cgp 12177 has been researched along with Cardiomyopathy, Hypertrophic Obstructive in 3 studies
CGP 12177 : A benzimidazole that is benzimidazol-2-one substituted at position 4 by a 3-(tert-butylamino)-2-hydroxypropoxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In secondary left ventricular hypertrophy, beta-adrenoceptor was 6." | 1.29 | Myocardial beta adrenoceptor density in primary and secondary left ventricular hypertrophy. ( Camici, PG; Choudhury, L; Lefroy, DC; Nihoyannopoulos, P; Oakley, CM; Rosen, SD, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Steinfath, M | 1 |
| Lavicky, J | 1 |
| Schmitz, W | 1 |
| Scholz, H | 1 |
| Döring, V | 1 |
| Kalmár, P | 1 |
| Choudhury, L | 1 |
| Rosen, SD | 2 |
| Lefroy, DC | 1 |
| Nihoyannopoulos, P | 1 |
| Oakley, CM | 1 |
| Camici, PG | 2 |
| de Jong, RM | 1 |
| Rhodes, CG | 1 |
| Anthonio, RL | 1 |
| Willemsen, AT | 1 |
| Blanksma, PK | 1 |
| Lammertsma, AA | 1 |
| Vaalburg, W | 1 |
| Crijns, HJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Exercise Training Following Cardiac Resynchronization Therapy in Patients With Chronic Heart Failure[NCT02413151] | 62 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT02413151)
Timeframe: 6 months after CRT implantation
| Intervention | mGy/MBq (Median) |
|---|---|
| Exercise Training Program | -0.012 |
| Control | -0.04 |
(NCT02413151)
Timeframe: 6 months after CRT implantation
| Intervention | mGy/MBq (Median) |
|---|---|
| Exercise Training Program | -0.07 |
| Control | -0.02 |
washout provides information on the sympathetic drive. The in-vivo visualization of cardiac innervation is evaluated on planar anterior images, which are acquired early and 3 to 5 hours after tracer injection. (NCT02413151)
Timeframe: 6 months after CRT implantation
| Intervention | percent change (Median) |
|---|---|
| Exercise Training Program | 3.56 |
| Control | -3.34 |
"The New York Heart Association (NYHA) Functional Classification provides a simple way of classifying the extent of heart failure. It places patients in one of four categories based on how much they are limited during physical activity; the limitations/symptoms are in regard to normal breathing and varying degrees in shortness of breath and/or angina.~I - Cardiac disease, but no symptoms and no limitation in ordinary physical activity, e.g. no shortness of breath when walking, climbing stairs etc.~II - Mild symptoms (mild shortness of breath and/or angina) and slight limitation during ordinary activity.~III - Marked limitation in activity due to symptoms, even during less-than-ordinary activity, e.g. walking short distances (20-100 m).~Comfortable only at rest. IV - Severe limitations. Experiences symptoms even while at rest. Mostly bedbound patients." (NCT02413151)
Timeframe: 6 months after CRT implantation
| Intervention | scores on a scale (Median) |
|---|---|
| Exercise Training Program | -1.52 |
| Control | -1.0 |
HeartQoL scale response of 0-3 (poor-better), higher scores indicate better quality of life. Maximum score: 42 (better prognosis); Minimum score:0 (poor prognosis) (NCT02413151)
Timeframe: 6 months after CRT implantation
| Intervention | t scores (Median) |
|---|---|
| Exercise Training Program | 1.26 |
| Control | 0.94 |
(NCT02413151)
Timeframe: 6 months after CRT implantation
| Intervention | percentage of blood eject (Median) |
|---|---|
| Exercise Training Program | 11.86 |
| Control | 10.41 |
(NCT02413151)
Timeframe: 6 months after CRT implantation
| Intervention | seconds (Median) |
|---|---|
| Exercise Training Program | 235.13 |
| Control | 24.00 |
(NCT02413151)
Timeframe: 6 months after CRT implantation
| Intervention | bpm (Median) |
|---|---|
| Exercise Training Program | -2.19 |
| Control | -15.46 |
(NCT02413151)
Timeframe: 6 months after CRT implantation
| Intervention | ml/kg/min (Median) |
|---|---|
| Exercise Training Program | 2.18 |
| Control | 0.25 |
(NCT02413151)
Timeframe: 6 months after CRT implantation
| Intervention | pg/mL (Median) |
|---|---|
| Exercise Training Program | -67.81 |
| Control | -116.29 |
(NCT02413151)
Timeframe: 6 months after CRT implantation
| Intervention | µg/ml (Median) |
|---|---|
| Exercise Training Program | -1.08 |
| Control | 0.12 |
Reactive hyperaemia index (RHI) is a functional marker of endothelial dysfunction. The RHI was measured using an EndoPAT recorder. (NCT02413151)
Timeframe: 6 months after CRT implantation
| Intervention | ratio of the post-to pre occlusion (Median) |
|---|---|
| Exercise Training Program | 1.1 |
| Control | 0.20 |
3 other studies available for cgp 12177 and Cardiomyopathy, Hypertrophic Obstructive
| Article | Year |
|---|---|
Changes in cardiac beta-adrenoceptors in human heart diseases: relationship to the degree of heart failure and further evidence for etiology-related regulation of beta 1 and beta 2 subtypes.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aortic Valve; Cardiomyopathy, Hypertrophic; Down-Reg | 1993 |
Myocardial beta adrenoceptor density in primary and secondary left ventricular hypertrophy.
Topics: Adult; Aged; Aged, 80 and over; Cardiomyopathy, Hypertrophic; Catecholamines; Down-Regulation; Echoc | 1996 |
Parametric polar maps of regional myocardial beta-adrenoceptor density.
Topics: Adrenergic beta-Antagonists; Carbon Radioisotopes; Cardiomyopathy, Hypertrophic; Case-Control Studie | 1999 |