Page last updated: 2024-10-24

cgp 37157 and Leigh Disease

cgp 37157 has been researched along with Leigh Disease in 1 studies

CGP 37157: benzothiazepine derivative of clonazepam; inhibits the in vitro activity of mitochondrial sodium-calcium exchange

Leigh Disease: A group of metabolic disorders primarily of infancy characterized by the subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, dysphagia, and lactic acidosis. Pathological features include spongy degeneration of the neuropile of the basal ganglia, thalamus, brain stem, and spinal cord. Patterns of inheritance include X-linked recessive, autosomal recessive, and mitochondrial. Leigh disease has been associated with mutations in genes for the PYRUVATE DEHYDROGENASE COMPLEX; CYTOCHROME-C OXIDASE; ATP synthase subunit 6; and subunits of mitochondrial complex I. (From Menkes, Textbook of Child Neurology, 5th ed, p850).

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Visch, HJ1
Rutter, GA1
Koopman, WJ1
Koenderink, JB1
Verkaart, S1
de Groot, T1
Varadi, A1
Mitchell, KJ1
van den Heuvel, LP1
Smeitink, JA1
Willems, PH1

Other Studies

1 other study available for cgp 37157 and Leigh Disease

ArticleYear
Inhibition of mitochondrial Na+-Ca2+ exchange restores agonist-induced ATP production and Ca2+ handling in human complex I deficiency.
    The Journal of biological chemistry, 2004, Sep-24, Volume: 279, Issue:39

    Topics: Adenosine Triphosphate; Bradykinin; Calcium; Cell Nucleus; Clonazepam; Cytosol; Electron Transport C

2004