cgs 15943 has been researched along with Epilepsy in 2 studies
9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine: non-xanthine triazoloquinazoline adenosine antagonist
CGS 15943 : A member of the class of triazoloquinazolines that is [1,2,4]triazolo[1,5-c]quinazoline substited at positions 2, 5 and 9 by furan-2-yl, amino and chloro groups respectively. A potent antagonist at adenosine A1 and adenosine A2A receptors.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "CGS 15943 A (1 mg/kg) was given 15 min before both tests and all the drugs were administered i." | 1.28 | Influence of CGS 15943 A (a nonxanthine adenosine antagonist) on the protection offered by a variety of antiepileptic drugs against maximal electroshock-induced seizures in mice. ( Czuczwar, SJ; Janusz, W; Kleinrok, Z; Szczepanik, B, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Roseti, C | 1 |
| Martinello, K | 1 |
| Fucile, S | 1 |
| Piccari, V | 1 |
| Mascia, A | 1 |
| Di Gennaro, G | 1 |
| Quarato, PP | 1 |
| Manfredi, M | 1 |
| Esposito, V | 1 |
| Cantore, G | 1 |
| Arcella, A | 1 |
| Simonato, M | 1 |
| Fredholm, BB | 1 |
| Limatola, C | 1 |
| Miledi, R | 1 |
| Eusebi, F | 1 |
| Czuczwar, SJ | 1 |
| Janusz, W | 1 |
| Szczepanik, B | 1 |
| Kleinrok, Z | 1 |
2 other studies available for cgs 15943 and Epilepsy
| Article | Year |
|---|---|
Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors.
Topics: Adenosine; Adenosine Deaminase; Adult; Animals; Anticonvulsants; Cerebral Cortex; Epilepsy; Female; | 2008 |
Influence of CGS 15943 A (a nonxanthine adenosine antagonist) on the protection offered by a variety of antiepileptic drugs against maximal electroshock-induced seizures in mice.
Topics: Adenosine; Animals; Anticonvulsants; Disease Susceptibility; Drug Interactions; Electroshock; Epilep | 1991 |