cgs-12066b and Spinal-Cord-Injuries

cgs-12066b has been researched along with Spinal-Cord-Injuries* in 1 studies

Other Studies

1 other study(ies) available for cgs-12066b and Spinal-Cord-Injuries

Article	Year
The serotonergic agonists quipazine, CGS-12066A, and alpha-methylserotonin alter motor activity and induce hindlimb stepping in the intact and spinal rat fetus. Behavioral neuroscience, 2005, Volume: 119, Issue:3 The effects of serotonergic agonists were examined in intact and spinal fetuses, using an in vivo fetal rat preparation. On Gestational Day 20, fetuses were prepared with a midthoracic or sham spinal transection. Dose-response curves were obtained for quipazine (nonselective 5-hydroxytryptamine [5-HT] agonist; 1.0-10.0 mg/kg), CGS-12066A (5-HT-sub(1B) agonist; 1.0-30.0 mg/kg), and alpha-methylserotonin (alpha-Me-5-HT; 5-HT-sub-2 agonist; 0.2-15.0 mg/kg). During a 10-min test, each of the agonists (delivered via intraperitoneal injection) influenced fetal behavior: They increased the occurrence of head movements, mouthing, and hindlimb stepping. Quipazine and alpha-Me-5-HT also promoted hindlimb activity in spinal fetuses. Thus, stimulation of the fetal 5-HT system modulates motor activity at multiple levels of the developing central nervous system. Topics: Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Hindlimb; Male; Motor Activity; Pregnancy; Psychomotor Performance; Quinoxalines; Quipazine; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Receptor Agonists; Spinal Cord Injuries	2005

Article

Year

The serotonergic agonists quipazine, CGS-12066A, and alpha-methylserotonin alter motor activity and induce hindlimb stepping in the intact and spinal rat fetus.

Behavioral neuroscience, 2005, Volume: 119, Issue:3

The effects of serotonergic agonists were examined in intact and spinal fetuses, using an in vivo fetal rat preparation. On Gestational Day 20, fetuses were prepared with a midthoracic or sham spinal transection. Dose-response curves were obtained for quipazine (nonselective 5-hydroxytryptamine [5-HT] agonist; 1.0-10.0 mg/kg), CGS-12066A (5-HT-sub(1B) agonist; 1.0-30.0 mg/kg), and alpha-methylserotonin (alpha-Me-5-HT; 5-HT-sub-2 agonist; 0.2-15.0 mg/kg). During a 10-min test, each of the agonists (delivered via intraperitoneal injection) influenced fetal behavior: They increased the occurrence of head movements, mouthing, and hindlimb stepping. Quipazine and alpha-Me-5-HT also promoted hindlimb activity in spinal fetuses. Thus, stimulation of the fetal 5-HT system modulates motor activity at multiple levels of the developing central nervous system.

Topics: Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Hindlimb; Male; Motor Activity; Pregnancy; Psychomotor Performance; Quinoxalines; Quipazine; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Receptor Agonists; Spinal Cord Injuries

2005