Phytotherapy; Plant Roots; Rats; Rats, Wistar; Rotarod Performance Test; Tibial Nerve | 2013 |
The synthesis and evaluation of novel hydroxyl substituted chalcone analogs with in vitro anti-free radicals pharmacological activity and in vivo anti-oxidation activity in a free radical-injury Alzheimer's model.
Topics: Alzheimer Disease; Animals; Benzophenones; Biphenyl Compounds; Brain; Chalcone; Disease Models, Animal; Free Radical Scavengers; Free Radicals; Glutathione Peroxidase; Hydroxylation; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Malondialdehyde; Mice; Oxidation-Reduction; Picrates; Scopolamine; Superoxide Dismutase | 2013 |
[The effects of safflor yellow on microcirculation and hemorheology of acute blood stasis rats].
Topics: Animals; Chalcone; Disease Models, Animal; Drugs, Chinese Herbal; Hematologic Diseases; Hemorheology; Medicine, Chinese Traditional; Microcirculation; Quinones; Rats | 2001 |
Neuroprotective effects of hydroxysafflor yellow A: in vivo and in vitro studies.
Topics: Animals; Brain Ischemia; Carthamus tinctorius; Chalcone; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Mice; Neuroprotective Agents; Phytotherapy; Plant Extracts; Quinones; Rats; Rats, Inbred WKY; Sodium Cyanide | 2003 |
In vivo antitumor activity by 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone in a solid human carcinoma xenograft model.
Topics: Animals; Carcinoma; Chalcone; Chalcones; Disease Models, Animal; Drug Screening Assays, Antitumor; Liver Neoplasms; Mice; Myrtaceae; Plant Extracts; Transplantation, Heterologous | 2005 |
Hydroxysafflor yellow A protects rat brains against ischemia-reperfusion injury by antioxidant action.
Topics: Animals; Antioxidants; Brain; Cerebral Infarction; Chalcone; Disease Models, Animal; Free Radical Scavengers; Ischemic Attack, Transient; Malondialdehyde; Molecular Structure; Neuroprotective Agents; Oxidative Stress; Quinones; Rats; Reperfusion Injury; Superoxide Dismutase; Treatment Outcome | 2005 |
Protective effects of isoliquiritigenin in transient middle cerebral artery occlusion-induced focal cerebral ischemia in rats.
Topics: Adenine Nucleotides; Animals; Antioxidants; Brain; Brain Edema; Brain Ischemia; Catalase; Chalcone; Chalcones; Disease Models, Animal; Dose-Response Relationship, Drug; Glycyrrhiza; Infarction, Middle Cerebral Artery; Male; Malondialdehyde; Plant Roots; Premedication; Rats; Reperfusion Injury; Sodium-Potassium-Exchanging ATPase; Superoxide Dismutase | 2006 |
Effects of the potential chemopreventive agent DMU-135 on adenoma development in the ApcMin+ mouse.
Topics: Adenoma; Animals; Antineoplastic Agents; Chalcone; Colon; Disease Models, Animal; Genes, APC; Hematocrit; Intestinal Neoplasms; Intestine, Small; Mice; Mice, Inbred C57BL; Prodrugs; Protein-Tyrosine Kinases | 2006 |
Protective effects of hydroxysafflor yellow A on acute and chronic congestive cardiac failure mediated by reducing ET-1, NOS and oxidative stress in rats.
Topics: Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Viscosity; Cardiotonic Agents; Chalcone; Chronic Disease; Coronary Vessels; Creatine Kinase; Diltiazem; Disease Models, Animal; Echocardiography; Endothelin-1; Heart Failure; Hemodynamics; L-Lactate Dehydrogenase; Ligation; Malondialdehyde; Nitric Oxide Synthase; Oxidative Stress; Quinones; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2008 |
Influence of chalcone analogues on serum glucose levels in hyperglycemic rats.
Topics: Administration, Oral; Animals; Blood Glucose; Chalcone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Glucose; Hyperglycemia; Hypoglycemic Agents; Insulin; Male; Molecular Structure; Rats; Rats, Wistar; Stereoisomerism; Time Factors; Tolbutamide | 2008 |
The effect of sofalcone on indomethacin-induced gastric ulcers in a Helicobacter pylori-infected gnotobiotic murine model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell Adhesion; Chalcone; Chalcones; Disease Models, Animal; Helicobacter Infections; Helicobacter pylori; Humans; Indomethacin; Interleukin-8; Mice; Mice, Inbred BALB C; Stomach Ulcer | 2000 |
Chalcone, acyl hydrazide, and related amides kill cultured Trypanosoma brucei brucei.
Topics: Amides; Animals; Cathepsin L; Cathepsins; Chalcone; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Endopeptidases; Humans; Hydrazines; Inhibitory Concentration 50; Kinetics; Mice; Mice, Inbred BALB C; Molecular Structure; Sheep; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis | 2000 |