Page last updated: 2024-10-24

cgp 12177 and Heart Failure

cgp 12177 has been researched along with Heart Failure in 9 studies

CGP 12177 : A benzimidazole that is benzimidazol-2-one substituted at position 4 by a 3-(tert-butylamino)-2-hydroxypropoxy group.

Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"Xamoterol was considerably less effective than isoproterenol in stimulating adenylate cyclase activity but the difference was narrowed by 1 microM forskolin, presumably by inducing more efficient coupling to the catalytic subunit of the enzyme."1.28Effects of xamoterol on the reversible cycling of cardiac beta-adrenoceptors. ( Limas, C; Limas, CJ, 1990)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (33.33)18.2507
2000's4 (44.44)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kiriazis, H1
Tugiono, N1
Xu, Q1
Gao, XM1
Jennings, NL1
Ming, Z1
Su, Y1
Klenowski, P1
Summers, RJ1
Kaumann, A1
Molenaar, P1
Du, XJ1
Gaemperli, O1
Liga, R1
Spyrou, N1
Rosen, SD1
Foale, R1
Kooner, JS1
Rimoldi, OE1
Camici, PG1
Tsukamoto, T1
Morita, K1
Naya, M1
Inubushi, M1
Katoh, C1
Nishijima, K1
Kuge, Y1
Okamoto, H1
Tsutsui, H1
Tamaki, N1
Steinfath, M1
Lavicky, J1
Schmitz, W1
Scholz, H1
Döring, V1
Kalmár, P1
Re, G1
Bergamasco, L1
Badino, P1
Borgarelli, M1
Odore, R1
Tarducci, A1
Zanatta, R1
Girardi, C1
Yonemochi, H1
Yasunaga, S1
Teshima, Y1
Takahashi, N1
Nakagawa, M1
Ito, M1
Saikawa, T1
de Jong, RM1
Blanksma, PK1
van Waarde, A1
van Veldhuisen, DJ1
Schäfers, M1
Riemann, B1
Levkau, B1
Wichter, T1
Schäfers, K1
Kopka, K1
Breithardt, G1
Schober, O1
Limas, CJ1
Limas, C1

Reviews

1 review available for cgp 12177 and Heart Failure

ArticleYear
Measurement of myocardial beta-adrenoceptor density in clinical studies: a role for positron emission tomography?
    European journal of nuclear medicine and molecular imaging, 2002, Volume: 29, Issue:1

    Topics: Carbon Radioisotopes; Heart; Heart Failure; Humans; Myocardial Contraction; Myocardium; Propanolamin

2002

Other Studies

8 other studies available for cgp 12177 and Heart Failure

ArticleYear
Chronic activation of the low affinity site of β1-adrenoceptors stimulates haemodynamics but exacerbates pressure-overload cardiac remodelling.
    British journal of pharmacology, 2013, Volume: 170, Issue:2

    Topics: Adrenergic beta-Antagonists; Animals; Binding Sites; Cardiomegaly; Disease Models, Animal; Disease P

2013
Myocardial beta-adrenoceptor down-regulation early after infarction is associated with long-term incidence of congestive heart failure.
    European heart journal, 2010, Volume: 31, Issue:14

    Topics: Adrenergic beta-Antagonists; Adult; Coronary Circulation; Down-Regulation; Female; Heart; Heart Fail

2010
Decreased myocardial beta-adrenergic receptor density in relation to increased sympathetic tone in patients with nonischemic cardiomyopathy.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2007, Volume: 48, Issue:11

    Topics: 3-Iodobenzylguanidine; Aged; Carbon Radioisotopes; Cardiomyopathies; Female; Heart; Heart Failure; H

2007
Changes in cardiac beta-adrenoceptors in human heart diseases: relationship to the degree of heart failure and further evidence for etiology-related regulation of beta 1 and beta 2 subtypes.
    Journal of cardiothoracic and vascular anesthesia, 1993, Volume: 7, Issue:6

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aortic Valve; Cardiomyopathy, Hypertrophic; Down-Reg

1993
Canine dilated cardiomyopathy: lymphocyte and cardiac alpha(1)- and beta-adrenoceptor concentrations in normal and affected great danes.
    Veterinary journal (London, England : 1997), 1999, Volume: 158, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cardiomyopathy, Dilated; Catecho

1999
Rapid electrical stimulation of contraction reduces the density of beta-adrenergic receptors and responsiveness of cultured neonatal rat cardiomyocytes. Possible involvement of microtubule disassembly secondary to mechanical stress.
    Circulation, 2000, Jun-06, Volume: 101, Issue:22

    Topics: Acetylcholine; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Animals, Newborn; Ant

2000
Current status and future applications of cardiac receptor imaging with positron emission tomography.
    Nuclear medicine communications, 2002, Volume: 23, Issue:2

    Topics: Adrenergic beta-Antagonists; Arteriosclerosis; Carbon Radioisotopes; Heart Failure; Humans; Myocardi

2002
Effects of xamoterol on the reversible cycling of cardiac beta-adrenoceptors.
    Journal of cardiovascular pharmacology, 1990, Volume: 16, Issue:6

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cell-Free System;

1990