chalcone has been researched along with Carcinoma, Hepatocellular in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 1 (4.35) | 18.2507 |
| 2000's | 3 (13.04) | 29.6817 |
| 2010's | 14 (60.87) | 24.3611 |
| 2020's | 4 (17.39) | 2.80 |
| Authors | Studies |
|---|---|
| Cheng, C; Fu, H; Hu, Z; Jin, L; Lang, J; Liu, X; Mao, W; Shou, Q | 1 |
| Bai, Z; Li, J; Ma, R; Tian, J; Xi, J; Xi, L; Zhang, B; Zhang, M | 1 |
| Bortoleti, BTDS; Concato, VM; Conchon-Costa, I; Costa, IN; Gonçalves, MD; Junior, WAV; Mantovani, MS; Miranda-Sapla, MM; Panis, C; Pavanelli, WR; Silva, TF; Siqueira, EDS; Tomiotto-Pellissier, F | 1 |
| Li, X; Liang, R | 1 |
| Wu, Z | 1 |
| Fan, A; Ge, D; Liu, L; Ma, L; Ma, Y; Song, C; Wang, X; Xie, H; Xu, Y; Yu, X; Zhang, Q | 1 |
| Bai, X; Li, J; Liu, D; Song, H; Xiong, Y; Zhang, J | 1 |
| Gao, H; Gao, M; Gong, Z; Han, M; Li, Z; Liu, K; Lu, K; Shi, X; Xing, L; Zhang, L; Zhang, Z | 1 |
| Fang, K; Gao, H; Gong, Z; Han, M; Li, Z; Lin, X; Liu, X; Lu, K; Shi, X; Xie, J; Yang, X; Zhang, L; Zhang, Z | 1 |
| Chen, L; Duan, X; Fan, Y; Han, X; He, S; Hu, J; Huang, L; Li, X; Mao, Y; Pei, H; Tang, M; Wan, L; Wang, G; Wang, X; Wei, Y; Wu, W; Xie, C; Ye, H; Yuan, Z; Zhang, R | 1 |
| Bai, X; Chen, S; Li, J; Wang, D; Yang, F; Zhu, J | 1 |
| Fan, LM; Gong, LL; Lin, RX; Yang, SL; Zhao, ZK | 1 |
| Ahn, Y; Hwang, GS; Jang, HJ; Kang, KS; Kim, KH; Lee, D; Lee, H; Lee, JW; Moon, SW; Park, CS; Yamabe, N | 1 |
| Cao, L; Zhang, L; Zhang, Y; Zhao, X | 1 |
| Katare, DP; Mishra, S | 1 |
| Baytas, SN; Cetin Atalay, R; Eren, F; Hawash, MM; Kahraman, DC | 1 |
| Cho, M; Choi, S; Kim, HJ; Kim, YM; Kwak, TK; Lee, JW; Lee, MJ; Lee, SA; Park, KH; Ryu, HW | 1 |
| Jung, O; Kang, M; Kim, H; Kim, HJ; Kwak, TK; Lee, JW; Lee, MS; Lee, SA; Park, KH; Ryu, HW | 1 |
| Biswas, S; Jain, SK; Katare, DP; Malik, S; Sikander, M; Yadav, D | 1 |
| Fong, HH; Graham, JG; Gu, JQ; Kinghorn, AD; Park, EJ; Pezzuto, JM; Vigo, JS | 1 |
| Cheng, LY; Mack, P; Yang, EB; Zhang, K | 1 |
| Bozak, RE; Dinkova-Kostova, AT; Hicks, RJ; Massiah, MA; Talalay, P | 1 |
| Bababunmi, EA; Okorie, DA; Uwaifo, AO | 1 |
1 review(s) available for chalcone and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Comment on: an orally antitumor chalcone hybrid inhibited HepG2 cells growth and migration as the tubulin binding agent.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Chalcone; Chalcones; China; Hep G2 Cells; Humans; Liver Neoplasms; Mice; Mice, Nude; Tubulin | 2021 |
22 other study(ies) available for chalcone and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Safflower yellow reduces DEN-induced hepatocellular carcinoma by enhancing liver immune infiltration through promotion of collagen degradation and modulation of gut microbiota.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Chalcone; Collagen; Diethylnitrosamine; Gastrointestinal Microbiome; Humans; Liver; Liver Neoplasms; Macrophages, Peritoneal; Male; Mice; Neoplasms, Experimental; Tumor Microenvironment | 2021 |
(2E)-1-(2,4,6-Trimethoxyphenyl)-3-(4-chlorophenyl)prop-2-en-1-one, a Chalcone Derivative, Promotes Apoptosis by Suppressing RAS-ERK and AKT/FOXO3a Pathways in Hepatocellular Carcinoma Cells.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chalcone; Chalcones; Humans; Liver Neoplasms; Molecular Docking Simulation; Proto-Oncogene Proteins c-akt | 2023 |
Trans-chalcone induces death by autophagy mediated by p53 up-regulation and β-catenin down-regulation on human hepatocellular carcinoma HuH7.5 cell line.
Topics: Apoptosis; Autophagy; beta Catenin; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Chalcone; Chalcones; Down-Regulation; Humans; Liver Neoplasms; Tumor Suppressor Protein p53; Up-Regulation | 2021 |
Regulation of Apoptosis by SYB in HepG2 Liver Cancer Cells is Mediated by the P53/Caspase 9 Axis.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Carthamus tinctorius; Caspase 9; Cell Proliferation; Chalcone; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; MicroRNAs; Signal Transduction; Tumor Suppressor Protein p53 | 2017 |
The Role of E-Cadherin/β-Catenin in Hydroxysafflor Yellow A Inhibiting Adhesion, Invasion, Migration and Lung Metastasis of Hepatoma Cells.
Topics: Animals; beta Catenin; Cadherins; Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Chalcone; Humans; Liver Neoplasms; Lung Neoplasms; Male; Mice; Quinones | 2017 |
Hydroxysafflor yellow A suppresses angiogenesis of hepatocellular carcinoma through inhibition of p38 MAPK phosphorylation.
Topics: Animals; Carcinoma, Hepatocellular; Chalcone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hep G2 Cells; Humans; Liver Neoplasms; Male; Mice; Neovascularization, Pathologic; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pigments, Biological; Quinones | 2019 |
Endoplasmic reticulum stress triggers Xanthoangelol-induced protective autophagy via activation of JNK/c-Jun Axis in hepatocellular carcinoma.
Topics: Animals; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Proliferation; Chalcone; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Humans; Liver Neoplasms; Male; MAP Kinase Signaling System; Mice; Mice, Nude; Proton Pump Inhibitors | 2019 |
Autophagy induction by xanthoangelol exhibits anti-metastatic activities in hepatocellular carcinoma.
Topics: Angelica; Antineoplastic Agents, Phytogenic; Autophagy; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Chalcone; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Liver Neoplasms; Neoplasm Metastasis; Structure-Activity Relationship; Tumor Cells, Cultured | 2019 |
Millepachine, a novel chalcone, induces G2/M arrest by inhibiting CDK1 activity and causing apoptosis via ROS-mitochondrial apoptotic pathway in human hepatocarcinoma cells in vitro and in vivo.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; CDC2 Protein Kinase; Chalcone; Chalcones; Cyclin B; Cyclin-Dependent Kinases; Cytosol; DNA Damage; Dose-Response Relationship, Drug; Enzyme Activation; Female; Flow Cytometry; G2 Phase Cell Cycle Checkpoints; Hep G2 Cells; Humans; Inhibitory Concentration 50; Liver Neoplasms; Membrane Potentials; Mice; Mice, Inbred BALB C; Mice, Nude; Millettia; Mitochondria; Phosphorylation; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2013 |
Hydroxysafflor yellow A inhibits angiogenesis of hepatocellular carcinoma via blocking ERK/MAPK and NF-κB signaling pathway in H22 tumor-bearing mice.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chalcone; Liver Neoplasms; Male; MAP Kinase Signaling System; Mice; Neoplasm Transplantation; Neovascularization, Pathologic; NF-kappa B; Quinones | 2015 |
Role of ursolic acid chalcone, a synthetic analogue of ursolic acid, in inhibiting the properties of CD133(+) sphere-forming cells in liver stem cells.
Topics: AC133 Antigen; Antigens, CD; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Differentiation; Cell Line, Tumor; Cell Separation; Chalcone; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Glycoproteins; Humans; Liver Neoplasms; Neoplastic Stem Cells; Peptides; Triterpenes; Ursolic Acid | 2015 |
Synthesis of apoptotic chalcone analogues in HepG2 human hepatocellular carcinoma cells.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspase 8; Cell Survival; Chalcone; Hep G2 Cells; Humans; Liver Neoplasms; Poly(ADP-ribose) Polymerases | 2015 |
A Hybrid Chalcone Combining the Trimethoxyphenyl and Isatinyl Groups Targets Multiple Oncogenic Proteins and Pathways in Hepatocellular Carcinoma Cells.
Topics: Antineoplastic Agents; Apoptosis; Bibenzyls; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; Chalcone; Cytoskeleton; Focal Adhesions; Hep G2 Cells; Humans; Isatin; Liver Neoplasms; Molecular Targeted Therapy; Oncogene Proteins; Paxillin; Protein Multimerization; Protein Structure, Quaternary; Tubulin; Vacuoles; Wnt Signaling Pathway | 2016 |
Synergistic Combination for Chemoprevention of Hepatocellular Carcinoma: An In Silico and In Vitro Approach.
Topics: Alanine Transaminase; Antineoplastic Combined Chemotherapy Protocols; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Chalcone; Chemoprevention; Drug Synergism; Hep G2 Cells; Humans; Liver Neoplasms; Molecular Docking Simulation; Niacinamide; Oxidative Stress; Phenylurea Compounds; Protein Interaction Maps; Sorafenib; Vitamin K 1 | 2017 |
Synthesis and biological evaluation of novel pyrazolic chalcone derivatives as novel hepatocellular carcinoma therapeutics.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Chalcone; G2 Phase; Humans; Liver Neoplasms; Pyrazoles; Structure-Activity Relationship | 2017 |
Blockade of four-transmembrane L6 family member 5 (TM4SF5)-mediated tumorigenicity in hepatocytes by a synthetic chalcone derivative.
Topics: Animals; Carcinogenicity Tests; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chalcone; Chalcones; Contact Inhibition; Glycosylation; Hepatocytes; Humans; Liver Neoplasms; Membrane Proteins; Mice; Phenotype; Point Mutation; Protein Interaction Domains and Motifs; Structure-Activity Relationship; Sulfonamides | 2009 |
Differential inhibition of transmembrane 4 L six family member 5 (TM4SF5)-mediated tumorigenesis by TSAHC and sorafenib.
Topics: Animals; Antineoplastic Agents; Benzenesulfonates; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chalcone; Drug Discovery; Humans; Liver Neoplasms; Membrane Proteins; Mice; Mice, Nude; Niacinamide; Phenylurea Compounds; Pyridines; Signal Transduction; Sorafenib; Sulfonamides; Xenograft Model Antitumor Assays | 2011 |
Cytoprotective activity of a trans-chalcone against hydrogen peroxide induced toxicity in hepatocellular carcinoma (HepG2) cells.
Topics: Antioxidants; Carcinoma, Hepatocellular; Cell Proliferation; Chalcone; Cytoprotection; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Hep G2 Cells; Humans; Hydrogen Peroxide; Lipid Peroxidation; Liver Neoplasms; Oxidative Stress | 2011 |
Activity-guided isolation of constituents of Renealmia nicolaioides with the potential to induce the phase II enzyme quinone reductase.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Chalcone; Chalcones; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Inhibitory Concentration 50; Mice; Molecular Conformation; Molecular Structure; NAD(P)H Dehydrogenase (Quinone); Peru; Plant Roots; Plants, Medicinal; Structure-Activity Relationship; Tumor Cells, Cultured; Zingiberaceae | 2002 |
Butein, a specific protein tyrosine kinase inhibitor.
Topics: Carcinoma, Hepatocellular; Chalcone; Chalcones; CSK Tyrosine-Protein Kinase; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Humans; Kinetics; Molecular Structure; Phenols; Phosphorylation; Polymers; Polyphenols; Protein Kinase C; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; src-Family Kinases; Tumor Cells, Cultured | 1998 |
Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups.
Topics: Animals; Benzylidene Compounds; Butanones; Carcinoma, Hepatocellular; Chalcone; Cinnamates; Coumarins; Cyclohexanones; Cyclopentanes; Enzyme Induction; FMN Reductase; Glutathione; Glutathione Transferase; Humans; Liver Neoplasms; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; NADH, NADPH Oxidoreductases; Sulfhydryl Compounds; Tumor Cells, Cultured | 2001 |
Mutagenicity of chamuvaritin: a benzyldihydrochalcone isolated from a medicinal plant.
Topics: Animals; Carcinoma, Hepatocellular; Chalcone; Humans; Liver Neoplasms; Medicine, Traditional; Microsomes, Liver; Mutagens; Mutation; Nigeria; Plants, Medicinal; Propiophenones; Rats; Salmonella typhimurium; Xanthenes | 1979 |