cgp 12177 has been researched along with Glial Cell Tumors in 12 studies
CGP 12177 : A benzimidazole that is benzimidazol-2-one substituted at position 4 by a 3-(tert-butylamino)-2-hydroxypropoxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Agonist treatment of C6-glioma cells induces two altered states in beta-adrenergic receptors, a low affinity for the hydrophilic antagonist CGP-12177 and a low affinity for agonists like isoproterenol." | 3.67 | Evidence for the appearance of an uncoupled form of the beta-adrenergic receptor distinct from the internalized receptor. ( Hertel, C; Portenier, M; Staehelin, M, 1986) |
| "The reappearance of beta-adrenergic receptors in C6-glioma cells after desensitization with isoproterenol was studied using the antagonist [3H]CGP-12177." | 3.66 | Reappearance of beta-adrenergic receptors after isoproterenol treatment in intact C6-cells. ( Hertel, C; Staehelin, M, 1983) |
| " In two cell lines, C6 glioma and WEHI 7 lymphoma cells, -50% of the cell surface receptors disappear within minutes of incubation of the cells with isoproterenol." | 3.66 | Rapid and reversible disappearance of beta-adrenergic cell surface receptors. ( Simons, P; Staehelin, M, 1982) |
| "Isoprenaline treatment of C6-glioma cells induced a fast decrease in the number of beta-adrenergic receptors as determined by binding of [3H]CGP-12177, which paralleled the decrease in the hormonally stimulated adenylate cyclase activity." | 1.27 | Determination of the desensitization of beta-adrenergic receptors by [3H]CGP-12177. ( Hertel, C; Müller, P; Portenier, M; Staehelin, M, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (83.33) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Portenier, M | 4 |
| Hertel, C | 7 |
| Müller, P | 2 |
| Staehelin, M | 9 |
| Simons, P | 2 |
| Jaeggi, K | 2 |
| Wigger, N | 1 |
| Perkins, JP | 1 |
| Bergström, D | 1 |
| Jacobsson, SO | 1 |
| Fowler, CJ | 2 |
| Brännström, G | 1 |
| Volker, TT | 1 |
| Pianet, I | 1 |
| Labouesse, J | 1 |
| Teissié, J | 1 |
| Affolter, H | 1 |
12 other studies available for cgp 12177 and Glial Cell Tumors
| Article | Year |
|---|---|
Some unique properties of CGP-12177.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cyclic AMP; Digitonin; Dihydroalprenolol; Glioma; Isoproteren | 1984 |
CGP-12177. A hydrophilic beta-adrenergic receptor radioligand reveals high affinity binding of agonists to intact cells.
Topics: Adrenergic beta-Antagonists; Animals; Cell Line; Cell Membrane; Erythrocyte Membrane; Glioma; Kineti | 1983 |
[3H]CGP-12177, a beta-adrenergic ligand suitable for measuring cell surface receptors.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cell Membrane; Cells, Cultured; Glio | 1983 |
Reappearance of beta-adrenergic receptors after isoproterenol treatment in intact C6-cells.
Topics: Adrenergic beta-Antagonists; Animals; Cations; Cell Line; Cycloheximide; Glioma; Isoproterenol; Kine | 1983 |
Determination of the desensitization of beta-adrenergic receptors by [3H]CGP-12177.
Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Binding Sites; Binding, Competitive; Cell Line; Cell | 1983 |
Evidence for intravesicular beta-adrenergic receptors in membrane fractions from desensitized cells: binding of the hydrophilic ligand CGP-12177 only in the presence of alamethicin.
Topics: Alamethicin; Animals; Anti-Bacterial Agents; Cells, Cultured; Centrifugation, Density Gradient; Glio | 1983 |
Rapid and reversible disappearance of beta-adrenergic cell surface receptors.
Topics: Animals; Cell Line; Endocytosis; Glioma; Isoproterenol; Lymphoma; Propanolamines; Receptors, Adrener | 1982 |
The effect of hydrogen peroxide upon beta-adrenoceptor density and function in C6 rat glioma cells.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Cell Death; Colforsin; Culture Media, Serum-Fr | 1999 |
Reduction in beta-adrenoceptor density in cultured rat glioma C6 cells after incubation with antidepressants is dependent upon the culturing conditions used.
Topics: Adrenergic beta-Antagonists; Animals; Antidepressive Agents; Cell Division; Desipramine; Glioma; Pro | 1990 |
Signal transduction by membrane receptors in viable electropermeabilized cells: isoproterenol-stimulated cyclic AMP synthesis in C6 glioma cells.
Topics: Adenosine Triphosphate; Adrenergic beta-Antagonists; Animals; Cell Line; Cell Membrane; Cell Membran | 1989 |
(-)-S-[3H]CGP-12177 and its use to determine the rate constants of unlabeled beta-adrenergic antagonists.
Topics: Adrenergic beta-Antagonists; Alprenolol; Animals; Cell Line; Computers; Glioma; Kinetics; Pindolol; | 1985 |
Evidence for the appearance of an uncoupled form of the beta-adrenergic receptor distinct from the internalized receptor.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cell Membrane; Cells, Cultured; Dose | 1986 |