chaetominine and Colonic-Neoplasms

chaetominine has been researched along with Colonic-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for chaetominine and Colonic-Neoplasms

Article	Year
Chaetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp. IFB-E015. Organic letters, 2006, Dec-07, Volume: 8, Issue:25 Chaetominine (1), an alkaloidal metabolite with a new framework, was characterized from the solid-substrate culture of Chaetomium sp. IFB-E015, an endophytic fungus on the apparently healthy Adenophora axilliflora leaves. Its structure was determined by a combination of its spectral data and single-crystal X-ray diffraction analysis, with its absolute configuration elucidated by Marfey's method. Chaetominine was more cytotoxic than 5-fluorouracil against the human leukemia K562 and colon cancer SW1116 cell lines. [structure: see text] Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Campanulaceae; Cell Line, Tumor; Chaetomium; Circular Dichroism; Colonic Neoplasms; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Indole Alkaloids; K562 Cells; Magnetic Resonance Spectroscopy; Plant Leaves; Spectrometry, Mass, Electrospray Ionization; Tetrazolium Salts; Thiazoles	2006

Article

Year

Chaetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp. IFB-E015.

Organic letters, 2006, Dec-07, Volume: 8, Issue:25

Chaetominine (1), an alkaloidal metabolite with a new framework, was characterized from the solid-substrate culture of Chaetomium sp. IFB-E015, an endophytic fungus on the apparently healthy Adenophora axilliflora leaves. Its structure was determined by a combination of its spectral data and single-crystal X-ray diffraction analysis, with its absolute configuration elucidated by Marfey's method. Chaetominine was more cytotoxic than 5-fluorouracil against the human leukemia K562 and colon cancer SW1116 cell lines. [structure: see text]

Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Campanulaceae; Cell Line, Tumor; Chaetomium; Circular Dichroism; Colonic Neoplasms; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Indole Alkaloids; K562 Cells; Magnetic Resonance Spectroscopy; Plant Leaves; Spectrometry, Mass, Electrospray Ionization; Tetrazolium Salts; Thiazoles

2006