cgp 12177 and Glioma
cgp 12177 has been researched along with Glioma in 12 studies
CGP 12177 : A benzimidazole that is benzimidazol-2-one substituted at position 4 by a 3-(tert-butylamino)-2-hydroxypropoxy group.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Agonist treatment of C6-glioma cells induces two altered states in beta-adrenergic receptors, a low affinity for the hydrophilic antagonist CGP-12177 and a low affinity for agonists like isoproterenol." | 3.67 | Evidence for the appearance of an uncoupled form of the beta-adrenergic receptor distinct from the internalized receptor. ( Hertel, C; Portenier, M; Staehelin, M, 1986) |
| "The reappearance of beta-adrenergic receptors in C6-glioma cells after desensitization with isoproterenol was studied using the antagonist [3H]CGP-12177." | 3.66 | Reappearance of beta-adrenergic receptors after isoproterenol treatment in intact C6-cells. ( Hertel, C; Staehelin, M, 1983) |
| " In two cell lines, C6 glioma and WEHI 7 lymphoma cells, -50% of the cell surface receptors disappear within minutes of incubation of the cells with isoproterenol." | 3.66 | Rapid and reversible disappearance of beta-adrenergic cell surface receptors. ( Simons, P; Staehelin, M, 1982) |
| "Isoprenaline treatment of C6-glioma cells induced a fast decrease in the number of beta-adrenergic receptors as determined by binding of [3H]CGP-12177, which paralleled the decrease in the hormonally stimulated adenylate cyclase activity." | 1.27 | Determination of the desensitization of beta-adrenergic receptors by [3H]CGP-12177. ( Hertel, C; Müller, P; Portenier, M; Staehelin, M, 1983) |
Research
Studies (12)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (83.33) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Portenier, M | 4 |
| Hertel, C | 7 |
| Müller, P | 2 |
| Staehelin, M | 9 |
| Simons, P | 2 |
| Jaeggi, K | 2 |
| Wigger, N | 1 |
| Perkins, JP | 1 |
| Bergström, D | 1 |
| Jacobsson, SO | 1 |
| Fowler, CJ | 2 |
| Brännström, G | 1 |
| Volker, TT | 1 |
| Pianet, I | 1 |
| Labouesse, J | 1 |
| Teissié, J | 1 |
| Affolter, H | 1 |
Other Studies
12 other studies available for cgp 12177 and Glioma
| Article | Year |
|---|---|
Some unique properties of CGP-12177.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cyclic AMP; Digitonin; Dihydroalprenolol; Glioma; Isoproteren | 1984 |
CGP-12177. A hydrophilic beta-adrenergic receptor radioligand reveals high affinity binding of agonists to intact cells.
Topics: Adrenergic beta-Antagonists; Animals; Cell Line; Cell Membrane; Erythrocyte Membrane; Glioma; Kineti | 1983 |
[3H]CGP-12177, a beta-adrenergic ligand suitable for measuring cell surface receptors.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cell Membrane; Cells, Cultured; Glio | 1983 |
Reappearance of beta-adrenergic receptors after isoproterenol treatment in intact C6-cells.
Topics: Adrenergic beta-Antagonists; Animals; Cations; Cell Line; Cycloheximide; Glioma; Isoproterenol; Kine | 1983 |
Determination of the desensitization of beta-adrenergic receptors by [3H]CGP-12177.
Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Binding Sites; Binding, Competitive; Cell Line; Cell | 1983 |
Evidence for intravesicular beta-adrenergic receptors in membrane fractions from desensitized cells: binding of the hydrophilic ligand CGP-12177 only in the presence of alamethicin.
Topics: Alamethicin; Animals; Anti-Bacterial Agents; Cells, Cultured; Centrifugation, Density Gradient; Glio | 1983 |
Rapid and reversible disappearance of beta-adrenergic cell surface receptors.
Topics: Animals; Cell Line; Endocytosis; Glioma; Isoproterenol; Lymphoma; Propanolamines; Receptors, Adrener | 1982 |
The effect of hydrogen peroxide upon beta-adrenoceptor density and function in C6 rat glioma cells.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Cell Death; Colforsin; Culture Media, Serum-Fr | 1999 |
Reduction in beta-adrenoceptor density in cultured rat glioma C6 cells after incubation with antidepressants is dependent upon the culturing conditions used.
Topics: Adrenergic beta-Antagonists; Animals; Antidepressive Agents; Cell Division; Desipramine; Glioma; Pro | 1990 |
Signal transduction by membrane receptors in viable electropermeabilized cells: isoproterenol-stimulated cyclic AMP synthesis in C6 glioma cells.
Topics: Adenosine Triphosphate; Adrenergic beta-Antagonists; Animals; Cell Line; Cell Membrane; Cell Membran | 1989 |
(-)-S-[3H]CGP-12177 and its use to determine the rate constants of unlabeled beta-adrenergic antagonists.
Topics: Adrenergic beta-Antagonists; Alprenolol; Animals; Cell Line; Computers; Glioma; Kinetics; Pindolol; | 1985 |
Evidence for the appearance of an uncoupled form of the beta-adrenergic receptor distinct from the internalized receptor.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cell Membrane; Cells, Cultured; Dose | 1986 |