Page last updated: 2024-10-24

cgp 12177 and Left Ventricular Hypertrophy

cgp 12177 has been researched along with Left Ventricular Hypertrophy in 2 studies

CGP 12177 : A benzimidazole that is benzimidazol-2-one substituted at position 4 by a 3-(tert-butylamino)-2-hydroxypropoxy group.

Research Excerpts

Excerpt	Relevance	Reference
"In secondary left ventricular hypertrophy, beta-adrenoceptor was 6."	1.29	Myocardial beta adrenoceptor density in primary and secondary left ventricular hypertrophy. ( Camici, PG; Choudhury, L; Lefroy, DC; Nihoyannopoulos, P; Oakley, CM; Rosen, SD, 1996)

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (50.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Choudhury, L	1
Rosen, SD	1
Lefroy, DC	1
Nihoyannopoulos, P	1
Oakley, CM	1
Camici, PG	1
León-Velarde, F	1
Bourin, MC	1
Germack, R	1
Mohammadi, K	1
Crozatier, B	1
Richalet, JP	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Exercise Training Following Cardiac Resynchronization Therapy in Patients With Chronic Heart Failure[NCT02413151]				62 participants (Actual)	Interventional	2012-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Changes in 123I-MIBG Cardiac Scintigraphy - Heart-to-mediastinum Ratio (HMR) Early

(NCT02413151)
Timeframe: 6 months after CRT implantation

Intervention	mGy/MBq (Median)
Exercise Training Program	-0.012
Control	-0.04

Changes in 123I-MIBG Cardiac Scintigraphy - Heart-to-mediastinum Ratio (HMR) Late

(NCT02413151)
Timeframe: 6 months after CRT implantation

Intervention	mGy/MBq (Median)
Exercise Training Program	-0.07
Control	-0.02

Changes in 123I-MIBG Cardiac Scintigraphy - Wash Out (WO)

washout provides information on the sympathetic drive. The in-vivo visualization of cardiac innervation is evaluated on planar anterior images, which are acquired early and 3 to 5 hours after tracer injection. (NCT02413151)
Timeframe: 6 months after CRT implantation

Intervention	percent change (Median)
Exercise Training Program	3.56
Control	-3.34

Changes in a Composite Measure of Clinical Status - New York Heart Association Functional Class

"The New York Heart Association (NYHA) Functional Classification provides a simple way of classifying the extent of heart failure. It places patients in one of four categories based on how much they are limited during physical activity; the limitations/symptoms are in regard to normal breathing and varying degrees in shortness of breath and/or angina.~I - Cardiac disease, but no symptoms and no limitation in ordinary physical activity, e.g. no shortness of breath when walking, climbing stairs etc.~II - Mild symptoms (mild shortness of breath and/or angina) and slight limitation during ordinary activity.~III - Marked limitation in activity due to symptoms, even during less-than-ordinary activity, e.g. walking short distances (20-100 m).~Comfortable only at rest. IV - Severe limitations. Experiences symptoms even while at rest. Mostly bedbound patients." (NCT02413151)
Timeframe: 6 months after CRT implantation

Intervention	scores on a scale (Median)
Exercise Training Program	-1.52
Control	-1.0

Changes in a Composite Measure of Quality of Life - HeartQoL T Score

HeartQoL scale response of 0-3 (poor-better), higher scores indicate better quality of life. Maximum score: 42 (better prognosis); Minimum score:0 (poor prognosis) (NCT02413151)
Timeframe: 6 months after CRT implantation

Intervention	t scores (Median)
Exercise Training Program	1.26
Control	0.94

Changes in Cardiac Function - Left Ventricular Ejection Fraction

(NCT02413151)
Timeframe: 6 months after CRT implantation

Intervention	percentage of blood eject (Median)
Exercise Training Program	11.86
Control	10.41

Changes in Exercise Testing Variables - Duration of Cardiopulmonary Testing (CPETduration)

(NCT02413151)
Timeframe: 6 months after CRT implantation

Intervention	seconds (Median)
Exercise Training Program	235.13
Control	24.00

Changes in Exercise Testing Variables - Heart Rate Recovery at 1st Minute (HRR1)

(NCT02413151)
Timeframe: 6 months after CRT implantation

Intervention	bpm (Median)
Exercise Training Program	-2.19
Control	-15.46

Changes in Exercise Testing Variables - Maximum Rate of Oxygen Consumption (VO2peak)

(NCT02413151)
Timeframe: 6 months after CRT implantation

Intervention	ml/kg/min (Median)
Exercise Training Program	2.18
Control	0.25

Changes in Inflammatory Markers - Plasmatic Brain Natriuretic Peptide (BNP)

(NCT02413151)
Timeframe: 6 months after CRT implantation

Intervention	pg/mL (Median)
Exercise Training Program	-67.81
Control	-116.29

Changes in Inflammatory Markers - Plasmatic Tumor Necrotic Factor Alpha (TNF-alpha)

(NCT02413151)
Timeframe: 6 months after CRT implantation

Intervention	µg/ml (Median)
Exercise Training Program	-1.08
Control	0.12

Changes in Peripheral Artery Tonometry - Reactive Hyperemia (RHI)

Reactive hyperaemia index (RHI) is a functional marker of endothelial dysfunction. The RHI was measured using an EndoPAT recorder. (NCT02413151)
Timeframe: 6 months after CRT implantation

Intervention	ratio of the post-to pre occlusion (Median)
Exercise Training Program	1.1
Control	0.20

Other Studies

2 other studies available for cgp 12177 and Left Ventricular Hypertrophy

Article	Year
Myocardial beta adrenoceptor density in primary and secondary left ventricular hypertrophy. European heart journal, 1996, Volume: 17, Issue:11 Topics: Adult; Aged; Aged, 80 and over; Cardiomyopathy, Hypertrophic; Catecholamines; Down-Regulation; Echoc	1996
Differential alterations in cardiac adrenergic signaling in chronic hypoxia or norepinephrine infusion. American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 280, Issue:1 Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Cholera Toxin; Chroni	2001