cgs-27023a and Anthrax

cgs-27023a has been researched along with Anthrax* in 1 studies

Other Studies

1 other study(ies) available for cgs-27023a and Anthrax

Article	Year
The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection. Bioorganic & medicinal chemistry letters, 2006, Feb-15, Volume: 16, Issue:4 A potent and selective anthrax LF inhibitor 40, (2R)-2-[(4-fluoro-3-methylphenyl)sulfonylamino]-N-hydroxy-2-(tetrahydro-2H-pyran-4-yl)acetamide, was identified through SAR study of a high throughput screen lead. It has an IC50 of 54 nM in the enzyme assay and an IC50 of 210 nM in the macrophage cytotoxicity assay. Compound 40 is also effective in vivo in several animal model studies. Topics: Animals; Anthrax; Antigens, Bacterial; Bacterial Toxins; Biological Availability; Dogs; Drug Evaluation, Preclinical; Macaca mulatta; Metalloproteases; Mice; Molecular Structure; Pyrans; Rabbits; Stereoisomerism; Structure-Activity Relationship	2006

Article

Year

The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection.

Bioorganic & medicinal chemistry letters, 2006, Feb-15, Volume: 16, Issue:4

A potent and selective anthrax LF inhibitor 40, (2R)-2-[(4-fluoro-3-methylphenyl)sulfonylamino]-N-hydroxy-2-(tetrahydro-2H-pyran-4-yl)acetamide, was identified through SAR study of a high throughput screen lead. It has an IC50 of 54 nM in the enzyme assay and an IC50 of 210 nM in the macrophage cytotoxicity assay. Compound 40 is also effective in vivo in several animal model studies.

Topics: Animals; Anthrax; Antigens, Bacterial; Bacterial Toxins; Biological Availability; Dogs; Drug Evaluation, Preclinical; Macaca mulatta; Metalloproteases; Mice; Molecular Structure; Pyrans; Rabbits; Stereoisomerism; Structure-Activity Relationship

2006