cgp-52608 and Central-Nervous-System-Neoplasms

cgp-52608 has been researched along with Central-Nervous-System-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for cgp-52608 and Central-Nervous-System-Neoplasms

Article	Year
Cytotoxicity and oncostatic activity of the thiazolidinedione derivative CGP 52608 on central nervous system cancer cells. Cancer letters, 2004, Jul-28, Volume: 211, Issue:1 Oncostatic activity of CGP 52608 at concentrations 1 microM or lower, and cytotoxicity at 5 and 10 microM, are showed in central nervous system cancer cell lines. Inhibition of cell growth is accompanied by arrest of the cell cycle in G0/G1 or G2/M, depending on the cells, and suggests different intracellular pathways used on each cell type. Cytotoxicity is not mediated by oxidative stress, since no intra or extracellular peroxides were found after treatment and antioxidants failed to rescue cells from apoptosis induced by CGP 52608. Its use as anticancer drug susceptible of being concomitantly administered with antioxidants must be considered provided its antitumoral effects do not rely on free radical production. Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Caspases; Cell Cycle; Cell Division; Central Nervous System Neoplasms; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Mice; Oxidative Stress; PC12 Cells; Rats; Thiazoles; Thiosemicarbazones; Tumor Cells, Cultured	2004

Article

Year

Cytotoxicity and oncostatic activity of the thiazolidinedione derivative CGP 52608 on central nervous system cancer cells.

Cancer letters, 2004, Jul-28, Volume: 211, Issue:1

Oncostatic activity of CGP 52608 at concentrations 1 microM or lower, and cytotoxicity at 5 and 10 microM, are showed in central nervous system cancer cell lines. Inhibition of cell growth is accompanied by arrest of the cell cycle in G0/G1 or G2/M, depending on the cells, and suggests different intracellular pathways used on each cell type. Cytotoxicity is not mediated by oxidative stress, since no intra or extracellular peroxides were found after treatment and antioxidants failed to rescue cells from apoptosis induced by CGP 52608. Its use as anticancer drug susceptible of being concomitantly administered with antioxidants must be considered provided its antitumoral effects do not rely on free radical production.

Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Caspases; Cell Cycle; Cell Division; Central Nervous System Neoplasms; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Mice; Oxidative Stress; PC12 Cells; Rats; Thiazoles; Thiosemicarbazones; Tumor Cells, Cultured

2004