Page last updated: 2024-10-24

cgp 12177 and Cardiomyopathy, Dilated

cgp 12177 has been researched along with Cardiomyopathy, Dilated in 4 studies

CGP 12177 : A benzimidazole that is benzimidazol-2-one substituted at position 4 by a 3-(tert-butylamino)-2-hydroxypropoxy group.

Cardiomyopathy, Dilated: A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (75.00)	18.2507
2000's	1 (25.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Naya, M	1
Tsukamoto, T	1
Morita, K	1
Katoh, C	1
Nishijima, K	1
Komatsu, H	1
Yamada, S	1
Kuge, Y	1
Tamaki, N	1
Tsutsui, H	1
Merlet, P	1
Delforge, J	1
Syrota, A	1
Angevin, E	1
Mazière, B	1
Crouzel, C	1
Valette, H	1
Loisance, D	1
Castaigne, A	1
Randé, JL	1
Saffitz, JE	1
Beau, SL	1
Re, G	1
Bergamasco, L	1
Badino, P	1
Borgarelli, M	1
Odore, R	1
Tarducci, A	1
Zanatta, R	1
Girardi, C	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Exercise Training Following Cardiac Resynchronization Therapy in Patients With Chronic Heart Failure[NCT02413151]				62 participants (Actual)	Interventional	2012-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Changes in 123I-MIBG Cardiac Scintigraphy - Heart-to-mediastinum Ratio (HMR) Early

(NCT02413151)
Timeframe: 6 months after CRT implantation

Intervention	mGy/MBq (Median)
Exercise Training Program	-0.012
Control	-0.04

Changes in 123I-MIBG Cardiac Scintigraphy - Heart-to-mediastinum Ratio (HMR) Late

(NCT02413151)
Timeframe: 6 months after CRT implantation

Intervention	mGy/MBq (Median)
Exercise Training Program	-0.07
Control	-0.02

Changes in 123I-MIBG Cardiac Scintigraphy - Wash Out (WO)

washout provides information on the sympathetic drive. The in-vivo visualization of cardiac innervation is evaluated on planar anterior images, which are acquired early and 3 to 5 hours after tracer injection. (NCT02413151)
Timeframe: 6 months after CRT implantation

Intervention	percent change (Median)
Exercise Training Program	3.56
Control	-3.34

Changes in a Composite Measure of Clinical Status - New York Heart Association Functional Class

"The New York Heart Association (NYHA) Functional Classification provides a simple way of classifying the extent of heart failure. It places patients in one of four categories based on how much they are limited during physical activity; the limitations/symptoms are in regard to normal breathing and varying degrees in shortness of breath and/or angina.~I - Cardiac disease, but no symptoms and no limitation in ordinary physical activity, e.g. no shortness of breath when walking, climbing stairs etc.~II - Mild symptoms (mild shortness of breath and/or angina) and slight limitation during ordinary activity.~III - Marked limitation in activity due to symptoms, even during less-than-ordinary activity, e.g. walking short distances (20-100 m).~Comfortable only at rest. IV - Severe limitations. Experiences symptoms even while at rest. Mostly bedbound patients." (NCT02413151)
Timeframe: 6 months after CRT implantation

Intervention	scores on a scale (Median)
Exercise Training Program	-1.52
Control	-1.0

Changes in a Composite Measure of Quality of Life - HeartQoL T Score

HeartQoL scale response of 0-3 (poor-better), higher scores indicate better quality of life. Maximum score: 42 (better prognosis); Minimum score:0 (poor prognosis) (NCT02413151)
Timeframe: 6 months after CRT implantation

Intervention	t scores (Median)
Exercise Training Program	1.26
Control	0.94

Changes in Cardiac Function - Left Ventricular Ejection Fraction

(NCT02413151)
Timeframe: 6 months after CRT implantation

Intervention	percentage of blood eject (Median)
Exercise Training Program	11.86
Control	10.41

Changes in Exercise Testing Variables - Duration of Cardiopulmonary Testing (CPETduration)

(NCT02413151)
Timeframe: 6 months after CRT implantation

Intervention	seconds (Median)
Exercise Training Program	235.13
Control	24.00

Changes in Exercise Testing Variables - Heart Rate Recovery at 1st Minute (HRR1)

(NCT02413151)
Timeframe: 6 months after CRT implantation

Intervention	bpm (Median)
Exercise Training Program	-2.19
Control	-15.46

Changes in Exercise Testing Variables - Maximum Rate of Oxygen Consumption (VO2peak)

(NCT02413151)
Timeframe: 6 months after CRT implantation

Intervention	ml/kg/min (Median)
Exercise Training Program	2.18
Control	0.25

Changes in Inflammatory Markers - Plasmatic Brain Natriuretic Peptide (BNP)

(NCT02413151)
Timeframe: 6 months after CRT implantation

Intervention	pg/mL (Median)
Exercise Training Program	-67.81
Control	-116.29

Changes in Inflammatory Markers - Plasmatic Tumor Necrotic Factor Alpha (TNF-alpha)

(NCT02413151)
Timeframe: 6 months after CRT implantation

Intervention	µg/ml (Median)
Exercise Training Program	-1.08
Control	0.12

Changes in Peripheral Artery Tonometry - Reactive Hyperemia (RHI)

Reactive hyperaemia index (RHI) is a functional marker of endothelial dysfunction. The RHI was measured using an EndoPAT recorder. (NCT02413151)
Timeframe: 6 months after CRT implantation

Intervention	ratio of the post-to pre occlusion (Median)
Exercise Training Program	1.1
Control	0.20

Other Studies

4 other studies available for cgp 12177 and Cardiomyopathy, Dilated

Article	Year
Myocardial beta-adrenergic receptor density assessed by 11C-CGP12177 PET predicts improvement of cardiac function after carvedilol treatment in patients with idiopathic dilated cardiomyopathy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2009, Volume: 50, Issue:2 Topics: Adrenergic beta-Antagonists; Aged; Carbazoles; Carbon Radioisotopes; Cardiomyopathy, Dilated; Carved	2009
Positron emission tomography with 11C CGP-12177 to assess beta-adrenergic receptor concentration in idiopathic dilated cardiomyopathy. Circulation, 1993, Volume: 87, Issue:4 Topics: Adrenergic beta-Antagonists; Carbon Radioisotopes; Cardiomyopathy, Dilated; Dobutamine; Female; Hear	1993
Noninvasive quantification of myocardial beta-adrenergic receptors. A first step. Circulation, 1993, Volume: 87, Issue:4 Topics: Adrenergic beta-Antagonists; Cardiomyopathy, Dilated; Heart; Humans; Myocardium; Propanolamines; Rec	1993
Canine dilated cardiomyopathy: lymphocyte and cardiac alpha(1)- and beta-adrenoceptor concentrations in normal and affected great danes. Veterinary journal (London, England : 1997), 1999, Volume: 158, Issue:2 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cardiomyopathy, Dilated; Catecho	1999