cgp 12177 has been researched along with Obesity in 14 studies
CGP 12177 : A benzimidazole that is benzimidazol-2-one substituted at position 4 by a 3-(tert-butylamino)-2-hydroxypropoxy group.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Recently, a mutation in the corresponding gene resulting in the replacement of tryptophan by arginine in position 64 (Trp64Arg) has been demonstrated, which associated with obesity and metabolic complications of obesity." | 3.69 | Phenotypic characterization of the Trp64Arg polymorphism in the beta 3-adrenergic receptor gene in normal weight and obese subjects. ( Arner, P; Li, LS; Lönnqvist, F; Luthman, H, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 11 (78.57) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lönnqvist, F | 4 |
| Thöme, A | 1 |
| Nilsell, K | 1 |
| Hoffstedt, J | 4 |
| Arner, P | 8 |
| Marette, A | 1 |
| Mauriège, P | 1 |
| Després, JP | 1 |
| Tulp, OL | 1 |
| Bukowiecki, LJ | 1 |
| Li, LS | 1 |
| Luthman, H | 1 |
| Hellström, L | 1 |
| Reynisdottir, S | 3 |
| Langin, D | 1 |
| Rössner, S | 1 |
| Yoshida, T | 1 |
| Hayashi, M | 1 |
| Monkawa, T | 1 |
| Saruta, T | 1 |
| Barbe, P | 1 |
| Stich, V | 1 |
| Galitzky, J | 1 |
| Kunesova, M | 1 |
| Hainer, V | 1 |
| Lafontan, M | 1 |
| Berlan, M | 1 |
| Large, V | 2 |
| Eleborg, L | 1 |
| van Harmelen, V | 2 |
| Strömmer, L | 1 |
| Hellers, G | 1 |
| Li, H | 1 |
| Matheny, M | 1 |
| Scarpace, PJ | 1 |
| Thörne, A | 1 |
| Wennlund, A | 1 |
| Rydén, M | 1 |
| Eriksson, P | 1 |
| Bringman, S | 1 |
| Näslund, E | 1 |
| Kobatake, T | 1 |
| Watanabe, Y | 1 |
| Matsuzawa, Y | 1 |
| Tokunaga, K | 1 |
| Fujioka, S | 1 |
| Kawamoto, T | 1 |
| Keno, Y | 1 |
| Tarui, S | 1 |
| Yoshida, H | 1 |
| Raasmaja, A | 1 |
| York, DA | 1 |
14 other studies available for cgp 12177 and Obesity
| Article | Year |
|---|---|
A pathogenic role of visceral fat beta 3-adrenoceptors in obesity.
Topics: Adipose Tissue; Adrenergic Agonists; Adult; Brimonidine Tartrate; Dobutamine; Dose-Response Relation | 1995 |
Norepinephrine- and insulin-resistant glucose transport in brown adipocytes from diabetic SHR/N-cp rats.
Topics: Adipose Tissue, Brown; Animals; Biological Transport; Diabetes Mellitus; Drug Resistance; Female; Gl | 1993 |
Phenotypic characterization of the Trp64Arg polymorphism in the beta 3-adrenergic receptor gene in normal weight and obese subjects.
Topics: Adipocytes; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Arginine; DNA Primers; Fe | 1996 |
Regulation of lipolysis in fat cells of obese women during long-term hypocaloric diet.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adipocytes; Adrenergic beta-Agonists; Adult; Brimonidine Tar | 1996 |
Regulation of obese mRNA expression by hormonal factors in primary cultures of rat adipocytes.
Topics: Adipocytes; Adrenergic beta-Agonists; Animals; Cells, Cultured; Cloning, Molecular; Dexamethasone; D | 1996 |
In vivo increase in beta-adrenergic lipolytic response in subcutaneous adipose tissue of obese subjects submitted to a hypocaloric diet.
Topics: Adipose Tissue; Adrenergic beta-Agonists; Adult; Diet, Reducing; Dobutamine; Energy Intake; Female; | 1997 |
Lipolysis in human fat cells obtained under local and general anesthesia.
Topics: Abdomen; Adenylyl Cyclases; Adipocytes; Adrenergic beta-Agonists; Adult; Anesthesia, General; Anesth | 1997 |
Variation in adrenergic regulation of lipolysis between omental and subcutaneous adipocytes from obese and non-obese men.
Topics: Adipocytes; Adipose Tissue; Adrenergic Agonists; Adult; Biopsy; Brimonidine Tartrate; Dobutamine; Do | 1997 |
beta 3-Adrenergic-mediated suppression of leptin gene expression in rats.
Topics: Adipose Tissue; Adipose Tissue, Brown; Adrenergic beta-Agonists; Animals; Body Weight; Carrier Prote | 1997 |
Noradrenaline-induced lipolysis in isolated mesenteric, omental and subcutaneous adipocytes from obese subjects.
Topics: Adipocytes; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adult; Dobutamine; Dose-Response Re | 1997 |
The Arg 389 Gly beta1-adrenergic receptor gene polymorphism and human fat cell lipolysis.
Topics: Adipocytes; Adrenergic Agonists; Adult; Aged; Catecholamines; DNA Primers; Dobutamine; Female; Human | 2001 |
Calpain-10 gene polymorphism is associated with reduced beta(3)-adrenoceptor function in human fat cells.
Topics: Adipocytes; Adrenergic beta-3 Receptor Agonists; Adrenergic beta-Agonists; Adult; Aged; Calpain; Fem | 2002 |
Age-related changes in adrenergic alpha 1, alpha 2, and beta receptors of rat white fat cell membranes: an analysis using [3H]bunazosin as a novel ligand for the alpha 1 adrenoceptor.
Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aging; Animals; Binding S | 1991 |
Alpha 1- and beta-adrenergic receptors in brown adipose tissue of lean (Fa/?) and obese (fa/fa) Zucker rats. Effects of cold-acclimation, sucrose feeding and adrenalectomy.
Topics: Adipose Tissue, Brown; Adrenalectomy; Adrenergic beta-Antagonists; Animals; Binding Sites; Cell Memb | 1988 |