chalcone has been researched along with Acute Confusional Senile Dementia in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 15 (42.86) | 24.3611 |
| 2020's | 20 (57.14) | 2.80 |
| Authors | Studies |
|---|---|
| Adhikari, B; Dhakal, S; Macreadie, I; Ramsland, PA | 1 |
| Ceyhun, İ; Kaplancıklı, ZA; Karaca, Ş; Levent, S; Osmaniye, D; Özkay, Y; Sağlık, BN | 1 |
| Cao, Z; Deng, Y; Sang, Z; Song, Q; Zhang, L | 1 |
| Alanazi, MM; Amran, SI; Biswas, S; Chander, S; Das, B; Hadda, TB; Hasan, AH; Jamalis, J; Murugesan, S; Pratama, MRF; Shakya, S | 1 |
| Dai, R; Han, C; Li, B; Liu, Y | 1 |
| Al-Sehemi, AG; George, G; Kim, H; Koyiparambath, VP; Mathew, B; Nair, AS; Pappachan, LK; Sukumaran, S | 1 |
| Ali, H; Amanat, S; Azhar, A; Khan, A; Khan, S; Kil, YS; Seo, EK; Shal, B; Syed, Z | 1 |
| Bai, P; Ban, Y; Hu, J; Mi, J; Sang, Z; Tan, Z; Tang, L; Wang, C; Wang, J; Wang, K; Wu, A; Xu, R; Zhang, J; Zhu, G | 1 |
| Al-Hazmy, SM; Alhagri, IA; Amri, N; Arfaoui, Y; Hamdi, N; Zouaghi, MO | 1 |
| Ahmadian, S; Ebrahim-Habibi, A; Omidi-Shahsavandi, M; Yaghmaei, P | 1 |
| Asti, M; Capponi, PC; Ferrari, E; Mari, M | 1 |
| Burgos, CF; Castillo, C; F de la Torre, A; Fuentealba, J; Jiménez, CA; López, JJ; Sáez-Orellana, F; Sánchez, Y | 1 |
| Ahmad, SF; Sharma, P; Singh, M; Singh, T; Singh, TG; Singh, V | 1 |
| Cao, Z; Deng, Y; He, Y; Qiang, X; Song, Q; Tian, C; Ye, C; Zhang, L | 1 |
| Hou, J; Hu, Y; Mo, Y; Pang, J; Qu, Z; Ren, M; Yang, G; Zhou, Z | 1 |
| Hou, J; Hu, Y; Qu, Z; Ren, M; Wang, C; Yang, G; Zhang, M | 1 |
| Du, C; Hou, J; Hu, Y; Wang, C; Yang, G; Zhang, M; Zheng, Y | 1 |
| Gurung, P; Lee, ES; Sharma, M; Sharma, R; Singh, V; Suo, WZ; Thapa, P; Upadhyay, SP | 1 |
| Cao, Z; Deng, Y; Sang, Z; Song, Q; Tan, Z; Zhang, L | 1 |
| Chen, J; Jiang, ZX; Luo, Y; Tang, N; Wang, Q; Wang, Y; Yao, LH | 1 |
| Bartolini, M; Belluti, F; Bisi, A; Cavalli, A; Falchi, F; Feoli, A; Gobbi, S; Montanari, S; Pruccoli, L; Rampa, A; Tarozzi, A | 1 |
| Liu, W; Sang, Z; Shi, J; Tan, Z; Wang, K; Zhang, P | 1 |
| Chen, J; He, ZF; Lu, YQ; Luo, Y; Wang, Y; Yan, BL; Yu, Q | 1 |
| Hui, X; Pan, J; Wu, Z; Xu, Y; Zhang, Z; Zhu, X | 1 |
| Hui, XC; Wu, ZZ; Xu, Y; Yang, H; Yin, KL; Yu, LJ; Zhang, ZH | 1 |
| Fuchigami, T; Haratake, M; Nakayama, M; Ono, M; Yamashita, Y; Yoshida, S | 1 |
| Adhikari, A; Chauhan, K; Chuttani, K; Datta, A; Kumar Singh, A; Mishra, AK | 1 |
| Dodda, RP; Haque, R; Jadiya, P; Kumar, M; Kumar, V; Modukuri, RK; Nazir, A; Sashidhara, KV; Siddiqi, MI; Sridhar, B | 1 |
| Hu, YL; Ma, Q; Ruan, YY; Shi, XM; Wang, ZX; Xu, H | 1 |
| Belluti, F; Bisi, A; De Simone, A; Di Martino, RM; Gobbi, S; Mancini, F; Palomba, F; Pruccoli, L; Rampa, A; Tarozzi, A; Zaccheroni, N | 1 |
| Haratake, M; Nakayama, M; Ono, M; Saji, H; Watanabe, H; Watanabe, R | 1 |
| Cui, M; Kimura, H; Liu, BL; Ono, M; Saji, H | 1 |
| Choi, HK; Choi, KC; Jun, W; Kim, MJ; Kwak, J; Lee, YH; Park, HJ; Yoon, HG | 1 |
| Fuchigami, T; Haratake, M; Ikeoka, R; Kimura, H; Nakayama, M; Ono, M; Saji, H; Watanabe, H | 1 |
| Chen, Y; Li, Q; Pan, Y; Wang, J; Yu, X; Zheng, J | 1 |
3 review(s) available for chalcone and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Structural Modifications on Chalcone Framework for Developing New Class of Cholinesterase Inhibitors.
Topics: Alzheimer Disease; Chalcone; Chalcones; Cholinesterase Inhibitors; Drug Discovery; Humans; Structure-Activity Relationship | 2022 |
Radiolabeled Chalcone Derivatives as Potential Radiotracers for β-Amyloid Plaques Imaging.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Brain; Chalcone; Chalcones; Humans; Plaque, Amyloid; Positron-Emission Tomography; Tissue Distribution; Tomography, Emission-Computed, Single-Photon | 2023 |
Chalcone and its analogs: Therapeutic and diagnostic applications in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Chalcone; Humans; Molecular Structure | 2021 |
32 other study(ies) available for chalcone and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Topics: Alzheimer Disease; Amyloid beta-Peptides; Chalcone; Drug Evaluation, Preclinical; Flavanones; Humans; Models, Biological; Oxidative Stress; Peptide Fragments; Protective Agents; Reactive Oxygen Species; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2021 |
Design and synthesis of novel chalcone derivatives and evaluation of their inhibitory activities against acetylcholinesterase.
Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Chalcone; Chalcones; Cholinesterase Inhibitors; Humans; Molecular Docking Simulation; Structure-Activity Relationship | 2022 |
Design, synthesis, and evaluation of chalcone-Vitamin E-donepezil hybrids as multi-target-directed ligands for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Chalcone; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Electrophorus; Humans; Ligands; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; PC12 Cells; Protein Aggregates; Rats; Structure-Activity Relationship; Vitamin E | 2022 |
Novel thiophene Chalcones-Coumarin as acetylcholinesterase inhibitors: Design, synthesis, biological evaluation, molecular docking, ADMET prediction and molecular dynamics simulation.
Topics: Acetylcholinesterase; Alzheimer Disease; Cells, Cultured; Chalcone; Cholinesterase Inhibitors; Coumarins; Dose-Response Relationship, Drug; Drug Design; Humans; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Thiophenes | 2022 |
Rational design, synthesis and activities of hydroxylated chalcones as highly potent dual functional agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Chalcone; Chalcones; Cholinesterase Inhibitors; Drug Design; Molecular Docking Simulation; Neurodegenerative Diseases; Peptide Fragments; Structure-Activity Relationship | 2022 |
Pharmacological mechanism of xanthoangelol underlying Nrf-2/TRPV1 and anti-apoptotic pathway against scopolamine-induced amnesia in mice.
Topics: Alzheimer Disease; Amnesia; Animals; Antioxidants; Chalcone; GA-Binding Protein Transcription Factor; Hydrogen Peroxide; Maze Learning; Mice; Neuroprotective Agents; Oxidative Stress; Scopolamine; TRPV Cation Channels | 2022 |
Novel donepezil-chalcone-rivastigmine hybrids as potential multifunctional anti-Alzheimer's agents: Design, synthesis, in vitro biological evaluation, in vivo and in silico studies.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Chalcone; Chalcones; Chalones; Cholinesterase Inhibitors; Donepezil; Drug Design; Neuroprotective Agents; Positron Emission Tomography Computed Tomography; Rats; Rivastigmine; Structure-Activity Relationship | 2022 |
DFT Study of Regio- and Stereoselective 13DC Reaction between Diazopropane and Substituted Chalcone Derivatives: Molecular Docking of Novel Pyrazole Derivatives as Anti-Alzheimer's Agents.
Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Chalcone; Chalcones; Cholinesterase Inhibitors; Humans; Molecular Docking Simulation; Molecular Structure; Pyrazoles; Structure-Activity Relationship | 2023 |
Effect of silibinin and trans-chalcone in an Alzheimer's disease-like model generated by insulin amyloids.
Topics: Alzheimer Disease; Animals; Chalcone; Chalcones; Insulin; Rats; Silybin | 2023 |
New Benzodihydrofuran Derivatives Alter the Amyloid β Peptide Aggregation: Strategies To Develop New Anti-Alzheimer Drugs.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Chalcone; Chalcones; Fluorine; Humans | 2023 |
Recent Development of Novel Aminoethyl-Substituted Chalcones as Potential Drug Candidates for the Treatment of Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Chalcone; Chalcones; Molecular Docking Simulation; Molecular Dynamics Simulation; Pain; Rats | 2023 |
Flurbiprofen-chalcone hybrid Mannich base derivatives as balanced multifunctional agents against Alzheimer's disease: Design, synthesis and biological evaluation.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Chalcone; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Flurbiprofen; Humans; Mannich Bases; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Organometallic Compounds; Peptide Fragments; Protein Aggregates; Structure-Activity Relationship | 2020 |
Safflower Yellow Improves Synaptic Plasticity in APP/PS1 Mice by Regulating Microglia Activation Phenotypes and BDNF/TrkB/ERK Signaling Pathway.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Arginase; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Chalcone; Dendritic Spines; Disease Models, Animal; Donepezil; Drugs, Chinese Herbal; Enzyme Induction; Escape Reaction; Female; Hippocampus; Male; MAP Kinase Signaling System; Membrane Glycoproteins; Memory, Long-Term; Memory, Short-Term; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Morris Water Maze Test; Nerve Tissue Proteins; Neuronal Plasticity; Nitric Oxide Synthase Type II; Phytotherapy; Presenilin-1; Protein-Tyrosine Kinases; Random Allocation | 2020 |
Safflower Yellow Improves the Synaptic Structural Plasticity by Ameliorating the Disorder of Glutamate Circulation in Aβ
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Chalcone; Dendritic Spines; Female; Glutamic Acid; Hippocampus; Learning; Male; Memory; Neuronal Plasticity; Neuroprotective Agents; Nootropic Agents; Peptide Fragments; Quinones; Rats, Sprague-Dawley; Synapses | 2020 |
Effects of safflower yellow on cholesterol levels in serum and brain tissue of APP/PS1 mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Anticholesteremic Agents; Avoidance Learning; Brain; Chalcone; Cholesterol; Female; Male; Maze Learning; Mice; Mice, Transgenic; Presenilin-1 | 2021 |
Design, synthesis and evaluation of novel dimethylamino chalcone-O-alkylamines derivatives as potential multifunctional agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amines; Amyloid beta-Peptides; Animals; Antioxidants; Binding Sites; Cell Survival; Chalcone; Drug Design; Humans; Kinetics; Metals; Molecular Docking Simulation; Monoamine Oxidase; Neuroprotective Agents; PC12 Cells; Protein Aggregates; Rats; Structure-Activity Relationship | 2021 |
Protective Effect of Hydroxysafflor Yellow A against Chronic Mild Stress-induced Memory Impairments by Suppressing Tau Phosphorylation in Mice.
Topics: Alzheimer Disease; Animals; Brain-Derived Neurotrophic Factor; Calcium-Binding Proteins; Chalcone; Disease Models, Animal; Gene Expression Regulation; Glycogen Synthase Kinase 3; Humans; Learning Disabilities; Membrane Glycoproteins; Memory Disorders; Mice; Muscle Proteins; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Quinones; TOR Serine-Threonine Kinases | 2021 |
Chalcone-based carbamates for Alzheimer's disease treatment.
Topics: Alzheimer Disease; Carbamates; Cell Line, Tumor; Cell Survival; Chalcone; Cholinesterase Inhibitors; Cholinesterases; Humans; Molecular Structure; Neuroprotective Agents | 2017 |
Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Chalcone; Cholinesterase Inhibitors; Drug Design; Eels; Horses; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Peptide Fragments; Protein Aggregates | 2019 |
Hydroxysafflor yellow A ameliorates homocysteine-induced Alzheimer-like pathologic dysfunction and memory/synaptic disorder.
Topics: Alzheimer Disease; Animals; Blotting, Western; Chalcone; Enzyme-Linked Immunosorbent Assay; Homocysteine; Male; Maze Learning; Memory Disorders; Quinones; Rats; Rats, Sprague-Dawley; Synapses | 2013 |
Hydroxy-safflor yellow A inhibits neuroinflammation mediated by Aβ₁₋₄₂ in BV-2 cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Apoptosis; Cell Line; Chalcone; Humans; Inflammation; Microglia; Neurons; Neuroprotective Agents; Quinones; Signal Transduction | 2014 |
Hydroxy-safflor yellow A attenuates Aβ₁₋₄₂-induced inflammation by modulating the JAK2/STAT3/NF-κB pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cells, Cultured; Chalcone; Inflammation; Janus Kinase 2; Male; Mice; Mice, Inbred ICR; Microglia; NF-kappa B; Peptide Fragments; Quinones; Signal Transduction; Spatial Learning; STAT3 Transcription Factor | 2014 |
Synthesis and evaluation of ethyleneoxylated and allyloxylated chalcone derivatives for imaging of amyloid β plaques by SPECT.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Chalcone; Chalcones; Ethylenes; Female; Humans; Iodine Radioisotopes; Mice; Mice, Transgenic; Peptide Fragments; Radiopharmaceuticals; Tissue Distribution; Tomography, Emission-Computed, Single-Photon | 2014 |
(68)Ga based probe for Alzheimer's disease: synthesis and preclinical evaluation of homodimeric chalcone in β-amyloid imaging.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Chalcone; Chelating Agents; Gallium Radioisotopes; Humans; Kinetics; Ligands; Molecular Structure; Positron-Emission Tomography; Rabbits; Thermodynamics | 2014 |
Benzofuran-chalcone hybrids as potential multifunctional agents against Alzheimer's disease: synthesis and in vivo studies with transgenic Caenorhabditis elegans.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Antioxidants; Benzofurans; Binding Sites; Caenorhabditis elegans; Chalcone; Chalcones; Crystallography, X-Ray; Disease Models, Animal; Humans; Microscopy, Fluorescence; Molecular Conformation; Molecular Docking Simulation; Oxidative Stress; Protein Structure, Tertiary; Structure-Activity Relationship; Thiophenes | 2014 |
Safflower yellow reduces lipid peroxidation, neuropathology, tau phosphorylation and ameliorates amyloid β-induced impairment of learning and memory in rats.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Chalcone; Disease Models, Animal; Hippocampus; Lipid Peroxidation; Male; Maze Learning; Memory Disorders; Neurons; Peptide Fragments; Phosphorylation; Rats; Rats, Wistar; tau Proteins | 2015 |
Naturally Inspired Molecules as Multifunctional Agents for Alzheimer's Disease Treatment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Chalcone; Chelating Agents; Drug Combinations; Humans; Ions; Ligands; Metals; Neuroprotective Agents; Oxidative Stress; Protein Aggregation, Pathological; Reactive Oxygen Species | 2016 |
Diphenylpropynone derivatives as probes for imaging β-amyloid plaques in Alzheimer's brains.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Chalcone; Contrast Media; Humans; Mice; Mice, Transgenic; Molecular Probes; Peptide Fragments; Plaque, Amyloid; Positron-Emission Tomography | 2011 |
Synthesis and biological evaluation of indole-chalcone derivatives as β-amyloid imaging probe.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Autoradiography; Chalcone; Fluorescent Dyes; Indoles; Iodine Radioisotopes; Mice; Mice, Transgenic; Microscopy, Fluorescence; Peptide Fragments; Pyrazoles; Radionuclide Imaging; Tissue Distribution | 2011 |
The chalcone derivative Chana 1 protects against amyloid β peptide-induced oxidative stress and cognitive impairment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Cell Survival; Chalcone; Chalcones; Cognition Disorders; Lethal Dose 50; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred ICR; Neuroprotective Agents; Oxidative Stress; Oximes; PC12 Cells; Random Allocation; Rats | 2012 |
Synthesis and evaluation of novel chalcone derivatives with (99m)Tc/Re complexes as potential probes for detection of β-amyloid plaques.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Chalcone; Drug Evaluation, Preclinical; Female; Mice; Mice, Transgenic; Plaque, Amyloid; Radionuclide Imaging; Technetium; Tissue Distribution | 2010 |
The synthesis and evaluation of novel hydroxyl substituted chalcone analogs with in vitro anti-free radicals pharmacological activity and in vivo anti-oxidation activity in a free radical-injury Alzheimer's model.
Topics: Alzheimer Disease; Animals; Benzophenones; Biphenyl Compounds; Brain; Chalcone; Disease Models, Animal; Free Radical Scavengers; Free Radicals; Glutathione Peroxidase; Hydroxylation; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Malondialdehyde; Mice; Oxidation-Reduction; Picrates; Scopolamine; Superoxide Dismutase | 2013 |