cgp-39393 and Hypertension--Pulmonary

cgp-39393 has been researched along with Hypertension--Pulmonary* in 1 studies

Other Studies

1 other study(ies) available for cgp-39393 and Hypertension--Pulmonary

ArticleYear
Chronic hypoxic pulmonary hypertension. Is thrombin involved?
    The American review of respiratory disease, 1993, Volume: 148, Issue:4 Pt 1

    Thrombin contracts vascular smooth muscle and stimulates its proliferation. Using a specific thrombin inhibitor, hirudin, we studied whether thrombin contributes to the pulmonary vasoconstriction and vascular proliferation that occurs in pulmonary hypertension. Hirudin was infused intravenously (0.2 mg/h/kg) by minipumps in nine rats during a 3-wk exposure to hypobaric hypoxia (HH). Vehicle (normal saline) was infused in eight hypoxic control (HC) and seven normoxic control (NC) rats. Sufficient hirudin delivery was confirmed by a failure of undiluted plasma from HH, but not from NC and HC, to clot in response to thrombin. When the plasma samples were diluted 1:10, the thrombin time was significantly prolonged in HH when compared with that in both NC and HC. Although hirudin slightly reduced mean pulmonary arterial pressure in open-chest rats, there was no significant difference between the hypoxic groups in total pulmonary resistance, right ventricle weight, morphologic remodeling of lung vessels, or the perfusion pressure-flow relationship in isolated lungs. Vasoconstrictor responses of isolated lungs to angiotensin II and acute hypoxic challenges were not affected by hirudin treatment. We conclude that hirudin, in a dose sufficient to reduce thrombin's catalytic effect on fibrinogen, does not significantly prevent the development of chronic hypoxic pulmonary hypertension.

    Topics: Animals; Chronic Disease; Hemodynamics; Hirudins; Hypertension, Pulmonary; Hypoxia; Infusion Pumps, Implantable; Lung; Male; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Specific Pathogen-Free Organisms; Thrombin; Thrombin Time

1993
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