cgs 15943 and Hypoxia
cgs 15943 has been researched along with Hypoxia in 2 studies
9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine: non-xanthine triazoloquinazoline adenosine antagonist
CGS 15943 : A member of the class of triazoloquinazolines that is [1,2,4]triazolo[1,5-c]quinazoline substited at positions 2, 5 and 9 by furan-2-yl, amino and chloro groups respectively. A potent antagonist at adenosine A1 and adenosine A2A receptors.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "The respiratory effects of caffeine and paraxanthine, two xanthine adenosine antagonists with phosphodiesterase (PDE) activity, CGS 15943, a non-xanthine adenosine antagonist lacking PDE inhibitory activity, and rolipram, a non-xanthine PDE inhibitor lacking adenosine antagonist activity, were characterized in unanesthetized, seated rhesus monkeys exposed to 10% O2 balanced in N2 (hypoxia)." | 7.69 | Attenuation of hypoxia-induced increases in ventilation by adenosine antagonists in rhesus monkeys. ( Howell, LL; Landrum, AM, 1995) |
| "The respiratory effects of caffeine and paraxanthine, two xanthine adenosine antagonists with phosphodiesterase (PDE) activity, CGS 15943, a non-xanthine adenosine antagonist lacking PDE inhibitory activity, and rolipram, a non-xanthine PDE inhibitor lacking adenosine antagonist activity, were characterized in unanesthetized, seated rhesus monkeys exposed to 10% O2 balanced in N2 (hypoxia)." | 3.69 | Attenuation of hypoxia-induced increases in ventilation by adenosine antagonists in rhesus monkeys. ( Howell, LL; Landrum, AM, 1995) |
Research
Studies (2)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Kribben, A | 1 |
| Feldkamp, T | 1 |
| Horbelt, M | 1 |
| Lange, B | 1 |
| Pietruck, F | 1 |
| Herget-Rosenthal, S | 1 |
| Heemann, U | 1 |
| Philipp, T | 1 |
| Howell, LL | 1 |
| Landrum, AM | 1 |
Other Studies
2 other studies available for cgs 15943 and Hypoxia
| Article | Year |
|---|---|
ATP protects, by way of receptor-mediated mechanisms, against hypoxia-induced injury in renal proximal tubules.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Energy M | 2003 |
Attenuation of hypoxia-induced increases in ventilation by adenosine antagonists in rhesus monkeys.
Topics: Adenosine; Animals; Hypoxia; Macaca mulatta; Male; Phosphodiesterase Inhibitors; Pyrrolidinones; Qui | 1995 |