cgp 12177 has been researched along with Muscle Relaxation in 31 studies
CGP 12177 : A benzimidazole that is benzimidazol-2-one substituted at position 4 by a 3-(tert-butylamino)-2-hydroxypropoxy group.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (32.26) | 18.2507 |
| 2000's | 20 (64.52) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Obara, K | 1 |
| Shigematsu, M | 1 |
| Takahasi, H | 1 |
| Iiboshi, Y | 1 |
| Yoshioka, K | 1 |
| Kasuya, Y | 1 |
| Tanaka, Y | 3 |
| Horinouchi, T | 11 |
| Koike, K | 13 |
| Sarsero, D | 1 |
| Russell, FD | 1 |
| Lynham, JA | 1 |
| Rabnott, G | 1 |
| Yang, I | 1 |
| Fong, KM | 1 |
| Li, L | 1 |
| Kaumann, AJ | 2 |
| Molenaar, P | 2 |
| Tomiyama, Y | 1 |
| Murakami, M | 1 |
| Yamazaki, Y | 3 |
| Kojima, M | 1 |
| Akahane, M | 3 |
| Mallem, MY | 2 |
| Toumaniantz, G | 1 |
| Serpillon, S | 1 |
| Gautier, F | 1 |
| Gogny, M | 3 |
| Desfontis, JC | 3 |
| Gauthier, C | 1 |
| Arch, JR | 1 |
| Mallem, Y | 1 |
| Holopherne, D | 1 |
| Reculeau, O | 2 |
| Le Coz, O | 2 |
| Badawi, JK | 2 |
| Uecelehan, H | 2 |
| Hatzinger, M | 1 |
| Michel, MS | 1 |
| Haferkamp, A | 1 |
| Bross, S | 2 |
| Frazier, EP | 1 |
| Schneider, T | 1 |
| Michel, MC | 1 |
| Matsushita, M | 1 |
| Seja, T | 1 |
| Honeck, P | 1 |
| Kwon, ST | 1 |
| Langbein, S | 1 |
| Takayanagi, I | 4 |
| Muramatsu, M | 1 |
| Ohki, S | 1 |
| Re, G | 1 |
| Belloli, C | 1 |
| Badino, P | 1 |
| Arioli, F | 1 |
| Novelli, A | 1 |
| Girardi, C | 1 |
| Beretta, C | 1 |
| Igawa, Y | 2 |
| Takeda, H | 2 |
| Hayakawa, K | 1 |
| Ajisawa, Y | 2 |
| Yoneyama, T | 1 |
| Nishizawa, O | 2 |
| Andersson, KE | 1 |
| de Ponti, F | 1 |
| Modini, C | 1 |
| Gibelli, G | 1 |
| Crema, F | 1 |
| Frigo, G | 1 |
| Suzuki, H | 1 |
| Shindo, K | 1 |
| Ueno, A | 1 |
| Miura, T | 1 |
| Takei, M | 1 |
| Sakakibara, M | 1 |
| Fukamachi, H | 1 |
| Tanaka, J | 1 |
| Higa, T | 1 |
| Tsujitani, M | 1 |
| Cohen, ML | 1 |
| Bloomquist, W | 1 |
| Ito, M | 1 |
| Lowell, BB | 1 |
| Oostendorp, J | 1 |
| Preitner, F | 1 |
| Moffatt, J | 1 |
| Jimenez, M | 1 |
| Giacobino, JP | 1 |
| Manara, L | 1 |
| Croci, T | 1 |
| Aureggi, G | 1 |
| Guagnini, F | 1 |
| Maffrand, JP | 1 |
| Le Fur, G | 1 |
| Mukenge, S | 1 |
| Ferla, G | 1 |
| Komatsu, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| To Explore the Effect of beta3-adrenoceptor Agonist on Patients With Overactive Bladder and Develop Its Urinary Biomarker[NCT04693897] | 400 participants (Anticipated) | Observational [Patient Registry] | 2021-03-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for cgp 12177 and Muscle Relaxation
| Article | Year |
|---|---|
Beta3-adrenoceptor mechanisms in guinea-pig taenia caecum.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cecum; Ethanolamines; Guinea Pigs; M | 1998 |
30 other studies available for cgp 12177 and Muscle Relaxation
| Article | Year |
|---|---|
Pharmacological properties of β-adrenoceptors mediating rat superior mesenteric artery relaxation and the effects of chemical sympathetic denervation.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Isoproterenol; Male; Mesenteric Arte | 2020 |
Evidence for the primary role for 4-aminopyridine-sensitive K(v) channels in beta(3)-adrenoceptor-mediated, cyclic AMP-independent relaxations of guinea-pig gastrointestinal smooth muscles.
Topics: 4-Aminopyridine; Adrenergic Agonists; Animals; Catecholamines; Cyclic AMP; Epinephrine; Ethanolamine | 2003 |
(-)-CGP 12177 increases contractile force and hastens relaxation of human myocardial preparations through a propranolol-resistant state of the beta 1-adrenoceptor.
Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-1 Receptor Antagonists; Adult; Aged; Dose-Respo | 2003 |
Comparison between CL-316243- and CGP-12177A-induced relaxations in isolated canine ureter.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Dioxoles; Dogs; Female; In Vitro Tec | 2003 |
Impairment of the low-affinity state beta1-adrenoceptor-induced relaxation in spontaneously hypertensive rats.
Topics: Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Enzyme Inhi | 2004 |
Do low-affinity states of beta-adrenoceptors have roles in physiology and medicine?
Topics: Aorta, Thoracic; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Muscle Relaxation; Muscle, Smoot | 2004 |
Beta-adrenoceptor-mediated vascular relaxation in spontaneously hypertensive rats.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Dose-Response Relat | 2005 |
Low-affinity state beta1-adrenoceptor-induced vasodilation in SHR.
Topics: Adrenergic beta-1 Receptor Agonists; Alprenolol; Animals; Aorta; Blood Pressure; Dose-Response Relat | 2005 |
Relaxant effects of beta-adrenergic agonists on porcine and human detrusor muscle.
Topics: Adrenergic beta-Agonists; Aged; Albuterol; Animals; Dioxoles; Dose-Response Relationship, Drug; Epin | 2005 |
Effects of gender, age and hypertension on beta-adrenergic receptor function in rat urinary bladder.
Topics: Adrenergic beta-3 Receptor Agonists; Adrenergic beta-Agonists; Age Factors; Animals; Ethanolamines; | 2006 |
Studies on the mechanisms underlying beta-adrenoceptor-mediated relaxation of rat abdominal aorta.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Aorta, Abdominal; Cyclic AMP; In Vit | 2006 |
Relaxation of human detrusor muscle by selective beta-2 and beta-3 agonists and endogenous catecholamines.
Topics: Adrenergic beta-Agonists; Aged; Catecholamines; Clenbuterol; Dose-Response Relationship, Drug; Ethan | 2007 |
Signal transduction pathway involved in beta 3-adrenoceptor-mediated relaxation in guinea pig taenia caecum.
Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Animals; Butoxamine; Cecum; Culture Techniques; Cycl | 1995 |
Involvement of beta 3-adrenoceptor in the relaxation response in guinea pig taenia caecum.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Binding, Competitive; Butoxamine; Cecum; Dose-Respon | 1994 |
Effect of bupranolol on CGP 12177-induced relaxation and cAMP accumulation in the guinea pig taenia caecum.
Topics: Adrenergic beta-Antagonists; Animals; Bupranolol; Cyclic AMP; Dose-Response Relationship, Drug; Guin | 1995 |
Identification of beta-adrenergic receptor subtypes mediating relaxation in isolated equine ileum.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Binding, Competitive; Cell Membrane; | 1997 |
Functional and molecular biological evidence for a possible beta3-adrenoceptor in the human detrusor muscle.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-1 Receptor Agonists; Adrenergic beta-1 Receptor Antagonis | 1999 |
Atypical beta-adrenoceptors mediating relaxation in the human colon: functional evidence for beta3-rather than beta4-adrenoceptors.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Colon; Ethano | 1999 |
S1319: a novel beta2-andrenoceptor agonist from a marine sponge Dysidea sp.
Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Animals; Benzothiazoles; Binding, Com | 1999 |
Pharmacological analysis of atypical beta-adrenoceptors in the guinea pig gastric fundus using the beta(3)-adrenoceptor antagonist bupranolol.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Atenolol; Bupranolol; Butoxamine; Ca | 1999 |
[Pharmacological analysis of atypical beta-adrenoceptors in the guinea pig gastrointestinal tissue systems].
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Bupranolol; Digestive System; Duoden | 1999 |
Beta3 receptors mediate relaxation in stomach fundus whereas a fourth beta receptor mediates tachycardia in atria from transgenic beta3 receptor knockout mice.
Topics: Adrenergic beta-Agonists; Animals; Atrial Function; Heart Atria; Humans; Mice; Mice, Knockout; Mice, | 2000 |
Contribution of beta-adrenoceptor subtypes to relaxation of colon and oesophagus and pacemaker activity of ureter in wildtype and beta(3)-adrenoceptor knockout mice.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Agon | 2000 |
Functional assessment of beta adrenoceptor subtypes in human colonic circular and longitudinal (taenia coli) smooth muscle.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aged; Colon; Female; Humans; Imidazoles; Isop | 2000 |
Partial agonist activity of carteolol on atypical beta-adrenoceptors in the guinea pig duodenum.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Bupranolol; Carteolol; Dose-Response | 2000 |
Characterization of beta-adrenoceptor subtypes in the ferret urinary bladder in vitro and in vivo.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Anesthesia; Animals; Blood Pressure; Dioxoles | 2000 |
(+/-)-Pindolol acts as a partial agonist at atypical beta-adrenoceptors in the guinea pig duodenum.
Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Recep | 2001 |
Functional identification of beta3-adrenoceptors in the guinea-pig ileum using the non-selective beta-adrenoceptor antagonist (+/-)-bupranolol.
Topics: Adipocytes; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Bupranolol; Catecholamin | 2000 |
Functional properties of atypical beta-adrenoceptors on the guinea pig duodenum.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Alprenolol; Animals; Bupranolol; C | 2001 |
Cyclic AMP-independent relaxation mediated by beta3-adrenoceptors on guinea pig gastrointestine.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals | 2002 |