cgp 12177 has been researched along with Tachycardia in 4 studies
CGP 12177 : A benzimidazole that is benzimidazol-2-one substituted at position 4 by a 3-(tert-butylamino)-2-hydroxypropoxy group.
Tachycardia: Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.
| Excerpt | Relevance | Reference |
|---|---|---|
| " (-)-Bupranolol and compounds (-)-GD-6, (+)-GD-6, (-)-DZ-13, (+)-DZ-13, DZ-51 and DZ-52 antagonized the CGP 12177-induced tachycardia in pithed rats with "apparent pA(2) values" of 6." | 3.75 | Four close bupranolol analogues are antagonists at the low-affinity state of beta1-adrenoceptors. ( Baranowska, M; Baranowska, U; Kiec-Kononowicz, K; Kozlowska, H; Malinowska, B; Reutelsterz, A; Schlicker, E; Zelaszczyk, D, 2009) |
| " The in vitro activity of four aryl propanolamines was compared to two prototypic beta3 receptor agonists, CGP 12177 and CL316243 at the human beta3 receptor, the rat beta3 receptor in the stomach fundus and receptors mediating atrial tachycardia." | 3.70 | Aryl propanolamines: comparison of activity at human beta3 receptors, rat beta3 receptors and rat atrial receptors mediating tachycardia. ( Bloomquist, W; Calligaro, D; Cohen, ML; Kriauciunas, A; Shuker, A, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Galindo-Tovar, A | 1 |
| Vargas, ML | 1 |
| Kaumann, AJ | 1 |
| Zelaszczyk, D | 1 |
| Kozlowska, H | 1 |
| Baranowska, U | 2 |
| Baranowska, M | 1 |
| Reutelsterz, A | 1 |
| Kiec-Kononowicz, K | 1 |
| Malinowska, B | 2 |
| Schlicker, E | 2 |
| Godlewski, G | 1 |
| Cohen, ML | 1 |
| Bloomquist, W | 1 |
| Kriauciunas, A | 1 |
| Shuker, A | 1 |
| Calligaro, D | 1 |
4 other studies available for cgp 12177 and Tachycardia
| Article | Year |
|---|---|
Phosphodiesterases PDE3 and PDE4 jointly control the inotropic effects but not chronotropic effects of (-)-CGP12177 despite PDE4-evoked sinoatrial bradycardia in rat atrium.
Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-Agonists; Animals; Arrhythmia, Sinus; Atrial Fu | 2009 |
Four close bupranolol analogues are antagonists at the low-affinity state of beta1-adrenoceptors.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Binding Sites; Buprano | 2009 |
Recruitment of functionally active heart beta2-adrenoceptors in the initial phase of endotoxic shock in pithed rats.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cardiovascular Physiological Phenome | 2006 |
Aryl propanolamines: comparison of activity at human beta3 receptors, rat beta3 receptors and rat atrial receptors mediating tachycardia.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Atrial Function; Dioxoles; Humans; M | 1999 |